Article
Endocrinology & Metabolism
Fumimaru Niwano, Naru Babaya, Yoshihisa Hiromine, Ippei Matsumoto, Keiko Kamei, Shinsuke Noso, Yasunori Taketomo, Yoshifumi Takeyama, Yumiko Kawabata, Hiroshi Ikegami
Summary: This study aimed to analyze changes in glucose metabolism and endocrine and exocrine function before and after partial pancreatectomy in patients with pancreaticoduodenectomy (PD) and distal pancreatectomy (DP). Results showed significant differences in blood glucose levels and insulin secretion rate between PD and DP populations post-pancreatectomy, highlighting the importance of individualized management for metabolism and nutrition in these patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Shuzo Imamura, Fumimaru Niwano, Naru Babaya, Yoshihisa Hiromine, Ippei Matsumoto, Keiko Kamei, Yuta Yoshida, Yasunori Taketomo, Sawa Yoshida, Yoshifumi Takeyama, Shinsuke Noso, Norikazu Maeda, Hiroshi Ikegami
Summary: Glucose tolerance worsens after distal pancreatectomy, leading to an increased incidence of diabetes. Reduced insulin secretion is a key factor in the development of diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Jason T. Wiseman, Jeffery Chakedis, Eliza W. Beal, Anghela Paredes, Amy McElhany, Andrew Fang, Andrei Manilchuk, Christopher Ellison, George Van Buren, Timothy M. Pawlik, Carl R. Schmidt, William E. Fisher, Mary Dillhoff
Summary: This study found that preoperative levels of HbA1c and blood glucose were associated with the risk of developing new IDDM after pancreatic resection. By setting predictive cutoffs at HbA1c of 6.25% and glucose of 121 mg/dL, high-risk patients can be accurately identified. Patients who developed new IDDM after surgery had higher rates of complications and discharge to nursing facilities.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Multidisciplinary Sciences
Luisa Castro, Luisa Brant, Maria de Fatima Diniz, Paulo Lotufo, Isabela Judith Bensenor, Dora Chor, Rosane Griep, Sandhi Maria Barreto, Antonio Luiz Ribeiro
Summary: Insulin resistance is associated with an increased risk of prehypertension and hypertension in the Brazilian population, independent of overweight or obesity. The presence of insulin resistance at baseline significantly increased the chances of developing prehypertension by 51% and hypertension by 150%. This association remained significant in individuals with a BMI less than 25 kg/m(2).
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Qi Chen, Wei Wang, Ming-Feng Xia, You-li Lu, Hua Bian, Chen Yu, Xiao-Ying Li, Mathew A. Vadas, Xin Gao, Huan-Dong Lin, Pu Xia
Summary: Circulating levels of dhS1P and dhS1P/dhSph ratio are strongly associated with increased risk of T2DM, and could serve as a useful biomarker for predicting incident T2DM in normoglycemic populations.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Francesco Liguori, Elisa Mascolo, Fiammetta Verni
Summary: Diabetes mellitus is a heterogeneous disease characterized by high blood sugar caused by a combination of genetic and environmental factors, with both monogenic and multigenic forms. While many putative causative genes have been identified, a large percentage of cases remain undiagnosed, indicating a need for further research to identify causal variants of diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Tianyi Zhao, Yong Fu, Taiping Zhang, Junchao Guo, Quan Liao, Shuoning Song, Yanbei Duo, Yuting Gao, Tao Yuan, Weigang Zhao
Summary: This study evaluated the glycemic control and insulin therapy of patients undergoing TP during the perioperative and long-term follow-up period. It found that most patients had good glycemic control during hospitalization after TP, but a portion experienced hypoglycemic events. During long-term follow-up, glycemic control and variability in TP patients were comparable to those with complete insulin deficiency type 1 diabetes mellitus, but with lower insulin needs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Bo Sun, Hui Chen, Jisu Xue, Peiwu Li, Xu Fu
Summary: The glucose transporter family, especially GLUT2, plays a crucial role in the initial stage of glucose metabolism, transporting glucose into multiple organs and maintaining glucose homeostasis. Variations in GLUT2 are associated with endocrine and metabolic disorders. This study examines the role of GLUT2 in glucose metabolism and regulation in various organs and tissues.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Nutrition & Dietetics
Yanan Wang, Qing Liu, Seong-Gook Kang, Kunlun Huang, Tao Tong
Summary: Research indicates that cAMP plays a crucial role in metabolism and glucose homeostasis in various organs, while bioactive compounds in diet can influence diabetes pathogenesis by targeting cAMP signaling pathway.
Review
Biochemistry & Molecular Biology
Anna Fosch, Sebastian Zagmutt, Nuria Casals, Rosalia Rodriguez-Rodriguez
Summary: SF1 neurons in the ventromedial hypothalamus play a crucial role in sensing glucose levels and mediating insulin and leptin signaling, as well as in energy expenditure and glucose homeostasis, particularly in the early stages of obesity. While studies have provided insight into the central role of these neurons in whole-body energy homeostasis, they have also raised new questions regarding the existence of neuronal sub-populations and the complexity of neurocircuitry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Caroline T. B. Juel, Thomas F. Dejgaard, Carsten P. Hansen, Jan H. Storkholm, Tina Vilsboll, Asger Lund, Filip K. Knop
Summary: The study evaluated glycemic variability in totally pancreatectomized patients and compared it with HbA(1c)-matched patients with long-standing type 1 diabetes. Results showed higher CONGA(60 min) and time spent above range in PX patients compared to T1D patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Surgery
Ahmad Hamad, J. Madison Hyer, Varna Thayaparan, Aneesa Salahuddin, Jordan M. Cloyd, Timothy M. Pawlik, Aslam Ejaz
Summary: This study aimed to determine the long-term incidence of pancreatogenic diabetes mellitus (P-DM) and its clinical impact after partial pancreatic resection. The results showed that approximately one in five patients developed P-DM after the surgery. Risk factors for developing P-DM included male sex, undergoing a distal pancreatectomy, having a malignant diagnosis, a family history of diabetes, and being classified as prediabetic in the preoperative setting.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Chemistry, Multidisciplinary
Qi Lu, Zihe Wang, Shumin Bai, Ying Wang, Cheng Liao, Yaru Sun, Yi Zhang, Wei Li, Qingsong Mei
Summary: Optogenetics-based synthetic biology has great potential as a cell-based therapy for incurable diseases; however, controlling genetic expression strength and timing through closed-loop regulation based on disease state remains a challenge. In this study, we developed a smart hydrogel platform that combines glucose reversible responsive upconversion nanoprobes and optogenetic engineered cells, allowing adaptive control of optogenetic expressions for insulin secretion based on blood glucose levels. This intelligent system enables convenient maintenance of glycemic homeostasis without the need for additional glucose concentration monitoring, thereby avoiding hypoglycemia induced by genetic overexpression. This proof-of-concept strategy combines diagnostics with optogenetics-based synthetic biology, opening up a new avenue for nano-optogenetics.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Endocrinology & Metabolism
Elena Flowers, Bradley E. Aouizerat, Alka M. Kanaya, Jose C. Florez, Xingyue Gong, Li Zhang
Summary: This study identified 5 miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that can effectively predict the incidence of type 2 diabetes. After adjusting for covariates, the HR for the highest quartile risk group compared with the lowest quartile risk group was 5.91. There was significant interaction between the intensive lifestyle and metformin groups compared with placebo. These findings may have potential clinical utility for risk stratification of individuals with prediabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Ana P. D. Taschetto, Priscila L. Zimath, Renata Silverio, Cristiane dos Santos, Antonio C. Boschero, Gustavo J. dos Santos, Alex Rafacho
Summary: The study showed that insulin sensitivity and clearance increase in early pregnancy but decrease in late pregnancy, possibly due to reduced hepatic insulin-degrading enzyme (IDE) activity and increased pancreatic beta-cell mass. This physiological process may be important in understanding gestational diabetes mellitus caused by inadequate insulin supply during pregnancy.
Article
Medicine, Research & Experimental
David B. Dunger, Sylvaine F. A. Bruggraber, Adrian P. Mander, M. Loredana Marcovecchio, Timothy Tree, Piotr Jaroslaw Chmura, Mikael Knip, Anke M. Schulte, Chantal Mathieu
Summary: The INNODIA consortium has established an infrastructure to evaluate clinical data and identify biomarkers for future clinical trials in newly diagnosed type 1 diabetes. They have developed a master protocol to improve phase 2 studies, including standardized assessment, collection of mechanistic data, and evaluation of combination therapies.
Article
Cell Biology
Matilda Rehn, Anne Wenzel, Anne-Katrine Frank, Mikkel Bruhn Schuster, Sachin Pundhir, Nanna Jorgensen, Kristoffer Vitting-Seerup, Ying Ge, Johan Jendholm, Magali Michaut, Erwin M. Schoof, Tanja Lyholm Jensen, Nicolas Rapin, Russell T. Sapio, Kasper Langebjerg Andersen, Anders H. Lund, Michele Solimena, Martin Holzenberger, Dimitri G. Pestov, Bo Torben Porse
Summary: Ribosomopathies are a range of disorders that affect protein synthesis and primarily impact hematopoietic stem cells and erythroid development. This study demonstrates that the deletion of poly-pyrimidine-tract-binding protein 1 (PTBP1) in the hematopoietic compartment leads to a condition resembling ribosomopathy. The loss of PTBP1 results in reduced HSC self-renewal, erythroid differentiation, and protein synthesis, along with defects in splicing and ribosome biogenesis.
Article
Medicine, General & Internal
Norbert Stefan, Katrin Sippel, Martin Heni, Andreas Fritsche, Robert Wagner, Carolin E. M. Jakob, Hubert Preissl, Alexander von Werder, Yascha Khodamoradi, Stefan Borgmann, Maria Madeleine Ruethrich, Frank Hanses, Martina Haselberger, Christiane Piepel, Martin Hower, Jurgen vom Dahl, Kai Wille, Christoph Roemmele, Janne Vehreschild, Melanie Stecher, Michele Solimena, Michael Roden, Annette Schuermann, Baptist Gallwitz, Martin Hrabe de Angelis, David S. Ludwig, Matthias B. Schulze, Bjoern Erik Ole Jensen, Andreas L. Birkenfeld
Summary: Advanced age and male sex pose the greatest risk for severe COVID-19. Modifiable comorbidities such as obesity, diabetes, and hypertension increase the risk of COVID-19-related mortality in younger patients.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Olof Asplund, Petter Storm, Vikash Chandra, Gad Hatem, Emilia Ottosson-Laakso, Dina Mansour-Aly, Ulrika Krus, Hazem Ibrahim, Emma Ahlqvist, Tiinamaija Tuomi, Erik Renstrom, Olle Korsgren, Nils Wierup, Mark Ibberson, Michele Solimena, Piero Marchetti, Claes Wollheim, Isabella Artner, Hindrik Mulder, Ola Hansson, Timo Otonkoski, Leif Groop, Rashmi B. Prasad
Summary: The characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes is important for understanding islet function and disease development. Through RNA sequencing and genotyping, the Islet Gene View (IGW) platform was created to provide accessible information on islet gene expression. The platform identified differentially expressed genes in type 2 diabetes donor islets and found co-expression with islet hormone-encoding genes. Inhibition of two differentially expressed genes impacted insulin secretion and cell survival.
LIFE SCIENCE ALLIANCE
(2022)
Article
Emergency Medicine
Bruno Leonardo Bancke Laverde, Matthias Maak, Melanie Langheinrich, Stephan Kersting, Axel Denz, Christian Krautz, Georg Ferdinand Weber, Robert Gruetzmann, Maximilian Brunner
Summary: The purpose of this study was to identify risk factors associated with postoperative morbidity, major morbidity, prolonged length of hospital stay, and readmission in patients undergoing appendectomy for acute appendicitis. The study found that higher age, higher preoperative WBC-count and CRP, lower preoperative hemoglobin, longer time to surgery, and longer duration of surgery were independent risk factors for morbidity. Higher age, higher preoperative CRP, lower preoperative hemoglobin, and longer time to surgery were identified as independent risk factors for major morbidity. Higher age, higher preoperative WBC-count and CRP, lower preoperative hemoglobin, need for conversion, longer surgery duration, presence of intraoperative complicated appendicitis, and postoperative morbidity were independent risk factors for a prolonged length of hospital stay. Presence of malignancy and higher preoperative WBC-count were independent risk factors for readmission.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Medicine, General & Internal
Melanie Langheinrich, Alexander Reinhard Siebenhuener, Justus Baecker, Maximilian Miragall, Felix Wiesmueller, Vera Schellerer, Susanne Merkel, Maximilian Brunner, Christian Krautz, Klaus Weber, Robert Gruetzmann, Stephan Kersting
Summary: This study aimed to evaluate the value of different blood-based markers and assess the significance of a newly developed inflammatory-nutrition-related biomarker (NCR = BMI x albumin/CRP) in colon cancer patients. Lower preoperative NCR levels were associated with worse prognosis, tumor sidedness, undifferentiated histology, nodal involvement, and advanced UICC stage. The NCR proved to be a reliable indicator of poor prognosis for colon cancer patients and could be used for risk stratification and treatment selection.
Letter
Gastroenterology & Hepatology
Maximilian Brunner, Klaus Weber, Axel Denz, Melanie Langheinrich, Stephan Kersting, Georg F. Weber, Robert Gruetzmann, Christian Krautz
COLORECTAL DISEASE
(2023)
Article
Endocrinology & Metabolism
Carlotta Hoffmann, Peter E. Schwarz, Christos S. Mantzoros, Andreas L. Birkenfeld, Christian Wolfrum, Michele Solimena, Stefan R. Bornstein, Nikolaos Perakakis
Summary: This study aimed to compare the concentrations of GLP-1, glucagon, GIP, and glicentin during an OGTT in patients with different glycemic states. The results showed that hormonal levels did not differ between groups when all subjects were in a prediabetic state. However, one year later, patients progressing to diabetes had lower postprandial increases of glicentin and GLP-1, lower postprandial decrease of glucagon, and higher levels of fasting GIP compared to patients regressing to NGT. Changes in glicentin and GLP-1 were found to be negatively correlated with changes in glucose levels and beta-cell function markers.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Barbara Kneis, Stefan Wirtz, Klaus Weber, Axel Denz, Matthias Gittler, Carol Geppert, Maximilian Brunner, Christian Krautz, Alexander Reinhard Siebenhuener, Robert Schierwagen, Olaf Tyc, Abbas Agaimy, Robert Gruetzmann, Jonel Trebicka, Stephan Kersting, Melanie Langheinrich
Summary: In the current era of precision oncology, it is recognized that colorectal cancer (CRC) is a heterogeneous disease. The tumor location is crucial in determining disease progression and prognosis. The microbiome has been identified as an important factor in CRC, but previous studies have shown inconsistent results due to the heterogeneous nature of microbiomes and the lack of separate analysis of colon cancer (CC) and rectal cancer (RC). Our prospective study aimed to map the colon cancer landscape using 16S rRNA amplicon sequencing, and we found distinct microbiomes in right- and left-sided colon cancers, as well as a significant increase in potentially pathogenic bacteria in stool samples after surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aydar Khabipov, Dung Nguyen Trung, Julia van der Linde, Lea Miebach, Maik Lenz, Felix Erne, Wolfram von Bernstorff, Tobias Schulze, Stephan Kersting, Sander Bekeschus, Lars Ivo Partecke
Summary: Pancreatic cancer is characterized by a tumor microenvironment rich in stromal and immune cells that support cancer growth and resistance to therapy. Tumor-associated macrophages (TAMs), specifically, have properties that promote angiogenesis and metastasis, leading to the failure of conventional therapies. This study explores the effects of blocking the C-C chemokine receptor type 4 (CCR4) in pancreatic cancer-bearing mice through genetic or immunotherapeutic methods. The results show that CCR4 is critical for TAM generation and tumor progression in pancreatic cancer, and blockade of CCR4 may improve prognosis and extend the relapse-free period after curative surgery.
Article
Medicine, General & Internal
Bruno Leonardo Bancke Laverde, Matthias Maak, Melanie Langheinrich, Stephan Kersting, Axel Denz, Christian Krautz, Georg F. Weber, Robert Gruetzmann, Maximilian Brunner
Summary: The aim of this study was to identify risk factors for conversion from laparoscopic to open appendectomy in cases of acute appendicitis. The study found that a higher preoperative WBC count, presence of intraoperative perforation, necrosis or gangrene, perityphlitic abscess and peritonitis were all independent risk factors for conversion. Conversion was also associated with higher morbidity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Bruno Leonardo Bancke Laverde, Matthias Maak, Melanie Langheinrich, Stephan Kersting, Axel Denz, Christian Krautz, Georg F. Weber, Robert Grutzmann, Maximilian Brunner
Summary: This study investigated the impact of intraoperative swab during appendectomy on the postoperative outcome in patients with uncomplicated and complicated appendicitis. The results showed that a positive swab was significantly associated with worse postoperative outcomes and was an independent risk factor for postoperative morbidity and the need for adjustment of postoperative antibiotic therapy. However, the frequency of antibiotic regime changes based on the swab analysis was low.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Meeting Abstract
Oncology
Britta Buchhold, Stine Lutze, Jennis Freyer-Adam, Michael Juenger, Claudia Nordt, Sebastian Peters, Stephan Kersting
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Meeting Abstract
Oncology
Melanie C. Langheinrich, Stefan Wirtz, Barbara Kneis, Klaus Weber, Maximilian Brunner, Christian Krautz, Jonel Trebicka, Abbas Agaimy, Robert Gruetzmann, Stephan Kersting
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Article
Gastroenterology & Hepatology
Maximilian Brunner, Alaa Zu'bi, Klaus Weber, Axel Denz, Melanie Langheinrich, Stephan Kersting, Georg F. Weber, Robert Gruetzmann, Christian Krautz
Summary: This study compared the use of single-stapling technique (SST) and double-stapling technique (DST) in minimally invasive rectal anastomosis and found that using SST is associated with a lower rate of anastomotic complications, including leakage and stenosis. This suggests that SST may be an effective technique for reducing anastomotic complications.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)