Article
Chemistry, Medicinal
Jia Yang, Gangdan Jiang, Kaiwen Ni, Liming Fan, Wang Tong, Junchao Yang
Summary: Emodin can attenuate pulmonary fibrosis and epithelial-mesenchymal transition (EMT) by regulating the c-MYC/miR-182-5p/ZEB2 axis, providing evidence for the application of Emodin in the treatment of pulmonary fibrosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Wen Jia, Mohit Kumar Jolly, Herbert Levine
Summary: The epithelial-mesenchymal transition (EMT) is a crucial cellular process for wound healing, cancer metastasis, and embryonic development. Recent studies have shown that hybrid epithelial/mesenchymal states, possessing both epithelial and mesenchymal traits, play a significant role in cancer metastasis and resistance to therapies. NRF2 has been identified as a stabilizing factor for these hybrid states. This research incorporates a phenomenological epigenetic feedback effect into a computational model for EMT signaling and demonstrates its stabilizing effect on the hybrid state if NRF2 influences SNAIL at an epigenetic level.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yoshiko Hashimoto, Tomoko Tsuzuki-Nakao, Naoko Kida, Yoshiyuki Matsuo, Tetsuo Maruyama, Hidetaka Okada, Kiichi Hirota
Summary: The endometrium undergoes repeated changes during the menstrual cycle, and chronic endometritis can lead to implantation failure and miscarriage. In this study, the effects of inflammatory cytokines, hypoxia-inducible factor (HIF), and inflammation on endometrial epithelial cells were investigated. The results showed that pro-inflammatory factors and hypoxia activated HIF-1 and promoted epithelial-mesenchymal transition (EMT) in endometrial epithelial cells.
Article
Oncology
Yuchong Zhao, Yun Wang, Wei Chen, Shuya Bai, Wang Peng, Mengli Zheng, Yilei Yang, Bin Cheng, Zhou Luan
Summary: In pancreatic cancer, eIF4A1 downregulates E-cadherin expression through the c-MYC/miR-9 axis, promoting EMT and metastasis. Intervention on eIF4A1 and c-MYC can reduce the EMT and metastasis capabilities of pancreatic cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Zhenhua Zhou, Huiyan Wang, Xiwen Zhang, Minmin Song, Simin Yao, Peipei Jiang, Dan Liu, Zhiyin Wang, Haining Lv, Ruotian Li, Ying Hong, Jianwu Dai, Yali Hu, Guangfeng Zhao
Summary: Defective autophagy plays an important role in endometrial fibrosis by regulating EEC-EMT through the DIO2-MAPK/ERK-MTOR pathway.
Article
Anatomy & Morphology
Sourangshu Chakraborti, Aparajita Karmakar, Riana Guha, Christopher Ngan, Raunak Kumar Das, Noel Whitaker
Summary: This study investigates the induction of EMT by HPV16 in the C33A cell line. Immunofluorescence and RT-PCR were used to examine the expression of 8-catenin, EMT-TFs, and c-myc in HPV16 E6/E7 oncogene transfected and nontransfected C33A cells. ImageJ and Python programming were utilized for image analysis. The results show that HPV16 E6/E7 oncogene can induce EMT based on the increased expression of 8-catenin, c-myc, and EMT-TFs.
Article
Developmental Biology
Xi Cheng, Yu Zhang, Jinzhao Ma, Shuxian Wang, Rujun Ma, Xie Ge, Wei Zhao, Tongmin Xue, Li Chen, Bing Yao
Summary: The study found that NLRP3 is highly expressed in the human endometrium and transcriptionally up-regulated by estradiol through estrogen receptor beta. Additionally, NLRP3 promotes embryo implantation and epithelial-mesenchymal transition of Ishikawa cells through inflammasome-dependent and inflammasome-independent pathways, providing a novel insight into endometrial receptivity and embryo implantation.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Katrien De Clercq, Rieta Van Bree, Katrien Luyten, Daniela Annibali, Frederic Amant, Sileny Han, Els Van Nieuwenhuysen, Thais Baert, Karen Peeraer, Thomas Voets, Toon Van Gorp, Joris Vriens
Summary: The study revealed a strong association between TRP channel mRNA expression and cellular phenotypes in the endometrium. Specifically, TRPV2 and TRPC1 mRNA expression correlated with the mesenchymal phenotype, while TRPM4 mRNA expression was associated with the epithelial phenotype. These findings suggest that TRP channels could serve as biomarkers for high-risk endometrial cancer and potential targets for treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Aristeidis E. Boukouris, Yongneng Zhang, Bruno Saleme, Adam Kinnaird, Yuan Yuan Zhao, Yongsheng Liu, Sotirios D. Zervopoulos, Subhash K. Das, Rohan D. Mittal, Alois Haromy, Maria Areli Lorenzana-Carrillo, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Gopinath Sutendra, Evangelos D. Michelakis
Summary: Metabolic stress can induce the expression of CRMP2A in cancer cells, inhibiting epithelial-to-mesenchymal transition (EMT) and stemness. Loss of CRMP2A leads to microtubule remodeling, increased glutamine utilization, and enhanced EMT/stemness. The expression of CRMP2A is decreased in metastatic tumors compared to primary tumors in prostate cancer patients.
Review
Biochemistry & Molecular Biology
Fu Peng, Huali Fan, Sui Li, Cheng Peng, Xiaoqi Pan
Summary: MicroRNAs have been utilized as negative regulators in cancer treatment by down-regulating their targets, especially in the EMT process. Natural plant compounds can modulate deregulated microRNAs to inhibit EMT, which could potentially lead to the inhibition of cancer development. This review article highlights the significance of microRNAs in EMT as oncogenes and tumor suppressor genes, providing evidence for target therapy in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Rafael Jimenez-Izquierdo, Rosario Morrugares, Lucia Suanes-Cobos, Alejandro Correa-Saez, Martin Garrido-Rodriguez, Laura Cerero-Tejero, Omar M. Khan, Susana de la Luna, Rocio Sancho, Marco A. Calzado
Summary: FBXW7 is a member of the F-box protein family and acts as the substrate recognition component of SCF E3 ubiquitin ligase. It plays a crucial role in tumor suppression by controlling proteasome-mediated degradation of oncoproteins. This study reveals a novel regulatory mechanism of FBXW7 involving the serine/threonine protein kinase DYRK2. DYRK2 interacts with and phosphorylates FBXW7, leading to its degradation via the proteasome. This DYRK2-dependent regulation of FBXW7 contributes to cytotoxic effects in cancer cells, suggesting its potential as a therapeutic target.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Fanyun Kong, Lihong Ma, Xing Wang, Hongjuan You, Kuiyang Zheng, Renxian Tang
Summary: Research has found that lysine acetylation plays a role in modulating molecules involved in EMT, including marker proteins, transcription factors, and signal transduction molecules. Histone acetylation functions through epigenetic regulation, while non-histone acetylation is a post-translational modification, both contributing to the control of EMT. Inhibitors targeting KATs and KDACs have potential therapeutic value in cancer treatment by suppressing EMT and tumor development.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Nguyen-Tuong Ho, Shu-Wei Lin, Yi-Rong Lee, Chii-Ruey Tzeng, Shu-Huei Kao
Summary: OPNb and OPNc are overexpressed in endometriosis and adenomyosis, and CD44v and the epithelial-mesenchymal transition (EMT) process are also upregulated. Overexpression of OPNb and OPNc splice variants leads to morphological changes, actin remodeling, cell proliferation, cell migration, and EMT through binding with CD44 and alpha v beta 3, subsequently activating the PI3K and NF-kappa B pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shuangyu Liu, Lingyu Li, Dongmei Ren
Summary: Epithelial-mesenchymal transition (EMT) is a biological process that allows epithelial cells to transform into mesenchymal cells and acquire some cancer stem cell properties, contributing significantly to metastasis, invasion, and treatment resistance in cancer cells. Research has shown that phytochemicals, as potential sources of safe and effective anti-cancer medications, can disrupt signaling pathways related to malignant cell metastasis and drug resistance by suppressing or reversing the EMT process. This review briefly describes the pathophysiological properties and molecular mechanisms of EMT in cancer progression, and summarizes phytochemicals with diverse structures that can block the EMT process in different types of cancer, providing guidance for future research on phytochemicals targeting EMT.
Article
Immunology
Jinhui Liu, Guoliang Cui, Shuning Shen, Feng Gao, Hongjun Zhu, Yinghua Xu
Summary: This study aimed to establish a prognostic signature for endometrial cancer (EC) related to epithelial-mesenchymal transition (EMT). Through analyzing the expression of relevant genes and clinical data, 10 genes associated with the survival rate of EC patients were identified, and a predictive model for survival rate was constructed. Additionally, the study discovered differences in immune infiltrating, tumorigenesis pathways, and drug response between high and low-risk groups.
FRONTIERS IN IMMUNOLOGY
(2022)