Article
Endocrinology & Metabolism
Elena Weibert, Tobias Hofmann, Ulf Elbelt, Matthias Rose, Andreas Stengel
Summary: This study investigated the association between NUCB2 / nesfatin-1 and eating disorder symptoms, and found a positive correlation between NUCB2 / nesfatin-1 plasma levels and eating disorder symptoms in women with obesity.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Magnus Sjogren, Ismail Kizilkaya, Rene Klinkby Stoving
Summary: Inpatient weight restoration treatment is associated with a decrease in post-meal anxiety in patients with Anorexia Nervosa, demonstrating an early and clinically significant effect in those who stay in treatment. The study also found that baseline medication or scores of Major Depression Inventory did not affect the results, indicating that BMI increase and reduction in anxiety levels were independent of these factors.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Emilio J. Velez, Atefeh Nasri, Suraj Unniappan
Summary: The study revealed that NESF and NLP inhibit the transcription of PRL in pituitary cells and prevent the stimulatory effects of TRH on PRL expression. Knockdown of endogenous NUCB1 attenuates PRL expression in pituitary cells, while the actions of exogenous NESF or NLP are not affected by NUCB silencing. These findings suggest that NUCBs and encoded peptides are novel regulators of PRL. Future research should investigate whether these effects are maintained in vivo and at the posttranscriptional level.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xi Chen, Jing Dong, Qian Jiao, Xixun Du, Mingxia Bi, Hong Jiang
Summary: Ghrelin and nesfatin-1 are peptides secreted by the same type of endocrine cells in the stomach, with opposite effects on energy and glucose metabolism, but similar effects on inflammation and neuroprotection. Nesfatin-1's effects depend on the receptor of ghrelin.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Engineering, Biomedical
Qiaoyan Gu, Yuan Lei, Jianming Wu, Ting He, Juanjuan Li, Shanshan Song
Summary: This study aimed to evaluate the effect of NUCB2/Nesfatin-1 on model rats with chronic visceral hyperalgesia. The results showed that NUCB2/Nesfatin-1 could regulate visceral sensitivity in these rats, and the regulatory effect was related to the intervention approaches (central or peripheral) and sex.
APPLIED BIONICS AND BIOMECHANICS
(2022)
Article
Biochemistry & Molecular Biology
Chaeyoung Ahn, Sojung Sun, Jinah Ha, Hyunwon Yang
Summary: The polypeptide hormone Nesfatin-1, derived from the precursor protein NUCB2, has been found to be expressed in the testis of mice. The expression of NUCB2 mRNA is regulated by gonadotropins, and exogenous nesfatin-1 affects steroidogenesis in Leydig cells. This study provides important insight into the regulation of NUCB2/nesfatin-1 expression and its impact on steroidogenesis, with potential implications for male reproductive health.
Review
Medicine, General & Internal
Leah Puckett, Daniela Grayeb, Vishnupriya Khatri, Kamila Cass, Philip Mehler
Summary: Anorexia nervosa is a complex and deadly psychiatric disorder characterized by co-occurring psychiatric diseases and physiological changes affecting various organ systems. Early recognition and treatment are crucial to prevent serious consequences for patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Fisheries
Fan Liu, Qiming Xie, Xinxin Liu, Xilei Li, Ping Fu, Caixia Song, Jun Zhang, Shiping Su
Summary: The present study found that injection of 50 ng/g nesfatin-1 protein significantly reduced triglyceride and total cholesterol levels in the hepatopancreas of largemouth bass, while levels in plasma were not significantly altered. This suggests that nesfatin-1 affects lipid metabolism in the hepatopancreas of largemouth bass via the PPAR signaling pathway.
AQUACULTURE REPORTS
(2023)
Article
Endocrinology & Metabolism
Anna Szeliga, Agnieszka Podfigurna, Blazej Meczekalski
Summary: This study is the first to examine the concentration of nesfatin-1 in patients with functional hypothalamic amenorrhea (FHA). It was found that patients with FHA had decreased serum nesfatin-1 concentrations. This finding may be important for managing patients with FHA in the future.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Franziska Plessow, Francesca Galbiati, Kamryn T. Eddy, Madhusmita Misra, Karen K. Miller, Anne Klibanski, Anna Aulinas, Elizabeth A. Lawson
Summary: Anorexia nervosa (AN) is commonly accompanied by depression, anxiety, and socioemotional dysfunction. However, the relationship between oxytocin and psychopathology in individuals with primarily food restriction (AN/AtypAN-R) or restriction plus binge/purge behaviors (AN/AtypAN-BP) has not been explored, which is crucial for understanding the neurobiology of different AN presentations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Mariarita Caroleo, Elvira Anna Carbone, Biagio Arcidiacono, Marta Greco, Amedeo Primerano, Maria Mirabelli, Gilda Fazia, Marianna Rania, Marta Letizia Hribal, Luca Gallelli, Daniela Patrizia Foti, Pasquale De Fazio, Cristina Segura-Garcia, Antonio Brunetti
Summary: Nesfatin-1 is a new neuropeptide that regulates hunger/satiety, eating, and affective disorders. The secretion of nesfatin-1 in adipocytes and its relationship with NUCB2 and FTO gene polymorphisms, BMI, Eating Disorders (EDs), and pathological behaviors were investigated. Higher levels of nesfatin-1 were found in hypoxic adipocytes and omental visceral adipose tissue (VAT) of obese individuals. Nesfatin-1 levels were associated with grazing, emotional, sweet, and binge eating, hyperphagia, social eating, and childhood obesity. Obese individuals with certain NUCB2 and FTO gene polymorphisms had higher levels of nesfatin-1.
Article
Psychiatry
Elise Riquin, Agathe Raynal, Lama Mattar, Christophe Lalanne, France Hirot, Caroline Huas, Jeanne Duclos, Sylvie Berthoz, Nathalie Godart
Summary: The study found that the presence of depressive or anxiety comorbidities in patients with anorexia nervosa leads to more severe clinical conditions, especially when the comorbidities exist before the onset of anorexia nervosa. Patients with depressive or anxiety comorbidities show poorer quality of life and more severe eating symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Seley Gharanei, Manjunath Ramanjaneya, Aaran Hitesh Patel, Vanlata Patel, Kiran Shabir, Callum Auld, Emmanouil Karteris, Ioannis Kyrou, Harpal Singh Randeva
Summary: This study found that an obesogenic diet can trigger significant inflammation in the subcutaneous white adipose tissue (ScWAT) of NUCB2 knockout mice, while nesfatin-1 has a reducing effect on the inflammatory response in LPS-stimulated 3T3-L1 cells.
Article
Endocrinology & Metabolism
T. Dang, A. T. Faje, E. Meenaghan, M. A. Bredella, M. L. Bouxsein, A. Klibanski, P. K. Fazeli
Summary: This study found that although anorexia nervosa patients have decreased bone mineral density (BMD) and increased fracture risk, BMD does not predict fracture history in this disorder. On the other hand, bone marrow adipose tissue (BMAT) is associated with fracture history in these patients.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Jiayuan Zheng, Jing Han, Yu Wang, Zhanzhuang Tian
Summary: Since the discovery of NUCB2/nesfatin-1 as an anorexigenic factor, its expanding function has been studied. It has been found that NUCB2/nesfatin-1 is involved in the regulation of stress and stress-related gastrointestinal disorders. Different stressors and durations affect NUCB2/nesfatin-1-associated brain regions and serum corticosterone levels differently. NUCB2/nesfatin-1 mediates stress-related gastrointestinal disorders and may protect against inflammatory bowel disease.
Correction
Oncology
Peter Esser, Leon Sautier, Susanne Sarkar, Georgia Schilling, Carsten Bokemeyer, Uwe Koch, Matthias Rose, Michael Friedrich, Sandra Nolte, Otto Walter, Anja Mehnert-Theuerkauf
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Psychiatry
Tim J. Hartung, Michael Friedrich, Peter Esser, Anja Mehnert-Theuerkauf, Antje Lehmann-Laue, Anne Letsch, Matthias Rose, Uta Fendel
Summary: The objective of this study was to translate the cancer-specific Body Image Scale (BIS) into German and assess its psychometric properties. The German version of the BIS was found to be a valid tool to assess body image disturbance in patients with cancer.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Neurosciences
Tiemo Friedrich, Miriam Goebel-Stengel, Martha Anna Schalla, Peter Kobelt, Matthias Rose, Andreas Stengel
Summary: Research suggests that phoenixin is involved in stress reactions, as evidenced by the increased activity of phoenixin-immunoreactive brain nuclei in response to abdominal surgery. Interestingly, different stressors lead to specific changes in activity and immunoreactivity in phoenixin-containing nuclei, suggesting a stressor-specific involvement of phoenixin.
NEUROSCIENCE LETTERS
(2023)
Article
Health Care Sciences & Services
Claudia Hartmann, Felix Fischer, Christoph P. Klapproth, Robert Roehle, Matthias Rose, Maria M. Karsten
Summary: In this study, PROMIS-29 and EORTC QLQ-C30 were compared in terms of their scores and conceptual agreement in the assessment of health-related quality of life. The results showed that both instruments had similar scores and satisfactory agreement in conceptional and statistical analysis. This suggests that they can be made more comparable through the development of score transformation algorithms or calibration on common scales.
QUALITY OF LIFE RESEARCH
(2023)
Article
Otorhinolaryngology
Birgit Mazurek, Benjamin Boecking, Christian Dobel, Matthias Rose, Petra Brueggemann
Summary: Numerous studies have shown that chronic tinnitus is closely associated with psychosomatic and other related symptoms. This overview highlights the importance of both medical and psychosocial stress factors in addition to hearing loss. The impact of tinnitus-related distress involves various interconnected psychosomatic influences, including personality traits, stress reactivity, depression or anxiety, and cognitive difficulties, which should be addressed within a vulnerability-stress-reaction model. Furthermore, age, gender, and education level can contribute to increased vulnerability to stress. Therefore, an individualized, multidimensional, and interdisciplinary approach is necessary for the diagnosis and therapy of chronic tinnitus, with the aim of improving the quality of life for individuals affected by this condition. Counselling plays a vital role in the initial contact for accurate diagnosis and effective therapy.
LARYNGO-RHINO-OTOLOGIE
(2023)
Article
Medicine, General & Internal
Peter J. Blankestijn, Robin W. M. Vernooij, Carinna Hockham, Giovanni F. M. Strippoli, Bernard Canaud, Joergen Hegbrant, Claudia Barth, Adrian Covic, Krister Cromm, Andrea Cucui, Andrew Davenport, Matthias Rose, Marietta Torok, Mark Woodward, Michiel L. Bots
Summary: This study suggests that high-dose hemodiafiltration is more beneficial for patients with kidney failure compared to standard hemodialysis. A randomized controlled trial involving 1360 patients showed that those who received high-dose hemodiafiltration had a lower risk of death.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Health Care Sciences & Services
Alexander Obbarius, Christoph Paul Klapproth, Gregor Liegl, Paula M. Christmann, Udo Schneider, Felix Fischer, Matthias Rose
Summary: The purpose of this study was to calibrate the item parameters of the German PROMIS (R) Pain interference (PROMIS PI) items using an item-response theory (IRT) model and to investigate the psychometric properties of the item bank. The results showed that the German PROMIS PI item bank was a clinically valid and precise instrument for assessing pain interference in patients with chronic conditions.
QUALITY OF LIFE RESEARCH
(2023)
Article
Psychiatry
Jens Rohde, Alexander Obbarius, Barbara Voigt, Lea Sarrar, Silke Biesenthal-Matthes, Clara-Sophia Kind, Matthias Rose, Tobias Hofmann
Summary: This study systematically explored the differences in personality functioning and personality between anorexia nervosa subtypes (restricting type: AN-R; purging type: AN-P) and bulimia nervosa (BN) using three personality (functioning) constructs. The findings showed that AN-R patients displayed the highest levels of personality functioning, while BN patients showed the lowest levels. These findings can facilitate the development of stratified treatment approaches for eating disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Gregor Liegl, Felix H. Fischer, Mark Woodward, Marietta Torok, Giovanni F. M. Strippoli, Jorgen Hegbrant, Andrew Davenport, Krister Cromm, Bernard Canaud, Michiel L. Bots, Peter J. Blankestijn, Claudia Barth, Kathrin I. Fischer, Matthias Rose
Summary: The study aims to investigate whether the physical performance test (PPT) can be compared to the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function metric. Baseline data from the CONVINCE study, an international trial comparing different dialysis methods in end-stage kidney disease patients, was analyzed using item response theory (IRT) assumptions.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Amelie Rudolph, Andreas Stengel, Maria Suhs, Selina Schaper, Ellen Woelk, Matthias Rose, Tobias Hofmann, Maria Scherma
Summary: This study investigated the relationship between the Neuronatin gene and eating disorders and found a positive correlation between Neuronatin and body weight and fat mass. However, no significant correlations were found between Neuronatin and psychological outcomes in patients with eating disorders and obesity.
Article
Psychiatry
Stephan Doering, Stephan Herpertz, Magdalena Pape, Tobias Hofmann, Matthias Rose, Katrin Imbierowicz, Franziska Geiser, Antonie Louise Bierling, Kerstin Weidner, Joerg Rademacher, Silke Michalek, Eva Morawa, Yesim Erim, Per Teigelack, Martin Teufel, Armin Hartmann, Claas Lahmann, Eva Milena Johanne Peters, Johannes Kruse, Dirk von Boetticher, Christoph Herrmann-Lingen, Mariel Noehre, Martina de Zwaan, Ulrike Dinger, Hans-Christoph Friederich, Alexander Niecke, Christian Albus, Ruediger Zwerenz, Manfred Beutel, Heribert Christian Sattel, Peter Henningsen, Barbara Stein, Christiane Waller, Karsten Hake, Carsten Spitzer, Andreas Stengel, Stephan Zipfel, Katja Weimer, Harald Guendel, Henrik Kessler
Summary: This study aimed to evaluate the effectiveness of inpatient and day hospital treatment in German university departments of Psychosomatic Medicine and Psychotherapy. The findings showed that these treatments were effective in improving various symptoms of the patients, based on structured assessments.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Felix Fischer, Dario Zocholl, Geraldine Rauch, Brooke Levis, Andrea Benedetti, Brett Thombs, Matthias Rose, Polychronis Kostoulas
Summary: By re-analyzing the data from the European Health Interview Survey (EHIS) and accounting for the imperfect diagnostic accuracy of the PHQ-8, it was found that the prevalence of major depression in European countries is lower than previously reported.
Article
Psychology, Clinical
Uwe Wutzler, Ilona Croy, Ulrike Anderssen-Reuster, Antonie Bierling, Stefan Dorner, Thilo Hoffmann, Gunther Meinlschmidt, Martina Rauchfuss, Hans-Martin Rothe, Cornelia Ulrich, Thomas Villmann, Matthis Wankerl, Kerstin Weidner, Matthias Rose
Summary: To ensure the quality of inpatient treatment, it is important to measure the severity of the disease and the course of therapy. However, there is a lack of standardized diagnostics in psychosomatic facilities, leading to heterogeneous implementation. A basic documentation instrument called Psychosomatic Health Inventory (gi-ps) was developed using scientifically established test instruments. This instrument consists of three modules and allows for computer-based data collection, evaluation, and storage.
ZEITSCHRIFT FUR PSYCHOSOMATISCHE MEDIZIN UND PSYCHOTHERAPIE
(2023)
Article
Urology & Nephrology
F. Fischer, C. Kowalski, J. Simon, M. Graefen, M. Rose, B. Beyer
Summary: This study aims to compare the feasibility of the EPIC-26 sexuality domain with the IIEF-5 in the German treatment setting to evaluate historical patient cohorts. The analysis indicates that the IIEF-5 and the EPIC-26 measure similar constructs, but converting individual values is associated with significant uncertainty.