Article
Veterinary Sciences
H. M. Abdallah, N. Al Naiemi, Ibrahim Elsohaby, Abdallah F. A. Mahmoud, Gamal A. Salem, C. M. J. E. Vandenbroucke-Grauls
Summary: This study investigated the prevalence of extended-spectrum beta-lactamase production in Enterobacterales isolated from retail sheep meat in Zagazig, Egypt. The results showed that nearly one in five sheep meat samples was contaminated with ESBL-positive E. coli.
BMC VETERINARY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Richard Mayanja, Adrian Muwonge, Dickson Aruhomukama, Fred Ashaba Katabazi, Mudarshiru Bbuye, Edgar Kigozi, Annettee Nakimuli, Musa Sekikubo, Christine Florence Najjuka, David Patrick Kateete
Summary: This study aimed to investigate the source of EKE organisms for neonates in a maternity ward in Uganda. The results showed evidence of transmission of drug-resistant EKE bacteria in the ward and highlighted the high prevalence of drug resistance genes. This calls for more effective infection prevention/control measures and antimicrobial stewardship programs in hospitals to reduce the spread of drug-resistant bacteria and improve patient outcomes.
Article
Biology
L. Zainab, K. Ibrar, A. Sadiq, A. K. Hamid, Midrar Ullah, R. Noor
Summary: Poultry meat is an important component in human diet due to its nutritional value. However, it can be contaminated with pathogenic bacteria, including Escherichia coli, which can cause food borne infections. This study aimed to identify E. coli in chicken samples collected from three districts in KhyberPukhtunkhwa, Pakistan. The isolates were found to be resistant to certain antibiotics and carried multiple antibiotic resistance genes. The findings have implications for the management of E. coli-related diseases.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Food Science & Technology
Gokhan Inat, Belgin Siriken, Alper Ciftci, Irfan Erol, Ceren Baskan, Tuba Yildirim
Summary: The objectives of this study were to characterize ESBL-E using pheno- and genotyping methods, evaluate antimicrobial resistance, and investigate intI1 in Enterobacteriaceae isolates from chicken meat and ground beef. The study found that 68.7% of the isolates were capable of beta-lactamase activity and 47.5% were MDR. ESBL-E was found in 22.5% of the isolates, with predominant species being E. coli and Citrobacter braakii.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Article
Infectious Diseases
Siyao Guo, Kyaw Thu Aung, Pimlapas Leekitcharoenphon, Moon Y. F. Tay, Kelyn L. G. Seow, Yang Zhong, Lee Ching Ng, Frank Moller Aarestrup, Joergen Schlundt
Summary: The study revealed a high prevalence of ESBL-producing Escherichia coli in retail raw meats in Singapore, particularly in chicken. Most isolates carried multiple antibiotic resistance genes, including colistin resistance genes, highlighting potential food safety and public health risks.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Review
Food Science & Technology
Ryan Pearce, Beate Conrady, Luca Guardabassi
Summary: The objective of this study was to assess the prevalence and types of extended-spectrum β-lactamase (ESBL)-producing bacteria in retail seafood. A literature review found that the median prevalence of ESBL-contaminated products globally was 19.4%, with significantly higher rates in Asia compared to Europe and Africa. Among the analyzed isolates, 44.8% were ESBL-positive, with CTX-M being the predominant type (93.6%).
Article
Microbiology
Marita Vedovelli Cardozo, Apostolos Liakopoulos, Michael Brouwer, Arie Kant, Lucas Jose Luduverio Pizauro, Mariana Monezi Borzi, Dik Mevius, Fernando Antonio de Avila
Summary: This study in Sao Paolo, Brazil, investigated the phylogenetic diversity and epidemiology of ESBL-producing E. coli and K. pneumoniae from chicken, chicken meat, and human clinical isolates. The ESBL genes were characterized and their location determined on plasmids. The study found genetic diversity in isolates from chickens, chicken meat, and human feces, suggesting possible transmission of ESBL-producing pathogens from chickens to humans.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Mustafa Sadek, Jose Manuel Ortiz de la Rosa, Mohamed Abdelfattah Maky, Mohamed Korashe Dandrawy, Patrice Nordmann, Laurent Poirel
Summary: This study identified mcr-1-positive Enterobacterales from retail raw chicken in Egypt, highlighting the diversity and multidrug resistance of these isolates.
Article
Microbiology
Xiaopeng Jing, Yanyan Hu, Tingting Wu, Xing Zhang, Shaofeng Luo, Wei Wang, Xiaochun Min, Ruiling Sun, Ji Zeng
Summary: A method using MALDI-TOF MS with EDTA and PB was established to distinguish metallo-beta-lactamase and serine carbapenemases. The method showed high sensitivity and specificity, making it helpful for antibiotic selection in clinical practice.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Olga Lomovskaya, Mariana Castanheira, Jill Lindley, Debora Rubio-Aparicio, Kirk Nelson, Ruslan Tsivkovski, Dongxu Sun, Maxim Totrov, Jeffery Loutit, Michael Dudley
Summary: Recently, there has been a lack of comparative studies on the in vitro activity of beta-lactamase/beta-lactamase inhibitor (BL/BLI) combinations. This study compared the potency and spectrum of beta-lactamase inhibition by various BLIs and the in vitro potency of Xeruborbactam (XER) combined with beta-lactam antibiotics against carbapenem-resistant Enterobacterales (CRE). XER showed the highest potency against purified beta-lactamases and significantly enhanced the potency of other beta-lactam antibiotics. These results suggest the importance of further clinical development of XER combinations.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Amira A. Moawad, Helmut Hotzel, Hafez M. Hafez, Hazem Ramadan, Herbert Tomaso, Sascha D. Braun, Ralf Ehricht, Celia Diezel, Dominik Gary, Ines Engelmann, Islam M. Zakaria, Reem M. Reda, Samah Eid, Momtaz A. Shahien, Heinrich Neubauer, Stefan Monecke
Summary: Poultry, especially turkeys, are important reservoirs for multidrug-resistant pathogens, including E. coli. This study investigated the prevalence and antimicrobial resistance of E. coli isolated from healthy turkey flocks in Egypt. The isolates showed resistance to multiple antimicrobial agents, and different strains with distinct phenotypic and genotypic profiles were identified. The presence of various antimicrobial resistance genes, including beta-lactamase genes, chloramphenicol resistance genes, and aminoglycoside resistance genes, was detected among the isolates.
Article
Public, Environmental & Occupational Health
Gunasekaran Rameshkumar, Ranjithkumar Dhandapani, Prajna Lalitha, Siva Ganesa Karthikeyan Rajapandian, Velmurugan Palanivel, Sathiamoorthi Thangavelu, Abdullah A. Alyousef, Thamer Albalawi, Pravej Alam, Mohammad Zubair, Fayez M. Saleh, Fuad Abdullah Alatawi, Fohad M. Husain
Summary: In this study, the prevalence, antibacterial sensitivity patterns, and molecular characterization of MβL associated resistant genes in gram-negative bacteria isolated from ocular infections were investigated. The study found a high prevalence of MβL production in Pseudomonas aeruginosa, leading to high resistance to certain antibiotics. The bla(VIM) gene was also detected at a high rate in eye infections.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Kelly C. Gamble, Dusten T. Rose, Julia Sapozhnikov
Summary: The study aimed to evaluate the clinical outcomes of oral step-down antibiotics compared with continued intravenous therapy in non-bacteremic urinary tract infections. The results showed no significant difference between the two treatment groups in terms of clinical failure, readmission rate, and other outcomes. However, the switch group was associated with reduced hospital length of stay and antibiotic costs.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Felicia A. Owusu, Noah Obeng-Nkrumah, Esther Gyinae, Sarkodie Kodom, Rhodalyn Tagoe, Blessing Kofi Adu Tabi, Nicholas T. K. D. Dayie, Japheth A. Opintan, Beverly Egyir
Summary: Resistance to routine antimicrobials is observed in β-lactamase-producing Gram-negative bacteria (GNB) from clinical sources. The occurrence of carbapenemases, extended-spectrum β-lactamases (ESBLs), and AmpCs genes was also detected. Escherichia coli and Klebsiella pneumoniae were the most common GNB, with 46% and 17% prevalence respectively. Multi-drug resistance (MDR) was observed in 44% of the isolates.
Article
Microbiology
Felipe Alberto-Lei, Carolina S. S. Nodari, Ana Paula Streling, Francisco O. O. Bessa-Neto, Andre V. Siqueira, Rodrigo Cayo, Ana Cristina Gales
Summary: In this study, a multidrug-resistant Pseudomonas juntendi clinical isolate carrying bla(BKC-1) and a class 1 integron containing multiple resistance gene cassettes was characterized. This finding confirms the ability of Pseudomonas putida group isolates to acquire antimicrobial resistance determinants and act as resistance reservoirs.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Thierry Wirth, Marine Bergot, Jean-Philippe Rasigade, Bruno Pichon, Maxime Barbier, Patricia Martins-Simoes, Laurent Jacob, Rachel Pike, Pierre Tissieres, Jean-Charles Picaud, Angela Kearns, Philip Supply, Marine Butin, Frederic Laurent
NATURE MICROBIOLOGY
(2020)
Article
Oncology
Kirstine K. Sogaard, Katalin Veres, Christina M. J. E. Vandenbroucke-Grauls, Jan P. Vandenbroucke, Henrik T. Sorensen, Henrik C. Schonheyder
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Review
Public, Environmental & Occupational Health
Jan P. Vandenbroucke, Elizabeth B. Brickley, Christina M. J. E. Vandenbroucke-Grauls, Neil Pearce
Article
Public, Environmental & Occupational Health
Neil Pearce, Giovenale Moirano, Milena Maule, Manolis Kogevinas, Xavier Rodo, Deborah A. Lawlor, Jan Vandenbroucke, Christina Vandenbroucke-Grauls, Fernando P. Polack, Adnan Custovic
Summary: The death rate of Covid-19 increases exponentially with age, with the main risk factors being underlying conditions, and the relationship between CFR and age is approximately linear in various countries. Compared to SARS, Covid-19 and SARS have different age patterns in terms of death.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Infectious Diseases
Karuna E. W. Vendrik, Elisabeth M. Terveer, Ed J. Kuijper, Sam Nooij, Eline Boeije-Koppenol, Ingrid M. J. G. Sanders, Emilie van Lingen, Hein W. Verspaget, Eric K. L. Berssenbrugge, Josbert J. Keller, Joffrey van Prehn
Summary: The study evaluated the effectiveness of the donor-screening protocol of the Netherlands Donor Faeces Bank, showing that healthy donors may become colonised with multidrug-resistant organisms during donation activities, but the screening protocol was effective in reducing the spread of such organisms.
LANCET INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Tessel M. van Rossen, Laura J. van Dijk, Martijn W. Heymans, Olaf M. Dekkers, Christina M. J. E. Vandenbroucke-Grauls, Yvette H. van Beurden
Summary: The study aimed to externally validate clinical prediction tools for recurrent Clostridioides difficile infection, but found poor performance of the selected tools in the validation cohort. The AUC values for Cobo 2018 and Larrainzar-Coghen 2016 prediction tools were 0.43 and 0.42, respectively, indicating that currently identified clinical risk factors may not be sufficient for accurate prediction of rCDI.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Tessel M. van Rossen, Joffrey van Prehn, Alex Koek, Marcel Jonges, Robin van Houdt, Rosa van Mansfeld, Ed J. Kuijper, Christina M. J. E. Vandenbroucke-Grauls, Andries E. Budding
Summary: This study developed a rapid test for simultaneous detection and ribotyping of C. difficile directly on fecal samples, with results showing high sensitivity and specificity.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Medicine, General & Internal
Frederique Chammartin, Sara Lodi, Roger Logan, Lene Ryom, Amanda Mocroft, Ole Kirk, Antonella d'Arminio Monforte, Peter Reiss, Andrew Phillips, Wafaa El-Sadr, Camilla Hatleberg, Christian Pradier, Fabrice Bonnet, Matthew Law, Stephane De Wit, Caroline Sabin, Jens D. Lundgren, Heiner C. Bucher
Summary: Immediate initiation of antiretroviral therapy (ART) has small effects on the long-term risk for cancer in a cohort of young HIV-positive persons, with further data needed for non-AIDS-defining cancer risk.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Infectious Diseases
Roel P. J. Willems, Karin van Dijk, Cindy M. Dierikx, Jos W. R. Twisk, Fiona R. M. van der Klis, Sabine C. de Greeff, Christina M. J. E. Vandenbroucke-Grauls
Summary: In this population-based study, current use of acid suppressants was not associated with ESBL-E carriage. Travel to high-endemic regions and non-Western ethnicity were confirmed as risk factors, while a higher BMI emerged as a potential new risk for ESBL-E carriage.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Tessel M. van Rossen, Rogier E. Ooijevaar, Christina M. J. E. Vandenbroucke-Grauls, Olaf M. Dekkers, Ed J. Kuijper, Josbert J. Keller, Joffrey van Prehn
Summary: The study identifies age and the presence of multiple comorbidities as prognostic factors for severe CDI. Risk factors for recurrent CDI include age, healthcare-associated CDI, prior hospitalization, proton pump inhibitors (PPIs) started during or after CDI diagnosis, and previous recurrent CDI.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Letter
Public, Environmental & Occupational Health
Jan P. Vandenbroucke, Elizabeth B. Brickley, Neil Pearce, Christina M. J. E. Vandenbroucke-Grauls
Article
Public, Environmental & Occupational Health
M. G. Caris, N. A. de Jonge, H. J. Punt, D. M. Salet, V. M. T. de Jong, B. Lissenberg-Witte, S. Zweegman, C. M. J. E. Vandenbroucke-Grauls, M. A. van Agtmael, J. J. W. M. Janssen
Summary: Our study shows that the risk of central line associated bloodstream infections (CLABSI) does not appear to increase with longer indwelling time of peripherally inserted central catheters (PICC) in haematology patients. Routine replacement of PICCs is unlikely to prevent CLABSI in this population.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Public, Environmental & Occupational Health
Mireille Dekker, Rosa van Mansfeld, Christina M. J. E. Vandenbroucke-Grauls, Tessa E. Lauret, Bernadette C. F. M. Schutijser, Martine C. de Bruijne, Irene P. Jongerden
Summary: Empowered ICLN adjust and operationalize infection prevention policies to fit the conditions of their specific wards and provide practical instructions and feedback to their peers which enable better compliance to infection prevention policies. Support and inspiration from other ICLN, infection control practitioners and management contribute to this empowerment and consequently to taking impactful initiatives to improve practice.
JOURNAL OF INFECTION PREVENTION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Christina M. J. E. Vandenbroucke-Grauls, Jan A. J. W. Kluytmans
Summary: Antibiotic resistance genes evolve in the environment, animals, and humans, and it is crucial to take strategic action in all three areas to understand and limit resistance.
Article
Biochemistry & Molecular Biology
Alaa Eldin M. A. Morshdy, Karima M. E. Abdallah, Heba E. Abdallah, Fahad D. Algahtani, Mohamed Tharwat Elabbasy, Suleman Atique, Khursheed Ahmad, Mohammad A. A. Al-Najjar, Hossam M. Abdallah, Abdallah Fikry A. Mahmoud
Summary: This study found a high prevalence of Staphylococcus aureus in chicken meat samples from Egyptian markets, with a majority of the isolates being multidrug-resistant. The study also demonstrated the potential of certain natural phenolic compounds, particularly hydroquinone, as alternative antibacterial agents against these drug-resistant bacteria.