Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS – A Novel Therapeutic Opportunity

Rapid IgG heavy chain cleavage by the streptococcal IgG endopeptidase IdeS is mediated by IdeS monomers and is not due to enzyme dimerization

(2013) Reine Vindebro et al.   FEBS LETTERS

Automated quality control system for LC-SRM setups

(2013) Johan Teleman et al.   Journal of Proteomics

Proteome-wide selected reaction monitoring assays for the human pathogen Streptococcus pyogenes

(2012) Christofer Karlsson et al.   Nature Communications

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

(2010) Margaret E. Ackerman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Successful treatment of experimental glomerulonephritis with IdeS and EndoS, IgG-degrading streptococcal enzymes

(2010) R. Yang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

(2009) R. J. Brezski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rituximab and Intravenous Immune Globulin for Desensitization during Renal Transplantation

(2008) Ashley A. Vo et al.   NEW ENGLAND JOURNAL OF MEDICINE

IdeS: A Bacterial Proteolytic Enzyme with Therapeutic Potential

(2008) Björn P. Johansson et al.   PLoS One

Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid

(2007) Mary H. Ryan et al.   MOLECULAR IMMUNOLOGY