Article
Multidisciplinary Sciences
Ivan Cokic, Shing Fai Chan, Xingmin Guan, Anand R. Nair, Hsin-Jung Yang, Ting Liu, Yinyin Chen, Diego Hernando, Jane Sykes, Richard Tang, John Butler, Alice Dohnalkova, Libor Kovarik, Robert Finney, Avinash Kali, Behzad Sharif, Louis S. Bouchard, Rajesh Gupta, Mayil Singaram Krishnam, Keyur Vora, Balaji Tamarappoo, Andrew G. Howarth, Andreas Kumar, Joseph Francis, Scott B. Reeder, John C. Wood, Frank S. Prato, Rohan Dharmakumar
Summary: After myocardial infarction, intramyocardial hemorrhage contributes to fatty degeneration and adverse remodeling of the heart, but timely reduction of iron within the hemorrhagic infarction zone can mitigate these effects.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Nicole Zeinstra, Ariana L. Frey, Zhiying Xie, Leslie P. Blakely, Ruikang K. Wang, Charles E. Murry, Ying Zheng
Summary: A modular fabrication approach using stacked patterned collagen membranes is reported to generate thick, large, three-dimensional, perfusable networks of endothelialized vasculature. The perfusable vascular networks show remodeling and evenly distributed perfusion in vitro while maintaining their patterned, open-lumen architecture. Implanted onto infarcted rat hearts, the perfusable vascular networks achieve greater host vascular integration and higher perfusion rate compared to self-assembled controls. This success represents an important step forward for vascular bioengineering and opens possibilities for more complex, large scale, highly metabolic engineered tissues.
Article
Chemistry, Multidisciplinary
Xiao-Ling Luo, Yun Jiang, Qiang Li, Xiu-Jian Yu, Teng Ma, Hao Cao, Min-Xia Ke, Peng Zhang, Ji-Liang Tan, Yan-Shan Gong, Li Wang, Ling Gao, Huang-Tian Yang
Summary: This study finds that human embryonic stem cell-derived epicardial cells (hEPs) can improve myocardial infarction (MI) by promoting cardiomyocyte survival, angiogenesis, and lymphangiogenesis, as well as suppressing inflammatory responses. It also reveals that intelectin 1 (ITLN1) secreted by hEPs interacts with interferon-beta and contributes to the beneficial effects of hEPs in inflammation inhibition and cardiac repair.
Article
Chemistry, Multidisciplinary
Weirong Xiong, Xiaoxian Wang, Haien Guan, Fanxuan Kong, Zhaoming Xiao, Yihan Jing, Liu Cai, Honghao Hou, Xiaozhong Qiu, Leyu Wang
Summary: Conductive cardiac patches have been shown to promote angiogenesis but their conductive integrity, elasticity, and vascularization potential haven't been optimized yet. Prevascularization of these patches could be an effective strategy to connect them with the infarcted heart. In this study, a vascularized conductive elastic patch was created by incorporating a coronary artery casting into a graphene oxide/polypyrrole-infused methacrylate gel. The patches were successful in rebuilding functional blood vessels and integrating with infarcted hearts, leading to effective myocardial infarction repair.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander B. Veitinger, Audrey Komguem, Lena Assling-Simon, Martina Heep, Julia Schipke, Christian Muehlfeld, Bernd Niemann, Philippe Grieshaber, Kerstin Boengler, Andreas Boening
Summary: In non-infarcted rat hearts, esmolol-based cardioplegia, particularly ECCP, offers better myocardial protection than Calafiore. After an acute myocardial infarction, cardioprotection with esmolol-based cardioplegia is similar to that with Calafiore.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Chaojie Yu, Zhiwei Yue, Mingyue Shi, Lijie Jiang, Shuang Chen, Mengmeng Yao, Qingyu Yu, Xiaojun Wu, Hong Zhang, Fanglian Yao, Changyong Wang, Hong Sun, Junjie Li
Summary: An injectable mechanical-electrical coupling hydrogel patch (MEHP) with self-adaptive, high adhesiveness, and electrical conductivity has been developed to restore cardiac electrical conduction and pulsatile function, showing potential in the clinical application of cardiac tissue engineering.
Article
Biotechnology & Applied Microbiology
Ke Zhu, Yu Yao, Kun Wang, Fuqiang Shao, Ziyang Zhu, Yangmeihui Song, Zhangyongxue Zhou, Dawei Jiang, Xiaoli Lan, Chunxia Qin
Summary: This study reveals that berberine (BBR) treats myocardial infarction (MI) by regulating inflammatory responses, as determined by network pharmacology. Platelet membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles (BBR@PLGA@PLT NPs) are used to deliver BBR, which are more enriched in the infarcted myocardium and less uptaken in the liver compared to PLGA nanoparticles. BBR@PLGA@PLT NPs significantly increase the number of repaired macrophages and decrease the number of inflammatory macrophages and apoptotic cells in infarcted rat myocardium on day three after MI. On the 28th day after MI, the BBR@PLGA@PLT group shows a protective effect on cardiac function, reduced cardiac collagen deposition, improved scar tissue stiffness, and excellent angiogenesis effect.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Leyu Wang, Yuqing Liu, Genlan Ye, Yutong He, Bingyun Li, Yezhi Guan, Baoyong Gong, Kibret Mequanint, Malcolm M. Q. Xing, Xiaozhong Qiu
Summary: Injectable and electrically conductive scaffolds with shape-memory behavior and hierarchical porous structure show promising results in functional repair of infarcted heart muscle in rats and minipigs, by increasing fractional shortening, ejection fraction, and reducing the infarcted area.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Cen Xiang, Shoujia Yu, Qiyang Ren, Boyi Jiang, Jing Li, Donghang Zhang, Yiyong Wei
Summary: By studying the metabolites in rat hearts after the application of diazoxide, researchers found that diazoxide postconditioning improved cardiac function and this protective effect could be enhanced by a mitofilin modulator. Furthermore, through metabolite analysis, five metabolites were found to be associated with the cardioprotective effects of diazoxide postconditioning on myocardial ischemia/reperfusion injury.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Pharmacology & Pharmacy
Cheng-Che Lee, Wei-Ting Chen, Syue-Yi Chen, Tsung-Ming Lee
Summary: This study demonstrated that dapagliflozin attenuates post-myocardial infarction arrhythmias by modulating AMP-activated protein kinase and SGLT1, reducing reactive oxygen species production, increasing connexin43 levels, and significantly improving arrhythmic severity.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qianlong Wang, Tiantian Wang, Chonkit Lio, Xina Yu, Xiaoyi Chen, Lancong Liu, Youjiao Wu, Hui Huang, Linsen Qing, Pei Luo
Summary: This study demonstrates the use of surface hydrolysis-designed AuNPs-zwitterionic-glucose to label and track macrophages infiltration into the MI sites using CT imaging. The study also addresses the concern of cell tracking or AuNP tracking and improves the accuracy and precision of imaging and target delivery using zwitterionic and glucose-functionalized AuNPs. This is the first study to noninvasively visualize the infiltration of macrophages into MI hearts using CT.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Mechanics
Kevin L. Sack, Nicolas Mandel, Nicola M. Pugno, Deon Bezuidenhout, Georges Limbert, Francesco Moscato, Neil H. Davies, Thomas Franz, Tamer Abdalrahman
Summary: For tissue engineering applications, accurately predicting the effective mechanical properties of tissue scaffolds is crucial. This study developed a formulation to link the microscopic structure and macroscopic mechanics of a fibrous electrospun scaffold filled with a hydrogel, and demonstrated the feasibility of homogenization techniques to represent complex multiscale structural features. The predicted results showed the potential of using homogenization methods in the design and evaluation of tissue-engineered scaffolds.
Article
Cell & Tissue Engineering
Kashif Khan, Georges Makhoul, Bin Yu, Ghulam Jalani, Ida Derish, Alissa K. Rutman, Marta Cerruti, Adel Schwertani, Renzo Cecere
Summary: The study demonstrated that inserting human amniotic stromal mesenchymal stem cells (ASMCs) in a chitosan and hyaluronic acid (C/HA) based hydrogel significantly increased cardiac function and promoted new vessel formation in a rat myocardial infarction model. Proteomic profiling revealed that extracellular vesicles released from hypoxia-preconditioned ASMCs contained proteins involved in cytoprotection and angiogenesis.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Biology
Jieh-Neng Wang, Chung-Dann Kan, Lain-Tze Lee, Lynn L. H. Huang, Ya-Li Hsiao, Allen H. Chang, Wanchun Liu, Cheng Lin, Chou-Wen Lin
Summary: This study demonstrated that the herbal extract 417W from Codonopsis pilosula can enhance cardiogenic differentiation in ES cells and improve cardiac function in infarcted hearts. The results were evaluated in mouse ES cell-based model and rat myocardial infarction model, showing significant improvements in cardiac function parameters post-treatment with 417W.
Article
Biochemistry & Molecular Biology
Chao-Ping Wang, Cheng-Che Lee, De-Yu Wu, Syue-yi Chen, Tsung-Ming Lee
Summary: The study found that omega-3 fatty acids EPA and DHA have differential effects after myocardial infarction, with EPA being more effective in preventing fatal arrhythmias. EPA can inhibit inflammasome and sympathetic innervation, acting through the PPARγ-mediated GPR120-dependent and -independent signaling pathways.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)