Review
Pharmacology & Pharmacy
Jieun Bang, Mihyeon Jun, Soyun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: Hepatocellular carcinoma (HCC) is a significant global health concern, with its incidence steadily increasing. Recent progress has been made in understanding the molecular signaling pathways, particularly the EGFR/PI3K/AKT/mTOR pathway, which plays a central role in HCC. Preclinical studies have shown the effectiveness of targeting this signaling pathway for HCC therapy, offering potential therapeutic options for patients.
Article
Biochemistry & Molecular Biology
Lan Ma, Ruixue Zhang, Demin Li, Tingting Qiao, Xiaoying Guo
Summary: Fluoride inhibits chondrocyte proliferation and promotes autophagy through the PI3K/AKT/mTOR signaling pathway in chondrogenesis. The study also showed that fluoride downregulates the mTOR signaling pathway-related genes and is associated with changes in autophagy-related gene expressions. MHY1485, a small-molecular mTOR activator, can reverse the fluoride-induced promotion of autophagy and recover the downregulation of proliferative chondrocyte markers induced by fluoride in chondrogenic cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Review
Biochemistry & Molecular Biology
Silviu Stanciu, Florentina Ionita-Radu, Constantin Stefani, Daniela Miricescu, Iulia-Ioana Stanescu-Spinu, Maria Greabu, Alexandra Ripszky Totan, Mariana Jinga
Summary: Pancreatic cancer, although relatively rare, is becoming a leading cause of cancer death. Various risk factors, both modifiable and non-modifiable, contribute to its pathogenesis. Chronic inflammation plays a crucial role in the development of pancreatic cancer. The PI3K/AKT/mTOR signaling pathway is important in cell growth, survival, and motility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Aarti Sharma, Sidharth Mehan
Summary: The PI3K-AKT/mTOR signaling pathway plays a crucial role in various biological processes and its dysregulation can lead to neurodevelopmental disorders like autism. Inhibiting this pathway may hold therapeutic value for autism treatment. The use of PI3K-AKT/mTOR signaling pathway inhibitors is currently being explored for the treatment of autism and other neurodegenerative disorders.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Medicine, Research & Experimental
Martina S. Savova, Liliya Mihaylova, Daniel Tews, Martin Wabitsch, Milen I. Georgiev
Summary: Obesity is a growing disorder that damages patients' quality of life and increases healthcare costs. Developing safe and innovative prevention strategies and treatments for obesity is crucial. The pathophysiology of obesity is complex and involves multiple signaling pathways, including the PI3K/AKT pathway, which plays a critical role in metabolic homeostasis. Natural compounds have been shown to target the PI3K/AKT signaling pathway and have potential for managing obesity. This paper evaluates the druggability of PI3K as a target and suggests perspectives on using natural compounds to modulate the PI3K/AKT pathway for obesity management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Zhengxia Zhu, Jianyang Zhang, Peng Wu
Summary: The study revealed that ESM-1 expression was significantly upregulated in cervical cancer tissues and cells. Knockdown of ESM-1 inhibited the activation of the PI3K/Akt/mTOR signaling pathway, thereby suppressing cell proliferation, invasion, and migration of cervical cancer cells, promoting cell apoptosis, and holding potential for the treatment and prognosis of cervical cancer.
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane, Lionel Hebbard
Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.
Review
Biochemistry & Molecular Biology
Yu-Chieh Su, Wei-Chang Lee, Chih-Chun Wang, Shyh-An Yeh, Wen-Hui Chen, Po-Jen Chen
Summary: This review discusses the oncogenic significance of PI3K/AKT/mTOR signaling in HNSCC radiotherapy resistance and highlights the therapeutic potential of small molecule inhibitors against this pathway for radiosensitization in HNSCC treatment. It provides a mechanistic framework for the development of new drugs for radiosensitization in HNSCC radiotherapy via targeting the PI3K/AKT/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Zhi Zhou, Zhihua Tu, Juan Zhang, Can Tan, Xiaoyong Shen, Bangbei Wan, Yejuan Li, Anguo Wang, Liqiang Zhao, Jiajia Hu, Ning Ma, Jing Zhou, Lin Chen, Yanqin Song, Weiying Lu
Summary: miR-18b-5p is downregulated while PTEN is upregulated in follicular fluid exosomes of PCOS patients. Decreasing PTEN promotes KGN cell proliferation and limits apoptosis. Exosomes stimulate KGN cell proliferation and suppress apoptosis, decrease FSH, LH, and testosterone levels, and increase E2 levels. Upregulating miR-18b-5p enhances the inhibitory effects of exosomes on PCOS progression. miR-18b-5p improves PCOS by targeting PTEN and activating the PI3K/Akt/mTOR pathway. Circulating miR-18b-5p levels are associated with the progression of PCOS complications.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Reproductive Biology
Huixi Weng, Xiushan Feng, Yu Lan, Zhiqun Zheng
Summary: Upregulated TCP1 is associated with poor prognosis in OC patients. The mechanism of cancer progression promoted by TCP1 upregulation may be linked to the activation of the PI3K signaling pathway, making TCP1 a potential novel target for OC treatment.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yiqing Chen, Chunlin Chen, Junren Fang, Kui Su, Qian Yuan, Huan Hou, Huijuan Xin, Jianwu Sun, Chaohong Huang, Shuyi Li, Zhengqiang Yuan, Shengkang Luo
Summary: This study suggests that sunitinib effectively inhibits keloid development through suppression of the Akt/PI3K/mTOR pathway and may be potentially developed as a monotherapy or combination therapy for the effective treatment of keloid disease.
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Article
Cell Biology
Yanyi Xiao, Yilong Liu, Zhiwei Gao, Xian Li, Min Weng, Chenghao Shi, Cheng Wang, Linxiao Sun
Summary: Pancreatic cancer is a highly malignant tumor with increasing chemotherapeutic resistance, posing a challenge in clinical treatment. Fisetin, extracted from vegetables and fruits, shows potential as an anti-cancer agent for pancreatic cancer by targeting the PI3K/AKT/mTOR signaling cascade. Further research is needed to better understand the molecular mechanisms underlying fisetin's anti-cancer effects on pancreatic cancer.
Article
Neurosciences
Hai Yu, Xiaodong Li, Yi Li, Tuo Wang, Maode Wang, Ping Mao
Summary: Increasing evidence has shown that ALDH1A3 is closely associated with tumorigenesis, therapy resistance, and prognosis in various cancers. This study demonstrates that ALDH1A3 is highly expressed in GBM cells and plays a critical role in their proliferation and radioresistance. The study also identifies miR-4524b-5p as an upstream regulator of ALDH1A3 and shows that overexpression of miR-4524b-5p reduces proliferation and radioresistance in GBM cells. Targeting the miR-4524b-5p and ALDH1A3 axis could be a promising therapeutic strategy for treating GBM.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Genetics & Heredity
Yalan Yang, Min Zhu, Xinhao Fan, Yilong Yao, Junyu Yan, Yijie Tang, Siyuan Liu, Kui Li, Zhonglin Tang
Article
Genetics & Heredity
Zishuai Wang, Xikang Feng, Shuai Cheng Li
FRONTIERS IN GENETICS
(2019)
Correction
Genetics & Heredity
Zishuai Wang, Xikang Feng, Shuai Cheng Li
FRONTIERS IN GENETICS
(2019)
Article
Biochemical Research Methods
Xikang Feng, Zishuai Wang, Hechen Li, Shuai Cheng Li
BMC BIOINFORMATICS
(2019)
Article
Chemistry, Medicinal
Guoyong Yan, Jin Sun, Zishuai Wang, Pei-Yuan Qian, Lisheng He
Article
Agriculture, Dairy & Animal Science
Guoming Liang, Junyu Yan, Jin Guo, Zhonglin Tang
Article
Biochemistry & Molecular Biology
A. Adetula Et Al Abiola Adetula, Xinhao Fan, Yongsheng Zhang, Yilong Yao, Junyu Yan, Muya Chen, Yijie Tang, Yuwen Liu, Guoqiang Yi, Kui Li, Zhonglin Tang
Summary: RNA editing generates genetic diversity in mammals by altering amino acid and miRNA targeting site sequences, influencing RNA stability, and changing gene expression. This study identified a large number of A-to-I RNA editing sites across tissues in pigs and highlighted the impact on gene regulation, particularly in skeletal muscle. The findings suggest a new layer of regulation in understanding genetic mechanisms behind phenotype variance in animals.
Article
Genetics & Heredity
Yalan Yang, Junyu Yan, Xinhao Fan, Jiaxing Chen, Zishuai Wang, Xiaoqin Liu, Guoqiang Yi, Yuwen Liu, Yongchao Niu, Longchao Zhang, Lixian Wang, ShuaiCheng Li, Kui Li, Zhonglin Tang
Summary: This study investigated the genetic and molecular regulation of skeletal muscle development and diversity by comparing the genome and skeletal muscle transcriptome differences between Chinese local Tongcheng and commercial Landrace pigs. The results revealed the role of coding and non-coding RNAs, such as SATB2 and XLOC_036765, in skeletal muscle development and diversity, providing valuable insights for improving meat production traits in pig breeding.
Article
Agriculture, Dairy & Animal Science
Xinhua Hou, Zishuai Wang, Liangyu Shi, Ligang Wang, Fuping Zhao, Xin Liu, Hongmei Gao, Lijun Shi, Hua Yan, Lixian Wang, Longchao Zhang
Summary: The study explored the characteristics of imprinted genes in porcine skeletal muscle growth using DNA-seq and RNA-seq, revealing paternal-maternal conflict theory and the expression status of maternal gene H1-3 for the first time.
Article
Genetics & Heredity
Qiaowei Li, Liyuan Wang, Kai Xing, Yalan Yang, Adeyinka Abiola Adetula, Yuwen Liu, Guoqiang Yi, Hongfu Zhang, Torres Sweeney, Zhonglin Tang
Summary: This study compared the spatio-temporal expression pattern of circRNAs between different adipose deposition breeds in pigs. It identified circRNAs involved in the regulation of adipogenesis and analyzed the interaction between circRNAs and miRNAs. The study revealed important circRNAs and their target genes enriched in fatty acid biosynthesis, fatty acid metabolism, and Wnt/TGF-beta signaling pathways. These findings provide valuable insights into the molecular mechanism of circRNAs in pig adipose biology.
Review
Biochemistry & Molecular Biology
Shanying Yan, Yangli Pei, Jiju Li, Zhonglin Tang, Yalan Yang
Summary: Circular RNAs (circRNAs) are a highly conserved and specifically expressed class of covalently closed non-coding RNAs, which can function as miRNA sponges, protein scaffolds, and regulatory factors. They play various roles in development and other biological processes in mammals. Recent advances in circRNA-related studies of skeletal muscle and adipose in farm animals have been highlighted, including their biogenesis, properties, biological functions, and regulatory mechanisms. Furthermore, their effects on economic traits such as meat yield and quality have been comprehensively summarized. CircRNAs are proposed as potential novel targets to improve meat yield and quality traits during animal breeding.
Article
Genetics & Heredity
Md. Panir Choudhury, Zihao Wang, Min Zhu, Shaohua Teng, Jing Yan, Shuwei Cao, Guoqiang Yi, Yuwen Liu, Yuying Liao, Zhonglin Tang
Summary: This study conducted a comprehensive analysis of copy number variations (CNVs) in different horse breeds, and identified genomic regions associated with miniature features. Functional annotation revealed the biological functions and adaptations related to these CNVs.
Review
Biochemistry & Molecular Biology
Jiju Li, Yangli Pei, Rong Zhou, Zhonglin Tang, Yalan Yang
Summary: N-6-methyladenosine (m(6)A) modification is a widely conserved chemical modification in cellular RNAs that plays a critical role in skeletal muscle development. Exploration of the functions and mechanisms of m(6)A modification and its regulators provides a deeper understanding of the regulatory mechanisms underlying skeletal muscle development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yalan Yang, Xinhao Fan, Junyu Yan, Muya Chen, Min Zhu, Yijie Tang, Siyuan Liu, Zhonglin Tang
Summary: The study generated the first single-base resolution DNA methylome and transcriptome maps of porcine skeletal muscle across 27 developmental stages. The results showed a decrease in overall methylation level from embryo to adult, and identified over 40,000 developmentally differentially methylated CpGs.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xikang Feng, Lingxi Chen, Zishuai Wang, Shuai Cheng Li