Article
Immunology
Daisuke Kondo, Ruriko Suzuki, Ayako Matsumura, Hitomi Meguri, Masahiko Tanaka, Makoto Itakura, Naohide Hirashima
Summary: In this study, we found that methiothepin inhibits degranulation in mast cells by downregulating upstream signaling pathways and membrane fusion-related proteins, which may relieve allergic reactions.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Food Science & Technology
Meitong Liu, Jing Lu, Qingbin Liu, Yuelin Chen, Guang Wang, Qian Zhang, Shuang Guan
Summary: This study investigated the effects of sodium metabisulphite (SMB) on mitophagy and pyroptosis in mast cells. The results showed that SMB promoted the expression of pyroptosis markers and inhibited mitophagy, leading to mast cell degranulation. These findings are of great significance for understanding the sensitization mechanism and toxicology of SMB.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Do Yoon Kim, Kyung-Jong Won, Dae Il Hwang, Nan Young Kim, Bokyung Kim, Hwan Myung Lee
Summary: This study found that 1-iodohexadecane can alleviate the severity of AD lesions, possibly by disrupting SNARE protein-linked degranulation and enhancing the expressions of skin barrier-related proteins.
Article
Chemistry, Applied
Maxim A. Faraonov, Nikita R. Romanenko, Leokadiya V. Zorina, Salavat S. Khasanov, Dmitri V. Konarev
Summary: Mono-deprotonated HIndigo(-) anions were selectively generated through the direct interaction of H2Indigo with cesium metal. Chelated complexes of HIndigo(-) with cobalt(II) and nickel(II) halides were prepared, and their structures and properties were studied. The absorption bands of HIndigo(-) were found to be red-shifted compared to those of H2Indigo(·-), allowing for the differentiation between the reduced and deprotonated forms of trans-indigo.
Article
Biochemistry & Molecular Biology
Carina A. Valenzuela, Ella J. Baker, Camila O. De Souza, Elizabeth A. Miles, Philip C. Calder
Summary: Endothelial dysfunction and inflammation are key factors in atherosclerosis development. This study compared the effects of industrial and ruminant trans fatty acids on endothelial cells, finding that ruminant TFAs like TVA have anti-inflammatory properties while industrial TFAs like EA enhance inflammatory responses.
Review
Gastroenterology & Hepatology
Melissa Nelson, Xi Zhang, Zui Pan, Stuart Jon Spechler, Rhonda F. Souza
Summary: Mast cells play a major role in allergic disorders such as eosinophilic esophagitis, causing clinical manifestations and potential neurodegeneration in the esophagus. Their release of proinflammatory and cytotoxic mediators could impact esophageal muscle contraction and enteric neurons, contributing to conditions like achalasia.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Environmental Sciences
Barbara Rani-Borges, Richard Meitern, Paul Teesalu, Merilin Raudna-Kristoffersen, Randel Kreitsberg, Margit Heinlaan, Arvo Tuvikene, Angela Ivask
Summary: The lack of studies on the toxicity of microplastics (MP) at environmentally relevant concentrations and exposure times is concerning. In this study, the potential adverse effects of low density polyethylene (LDPE) microplastics on two species of competing amphipods were analyzed. The results showed that both amphipods effectively ingested and egested LDPE microplastics, and high concentrations of LDPE microplastics had negative impacts on mortality, swimming ability, and oxidative stress levels. G. lacustris was more sensitive to LDPE microplastics and may lose its competitiveness in MP polluted environments.
Article
Multidisciplinary Sciences
Houda Yasmine Ali Moussa, Yongsoo Park
Summary: This study reveals the regulatory mechanism of Ca2+ and PIP2 on the cis and trans-membrane interaction of synaptotagmin-1, using native purified vesicles and plasma membrane-mimicking liposomes.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
M. C. Kowarik, D. Astling, G. Lepennetier, A. Ritchie, B. Hemmer, G. P. Owens, Jeffrey L. Bennett
Summary: Natalizumab and fingolimod have differential effects on B cell populations in multiple sclerosis, with fingolimod treatment contracting peripheral blood B cells while natalizumab treatment expands them. The clonal overlap between CSF and PB B cells is reduced with natalizumab but remains stable with fingolimod therapy. These findings suggest that the two therapies have distinct impacts on the exchange and clonal expansion of B cells in MS patients.
Article
Immunology
Liliane Sena Pinheiro, Valter Viana Andrade-Neto, Marcio Mantuano-Barradas, Elisa Cavalcante Pereira, Rodrigo Cesar Fernandes Barbosa, Marcia Cristina Campos de Oliveira, Rubem Figueiredo Sadok Menna-Barreto, Edezio Ferreira Cunha-Junior, Eduardo Caio Torres-Santos
Summary: The study investigated the effects of exogenously added trans, trans-farnesol on the proliferation ability of Leishmania amazonensis. The results showed that trans, trans-farnesol inhibited the cell cycle and proliferation of L. amazonensis without causing DNA fragmentation or loss of mitochondrial functionality. Additionally, the study identified the presence of alpha-farnesene and beta-farnesene in the lipid secretome of the parasite and identified the farnesene synthase gene responsible for their production.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Oncology
Rahmat K. Sikder, Moataz Ellithi, Robert N. Uzzo, David J. Weader, Alexander L. Metz, Ali Behbahani, Erica R. McKenzie, Wafik S. El-Deiry, Philip H. Abbosh
Summary: Mutations in the CDKN1A gene in muscle-invasive bladder cancer affect the tumor suppressor protein p21, leading to different responses to cisplatin sensitivity. The loss of p21 results in impaired DNA repair and cell cycle regulation, while truncated p21 variants show varied effects on chemotherapy sensitivity.
MOLECULAR CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Petra Vande Zande, Mark S. Hill, Patricia J. Wittkopp
Summary: This study compares the effects of cis- and trans-regulatory mutations on gene expression and fitness, finding that trans-regulatory mutations have more widespread and deleterious effects on gene expression. The relative contribution of trans-regulatory mutations to expression differences decreases over evolutionary time.
Review
Chemistry, Inorganic & Nuclear
Debabrata Chatterjee, Maria Oszajca, Anna Katafias, Rudi van Eldik
Summary: The electrochemistry of Ru(edta) complexes has made significant progress over several decades, focusing on electron-transfer reaction mechanisms and activity of both mononuclear and binuclear complexes. Their potential as redox mediators or catalysts in electrochemical transformations of small molecules and enzymatic reactions is highlighted, aiming to contribute to the mechanistic understanding of Ru(edta) complexes in catalysis of such electrochemical transformations.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Veterinary Sciences
Ange Mouithys-Mickalad, Nazare Storms, Thierry Franck, Justine Ceusters, Geoffroy de la Rebiere de Pouyade, Ginette Deby-Dupont, Didier Serteyn
Summary: Juglone inhibits equine laminitis by modulating neutrophil activation, and it also suppresses neutrophil degranulation and the peroxidase activity of MPO.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Carla Ferreri, Alessandra Ferocino, Gessica Batani, Chryssostomos Chatgilialoglu, Vanda Randi, Maria Vittoria Riontino, Fabrizio Vetica, Anna Sansone
Summary: Plasmalogens are membrane phospholipids that play a role in peroxidation and have the potential for cis-trans double bond isomerization. Through experiments using representative molecules and liposomes under specific conditions, the reactivity and outcomes of these processes were studied. The results provide important insights for lipidomic applications and understanding radical stress in living organisms.
Article
Cell Biology
Pratikshya Adhikari, Hao Xu
INFLAMMATION RESEARCH
(2018)
Review
Biochemistry & Molecular Biology
Hao Xu, Na-Ryum Bin, Shuzo Sugita
BIOCHEMICAL SOCIETY TRANSACTIONS
(2018)
Correction
Cell Biology
Pratikshya Adhikari, Hao Xu
INFLAMMATION RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Joji Mima, Christopher M. Hickey, Hao Xu, Youngsoo Jun, William Wickner
Article
Biochemistry & Molecular Biology
Hao Xu, Youngsoo Jun, James Thompson, John Yates, William Wickner
Article
Biochemistry & Molecular Biology
Hao Xu, William Wickner
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Multidisciplinary Sciences
Hao Xu, Mahmood Mohtashami, Bryan Stewart, Gabrielle Boulianne, William S. Trimble
Article
Multidisciplinary Sciences
Hao Xu, Michael Zick, William T. Wickner, Youngsoo Jun
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Multidisciplinary Sciences
Hao Xu, William T. Wickner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Cell Biology
Tolulope E. Ayo, Pratikshya Adhikari, Shuzo Sugita, Hao Xu
Editorial Material
Biochemistry & Molecular Biology
Hao Xu
Summary: The study revealed that the transmembrane domains of syntaxin6 and syntaxin8 could be used for tau release, providing a new insight into the mechanism of tau secretion. This has significant implications for research on neurodegenerative diseases.
BIOCHEMICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Youngsoo Jun, Hao Xu, Naomi Thorngren, William Wickner
Article
Biochemistry & Molecular Biology
Hao Xu, William Wickner
JOURNAL OF BIOLOGICAL CHEMISTRY
(2006)
Article
Cell Biology
H Xu, GL Boulianne, WS Trimble
JOURNAL OF CELL SCIENCE
(2002)