In silico Mechano-Chemical Model of Bone Healing for the Regeneration of Critical Defects: The Effect of BMP-2

Oxygen as a critical determinant of bone fracture healing—A multiscale model

(2015) Aurélie Carlier et al.   JOURNAL OF THEORETICAL BIOLOGY

Mechanistic, Mathematical Model to Predict the Dynamics of Tissue Genesis in Bone Defects via Mechanical Feedback and Mediation of Biochemical Factors

(2014) Shannon R. Moore et al.   PLoS Computational Biology

High-concentration of BMP2 reduces cell proliferation and increases apoptosis via DKK1 and SOST in human primary periosteal cells

(2013) Harry K.W. Kim et al.   BONE

A new technique for studying directional cell migration in a hydrogel-based three-dimensional matrix for tissue engineering model systems

(2013) Gil Topman et al.   MICRON

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7

(2013) M.M.J. Caron et al.   OSTEOARTHRITIS AND CARTILAGE

Alginate-Based Biomaterials for Regenerative Medicine Applications

(2013) Jinchen Sun et al.   Materials

Inhibition of endogenous antagonists with an engineered BMP-2 variant increases BMP-2 efficacy in rat femoral defect healing

(2012) Hans-Jörg Sebald et al.   Acta Biomaterialia

Repairing a critical-sized bone defect with highly porous modified and unmodified baghdadite scaffolds

(2012) S.I. Roohani-Esfahani et al.   Acta Biomaterialia

Micro-computed tomography assessment of the progression of fracture healing in mice

(2012) Kevin R. O'Neill et al.   BONE

Chondrocyte BMP2 signaling plays an essential role in bone fracture healing

(2012) Meng Mi et al.   GENE

Mechanical Load Modulates the Stimulatory Effect of BMP2 in a Rat Nonunion Model

(2012) Carolin Schwarz et al.   TISSUE ENGINEERING PART A

Digit patterning during limb development as a result of the BMP-receptor interaction

(2012) Amarendra Badugu et al.   Scientific Reports

Analysis of the roles of microporosity and BMP-2 on multiple measures of bone regeneration and healing in calcium phosphate scaffolds

(2011) Samantha J. Polak et al.   Acta Biomaterialia

Effects of protein dose and delivery system on BMP-mediated bone regeneration

(2011) Joel D. Boerckel et al.   BIOMATERIALS

Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2)

(2011) Diah S. Bramono et al.   BONE

The biology of fracture healing

(2011) Richard Marsell et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

TNF-  promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells

(2011) G. E. Glass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Doses of Bone Morphogenetic Protein 2 Induce Structurally Abnormal Bone and Inflammation In Vivo

(2011) Janette N. Zara et al.   TISSUE ENGINEERING PART A

Integration of multiple cell-matrix interactions into alginate scaffolds for promoting cardiac tissue regeneration

(2010) Yulia Sapir et al.   BIOMATERIALS

An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects

(2010) Yash M. Kolambkar et al.   BIOMATERIALS

Connecting biology and mechanics in fracture healing: an integrated mathematical modeling framework for the study of nonunions

(2010) L. Geris et al.   Biomechanics and Modeling in Mechanobiology

Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healing

(2010) Qun Wang et al.   BONE

Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability

(2010) Zhinong Huang et al.   CYTOKINE

Internal forces and moments in the femur of the rat during gait

(2010) Tim Wehner et al.   JOURNAL OF BIOMECHANICS

The mechanical heterogeneity of the hard callus influences local tissue strains during bone healing: A finite element study based on sheep experiments

(2010) A. Vetter et al.   JOURNAL OF BIOMECHANICS

Emerging Bone Healing Therapies

(2010) Richard Marsell et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Approach

(2010) Liesbet Geris et al.   PLoS Computational Biology

Recent advances in BMP receptor signaling

(2009) Christina Sieber et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The extracellular regulation of bone morphogenetic protein signaling

(2009) D. Umulis et al.   DEVELOPMENT

Sensitivity of tissue differentiation and bone healing predictions to tissue properties

(2009) Hanna Isaksson et al.   JOURNAL OF BIOMECHANICS

Quantitative measures of femoral fracture repair in rats derived by micro-computed tomography

(2009) Jeffry S. Nyman et al.   JOURNAL OF BIOMECHANICS

Effect of cell seeding and mechanical loading on vascularization and tissue formation inside a scaffold: A mechano-biological model using a lattice approach to simulate cell activity

(2009) Sara Checa et al.   JOURNAL OF BIOMECHANICS

The effects of shockwave on bone healing and systemic concentrations of nitric oxide (NO), TGF-β1, VEGF and BMP-2 in long bone non-unions

(2009) Ching-Jen Wang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The Bone Morphogenesis Protein-2 (BMP-2) is Associated with Progression to Metastatic Disease in Gastric Cancer

(2009) Yong Park et al.   Cancer Research and Treatment

Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation

(2008) Andrew S. Rowlands et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Determining the most important cellular characteristics for fracture healing using design of experiments methods

(2008) Hanna Isaksson et al.   JOURNAL OF THEORETICAL BIOLOGY

Chondrogenesis, bone morphogenetic protein-4 and mesenchymal stem cells

(2008) N.D. Miljkovic et al.   OSTEOARTHRITIS AND CARTILAGE