Article
Clinical Neurology
Seo Yeon Yoon, Jaeyong Shin, Seok-Jae Heo, Jee Suk Chang, Mun Kyung Sunwoo, Yong Wook Kim
Summary: This study found that in individuals aged 65 and above, irritable bowel syndrome (IBS) may increase the risk of developing Parkinson's disease (PD), suggesting a potential early manifestation of PD in patients with IBS. Further research is needed to establish a causal link between the two diseases.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Yi-Hsien Chen, Wei-Ming Wang, Chi-Hsiang Chung, Chang-Huei Tsao, Wu-Chien Chien, Chih-Tsung Hung
Summary: The study found no increased risk of psychiatric disorders among Taiwanese patients with acne who were taking isotretinoin. Higher dosage or longer duration of isotretinoin treatment did not increase the risk for developing a psychiatric disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Huang-Hsi Chen, Kevin Sheng-Kai Ma, Chen Dong, Wen-Jung Chang, Kuan-Rong Gao, Wuu-Tsun Perng, Jing-Yang Huang, James Cheng-Chung Wei
Summary: This study found that patients with HPV infections have a significantly higher risk of primary Sjogren's syndrome (pSS), regardless of age and sex.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jonas F. Ludvigsson, Ola Olen, Henrik Larsson, Jonas Halfvarson, Catarina Almqvist, Paul Lichtenstein, Agnieszka Butwicka
Summary: Adult-onset inflammatory bowel disease is associated with an increased risk of psychiatric disorders and suicide attempts, particularly in the first year following diagnosis.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Medicine, General & Internal
Hao-Yuan Feng, Chi-Ho Chan, Yu-Cheng Chu, Xin-Man Qu, Yu-Hsun Wang, James Cheng-Chung Wei
Summary: This nationwide population-based cohort study showed that patients with AS have higher risks of irritable bowel syndrome (IBS) than those of the non-AS comparison group.
POSTGRADUATE MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ping-Huei Tseng, Han-Mo Chiu, Chia-Hung Tu, Ming-Shiang Wu, Hong-Nerng Ho, Mei-Jou Chen
Summary: Women with PCOS are more likely to have IBS and obesity, and are at higher risk of psychiatric morbidities compared to healthy women. Those with both PCOS and IBS have increased rates of sleep difficulties and psychiatric distress.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Chia-Peng Yu, Iau-Jin Lin, Bing-Long Wang, Chang-Huei Tsao, Shi-Hao Huang, Yao-Ching Huang, Chien-An Sun, Chi-Hsiang Chung, Je-Ming Hu, Wu-Chien Chien
Summary: This study found a higher risk of developing psychiatric disorders among patients with intestinal infectious diseases, with 13.32% of the patients developing psychiatric disorders overall. In particular, patients with refractory IIDs (seeking medical attention 3 or more times) had a significantly increased risk of developing psychiatric disorders.
Article
Clinical Neurology
Yao-Ching Huang, Wu-Chien Chien, Chi-Hsiang Chung, Hsin-An Chang, Yu-Chen Kao, Fang-Jung Wan, Shi-Hao Huang, Ren-Jei Chung, Richard S. Wang, Bing-Long Wang, Nian-Sheng Tzeng, Chien-An Sun
Summary: The study found that patients with multiple sclerosis (MS) have a higher risk of developing a wide range of psychiatric disorders, including depression, anxiety, bipolar disorder, etc. Some disease-modifying drugs were associated with a lower risk of anxiety or depression.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Gastroenterology & Hepatology
Zachary E. McPherson, Henrik T. Sorensen, Erzsebet Horvath-Puho, Ashish Agar, Minas T. Coroneo, Andrew White, Ian C. Francis, Louis R. Pasquale, Jae H. Kang, Sven Pettersson, Nicholas J. Talley, Mark A. McEvoy
Summary: Two large European cohort studies suggest that individuals with irritable bowel syndrome (IBS) may have an increased risk of developing glaucoma.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Neurosciences
Tuomas H. Mertsalmi, Anna But, Eero Pekkonen, Filip Scheperjans
Summary: A retrospective study indicates that patients with irritable bowel syndrome (IBS) have an increased risk of developing Parkinson's disease (PD) in the first two years, but not in the long term. The findings suggest that IBS may be a prodromal symptom of PD rather than an actual risk factor.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Gastroenterology & Hepatology
Kwangwoo Nam, Nayoung Kim, Hyun Joo Song, Gwang Ho Baik, Suck Chei Choi, Hyun Jin Kim, Ju Yup Lee, Kyung Sik Park, Sun-Young Park, Seun Ja Park
Summary: The overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS) is associated with more severe upper gastrointestinal symptoms and depression compared to non-overlap patients. Women with FD-IBS overlap experience more severe gastrointestinal and depression symptoms than men.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Environmental Sciences
Ta-Chuan Yeh, Ya-Mei Bai, Shih-Jen Tsai, Tzeng-Ji Chen, Chih-Sung Liang, Mu-Hong Chen
Summary: Offspring of parents with IBS are at a higher risk of developing IBS, ADHD, and MDD. There are gender differences, with paternal IBS increasing the risk of offspring developing ADHD, and maternal IBS increasing the risk of offspring developing MDD. This study highlights the importance of early prevention strategies for at-risk children.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Yuhan Fu, Michael Kurin, Marc Landsman, Ronnie Fass, Gengqing Song
Summary: The aim of the study was to determine whether IBS is an independent risk factor for developing opioid addiction and related gastrointestinal symptoms in patients with IBD. The results showed that patients with concomitant IBD and IBS were more likely to be prescribed oral opioids and develop opioid dependence or abuse.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Francis Creed
Summary: This study aims to evaluate the differences in risk factors between individuals with psychiatric disorders prior to irritable bowel syndrome (IBS) onset and those without. The results suggest that prior psychiatric disorder is an important risk factor for a quarter of IBS onsets, and negative health perception and multiple bodily symptoms are associated with all IBS onsets.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Psychiatry
Mao-Hsuan Huang, Yee-Lam E. Chan, Mu-Hong Chen, Ju-Wei Hsu, Kai-Lin Huang, Cheng-Ta Li, Shih-Jen Tsai, Tung-Ping Su, Ya-Mei Bai
Summary: This study reveals a bidirectional relationship between inflammation and depression in bipolar disorder (BD). Among patients in a depressed state, higher levels of pro-inflammatory markers are associated with more severe mood symptoms. In euthymic patients, baseline levels of pro-inflammatory markers can predict the onset of depression. Additionally, lithium appears to have a stronger effect in reducing inflammation compared to other mood stabilizers.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychiatry
Dian-Jeng Li, Mu-Hong Chen, Ya-Mei Bai, Shih-Jen Tsai, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Ta-Chuan Yeh, Chih-Sung Liang
Summary: This study found that offspring of parents with bipolar disorder have a higher risk of exposure to prescription opioids and developing pain disorders.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychiatry
Dian-Jeng Li, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Chih-Sung Liang, Mu-Hong Chen
Summary: This study aimed to investigate the association between a history of premenstrual dysphoric disorder (PMDD) and the subsequent risk of major affective disorders. The results showed that women with PMDD had a higher risk of developing unipolar depression and bipolar disorder compared to those without PMDD.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Shih-Jen Tsai, Chih-Ming Cheng, Wen-Han Chang, Ya-Mei Bai, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Evidence suggests a familial coaggregation of death by suicide with accidental death and major psychiatric disorders. Further studies are needed to understand the underlying pathological mechanisms.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Shih-Jen Tsai, Chung-Feng Kao, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Chen-Jee Hong, Ya-Mei Bai, Pei-Chi Tu, Mu-Hong Chen
Summary: The aim of this study was to analyze whether specific genes related to inflammatory processes and VEGF were associated with treatment response to low-dose ketamine in patients with treatment-resistant depression. The findings revealed that specific single nucleotide polymorphisms in IL1R1 and VEGFC were related to the rapid antidepressant effect, while single nucleotide polymorphisms in PIGF and TNFRSF8 were associated with the sustained antidepressant effect. The synergic modulation of inflammatory and VEGF systems may contribute to the antidepressant effect of ketamine.
Article
Clinical Neurology
Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Hui-Ju Wu, Shih-Jen Tsai, Ya-Mei Bai, Wei-Chung Mao, Pei-Chi Tu, Li-Fen Chen, Wei-Chi Li, Mu-Hong Chen
Summary: This study suggests that low-dose ketamine infusion is a safe and effective treatment for patients with TRD and prominent suicidal ideation. The timing of ketamine administration, specifically the duration of the current depressive episode and the number of failed antidepressant trials, plays an important role in achieving therapeutic response.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Jun-Ding Zhu, Yung-Fu Wu, Shih-Jen Tsai, Ching-Po Lin, Albert C. C. Yang
Summary: Brain-age prediction models were constructed using multimodal MRI, and deviations in aging trajectories in different brain regions of participants with schizophrenia were examined. The results showed accelerated aging in most gray matter regions, especially in the frontal lobe, temporal lobe, and insula. Deviations in aging trajectories were also observed in some white matter tracts. However, no accelerated brain aging was found in functional connectivity maps. These findings provide insights into the neuropathology of schizophrenia.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Developmental
Shih-Jen Tsai, Wen-Han Chang, Chih-Ming Cheng, Chih-Sung Liang, Ya-Mei Bai, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Evidence suggests that autistic individuals have increased risks of mortality, including natural-cause, suicide, and accident mortalities. A study conducted in Taiwan found that autistic individuals had higher likelihoods of all-cause mortality, natural-cause mortality, and suicide mortality compared with non-autistic individuals. Autistic males were more likely to die by suicide, and autistic females were more likely to die of accident compared with non-autistic individuals.
Article
Clinical Neurology
Ju-Wei Hsu, Li-Chi Chen, Shih-Jen Tsai, Kai-Lin Huang, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu -Hong Chen
Summary: Studies have shown that there is a positive relationship between resistance to antidepressants and the progression of bipolar disorder. However, the specific influence of different types of antidepressants, such as SSRIs and SNRIs, in this context has not been thoroughly investigated. This study recruited a total of 5,285 young people with antidepressant-resistant depression and 21,140 with antidepressant-responsive depression. It was found that those with resistance to antidepressants, especially to both SSRIs and SNRIs, were at an increased risk of developing bipolar disorder.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Cheng-Ta Li, Chih-Ming Cheng, Hui-Ching Lin, Skye Hsin-Hsieh Yeh, Jia-Shyun Jeng, Hui-Ting Wu, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Paul B. Fitzgerald
Summary: This double-blind, sham-controlled study aimed to investigate the antidepressant efficacy of 2 daily prolonged intermittent theta-burst stimulation (piTBS) sessions for treating major depressive disorder (MDD) patients. The results showed that the piTBS group had significantly more responders at week 2 than the sham group, but there was no evidence to support that longer piTBS treatment duration resulted in more rapid or better antidepressant effects. Longer treatment duration did not result in stronger placebo effects.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Tien-Wei Hsu, Mu-Hong Chen, Ya-Mei Bai, Wen-Han Chang, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Shih-Jen Tsai, Chih-Sung Liang
Summary: This study aimed to examine the risk of T1D, MDD, ADHD, and ASD in first-degree relatives of T1D patients. The results showed that FDRs of individuals with T1D had a higher risk of T1D and MDD compared to controls. Stratified by sex and kinship, female FDRs had an increased risk of MDD, while male FDRs had an increased risk of ADHD. Furthermore, FDRs of individuals with T1D and DKA had a higher risk of MDD and ADHD.
ACTA DIABETOLOGICA
(2023)
Article
Psychiatry
Chen-Lan Shen, Shih-Jen Tsai, Ching-Po Lin, Albert C. C. Yang
Summary: This study examined the structural and functional brain abnormalities in patients with schizophrenia, and found that these abnormalities progress at different rates and in different brain areas throughout the course of the illness. Using MRI scanning, the study found that in the early stages of schizophrenia, there were only limited functional abnormalities in certain brain regions, but as the illness progressed, the abnormalities spread to wider brain areas and also involved gray matter density. In the third decade of the illness, structural connectivity abnormalities affecting almost all white matter tracts emerged.
Article
Psychiatry
Jun-Ding Zhu, Shih-Jen Tsai, Ching-Po Lin, Yi-Ju Lee, Albert C. Yang
Summary: Brain-age prediction is a novel approach for assessing deviated brain aging trajectories in different diseases. This study aimed to investigate the presence of declined brain structures in schizophrenia using brain volume, cortical thickness, and fractional anisotropy as features. The results showed that individuals with schizophrenia had larger brain age gaps compared to healthy controls across different illness durations.