Article
Pharmacology & Pharmacy
Jinwu Bai, Jianxiang Xu, Kai Hang, Zhihui Kuang, Li Ying, Chenwei Zhou, Licheng Ni, Yibo Wang, Deting Xue
Summary: This study found that glycyrrhizic acid (GA) promotes osteogenic differentiation and enhances calcium deposition by modulating the Wnt/β-catenin signaling pathway. Experimental results demonstrated that GA-GelMA hydrogels accelerate bone healing, showing potential as a cost-effective treatment for bone defects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Jian Song, Nan Jiang, Xueqi Gan, Wei Zhi, Zhuoli Zhu
Summary: The study demonstrated that the local injection of argatroban can rescue bone loss in periodontal disease, while inducing osteogenic differentiation through activating the canonical Wnt signaling pathway. Therefore, argatroban has potential applications in promoting alveolar bone regeneration and remodeling based on BMSCs.
Article
Cell & Tissue Engineering
Junjie Shen, Yi Sun, Xuanzhe Liu, Yu Zhu, Bingbo Bao, Tao Gao, Yimin Chai, Jia Xu, Xianyou Zheng
Summary: EGFL6 was found to stimulate angiogenesis and osteogenic differentiation through the Wnt/beta-catenin signaling pathway in vitro, and promoted CD31(hi)EMCN(hi) type H-positive capillary formation in a rat tibia distraction osteogenesis model. It enhanced the osteogenic differentiation potential of BMSCs and accelerated bone regeneration by stimulating angiogenesis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Chiara Tomasoni, Corinne Arsuffi, Samantha Donsante, Alessandro Corsi, Mara Riminucci, Andrea Biondi, Alice Pievani, Marta Serafini
Summary: Acute myeloid leukemia (AML) cells have a negative impact on the osteogenic differentiation of normal bone marrow stromal cells (BMSCs), and direct interaction between AML cells and BMSCs plays a vital role in this process. AML-mediated activation of Notch signaling is involved in the ineffective osteogenic commitment of BMSCs, resulting in the formation of a pre-osteoblast-rich niche supportive of leukemia development in the bone marrow.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Ying Yu, Hongyan Mo, Hui Zhuo, Chen Yu, Youhua Liu
Summary: High-fat diet can cause kidney injury, with Wnt signaling pathway playing a crucial role. Inhibiting Wnt signaling may help alleviate the kidney damage caused by high-fat diet, serving as a potential therapeutic strategy for obesity-related nephropathy.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Haoran Li, Wuling Zhou, Shiwei Sun, Tianlong Zhang, Tieqi Zhang, Haitian Huang, Minghai Wang
Summary: This study found that MFAP5 regulates osteogenesis in BMSCs through the Wnt/beta-catenin and AMPK signaling pathways, and may serve as a therapeutic target for patients with osteoporosis.
MOLECULAR MEDICINE
(2021)
Article
Food Science & Technology
Xunhan Li, Muthukumaran Jayachandran, Baojun Xu
Summary: The study demonstrated that treatment with KGM can improve glucose metabolism, increase liver glycogen, enhance insulin signaling pathway, and decrease gluconeogenesis and liver marker enzymes expression in diabetic rats.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Cell Biology
Chih-Yi Yang, Rita Jui-Hsien Lu, Ming-Kang Lee, Felix Shih-Hsian Hsiao, Ya-Ping Yen, Chun-Chun Cheng, Pu-Sheng Hsu, Yi-Tzang Tsai, Shih-Kuo Chen, I-Hsuan Liu, Pao-Yang Chen, Shau-Ping Lin
Summary: MSCs lacking DNMT3L exhibit reduced colony forming ability and impaired osteogenesis in vitro, with differentially regulated genes associated with bone morphology-related phenotypes. The observed defects are hypothesized to result from pre-deposited epigenetic signatures from DNMT3L-expressing progenitors, rather than a direct effect of missing DNMT3L in MSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yongkun Wei, Huiling Ma, Haiqing Zhou, Hanrong Yin, Jie Yang, Yongcai Song, Binhui Yang
Summary: Research indicates that overexpression of miR-424-5p in BMSCs-derived exosomes can regulate osteogenic differentiation of osteoblasts through the WIF1/Wnt/beta-catenin pathway, suggesting miR-424-5p as a potential new biomarker for the treatment of osteoporosis.
Review
Biochemistry & Molecular Biology
Qiuyue Qin, Yiping Liu, Zhen Yang, Maierhaba Aimaijiang, Rui Ma, Yixin Yang, Yidi Zhang, Yanmin Zhou
Summary: Sufficient oxygen is crucial for normal cellular and physiological function, and both pathological hypoxia and environmental hypoxia can impact bone health. Adaptation to hypoxia is a key event in cellular development and differentiation, and hypoxia-inducible transcription factors (HIFs) are essential for regulating bone development and repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ana Borojevic, Aleksandra Jaukovic, Tamara Kukolj, Slavko Mojsilovic, Hristina Obradovic, Drenka Trivanovic, Milena Zivanovic, Zeljko Zecevic, Marija Simic, Borko Gobeljic, Dragana Vujic, Diana Bugarski
Summary: The precursor of vitamin D3, VD3, can stimulate proliferation and osteogenic differentiation potential of bone marrow stem cells (BM-MSCs), while reducing their senescence. These effects are partially mediated by the SIRT1 signaling pathway.
Article
Biochemistry & Molecular Biology
Jinwu Bai, Weijun Zhang, Chenwei Zhou, Guangfeng Zhao, Huiming Zhong, Kai Hang, Jianxiang Xu, Wei Zhang, Erman Chen, Jiaqi Wu, Ling Liu, Deting Xue
Summary: MFG-E8 promotes osteogenic differentiation of BMSCs by regulating the GSK3 beta/beta-catenin signaling pathway and therefore, is a potential therapeutic target. This study has important clinical significance in addressing fracture nonunion and bone defects.
Article
Cell Biology
Wu Duan, Huajie Zou, Nan Zang, Dongxia Ma, Bo Yang, Lin Zhu
Summary: Bone marrow adipose tissue (MAT) can have both local and systemic effects on metabolic homeostasis. The effects of metformin, a first-line drug for type 2 diabetes, on MAT and bone marrow mesenchymal stem cell (BM-MSC) differentiation are conflicting. In vivo and in vitro experiments showed that metformin increased MAT in mice tibia and promoted both osteogenic and lipogenic gene expression in mouse bone marrow. However, metformin inhibited lipogenesis and promoted osteogenesis of MSC in vitro. The increased MAT may be attributed to the filling of adipose tissue after metformin-induced apoptosis of bone marrow stromal cells.
Article
Veterinary Sciences
Maria Andonova, Petko Dzhelebov, Krastina Trifonova, Penka Yonkova, Nikola Kostadinov, Krasimira Nancheva, Veselin Ivanov, Krasimira Gospodinova, Nikola Nizamov, Ilia Tsachev, Chavdar Chernev
Summary: This study induced a T2DM model in rats through a high-fat diet and low dose streptozotocin, and found that increased values of glucose, HOMA-IR, HOMA-β, AI, total cholesterol, triacylglycerols, low- and very-low-density lipoproteins are important markers of the pre-diabetic state. The stable hyperglycemia and increased levels of TC, TG, VLDL, LDL, uric acid and AOPP strongly suggest the development of T2DM.
VETERINARY SCIENCES
(2023)
Review
Neurosciences
Emily Ling-Lin Pai, April M. Stafford, Daniel Vogt
Summary: The development and maturation of cortical GABAergic interneurons involve both transcriptional regulation via nuclear factors and cellular signaling cascades including mTOR, MAPK, and Wnt/beta-catenin pathways. These signaling families play important roles in regulating various developmental milestones and properties of interneurons. The coordination between transcriptional and signaling mechanisms is crucial for the complex diversity observed during cortical interneuron development and maturation.
FRONTIERS IN NEUROSCIENCE
(2023)
