Article
Endocrinology & Metabolism
Hye Rim Chung, Joon Ho Moon, Jung Sub Lim, Young Ah Lee, Choong Ho Shin, Joon-Seok Hong, Soo Heon Kwak, Sung Hee Choi, Hak Chul Jang
Summary: The offspring of mothers with gestational diabetes mellitus (OGDM) had higher total, truncal, and leg fat mass at age 5 compared to offspring of normoglycemic mothers. Maternal glucose concentrations during a 100g oral glucose tolerance test were positively correlated with fat mass in OGDM, especially trunk fat. No correlation was found between leg fat mass and maternal glucose tolerance test during pregnancy.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Developmental Biology
Linkai Zhu, Nicole Tillquist, Giovanna Scatolin, Rachael Gately, Mia Kawaida, Amanda Reiter, Sarah Reed, Steven Zinn, Kristen Govoni, Zongliang Jiang
Summary: Studies have shown that inadequate or excessive maternal nutrition during gestation does not affect semen characteristics in male sheep offspring, but it does result in significant changes in the composition and expression of small noncoding RNAs in sperm, as well as alterations in DNA methylation at specific genomic loci.
Article
Environmental Sciences
Na Zhu, Xiaotong Ji, Xilin Geng, Huifeng Yue, Guangke Li, Nan Sang
Summary: The study found that maternal exposure to fine particulate matters during pregnancy disrupted cell proliferation and impaired nutrient transport in the placenta, with significant changes observed at E18.5. This included altered mRNA expression of nutrient transporters and changes in glycogen and triglyceride content.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, General & Internal
Tom A. Bond, Rebecca C. Richmond, Ville Karhunen, Gabriel Cuellar-Partida, Maria Carolina Borges, Verena Zuber, Alexessander Couto Alves, Dan Mason, Tiffany C. Yang, Marc J. Gunter, Abbas Dehghan, Ioanna Tzoulaki, Sylvain Sebert, David M. Evans, Alex M. Lewin, Paul F. O'Reilly, Deborah A. Lawlor, Marjo-Riitta Jarvelin
Summary: This study investigates the causal relationship between maternal pre-/early pregnancy BMI and offspring adiposity. The results suggest that higher maternal BMI is not a key driver of higher adiposity in the next generation.
Article
Biochemistry & Molecular Biology
Chelsie B. Steinhauser, Colleen A. Lambo, Katharine Askelson, Gregory W. Burns, Susanta K. Behura, Thomas E. Spencer, Fuller W. Bazer, Michael Carey Satterfield
Summary: Placental development is modified in response to maternal nutrient restriction, leading to different fetal growth rates. Differences in gene expression and function were found between SGA and NR NonSGA placentomes, with overrepresentation of genes related to natural-killer-cell-mediated cytotoxicity in SGA placentomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Ellen C. Francis, Dana Dabelea, Brandy M. Ringham, Katherine A. Sauder, Wei Perng
Summary: This study found that children born to mothers with higher HbA(1c) levels during pregnancy had higher fasting glucose and lower insulin sensitivity in early childhood. However, these relationships were largely unaffected by the child's own adiposity.
Article
Agriculture, Dairy & Animal Science
Sarah A. Reed, Jeremy Balsbaugh, Xiaomeng Li, Timothy E. Moore, Amanda K. Jones, Sambhu M. Pillai, Maria L. Hoffman, Kristen E. Govoni, Steven A. Zinn
Summary: Over- or restricted-nutrition during gestation alters the proteome of the longissimus dorsi muscle (LM) in offspring, affecting protein synthesis and degradation, stress responses, metabolism, and oxidative stress. These protein changes may contribute to the poor growth and development observed in the offspring.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Hannes Hagstrom, Tracey G. Simon, Bjorn Roelstraete, Olof Stephansson, Jonas Soderling, Jonas F. Ludvigsson
Summary: This study revealed a strong association between maternal obesity and future NAFLD in offspring among young individuals in Sweden. Adjustment for socio-economic and metabolic factors did not change this finding, suggesting maternal obesity as an independent risk factor for NAFLD in offspring.
JOURNAL OF HEPATOLOGY
(2021)
Article
Endocrinology & Metabolism
William D. Thompson, Robin N. Beaumont, Alan Kuang, Nicole M. Warrington, Yingjie Ji, Jessica Tyrrell, Andrew R. Wood, Denise M. Scholtens, Bridget A. Knight, David M. Evans, William L. Lowe, Gillian Santorelli, Rafaq Azad, Dan Mason, Andrew T. Hattersley, Timothy M. Frayling, Hanieh Yaghootkar, Maria Carolina Borges, Deborah A. Lawlor, Rachel M. Freathy
Summary: The study shows that higher maternal adiposity does not necessarily lead to higher offspring birthweight. Higher maternal adiposity can lead to lower offspring birthweight if accompanied by a favourable metabolic profile.
Article
Public, Environmental & Occupational Health
Elizabeth A. DeVilbiss, Alexandra C. Purdue-Smithe, Lindsey A. Sjaarda, Brandie D. Taylor, Joshua R. Freeman, Neil J. Perkins, Robert M. Silver, Enrique F. Schisterman, Sunni L. Mumford
Summary: We examined the association between preconception adiposity and offspring sex and sex ratio. Among women attempting pregnancy, higher levels of adiposity were associated with reduced sex ratio, primarily driven by a decrease in male livebirths. Obesity and higher levels of serum leptin and skinfold measurements were significantly associated with lower sex ratios. This study highlights the importance of preconception adiposity in determining offspring sex and sex ratio.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Cell Biology
Runshuai Zhang, Jinan Fang, Ting Qi, Shihao Zhu, Luxia Yao, Guicun Fang, Yunsheng Li, Xiao Zang, Weina Xu, Wanyu Hao, Shouye Liu, Dan Yang, Di Chen, Jian Yang, Xianjue Ma, Lianfeng Wu
Summary: Maternal age at childbearing has a conserved effect on offspring adult traits, as revealed in humans, Drosophila, and Caenorhabditis elegans. Using C. elegans, we found that aging mothers transmit abnormal mitochondria to offspring, but these mitochondria are rejuvenated in early life through an AMPK-dependent mechanism. Furthermore, we showed that mitochondrial dysfunction activates AMPK, which in turn activates TGF-β signaling to increase offspring adult size.
Article
Genetics & Heredity
Yang Liu, Qiyue Ding, Steven J. Halderson, Sebastian I. Arriola Apelo, Amanda K. Jones, Sambhu M. Pillai, Maria L. Hoffman, Sarah Reed, Kristen E. Govoni, Steven A. Zinn, Wei Guo
Summary: Overfeeding during gestation can have long-lasting effects on offspring autophagy signaling, especially in later developmental stages and female offspring. Targeting autophagy pathways may be a strategy to mitigate the adverse effects in offspring of over-fed ewes.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Anika K. Anam, Katherine M. Cooke, Milana Bochkur Dratver, Jane O'Bryan, Lauren E. Perley, Seth M. Guller, Janice J. Hwang, Hugh S. Taylor, Leigh Goedeke, Harvey J. Kliman, Daniel F. Vatner, Clare A. Flannery
Summary: Maternal obesity increases the risk of excess adiposity in newborns, which may be attributed to alterations in maternal metabolism such as hyperinsulinemia under euglycemic conditions, affecting placental metabolism and leading to increased fetal adiposity.
MOLECULAR METABOLISM
(2022)
Article
Medicine, Research & Experimental
Michael J. Nash, Evgenia Dobrinskikh, Sean A. Newsom, Ilhem Messaoudi, Rachel C. Janssen, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Paul Kievit, Jacob E. Friedman, Stephanie R. Wesolowski
Summary: Maternal exposure to a Western-style diet during pregnancy can lead to early signs of fibrogenesis in the fetal liver, which can be halted by alleviating oxidative stress in the fetal liver caused by maternal Western-style diet.
Article
Cell Biology
Nicole Haroun, Imene Bennour, Eva Seipelt, Julien Astier, Charlene Couturier, Lourdes Mounien, Jean-Francois Landrier
Summary: Maternal vitamin D deficiency coupled with high-fat diet activates inflammatory pathways in offspring's adipose tissue, which is strongly associated with increased adiposity in males but not in females.
Article
Obstetrics & Gynecology
Hillary F. Huber, Anderson H. Kuo, Cun Li, Susan L. Jenkins, Kenneth G. Gerow, Geoffrey D. Clarke, Peter W. Nathanielsz
REPRODUCTIVE SCIENCES
(2019)
Article
Veterinary Sciences
Natalia Schlabritz-Loutsevitch, Maira Carrillo, Cun Li, Peter Nathanielsz, Christopher Maguire, James Maher, Edward Dick, Gene Hubbard, Jerzy Stanek
JOURNAL OF MEDICAL PRIMATOLOGY
(2019)
Article
Endocrinology & Metabolism
Eugenia Mata-Greenwood, Hillary F. Huber, Cun Li, Peter W. Nathanielsz
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2019)
Editorial Material
Neurosciences
Peter W. Nathanielsz
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Review
Behavioral Sciences
Katja Franke, Bea R. H. Van den Bergh, Susanne R. de Rooij, Nasim Kroegel, Peter W. Nathanielsz, Florian Rakers, Tessa J. Roseboom, Otto W. Witte, Matthias Schwab
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Geriatrics & Gerontology
Elena Zambrano, Luis A. Reyes-Castro, Guadalupe L. Rodriguez-Gonzalez, Roberto Chavira, Peter W. Nathanielsz
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Medicine, General & Internal
Teresa L. Serafim, Teresa Cunha-Oliveira, Claudia M. Deus, Vilma A. Sardao, Ines M. Cardoso, Shanshan Yang, John F. Odhiambo, Adel B. Ghnenis, Ashley M. Smith, Junfei Li, Peter W. Nathanielsz, Stephen P. Ford, Paulo J. Oliveira
Summary: Maternal obesity impacts foetal liver mitochondrial oxidative capacity and total mitochondrial phospholipid content, as well as the regulation of foetal liver redox pathways, revealing metabolic adaptations to a higher foetal lipid environment. In utero programming of foetal hepatic metabolism may persist and compromise mitochondrial bioenergetics in later life, increasing susceptibility to metabolic diseases.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Diana C. Castro-Rodriguez, Carlos A. Ibanez, Jorge Uribe, Marta Menjivar, Maria de los Angeles Granados-Silvestre, Kenneth G. Gerow, Peter W. Nathanielsz, Elena Zambrano
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Toxicology
Luis F. Grilo, Joao D. Martins, Chiara H. Cavallaro, Peter W. Nathanielsz, Paulo J. Oliveira, Susana P. Pereira
TOXICOLOGY IN VITRO
(2020)
Article
Behavioral Sciences
C. Akos Szabo, Melissa De La Garza, Robert Shade, Alexander M. Papanastassiou, Peter Nathanielsz
Summary: This study demonstrated the efficacy of cortical responsive neurostimulation (CRN) in a male baboon with genetic generalized epilepsy (GGE), showing a 38% median reduction in generalized tonic-clonic seizures (GTCS) under treatment. The ictal patterns and circadian distribution of GTCS were also altered by the RNS therapy, shifting gradually from night to daytime.
EPILEPSY & BEHAVIOR
(2021)
Editorial Material
Medicine, General & Internal
Peter W. Nathanielsz
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, General & Internal
Elena Zambrano, Peter W. Nathanielsz, Guadalupe L. Rodriguez-Gonzalez
Summary: Developmental programming can predispose offspring to metabolic, behavioral, and reproductive dysfunction in adult life, with evidence showing a connection between aging phenotype and longevity. Maternal nutrition during development can have effects on the male reproductive system's aging, impacting factors like hormone production, oxidative stress, and sperm quality. Understanding these developmental programming aging interactions can improve male health, longevity, and future generations' health.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, General & Internal
Elena Zambrano, Consuelo Lomas-Soria, Peter W. Nathanielsz
Summary: Compelling evidence suggests that developmental programming influences ageing, affecting organ phenotype and predisposing to diseases that shorten lifespan. Studies demonstrate effects of maternal under- and overnutrition on offspring's pancreatic islets, adipose tissue, and oxidative stress, impacting ageing.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Geriatrics & Gerontology
Daniel A. Adekunbi, Cun Li, Peter W. Nathanielsz, Adam B. Salmon
Summary: The study found that the resilience of cells in responding to homeostatic challenges varies based on the chronological age and sex of the donor, using baboon primary fibroblasts as a model.
Article
Biology
Consuelo Lomas-Soria, Guadalupe L. Rodriguez-Gonzalez, Carlos A. Ibanez, Luis A. Reyes-Castro, Peter W. Nathanielsz, Elena Zambrano
Summary: The present study explored the impact of maternal obesity on hepatic mitochondrial function in male and female offspring at different ages. The findings suggest that maternal obesity accelerates the age-related down-regulation of electron transport chain (ETC) gene expression, leading to oxidative stress, premature aging, and metabolic dysfunction in male offspring. These effects were not observed in female offspring until later in life. The study highlights the importance of mitochondria in the development of fatty liver and provides insights into the mechanisms underlying sexual dimorphism in aging.