Article
Clinical Neurology
Lydia Foster, Laura Robinson, Sharon D. Yeatts, Robin A. Conwit, Amjad Shehadah, Vasileios Lioutas, Magdy Selim
Summary: This study evaluated the trajectory of modified Rankin Scale (mRS) among patients with intracerebral hemorrhage (ICH) over a 6-month period and found that treatment with deferoxamine had a favorable effect on the trajectory. Future ICH trials should assess outcomes for a minimum of 6 months after 90 days.
Article
Nanoscience & Nanotechnology
Fang Zhu, Liu Zi, Peng Yang, Yang Wei, Rui Zhong, Yan Wang, Chao You, Yiwen Li, Meng Tian, Zhipeng Gu
Summary: Novel dual-functional macromolecular nanoscavengers designed in this study can efficiently remove iron and ROS, reducing cell death caused by iron overload. This provides a new direction for improving therapeutic strategies for ICH.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Neurosciences
Zhe Li, Yang Liu, Ruixue Wei, Suliman Khan, Ruiyi Zhang, Yan Zhang, Voon Wee Yong, Mengzhou Xue
Summary: This review summarizes recent progress in understanding the mechanisms by which deferoxamine may alleviate intracerebral hemorrhage (ICH) and discusses the potential clinical utility of deferoxamine.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Laurent Puy, Antoine Rauch, Vincent Deramecourt, Charlotte Cordonnier, Vincent Berezowski
Summary: This study conducted a postmortem examination to investigate acute microvascular lesions (microbleeds and microinfarcts) in the perihematomal area of patients with spontaneous intracerebral hemorrhage (ICH). It was found that these lesions may contribute to secondary brain tissue damage.
Article
Neurosciences
Yingfeng Wan, Katherine G. Holste, Ya Hua, Richard F. Keep, Guohua Xi
Summary: Intracerebral hemorrhage (ICH) is responsible for 10% of strokes in the USA, resulting in significant disability and mortality. It causes primary brain injury due to mechanical disruption and secondary injury through the release of clot-derived factors. ICH leads to brain edema and increased intracranial pressure, affecting patient prognosis. Currently, effective treatment methods for reducing perihematomal cerebral edema and intracranial pressure are limited. This review explores the mechanisms of edema formation, the influence of sex and age, and the progress in pharmacotherapy for ICH.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Immunology
Yihao Chen, Shengpan Chen, Jianbo Chang, Junji Wei, Ming Feng, Renzhi Wang
Summary: PHE is considered a promising therapeutic target for ICH, but existing research results are conflicting. Therefore, it is necessary to classify, compare, and summarize existing studies on PHE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Lotte Sondag, Axel Wolsink, Wilmar M. T. Jolink, Sabine Voigt, Marianne A. A. van Walderveen, Marieke J. H. Wermer, Catharina J. M. Klijn, Floris H. B. M. Schreuder
Summary: This study investigated the association between blood pressure variability and the development of perihematomal edema after intracerebral hemorrhage. The results suggest that blood pressure variability is not associated with edema development, indicating that other mechanisms such as inflammatory processes may play a more important role.
FRONTIERS IN NEUROLOGY
(2023)
Review
Critical Care Medicine
Sarah Marchina, Jorge A. Trevino-Calderon, Sara Hassani, Joseph M. Massaro, Vasileios-Arsenios Lioutas, Filipa Carvalho, Magdy Selim
Summary: This meta-analysis demonstrates that perihematomal edema (PHE) volume has a weak effect on functional outcome and mortality in patients with intracerebral hemorrhage (ICH), while PHE growth might have a slightly larger impact during the first 72 hours after ictus. Definitive conclusions are limited by the variability of PHE measures, heterogeneity of studies, and different evaluation time points.
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Audrey C. Leasure, Lindsey R. Kuohn, Kevin N. Vanent, Matthew B. Bevers, W. Taylor Kimberly, Thorsten Steiner, Stephan A. Mayer, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Summary: Higher admission IL-6 levels in patients with spontaneous intracerebral hemorrhage are associated with worse 90-day functional outcome, larger ICH volume, and larger perihematomal edema volume.
Article
Medicine, General & Internal
Jawed Nawabi, Sarah Elsayed, Andrea Morotti, Anna Speth, Melanie Liu, Helge Kniep, Rosalie McDonough, Gabriel Broocks, Tobias Faizy, Elif Can, Peter B. Sporns, Jens Fiehler, Bernd Hamm, Tobias Penzkofer, Georg Bohner, Frieder Schlunk, Uta Hanning
Summary: This study found that patients with oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) had lower levels of perihematomal edema (PHE) in the early stages compared to those with non-oral anticoagulant-associated intracerebral hemorrhage (NON-OAC-ICH), with NOAC patients also exhibiting significantly lower levels of edema expansion distance compared to NON-OAC-ICH patients. The increase in early PHE volume did not increase the likelihood of poor outcomes in OAC-ICH, but was independently associated with poor outcomes in NON-OAC-ICH.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Na Li, Jiahuan Guo, Kaijiang Kang, Jia Zhang, Zhe Zhang, Lijun Liu, Xinmin Liu, Yang Du, Yu Wang, Xingquan Zhao
Summary: This study found that cytotoxic edema (CE) was detected in nearly two thirds of patients with intracerebral hemorrhage (ICH) and CE within 7-12 days was associated with poor clinical outcomes. Therefore, CE may serve as a novel therapeutic target for ICH intervention.
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Jianhua Peng, Bastian Volbers, Maximilian I. Sprugel, Philip Hoelter, Tobias Engelhorn, Yong Jiang, Joji B. Kuramatsu, Hagen B. Huttner, Arnd Dorfler, Stefan Schwab, Stefan T. Gerner
Summary: Early enteral nutrition (EEN) was associated with reduced perihemorrhagic edema (PHE) in patients with intracerebral hemorrhage treated at a neurological ICU (NICU). However, this did not result in improved survival or functional outcomes at 3 and 12 months for the patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Yuhua Gong, Jia Deng, Yingqing Wu, Xiaoyun Xu, Zongkun Hou, Shilei Hao, Bochu Wang
Summary: This study found that the mass effect after intracerebral hemorrhage significantly increased iron deposition in neuronal cells and promoted the iron uptake and ferroptosis. Additionally, the inhibition of the pERK1/2 pathway reversed the upregulation of iron uptake and ferroptosis.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Lindsey R. Kuohn, Jens Witsch, Thorsten Steiner, Kevin N. Sheth, Hooman Kamel, Babak B. Navi, Alexander E. Merkler, Santosh B. Murthy, Stephan A. Mayer
Summary: This study examined the relationship between different locations (deep versus lobar) of intracerebral hemorrhage (ICH) and early neurological deterioration, hematoma expansion (HE), and outcome. The results showed that lobar ICH location was associated with more common HE and early neurological deterioration, while deep ICH location was associated with smaller hematoma size. However, after adjusting for prognostic variables, deep ICH was associated with worse outcome.
Article
Clinical Neurology
Zhe Li, Yang Liu, Ruixue Wei, Suliman Khan, Mengzhou Xue, V. Wee Yong
Summary: The combination therapy of deferoxamine and minocycline showed promising results in reducing iron accumulation, neuronal death, and inflammation in an adult rat model of intracerebral hemorrhage. Additionally, the combination treatment demonstrated better outcomes in neuroprotection and anti-inflammatory effects compared to monotherapy. The study suggests that this combinational therapy could be a potential therapeutic option for treating ICH.
NEUROLOGICAL RESEARCH
(2021)
