Article
Infectious Diseases
Junshu Yang, Christopher Brown, Wayland Noland, Timothy J. Johnson, Yinduo Ji
Summary: The slow discovery of new antibiotics and the rapid development of bacterial resistance have put us in a vulnerable position. We are running out of effective treatment options for antibiotic-resistant infections. However, a study has identified a promising molecule called MZ-01, which exhibits potent bactericidal activity against multidrug-resistant Gram-positive bacterial pathogens, including MRSA. MZ-01 also has low cytotoxicity, making it a potential scaffold for the development of novel antibacterial agents.
Article
Infectious Diseases
Abdelbagi Elfadil, Ahmad Mandeel Alzahrani, Hani Abdullah, Hamoud Alsamhan, Turki S. Abujamel, Hafsa Elawd Ahmed, Asif Jiman-Fatani
Summary: This study aims to evaluate the antibacterial activity of a quinoxaline derivative compound against MRSA in comparison with vancomycin as a reference drug. The results showed that the quinoxaline derivative compound had lower minimal inhibitory concentrations (MICs) for most MRSA isolates, indicating a promising effectiveness against MRSA.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Cell Biology
Zhimin Bai, Min Chen, Qiaofa Lin, Ying Ye, Hongmei Fan, Kaizhen Wen, Jianxing Zeng, Donghong Huang, Wenfei Mo, Ying Lei, Zhijun Liao
Summary: By extracting feature vectors from protein sequences and using classification tools, MRSA and MSSA were successfully distinguished. MRSA showed high resistance to penicillin and high pathogenic risk. Cross-infection between different types of MRSA was found in Quanzhou, and MRSA in traditional hospitals exhibited increasingly blurred molecular characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Infectious Diseases
Jing-Yi Liu, Jing-Jing Jia, Ming Liu, Hao Duan, Ming-Li Hu, Chang Liu, Ruo-Yi Xue, Zi-Li Jin, Shan-Shan Zhang, Guo-Cheng Li, Rang Feng, Zhe Jin, Hai-Bo Li, Ling He
Summary: In this study, a novel compound HL-J6 was found to inhibit the growth and biofilm formation of MRSA. It showed potential in combating MRSA infection by downregulating the transcription levels of certain genes and reducing the secretion of a major virulence factor.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
Junyuan Qin, Lei Yu, Fu Peng, Xin Ye, Gangmin Li, Chen Sun, Fang Cheng, Cheng Peng, Xiaofang Xie
Summary: In this study, tannins isolated from Penthorum chinense Pursh (TPCP) were found to exhibit antimicrobial and antibiofilm properties against Staphylococcus aureus. The study showed that TPCP effectively destroyed the bacterial biofilms formed by MRSA, inhibiting its growth and reducing exopolysaccharide and extracellular DNA secretion.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Infectious Diseases
Joshua. B. Parsons, Annette. C. Westgeest, Brian. P. B. Conlon, Vance. G. Fowler
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a deadly pathogen that can persist in the bloodstream for days despite appropriate antibiotics. Persistent MRSA bacteremia is common and associated with poor clinical outcomes. This review explores the factors related to host-pathogen interaction and discusses the clinical relevance of each element. Treatment options and diagnostic approaches for managing persistent MRSA bacteremia are also discussed.
Article
Food Science & Technology
Martina Florianova, Kristyna Korena, Helena Juricova
Summary: This study evaluated the prevalence of Staphylococcus aureus in dry-fermented salami and found multidrug-resistant and virulent strains. The source of contamination was identified as raw pork and human carriers. Therefore, maintaining high standards of hygiene and manufacturing practices in food processing is crucial.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Sara Quero, Marina Serras-Pujol, Noemi Parraga-Nino, Carmen Torres, Marian Navarro, Anna Vilamala, Emma Puigoriol, Javier Diez de los Rios, Elisenda Arque, Judit Serra-Pladevall, Alba Romero, Daniel Molina, Roger Paredes, Maria Luisa Pedro-Botet, Esteban Reynaga
Summary: This study investigated the prevalence of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) among workers in the pork production chain. The results showed that the prevalence of MRSA was high among workers in contact with live animals, especially in pig farms, livestock transporters, and slaughterhouses.
Article
Infectious Diseases
Jin Liang, Yuanfang Hu, Mingxia Fu, Na Li, Fengxia Wang, Xiaojun Yu, Bing Ji
Summary: The study investigated the molecular epidemiology of Staphylococcus aureus (S. aureus) in patients from the Yellow River Delta region and examined antibiotic resistance profiles in different genetic backgrounds. Antibiotic susceptibility testing, spa typing, and agr typing were conducted on all 204 strains. The results identified 39 MRSA strains and 22 hVISA isolates. The majority of MRSA isolates belonged to agrI and were associated with type IV SCCmec. The most common genotypes among MRSA population were ST59-t437-agrI-IVa and ST72-t2431-agrI-IVF. The study highlights the genetic diversity and drug resistance patterns among MSSA strains exhibiting phenotypic hVISA.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Pharmacology & Pharmacy
Dylan J. Burgin, Ryan Liu, Roger C. Hsieh, Lauren R. Heinzinger, Michael Otto
Summary: This paper explores novel therapeutic approaches to treat Staphylococcus aureus bacteremia, with a special focus on MRSA bacteremia. The safety concerns of combination antimicrobial therapy need to be addressed, and future investigations should focus on optimizing treatment duration and lowering drug dosage. Antibodies and bacteriophage lysins show potential as therapeutic candidates.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2022)
Article
Microbiology
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Summary: Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of MRSA osteomyelitis. The results showed that rifampin combination therapy was effective in reducing MRSA recovery without developing resistance. The combination of omadacycline and rifampin yielded negative MRSA detection, suggesting its potential as a treatment for osteomyelitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Feiteng Zhu, Hemu Zhuang, Shujuan Ji, Er Xu, Lingfang Di, Zhengan Wang, Shengnan Jiang, Haiping Wang, Lu Sun, Ping Shen, Yunsong Yu, Yan Chen
Summary: The study found that in households of CA-MRSA infected patients in China, most MRSA isolates belonged to epidemic CA-MRSA clones, while no MRSA was detected in the control group households. The research revealed that the home environment is an important reservoir for MRSA.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Hanbeen Kim, Jakyeom Seo
Summary: Two potential endolysins were identified, with one showing better efficacy against MRSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Low Yi Xin, Toh Hui Min, Puteri Nur Liyana Mohd Zin, Thiruchelvi Pulingam, Jimmy Nelson Appaturi, Thaigarajan Parumasivam
Summary: This study evaluates the antibacterial activities of 61 plant extracts from 49 Malaysian ethnomedicinal plants, with 7 plant extracts showing good efficacy against MSSA strains. When combined with vancomycin and ciprofloxacin, the active plant extracts showed no interaction against MSSA and MRSA strains.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Infectious Diseases
Jian Peng, Biswajit Mishra, Rajamohammed Khader, LewisOscar Felix, Eleftherios Mylonakis
Summary: In this study, a smaller antimicrobial peptide C18 derived from cecropin 4 showed high antibacterial activity against various bacteria and yeasts, with a remarkable effect on drug-resistant Staphylococcus aureus. C18 also exhibited the capability to eliminate persister cells, reduce biofilm adherence, interact with DNA, and down-regulate virulence factor genes. Moreover, C18 showed promising results in a Galleria mellonella model, highlighting its potential as a therapeutic candidate for severe MRSA infections.
Article
Dermatology
Mette Mogensen, Kristoffer Hendel, Vilde Ung, Emily Wenande, Katrine Togsverd-Bo, Julie L. Forman, Merete Haedersdal
Summary: This study demonstrated objective OCT and RCM assessment of skin rejuvenation after light and energy-based therapy in photoaged skin. The results showed trends towards improvement in epidermal features and skin tone, with superior outcomes in skin rejuvenation observed in the L-PDT group. Further studies are needed to confirm these findings and the modest value of non-randomized, non-blinded anti-aging trials was emphasized.
Letter
Public, Environmental & Occupational Health
Marie Louise Slott Jensen, Ming Chen, Mette Detlefsen, Janne Kudsk Klitgaard, Thomas Emil Andersen, Michael Kemp
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Liora Bik, Martijn van Doorn, Anders C. N. Hansen, Christian Janfelt, Uffe H. Olesen, Merete Haedersdal, Catharina M. Lerche, Kristoffer Hendel
Summary: The study demonstrated quantifiable and focal mid-dermal distribution of bleomycin administered by electronic pneumatic injection, indicating high skin bioavailability with great potential for clinical effects.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Surgery
Jens Eckardt, Marike Lijkendijk, Peter B. Licht, Michael Stenger
Summary: The study found that a new chest drainage unit with a built-in CO2-detector can effectively distinguish between true and false air leakage, thus potentially improving postoperative management.
SURGICAL INNOVATION
(2022)
Article
Surgery
Finn A. Dittberner, Lars Ladegaard, Peter B. Licht
Summary: Applying tension to a diaphragmatic traction suture can significantly improve the surgical field overview in selected patients, aiding in VATS procedures for elevated hemidiaphragm issues.
WORLD JOURNAL OF SURGERY
(2022)
Article
Microbiology
Troels Ronco, Line H. Kappel, Maria F. Aragao, Niccolo Biagi, Soren Svenningsen, Jorn B. Christensen, Anders Permin, Lasse Saaby, Kim Holmstrom, Janne K. Klitgaard, Artur J. Sabat, Viktoria Akkerboom, Monica Monaco, Marco Tinelli, Alexander W. Friedrich, Bimal Jana, Rikke H. Olsen
Summary: Multidrug-resistant pathogens are a serious global issue, and novel antimicrobials with new modes of action are urgently needed. In this study, a phenothiazine derivative (JBC 1847) was found to exhibit high antimicrobial activity against Staphylococcus aureus. The primary mechanism of action of JBC 1847 was the depolarization of the cell membrane, leading to the dissipation of the proton motive force and affecting essential bacterial processes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Thomas Decker Christensen, Morten Bendixen, Soren Helbo Skaarup, Jens-Ulrik Jensen, Rene Horsleben Petersen, Merete Christensen, Peter Licht, Kirsten Neckelmann, Bo Martin Bibby, Lars B. Moller, Uffe Bodtger, Morten Hornemann Borg, Zaigham Saghir, Sten Langfeldt, Stefan M. W. Harders, Eihab O. Bedawi, Babu Naidu, Najib Rahman, Christian B. Laursen
Summary: This study aims to determine the difference in outcome between surgery (video-assisted thoracoscopic surgery) and non-surgical treatment (thoracic ultrasound-guided drainage and intrapleural therapy) in patients with complex parapneumonic effusion and pleural empyema. The primary endpoint is length of hospital stay, and secondary endpoints include mortality, need for additional interventions, analgesia consumption, and quality of life.
Article
Anesthesiology
Jimmy Hojberg Holm, Peter Bjorn Licht, Palle Toft, Claus Andersen
Summary: This study provides new information on various aspects of epidural catheter insertion, including procedural pain, duration, failure rates, and the impact of experience. The study found differences between expected and actual pain levels, as well as the influence of placement technique and number of attempts. Long-term side effects such as persistent pain and sensory disturbances were also observed.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Oncology
Nicolai B. Palstrom, Martin Overgaard, Peter Licht, Hans C. Beck
Summary: Proteins found in pleural effusion can serve as biomarkers for the diagnosis of malignant pleural mesothelioma (MPM). The identification of these proteins can significantly improve the accuracy of MPM diagnosis. Therefore, analyzing the protein composition of pleural effusion can lead to new diagnostic methods for MPM.
Review
Endocrinology & Metabolism
Kristoffer Hendel, Tobias Stumpe, Kerem Ozer
Summary: Insulin infusion sets (IISs) are crucial for continuous subcutaneous insulin infusion in type 1 diabetes patients. The materials and designs of IISs can affect the subcutaneous response. This review examines the impact of IIS materials and designs, highlighting the need for further research on material-tissue interactions and the development of nonimmunogenic IISs.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Giuseppe Cardillo, Rene Horsleben Petersen, Sara Ricciardi, Akshay Patel, Joshil Lodhia, Michael R. Gooseman, Alessandro Brunelli, Joel Dunning, Wentao Fang, Dominique Gossot, Peter B. Licht, Eric Lim, Eric Dominique Roessner, Marco Scarci, Milan Milojevic
Summary: Pulmonary nodules are commonly encountered by respiratory physicians, radiologists, and thoracic surgeons. A collaborative effort by the European Association of Cardio-Thoracic Surgery and the European Society of Thoracic Surgeons aims to provide a comprehensive review of the management of pure ground-glass opacities and part-solid nodules. The literature suggests an increasing detection of early-stage lung cancer, emphasizing the importance of surgical resection and the need for guidelines. Multidisciplinary decision-making is recommended, considering radiologic characteristics, lesion evolution, patient fitness, and co-morbidities.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Dermatology
Kristoffer Hendel, Katrine Karmisholt, Lene Hedelund, Merete Haedersdal
Summary: This study compared the efficacy of ablative fractional CO2 laser (AFL) and microneedle radiofrequency (MNRF) treatments for acne scars. The results showed that both treatments were equally effective at improving the texture of the skin. AFL caused more intense local skin reactions, while MNRF was more painful. Overall, patients were generally satisfied with the outcome of both treatments.
LASERS IN SURGERY AND MEDICINE
(2023)
Article
Oncology
M. Rakaee, S. Andersen, K. Giannikou, E. -E Paulsen, T. K. Kilvaer, L. -T. R. Busund, T. Berg, E. Richardsen, A. P. Lombardi, E. Adib, M. I. Pedersen, M. Tafavvoghi, S. G. F. Wahl, R. H. Petersen, A. L. Bondgaard, C. W. Yde, C. Baudet, P. Licht, M. Lund-Iversen, B. H. Gronberg, L. Fjellbirkeland, A. Helland, M. Pohl, D. J. Kwiatkowski, T. Donnem
Summary: This study aimed to implement an immune cell score model in routine clinical practice for resected non-small-cell lung cancer patients. The model, based on machine learning, classified tumors into three categories based on the spatial distribution of CD8+ T cells. The study found significant associations between the immune phenotypes and adaptive immunity gene expression signatures.
ANNALS OF ONCOLOGY
(2023)
Article
Cell Biology
Dominique C. S. Evans, Amanda B. Khamas, Lisbeth Marcussen, Kristian S. Rasmussen, Janne K. Klitgaard, Birgitte H. Kallipolitis, Janni Nielsen, Daniel E. Otzen, Mark C. Leake, Rikke L. Meyer
Summary: This study demonstrates the feasibility of using the monomeric superfolder GFP (msfGFP) exported from Staphylococcus aureus as a fluorescent reporter. By fusing msfGFP to potential signal peptides, the secretion of proteins from S. aureus was successfully studied. Our findings suggest that msfGFP is an ideal fluorescent reporter to consider when studying proteins secreted by the Sec pathway in S. aureus.
Article
Computer Science, Information Systems
Yana A. Salchak, Noor M. Albadri, Tracey Bjorkman, Cora Lau, Esmaeil S. Nadimi, Peter Bollen, Hugo G. Espinosa, David Thiel
Summary: Wireless capsule endoscopy is a non-invasive method for gastrointestinal examination that can reduce mortality and morbidity. This study presents a new propagation model for precise localization of the capsule inside the abdomen and validates it through experiments on porcine animals. The model can be used for accurate range-based positioning of implanted transmitters.