Article
Plant Sciences
Xingwei Wang, Yanfei Hu, Wei Wang
Summary: This study compares the circadian characteristics of Arabidopsis and soybean, revealing notable differences and contrasting biological activities under circadian regulation.
Article
Biochemistry & Molecular Biology
Yi Ren, Yike Gao, Qixiang Zhang
Summary: In this study, the regulatory mechanisms of different flower opening times (FOTs) in two types of Hemerocallis were explored through transcriptome sequencing. The results showed an increase in genes related to photosynthetic metabolism, light and hormone signal transmission sensitivity after entering reproductive growth. Differential expression genes between the two Hemerocallis groups were related to environmental response and photosynthesis pathways. Twenty-three key circadian clock genes were identified, which may closely relate to FOTs in Hemerocallis.
Article
Plant Sciences
Liangyu Guo, Zhiming Xu, Shuo Wang, Yuqi Nie, Xiaoxue Ye, Xuejiao Jin, Jianhua Zhu, Wenwu Wu
Summary: This study investigates the regulatory networks involved in cold responses in three different species of rosids. It demonstrates that some transcription factors and RNA-binding proteins are conserved in the cold response across rosids, and it reveals a hierarchical regulation of differentially expressed genes and alternative splicing genes. The study also identifies a common enrichment related to circadian rhythm in the cold response pathways in all three studied species.
PHYSIOLOGIA PLANTARUM
(2023)
Article
Veterinary Sciences
Dengke Gao, Hongcong Zhao, Hao Dong, Yating Li, Jing Zhang, Haisen Zhang, Yu Zhang, Haizhen Jiang, Xiaoyu Wang, Aihua Wang, Yaping Jin, Huatao Chen
Summary: In this study, the circadian clock system in goats was investigated using goat embryonic fibroblasts (GEFs) as a cell model. The results showed that the expression of clock genes and clock-controlled genes exhibited rhythmic changes in GEFs after dexamethasone stimulation, and the protein levels of gBMAL1 and gNR1D1 also showed circadian rhythmic changes. The study further revealed that the transcriptional and translational loops of the circadian clock system were conserved in goats, but the robustness was not as strong as in mice.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Plant Sciences
Luis Cervela-Cardona, Benjamin Alary, Paloma Mas
Summary: A fundamental principle shared by all organisms is the conversion of nutrients into energy, requiring precise spatiotemporal programming. Cellular metabolism can adapt to external time, relying on the circadian clock. The circadian clock plays a prevalent role in controlling the timing of mitochondrial activity and cellular energy in Arabidopsis thaliana, with evidence showing metabolic signals can feedback to the clock.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Hang Zhao, Di Xu, Tian Tian, Fanying Kong, Ke Lin, Shuo Gan, Haisen Zhang, Gang Li
Summary: ELF3 and ELF4 are key negative regulators in plant circadian clock control, forming complexes to repress the transcription of multiple clock-related genes, affecting growth and flowering. They are also involved in thermomorphogenesis and shade responses, and form complexes with other proteins for transcriptional repression.
Article
Plant Sciences
Takahiro N. Uehara, Saori Takao, Hiromi Matsuo, Ami N. Saito, Eisuke Ota, Azusa Ono, Kenichiro Itami, Toshinori Kinoshita, Takafumi Yamashino, Junichiro Yamaguchi, Norihito Nakamichi
Summary: A novel synthetic small molecule called TU-892 has been found to affect the amount of PRR7 protein, leading to lengthening of the circadian clock period in plants. The study showed that TU-892 treatment upregulates the expression of CCA1 gene and reduces the amount of PRR7 protein. This novel clock modulator provides new tools and avenues for studying the circadian clock in plants.
PLANT AND CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hiroshi Takagi, Andrew K. Hempton, Takato Imaizumi
Summary: The timing of flowering is important for sexual reproduction, crop yield, biomass and lifespan. The mechanisms of flowering are conserved in angiosperms, and understanding the regulation of the FLOWERING LOCUS T (FT) gene is crucial. Many transcriptional regulators influence FT expression, but the coordination of their control on the spatiotemporal expression patterns of FT requires further investigation.
PLANT COMMUNICATIONS
(2023)
Review
Plant Sciences
Hang Xu, Xiling Wang, Jian Wei, Yi Zuo, Lei Wang
Summary: Global climatic change poses an increasing threat to plant adaptation and crop yields. The plant circadian clock plays a crucial role in synchronizing internal biological processes with external environmental cues, thereby benefiting plant adaptation and yield. This review focuses on the interaction between the plant circadian clock and environmental factors, summarizing recent progress on how the circadian clock affects crop yield. Additionally, potential strategies for utilizing circadian biology in crop production are proposed.
Article
Nutrition & Dietetics
Farnaz Roshanmehr, Yu Tahara, Saneyuki Makino, Ayako Tada, Nanako Abe, Mikiko Michie, Shigenobu Shibata
Summary: This study found that consuming a Japanese-style breakfast is not only associated with morning preference but also with a high intake of macro- and micronutrients. On the other hand, having a cereal-style breakfast is significantly associated with late wake-up time.
Article
Plant Sciences
Yongtao Yu, Sergi Portoles, Yi Ren, Guangyu Sun, Xiao-Fang Wang, Huihui Zhang, Shaogui Guo
Summary: The F-box protein ZEITLUPE (ZTL) negatively regulates ABA signaling in Arabidopsis thaliana during early seedling growth and stomatal closure induced by ABA. ZTL interacts with and ubiquitinates its substrate CHLH/ABAR to modulate CHLH stability. ABA induces ZTL phosphorylation and CHLH degradation, suggesting a reciprocal regulation mechanism between ABA signaling and the circadian clock.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biology
Pei Li, Huaqiang Cheng, Vikash Kumar, Cecylia Severin Lupala, Xuanxuan Li, Yingchen Shi, Chongjun Ma, Keehyoung Joo, Jooyoung Lee, Haiguang Liu, Yan-Wen Tan
Summary: This study explores the potential link between conformational changes in the carboxyl-terminal extension of cryptochrome and its downstream signaling functions. The researchers directly observe the displacement of the carboxyl-terminal extension upon blue light excitation and propose possible structures of full-length cryptochrome. These structures provide a molecular basis for understanding the light-induced changes in cryptochrome and its regulatory functions.
COMMUNICATIONS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sara M. Ortega-Campos, Eva M. Verdugo-Sivianes, Ana Amiama-Roig, Jose R. Blanco, Amancio Carnero
Summary: The molecular machinery of the circadian clock regulates gene expression and cellular activities to adapt to daily light-dark cycles. Disruption of the circadian rhythm is an independent risk factor for cancer and circadian genes may play dual roles as tumor suppressors and oncogenes. Understanding the molecular basis of the circadian clock can help identify new markers and targets for cancer prognosis and therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Plant Sciences
Satoshi Kidokoro, Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki
Summary: Recent studies have revealed the complexity and flexibility of the transcriptional regulatory network involved in cold-stress responses, highlighting the close association with other signaling pathways. How plants sense and transmit cold-stress signals to regulate gene expression remains unknown.
TRENDS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Mitsuhiko Muroya, Haruka Oshima, Shoko Kobayashi, Aya Miura, Yohei Miyamura, Hajime Shiota, Kiyoshi Onai, Masahiro Ishiura, Katsushi Manabe, Shinsuke Kutsuna
Summary: This study revealed that plant flower movements are regulated by the circadian clock, with wild-type flowers exhibiting regular opening and closing patterns, while mutant flowers show different closing speeds. Flower closing is controlled by the clock, while the opening process may also be influenced by other light-sensing pathways.
PLANT AND CELL PHYSIOLOGY
(2021)
Article
Hematology
Katherine J. Kearney, Nikoletta Pechlivani, Rhodri King, Christian Tiede, Fladia Phoenix, Ramsah Cheah, Fraser L. Macrae, Katie J. Simmons, Iain W. Manfield, Kerrie A. Smith, Benjamin E. J. Spurgeon, Khalid M. Naseem, Robert A. S. Ariens, Michael J. McPherson, Darren C. Tomlinson, Ramzi A. Ajjan
Article
Multidisciplinary Sciences
Sally Adams, Prachi Pathak, Hongguang Shao, James B. Lok, Andre Pires-daSilva
SCIENTIFIC REPORTS
(2019)
Article
Genetics & Heredity
Sophie Tandonnet, Georgios D. Koutsovoulos, Sally Adams, Delphine Cloarec, Manish Parihar, Mark L. Blaxter, Andre Pires-daSilva
G3-GENES GENOMES GENETICS
(2019)
Article
Biochemistry & Molecular Biology
Claire E. L. Smith, Laura L. E. Whitehouse, James A. Poulter, Laura Wilkinson Hewitt, Fatima Nadat, Brian R. Jackson, Iain W. Manfield, Thomas A. Edwards, Helen D. Rodd, Chris F. Inglehearn, Alan J. Mighell
HUMAN MOLECULAR GENETICS
(2020)
Review
Virology
Matthew J. Burke, Peter G. Stockley, Joan Boyes
Article
Hematology
Rui-Gang Xu, Julia S. Gauer, Stephen R. Baker, Alexandre Slater, Eleyna M. Martin, Helen R. McPherson, Cedric Duval, Iain W. Manfield, Arkadiusz M. Bonna, Steve P. Watson, Robert A. S. Ariens
Summary: The study demonstrates that dimeric GPVI binds to fibrinogen with higher affinity compared to the monomer, primarily through avidity effects. The interaction of GPVI with the α C-region of fibrinogen is crucial for its binding. These findings suggest that clustering of GPVI through the α C-region during fibrin polymerization may lead to downstream signaling, platelet activation, and clot growth.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Neurosciences
Guoliang Chai, Alice Webb, Chen Li, Danny Antaki, Sangmoon Lee, Martin W. Breuss, Nhi Lang, Valentina Stanley, Paula Anzenberg, Xiaoxu Yang, Trevor Marshall, Patrick Gaffney, Klaas J. Wierenga, Brian Hon-Yin Chung, Mandy Ho-Yin Tsang, Lynn S. Pais, Alysia Kern Lovgren, Grace E. VanNoy, Heidi L. Rehm, Ghayda Mirzaa, Eyby Leon, Jullianne Diaz, Alexander Neumann, Arnout P. Kalverda, Iain W. Manfield, David A. Parry, Clare Logan, Colin A. Johnson, David T. Bonthron, Elizabeth M. A. Valleley, Mahmoud Y. Issa, Sherif F. Abdel-Ghafar, Mohamed S. Abdel-Hamid, Patricia Jennings, Maha S. Zaki, Eamonn Sheridan, Joseph G. Gleeson
Summary: A new mechanism involving disrupted splicing integrity and major spliceosome-opathies has been identified as a cause of PCHM and neurodegeneration, shedding light on the non-enzymatic function of a spliceosomal proline isomerase.
Article
Virology
Farzad Fatehi, Richard J. Bingham, Eric C. Dykeman, Nikesh Patel, Peter G. Stockley, Reidun Twarock
Summary: This study presents a comprehensive model of intracellular HBV infection dynamics, revealing previously unsuspected kinetic behavior in the formation of sub-viral particles and the effectiveness of combination therapies with multiple capsid assembly inhibitors.
Article
Multidisciplinary Sciences
F. Fatehi, R. J. Bingham, E. C. Dykeman, P. G. Stockley, R. Twarock
Summary: Within-host models of COVID-19 infection dynamics were used to assess different forms of antiviral therapy in individual patients. The study revealed that combining antiviral and convalescent plasma therapy can effectively reduce the length of infection, but these synergistic effects decline with delayed treatment initiation. Early treatment with either therapy alone may actually prolong the duration of infection, suggesting careful control of these treatments in a clinical setting.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Plant Sciences
Mingkee Achom, Proyash Roy, Beatriz Lagunas, Emma Picot, Luke Richards, Roxanna Bonyadi-Pour, Alonso J. Pardal, Laura Baxter, Bethany L. Richmond, Nadine Aschauer, Eleanor M. Fletcher, Monique Rowson, Joseph Blackwell, Charlotte Rich-Griffin, Kirankumar S. Mysore, Jiangqi Wen, Sascha Ott, Isabelle A. Carre, Miriam L. Gifford
Summary: A nodule circadian clock coordinates metabolic and regulatory activity during symbiosis by involving the gene Late Elongated Hypocotyl and rhythmic expression of nodule-specific cysteine-rich peptides. The rhythmic expression of these peptides may play a vital role in temporal coordination between bacterial activity and the rhythms of the plant host.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biology
Nikesh Patel, Sam Clark, Eva U. Weiss, Carlos P. Mata, Jen Bohon, Erik R. Farquhar, Daniel P. Maskell, Neil A. Ranson, Reidun Twarock, Peter G. Stockley
Summary: The study investigated the roles of RNA sequence/structure motifs and Packaging Signals (PSs) in regulating assembly of an HBV genome transcript, revealing their crucial importance for correct assembly of core protein and RNA, and suggesting potential similar roles in vivo in coordination with other molecular factors.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yong Xu, Roberto Maya-Martinez, Nicolas Guthertz, George R. Heath, Iain W. Manfield, Alexander L. Breeze, Frank Sobott, Richard Foster, Sheena E. Radford
Summary: This study applied chemical kinetics to investigate the assembly mechanism of hIAPP and discovered two small-molecule modulators that can regulate hIAPP assembly, which can serve as promising starting-points for research on hIAPP aggregation and the development of therapeutics for T2D.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Amy Newman, Emma Picot, Sian Davies, Sally Hilton, Isabelle A. Carre, Gary D. Bending
Summary: Aberrant function of plant circadian clock can lead to altered rhythmicity of rhizosphere bacteria and fungi, resulting in changes in the composition of rhizosphere microbiome with potential consequences for plant health.
Article
Biochemistry & Molecular Biology
Matthew J. Burke, James N. F. Scott, Thomas C. Minshull, Zeqian Gao, Iain Manfield, Sinisa Savic, Peter G. Stockley, Antonio N. Calabrese, Joan Boyes
Summary: Broadly reactive bovine antibodies with ultralong CDRH3s can neutralize different variants of Sarbecovirus by recognizing the vulnerable site of the virus. This discovery demonstrates the potential of using bovine antibodies as antiviral therapeutics and for vaccine development.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Plant Sciences
Elizabeth Sands, Sian Davies, Richard John Puxty, Valerie Verge, Francois-Yves Bouget, David John Scanlan, Isabelle Alice Carre
Summary: This study investigates the physiological changes of phytoplankton in response to variations in light quality, and identifies different responses between two ecotypes. Different light quality environments may drive different patterns of adaptation and environmental niche partitioning.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)