Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Food Science & Technology
Faezeh Arasteh, Mohsen Barzegar, Hassan Ahmadi Gavlighi
Summary: The study aimed to investigate the antiglycation potential of fish, maize, and whey protein hydrolysates. The results showed that fish protein hydrolysate had the highest inhibitory effect, while maize protein hydrolysate had lower antiglycation activity. Whey protein hydrolysate showed the weakest inhibitory activity.
FOOD SCIENCE & NUTRITION
(2023)
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Nutrition & Dietetics
Julia S. Oliveira, Carolina de Almeida, Angela M. N. de Souza, Luciana D. da Cruz, Rita C. G. Alfenas
Summary: Critically analyzing studies on the effects of restricting dietary advanced glycation end-products (AGEs) on patients with type 2 diabetes, it was found that such restriction may help lower insulin resistance and blood sugar levels, but there is some controversy regarding its impact on inflammation and oxidative stress.
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
M. Vijaykrishnaraj, Kuiwu Wang
Summary: Natural products found in various natural foods have potential biological activities, including plants, fruits, vegetables, and marine life. The biochemical reaction known as advanced glycation end products (AGEs) in the human body contributes to the pathogenesis of diabetic complications. Researchers are exploring the use of food-derived natural products to control AGEs-related disease complications.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Lihong Niu, Keqiang Lai, Yiqun Huang
Summary: This research aimed to investigate the effects of sodium chloride on the formation of N epsilon-carboxymethyllysine and N epsilon-carboxyethyllysine in pork myofibrillar protein systems during commercial sterilization. The results showed that the addition of NaCl reduced the heat-induced production of CML and CEL. Additionally, the presence of NaCl altered the promoting effect of lipid oxidation on the formation of advanced glycation end-products in protein-reducing sugar systems.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Endocrinology & Metabolism
Xingyu Zhang, Xiaoyu Chen, Shengjie Li, Mengze Gao, Peipei Han, Liou Cao, Jing Gao, Qiongying Tao, Jiayi Zhai, Dongyu Liang, Li Qin, Qi Guo
Summary: This study found that elevated levels of AGEs are associated with sarcopenia, but not with presarcopenia. Osteoporosis plays a partial mediating role in the association between AGEs and sarcopenia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Xiao Yang, Cong-Jin Liu, Zhen-Zhen Wang, Dong Ding, Jing-Wen Shi, Xin-Tong Wu, Lian-Wen Sun, Yu-Bo Fan
Summary: AGEs negatively impact the mechanosensitivity of osteocytes, affecting the bone remodeling process. This study provides a new perspective on exploring the mechanism of osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Chenyang Han, Liping Zhai, Heping Shen, Jin Wang, Qiaobing Guan
Summary: This study aimed to explore the role and mechanism of advanced glycation end-products (AGEs) in inducing pyroptosis of cerebrovascular endothelial cells under oxygen glucose deprivation (OGD) condition. The results showed that AGEs induced pyroptosis in cerebral endothelial cells, increased the expression of inflammatory factors, and aggravated brain injury through the HIF-alpha-RAGE-NLRP3 pathway.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Patricia Budihartanti Liman, Karina Shasri Anastasya, Nabila Maudy Salma, Yenny Yenny, Meutia Atika Faradilla
Summary: The aim of this study was to analyze scientific articles on advanced glycation end products (AGEs) and obesity using bibliometric methods. The results showed an increase in studies on processed foods and obesity, with the United States making the largest contribution in this field. Open access journals had higher citation numbers and younger publication years compared to closed access journals.
Article
Biochemistry & Molecular Biology
Govigerel Bayarsaikhan, Delger Bayarsaikhan, Pyung Chun Oh, Woong Chol Kang, Bonghee Lee
Summary: Researchers investigated the utility of AGEs as prognostic biomarkers for AMI and found that CUPRAC-reactive AGEs exhibit various patterns of changes in serum samples of AMI patients.
Article
Oncology
Ziling Mao, Jacqueline Roshelli Baker, Masayoshi Takeuchi, Hideyuki Hyogo, Anne Tjonneland, Anne Kirstine Eriksen, Gianluca Severi, Joseph Rothwell, Nasser Laouali, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Domenico Palli, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Jeroen W. G. Derksen, Inger T. Gram, Guri Skeie, Torkjel M. Sandanger, Jose Ramon Quiros, Marta Crous-Bou, Maria-Jose Sanchez, Pilar Amiano, Sandra M. Colorado-Yohar, Marcela Guevara, Sophia Harlid, Ingegerd Johansson, Aurora Perez-Cornago, Heinz Freisling, Marc Gunter, Elisabete Weiderpass, Alicia K. Heath, Elom Aglago, Mazda Jenab, Veronika Fedirko
Summary: Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) are associated with the development and progression of colorectal cancer due to their oxidative and inflammatory properties. This study found that circulating glycer-AGEs concentrations are positively associated with both colorectal cancer-specific and all-cause mortality. The association between glycer-AGEs and colorectal cancer-specific mortality is stronger in patients with distal colon cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Medicine, General & Internal
Shanhu Qiu, Xue Cai, Changping Ju, Zilin Sun, Han Yin, Martina Zuegel, Stephanie Otto, Juergen M. Steinacker, Uwe Schumann
Review
Sport Sciences
Shanhu Qiu, Xue Cai, Zilin Sun, Uwe Schumann, Martina Zuegel, Juergen Michael Steinacker
Review
Endocrinology & Metabolism
X. Cai, S. H. Qiu, H. Yin, Z. L. Sun, C. P. Ju, M. Zuegel, J. M. Steinacker, U. Schumann
Article
Endocrinology & Metabolism
Shanhu Qiu, Xue Cai, Han Yin, Martina Zuegel, Zilin Sun, Juergen Michael Steinacker, Uwe Schumann
METABOLISM-CLINICAL AND EXPERIMENTAL
(2016)
Review
Cardiac & Cardiovascular Systems
Shanhu Qiu, Xue Cai, Zilin Sun, Ling Li, Martina Zuegel, Juergen Michael Steinacker, Uwe Schumann
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2017)
Article
Physiology
Shanhu Qiu, Xue Cai, Zilin Sun, Martina Zuegel, Juergen M. Steinacker, Uwe Schumann
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Gastroenterology & Hepatology
Shanhu Qiu, Xue Cai, Zilin Sun, Ling Li, Martina Zuegel, Juergen Michael Steinacker, Uwe Schumann
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Shanhu Qiu, Xue Cai, Han Yin, Zilin Sun, Martina Zuegel, Juergen Michael Steinacker, Uwe Schumann
CARDIOVASCULAR DIABETOLOGY
(2018)
Article
Sport Sciences
Shanhu Qiu, Edit Bosnyak, Gunnar Treff, Juergen Michael Steinacker, Andreas Michael Niess, Karsten Krueger, Frank Christoph Mooren, Martina Zuegel, Uwe Schumann
EUROPEAN JOURNAL OF SPORT SCIENCE
(2018)
Article
Obstetrics & Gynecology
Xue Cai, Shanhu Qiu, Ling Li, Martina Zuegel, Jurgen Michael Steinacker, Uwe Schumann
REPRODUCTIVE BIOMEDICINE ONLINE
(2018)
Article
Endocrinology & Metabolism
Shanhu Qiu, Xue Cai, Bingquan Yang, Ziwei Du, Min Cai, Zilin Sun, Martina Zuegel, Juergen Michael Steinacker, Uwe Schumann
Article
Cardiac & Cardiovascular Systems
Shanhu Qiu, Xue Cai, Jianing Liu, Bingquan Yang, Zilin Sun, Martina Zugel, Jurgen Michael Steinacker, Uwe Schumann
JOURNAL OF CARDIAC FAILURE
(2019)
Article
Cardiac & Cardiovascular Systems
Shanhu Qiu, Xue Cai, Jianing Liu, Bingquan Yang, Martina Zuegel, Juergen Michael Steinacker, Zilin Sun, Uwe Schumann
Article
Respiratory System
Shanhu Qiu, Xue Cai, Xuyi Wang, Can He, Martina Zuegel, Juergen Michael Steinacker, Uwe Schumann
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2018)
Review
Endocrinology & Metabolism
S. H. Qiu, C. Xue, Z. L. Sun, J. M. Steinacker, M. Zuegel, U. Schumann