Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

PCK2 activation mediates an adaptive response to glucose depletion in lung cancer

(2014) K Leithner et al.   ONCOGENE

Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase

(2014) Jose L. Izquierdo-Garcia et al.   PLoS One

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Adipose tissue and adipocytes support tumorigenesis and metastasis

(2013) Kristin M. Nieman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Exploiting the metabolism of PYC expressing HEK293 cells in fed-batch cultures

(2013) Cédric Vallée et al.   JOURNAL OF BIOTECHNOLOGY

Characterization of the Distal Promoter of the Human Pyruvate Carboxylase Gene in Pancreatic Beta Cells

(2013) Ansaya Thonpho et al.   PLoS One

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Wnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism

(2012) S. Y. Lee et al.   CANCER RESEARCH

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Comparative Metabolic Flux Profiling of Melanoma Cell Lines

(2011) David A. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Metabolic Transformation in Tumor Invasion and Metastasis in Mice with LM-8 Osteosarcoma Cell Transplantation

(2011) Yingqi Hua et al.   JOURNAL OF PROTEOME RESEARCH

Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase

(2011) Olivier Henry et al.   METABOLIC ENGINEERING

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the cyclic AMP responsive element (CRE) that mediates transcriptional regulation of the pyruvate carboxylase gene in HepG2 cells

(2010) Ansaya Thonpho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NADPH oxidase 4 is an oncoprotein localized to mitochondria

(2010) Kelly A. Graham et al.   CANCER BIOLOGY & THERAPY

Metabolomic Changes Accompanying Transformation and Acquisition of Metastatic Potential in a Syngeneic Mouse Mammary Tumor Model

(2010) Xin Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms of metastasis in breast cancer—clinical applications

(2010) Michal Mego et al.   Nature Reviews Clinical Oncology

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

(2009) Teresa WM Fan et al.   Molecular Cancer

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Structure, mechanism and regulation of pyruvate carboxylase

(2008) Sarawut Jitrapakdee et al.   BIOCHEMICAL JOURNAL

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE