Article
Cell Biology
Won Hoon Choi, Yejin Yun, Insuk Byun, Sumin Kim, Seho Lee, Jiho Sim, Shahar Levi, Seo Hyeong Park, Jeongmoo Jun, Oded Kleifeld, Kwang Pyo Kim, Dohyun Han, Tomoki Chiba, Chaok Seok, Yong Tae Kwon, Michael H. Glickman, Min Jae Lee
Summary: It is found that glucose starvation can dissociate 26S proteasomes into 20S and 19S subcomplexes. ECPAS is shown to mediate this structural remodeling process. Loss of ECPAS reduces 26S dissociation and leads to decreased degradation of 20S proteasome substrates.
Article
Cell Biology
Yingge Li, Xiaoya Zhou, Chen Cheng, Guangming Ding, Peng Zhao, Kai Tan, Lixia Chen, Norbert Perrimon, Jan A. Veenstra, Luoying Zhang, Wei Song
Summary: Severe sleep deprivation is associated with systemic energy wasting, and in this study, it was found that the gut-peptide hormone AstA plays an essential role in mediating this energy wasting. AstA promotes the release of the adipokinetic hormone Akh, which mobilizes systemic energy reserves. This regulation of energy metabolism by AstA was observed in both flies and mice, and the molecular mechanisms involved were also elucidated.
Article
Biochemistry & Molecular Biology
Andrea Sanchez-Navarro, Adrian Rafael Murillo-de-Ozores, Rosalba Perez-Villalva, Nadyeli Linares, Hector Carbajal-Contreras, Maria Elena Flores, Gerardo Gamba, Maria Castaneda-Bueno, Norma A. Bobadilla
Summary: This study demonstrates the relocation of serpinA3c/k to the apical tubular membrane in chronic kidney disease and its increased secretion during cellular stress. Atypical urinary excretion of serpinA3c/k was also observed in acute kidney injury, suggesting its potential as a biomarker for AKI.
Article
Endocrinology & Metabolism
Danilo A. Moraes, Ricardo B. Machado, Michael Koban, Gloria E. Hoffman, Deborah Suchecki
Summary: This study compared the stress responses of animals exposed to different stressors to those of animals subjected to paradoxical sleep deprivation (PSD). The results showed that the pituitary-adrenal response to PSD was similar to that induced by psychological stress.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaofeng Jiang, Michael R. MacArthur, J. Humberto Trevino-Villarreal, Peter Kip, C. Keith Ozaki, Sarah J. Mitchell, James R. Mitchell
Summary: The study revealed that DNA damage can elevate intracellular H2S levels by upregulating autophagy and H2S-generating enzyme CGL. Furthermore, exogenous H2S intervention can partially alleviate genotoxic stress in autophagy-deficient cells.
CELL CHEMICAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Jian Zhou, Qiang Li, Zhipeng Huang, Lu Zhang, Chengyan Mou, Zhongmeng Zhao, Han Zhao, Jun Du, Xiaojun Yang, Xufang Liang, Yuanliang Duan
Summary: Environmental factors, specifically light intensity, have a significant impact on the feeding behavior, stress response, and digestive capacity of Siniperca chuatsi. Under weak light conditions, S. chuatsi is more likely to consume compound feed and show lower stress levels, while higher light intensity increases the digestive capacity in stomach tissues. The results suggest that appropriate light intensity can enhance the adaptation and successful domestication of S. chuatsi.
Article
Multidisciplinary Sciences
Liam C. Hunt, Vishwajeeth Pagala, Anna Stephan, Boer Xie, Kiran Kodali, Kanisha Kavdia, Yong-Dong Wang, Abbas Shirinifard, Michelle Curley, Flavia A. Graca, Yingxue Fu, Suresh Poudel, Yuxin Li, Xusheng Wang, Haiyan Tan, Junmin Peng, Fabio Demontis
Summary: This study investigates the effects of decreased ubiquitination on cellular processes and organelle adaptations. The researchers identified a compensatory upregulation of other proteins in response to decreased ubiquitination, which helps maintain protein import in organelles.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yanxing Ma, Hainan Tian, Rao Lin, Wei Wang, Na Zhang, Saddam Hussain, Wenting Yang, Chen Zhang, Ganghua Zhou, Tianya Wang, Shucai Wang
Summary: The expression of stress response genes is regulated by ABA dependent and ABA independent pathways. A novel transcription factor, DRG, has been identified as a regulator of ABA response in Arabidopsis, with its homologs, AITRL, functioning as transcription repressors and affecting the ABA response of some ABA signaling component genes. The AITRLs are evolutionally conserved in embryophytes and play a role in modulating ABA responses in plants.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Xiaojian Gao, Zirui Zhang, Qieqi Qian, Qiyun Chen, Shuwen Gu, Jie Li, Yingjie Zhang, Congcong Wu, Qun Jiang, Xiaojun Zhang
Summary: Non-O1/O139 Vibrio cholerae can survive under starvation stress for a long period of time and cause disease by altering cell structure, upregulating stress resistance-related genes, and downregulating flagellum assembly-related genes. This knowledge can contribute to the development of intervention strategies for controlling non-O1/O139 V. cholerae infection in aquaculture.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Chao Jiang, Miao Mei, Ying Liu, Min Hou, Jun Jiao, Ya Tan, Xu Tan
Summary: The arms race between viruses and their hosts has influenced their evolutionary history and genetic composition. Restriction factors encoded by host genomes serve as the first line of defense against viral infections and are conserved throughout evolution to protect hosts from diseases, death, and even extinction. Recently characterized human restriction factor PSGL-1 demonstrates antiviral function in mice, as shown in vitro and in a knockout mouse model. The interaction between PSGL-1 and glycogag/glycoMA proteins from murine leukemia virus (MLV) demonstrates evidence of positive selection, reflecting the evolutionary pressure between PSGL-1 and its antagonists.
Article
Biochemistry & Molecular Biology
Miriam Merenciano, Josefa Gonzalez
Summary: Establishing causal links between adaptive mutations and ecologically relevant phenotypes is crucial but challenging. This study focuses on a natural transposable element insertion in Drosophila melanogaster and demonstrates its impact on the cold and immune stress response. The results highlight the complexity of gene-environment interactions and the importance of considering multiple developmental stages and environmental conditions when studying the effects of genetic variants.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Plant Sciences
Yushi Yoshitake, Daiki Shinozaki, Kohki Yoshimoto
Summary: Inorganic phosphate is essential for plant growth, but it is often limited in soil. This study found that autophagy-deficient mutants showed early depletion of phosphate and severe growth defects under phosphate starvation. The main cargo of autophagy induced by early phosphate depletion was the endoplasmic reticulum (ER), indicating the involvement of ER-phagy in the response to early phosphate starvation for recycling phosphate. This ER-phagy was induced by ER stress and was suppressed by iron limitation and inhibition of lipid-reactive oxygen species accumulation. Interestingly, membrane lipid remodeling, a response to late phosphate starvation, was accelerated in mutants under early phosphate-depleted conditions. Overall, this study reveals the importance of ER stress-mediated ER-phagy in phosphate recycling during the early phase of phosphate starvation and its role in suppressing acceleration of the late phase.
Article
Biochemistry & Molecular Biology
Jie Chen, Yuantai Huang, Guojun Qi
Summary: This study reveals the regulatory role of insulin receptor-associated lncRNA (IRAR) in the expression of insulin receptor transcripts under stress conditions in Drosophila melanogaster. The results also indicate the importance of IRAR in the sensitivity to environmental nutritional changes and its ability to affect the development of Drosophila through direct regulation of insulin receptor transcripts.
INSECT MOLECULAR BIOLOGY
(2022)
Article
Engineering, Marine
So-Sun Kim, Gyeong-Sik Han, Hae-Kyun Yoo, Ki-Tae Kim, Soon-Gyu Byun, Min-Min Jung, Woo-Jin Kim, Sung-Don Hwang
Summary: The study revealed that 27 degrees Celsius is the upper limit of tolerable water temperature for starry flounders, and survival was not affected when the water temperature dropped to below 27 degrees Celsius after starvation and feeding.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Ali Afrasiabi, Hamid Alinejad-Rokny, Azad Khosh, Mostafa Rahnama, Nigel Lovell, Zhenming Xu, Diako Ebrahimi
Summary: The zinc finger antiviral protein (ZAP) restricts viral replication by binding to CpG rich regions of viral RNA, but there is no evidence to suggest an evolutionary pressure specifically targeting CpG dinucleotides for the low CpG abundance in the SARS-CoV-2 genome.
SCIENTIFIC REPORTS
(2022)
Article
Evolutionary Biology
Li Ma, Mandy Ng, Corine M. van der Weele, Masato Yoshizawa, William R. Jeffery
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2020)
Article
Anesthesiology
John Manion, Thang Khuong, Dylan Harney, Jamie B. Littleboy, Travis Ruan, Lipin Loo, Michael Costigan, Mark Larance, Leslie Caron, G. Gregory Neely
Article
Biochemistry & Molecular Biology
Michael Orthofer, Armand Valsesia, Reedik Maegi, Qiao-Ping Wang, Joanna Kaczanowska, Ivona Kozieradzki, Alexandra Leopoldi, Domagoj Cikes, Lydia M. Zopf, Evgenii O. Tretiakov, Egon Demetz, Richard Hilbe, Anna Boehm, Melita Ticevic, Margit Noukas, Alexander Jais, Katrin Spirk, Teleri Clark, Sabine Amann, Maarja Lepamets, Christoph Neumayr, Cosmas Arnold, Zhengchao Dou, Volker Kuhn, Maria Novatchkova, Shane J. F. Cronin, Uwe J. F. Tietge, Simone Mueller, J. Andrew Pospisilik, Vanja Nagy, Chi-Chung Hui, Jelena Lazovic, Harald Esterbauer, Astrid Hagelkruys, Ivan Tancevski, Florian W. Kiefer, Tibor Harkany, Wulf Haubensak, G. Gregory Neely, Andres Metspalu, Jorg Hager, Nele Gheldof, Josef M. Penninger
Article
Cell Biology
Qiao-Ping Wang, Yong Qi Lin, Mei-Ling Lai, Zhiduan Su, Lisa J. Oyston, Teleri Clark, Scarlet J. Park, Thang M. Khuong, Man-Tat Lau, Victoria Shenton, Yan-Chuan Shi, David E. James, William W. Ja, Herbert Herzog, Stephen J. Simpson, G. Gregory Neely
Article
Biochemistry & Molecular Biology
Yagiz Alp Aksoy, Wei Deng, Jack Stoddart, Roger Chung, Gilles Guillemin, Nicholas James Cole, Graham Gregory Neely, Daniel Hesselson
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2020)
Article
Neurosciences
Shanker Karunanithi, Yong Qi Lin, G. Lorenzo Odierna, Hareesh Menon, Juan Mena Gonzalez, G. Gregory Neely, Peter G. Noakes, Nickolas A. Lavidis, Andrew J. Moorhouse, Bruno van Swinderen
JOURNAL OF NEUROSCIENCE
(2020)
Review
Immunology
M. D. Johansen, A. Irving, X. Montagutelli, M. D. Tate, I Rudloff, M. F. Nold, N. G. Hansbro, R. Y. Kim, C. Donovan, G. Liu, A. Faiz, K. R. Short, J. G. Lyons, G. W. McCaughan, M. D. Gorrell, A. Cole, C. Moreno, D. Couteur, D. Hesselson, J. Triccas, G. G. Neely, J. R. Gamble, S. J. Simpson, B. M. Saunders, B. G. Oliver, W. J. Britton, P. A. Wark, C. A. Nold-Petry, P. M. Hansbro
MUCOSAL IMMUNOLOGY
(2020)
Article
Clinical Neurology
Samar Khoury, Qiao-Ping Wang, Marc Parisien, Pavel Gris, Andrey Bortsov, Sarah D. Linnstaedt, Samuel A. McLean, Andrew S. Tungate, Tamar Sofer, Jiwon Lee, Tin Louie, Susan Redline, Mari Anneli Kaunisto, Eija A. Kalso, Hans Markus Munter, Andrea G. Nackley, Gary D. Slade, Shad B. Smith, Dmitri Zaykin, Roger B. Fillingim, Richard Ohrbach, Joel D. Greenspan, William Maixner, G. Gregory Neely, Luda Diatchenko
Summary: This study identified two new genetic loci associated with sleep quality, with NPY as an important sleep gene and MPP6 potentially impacting sleep quality as well. Further research may help elucidate the mechanisms through which these genes influence sleep variability in humans.
Review
Cell Biology
Elizabeth Ford, Jodie Pearlman, Travis Ruan, John Manion, Matthew Waller, Gregory G. Neely, Leslie Caron
Article
Biology
Motoko Iwashita, Masato Yoshizawa
Summary: Research has revealed that blind cavefish exhibit social-like interactions in familiar environments but suppress these interactions in unfamiliar environments. The level of social interaction suppression is positively correlated with that of stereotypic repetitive behavior. Treatment with a human antipsychotic drug targeting the dopaminergic system induces social-like interactions in cavefish, even in unfamiliar environments, while reducing repetitive behavior. These results suggest that the antagonistic association between repetitive and social-like behaviors is deeply shared from teleosts through mammals.
Article
Biology
Vania Filipa Lima Fernandes, Yannik Glaser, Motoko Iwashita, Masato Yoshizawa
Summary: This study investigates the relationship between laterality and environment using the Mexican tetra as a comparative study model. The results show that sensory laterality and behavioral shifts aid in adaptation to differences in food availability among caves.
Article
Biochemistry & Molecular Biology
Francesca Di Leva, Michele Filosi, Lisa Oyston, Erica Silvestri, Anne Picard, Alexandros A. Lavdas, Evy Lobbestael, Veerle Baekelandt, G. Gregory Neely, Peter P. Pramstaller, Andrew A. Hicks, Corrado Corti
Summary: Autosomal dominant mutations in the gene encoding alpha-synuclein (SNCA) were the first to be linked with hereditary Parkinson's disease (PD). Duplication and triplication of SNCA has been observed in PD patients, together with mutations at the N-terminal of the protein, among which A30P and A53T influence the formation of fibrils. Our data show that the expression of alpha-synuclein and ITPKB is correlated in pathological situations, as observed in SK-N-SH cells and cortex from PD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Man-Tat Lau, Shila Ghazanfar, Ashleigh Parkin, Angela Chou, Jourdin R. Rouaen, Jamie B. Littleboy, Danielle Nessem, Thang M. Khuong, Damien Nevoltris, Peter Schofield, David Langley, Daniel Christ, Jean Yang, Marina Pajic, G. Gregory Neely
Meeting Abstract
Biochemistry & Molecular Biology
A. Valsesia, Q. Wang, N. Gheldof, J. Carayol, V. Shenton, G. Lefebvre, S. Metairon, C. Chabert, O. Walter, P. Mironova, P. Lau, N. Viguerie, D. Langin, P. Descombes, M. Harper, G. Neely, A. Astrup, W. Saris, R. Dent, J. Hager
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Meeting Abstract
Zoology
A. J. McKenna, A. Smith, A. G. Gibbs
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2019)
