Article
Cardiac & Cardiovascular Systems
Parveen K. Garg, Mary L. Biggs, Jorge R. Kizer, Sanjiv J. Shah, Bruce Psaty, Mercedes Carnethon, John S. Gottdiener, David Siscovick, Kenneth J. Mukamal
Summary: This study evaluated the association between glucose dysregulation and subclinical cardiac dysfunction in an older population. The findings suggest that the relationship between glucose dysregulation and cardiac dysfunction is largely attenuated after adjusting for central adiposity.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Jun Huang, Guang-An Li, Jing Wang, Yu-Wen Jiao, Zhi-Feng Qian, Li Fan, Li-Ming Tang
Summary: Subclinical LV systolic dysfunction can be detected in obese patients using the global myocardial work technique, and an increased BMI is associated with a higher risk of impairment in LV systolic function.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Cardiac & Cardiovascular Systems
Chia-Te Liao, Han Siong Toh, Wei-Ting Chang, Chun-Ting Yang, Zhih-Cherng Chen, Hung-Jen Tang, Carol Strong
Summary: This study used speckle-tracking echocardiography to detect early cardiac impairment in Asian people living with HIV (PLWH) and investigated the associated risk factors. The results showed that hypertension and viral load are related to impaired myocardial strain. Therefore, timely antiretroviral therapy and hypertension control are crucial in preventing cardiovascular diseases in PLWH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Emergency Medicine
Li Sun, Qingshan Zhang, Nannan Li, Shuai Bao, Deqi Wang, Xiaolu Li
Summary: Cardiac cephalalgia, an uncommon symptom in coronary artery disease, can be difficult to identify and link to acute myocardial infarction due to lack of typical angina symptoms. Debate surrounds the diagnostic value of cardiac cephalalgia in acute myocardial infarction, but this case strongly suggests a close association between headache and acute myocardial infarction.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Nutrition & Dietetics
Nella Polidori, Eleonora Agata Grasso, Francesco Chiarelli, Cosimo Giannini
Summary: The impaired plasmatic levels of BCAAs in obese children and adolescents are associated with obesity-related metabolic disorders, potentially through the activation of the mTORC1 complex causing insulin resistance, and the accumulation of toxic metabolites leading to mitochondrial dysfunction and damage to pancreatic cells. These compounds may help in the early identification of complications related to pediatric obesity, but further studies are needed.
Article
Pediatrics
Riddhi Patel, Chetankumar Dave, Sajili Mehta, Hemangkumar Mendpara, Rishi Shukla, Anurag Bajpai
Summary: Obesity-related subclinical hypothyroidism is associated with increased fat percentage, android to gynoid ratio, and alanine aminotransferase (ALT) levels, predisposing to non-alcoholic steatohepatitis. The impact of thyroid supplementation in this setting needs further exploration.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Hematology
Jing-gang Xia, Bowen Li, Hao Zhang, Qin-xue Li, Sin Man Lam, Chun-lin Yin, He Tian, Guanghou Shui
Summary: This study used quantitative metabolomics to investigate the metabolic differences in acute myocardial infarction (AMI) patients with and without diabetes. The findings revealed that diabetes-AMI patients had more severe metabolic dysregulation, involving multiple pathways such as carbohydrate metabolism, lipid metabolism, glycolysis, tricarboxylic acid cycle, and amino acid metabolism. The key functional metabolites N-lactoyl-phenylalanine and lysophosphatidylcholines were identified, which were associated with mitochondrial dysfunction, glucose utilization, and inflammation, suggesting their potential as therapeutic targets for diabetes-AMI.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Green & Sustainable Science & Technology
Santos Villafaina, Juan Pedro Fuentes-Garcia, Juan Luis Leon-Llamas, Daniel Collado-Mateo
Summary: This systematic review analyzed the impact of physical-exercise interventions on HRV in obese children and adolescents. It was found that such interventions increased HRV and improved autonomic modulation, ultimately enhancing cardiovascular health.
Article
Agriculture, Dairy & Animal Science
Sabita Diana Stoeckle, Detlef Timmermann, Roswitha Merle, Heidrun Gehlen
Summary: Laminitic horses commonly suffer from an endocrine disease such as equine metabolic syndrome, with hyperinsulinemia considered a key factor. Resting plasma amino acid concentrations differed significantly between obese horses and those with insulin dysregulation and laminitis, suggesting the potential for diagnostic testing and feed supplements for horses at risk of developing laminitis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarv Priya, Sabarish Narayanasamy, Abigail Walling, Ravi C. Ashwath
Summary: This study evaluated subclinical cardiac dysfunction in student athletes after COVID-19 infection using feature tracking cardiac MRI strain analysis. The results showed that COVID-19 positive athletes had normal physiologic cardiac adaptations with higher end-diastolic volumes compared to healthy controls. However, their left ventricle longitudinal strain and circumferential strain values were relatively lower, while the global strain values were normal.
Article
Psychology, Developmental
Ju-Wei Hsu, Li-Chi Chen, Kai-Lin Huang, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Mu-Hong Chen
Summary: Appetite hormone dysregulation may be involved in the pathophysiology of bipolar disorder and chronic irritability, but its association with executive dysfunction in adolescents with bipolar disorder and disruptive mood dysregulation disorder (DMDD) is not well understood. This study examined fasting serum levels of appetite hormones and executive function in adolescents with bipolar disorder, DMDD, and healthy controls. The results showed that DMDD patients had elevated insulin levels and performed worse on tasks related to the first category, while patients with bipolar disorder performed worse on the number of categories completed. Increased insulin levels were also correlated with executive dysfunction in DMDD patients. Prospective studies are needed to explore the temporal association between appetite hormone dysregulation, executive dysfunction, and emotional dysregulation.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Sun, Li Wang, Yingjiong Lin, Yunfeng Liu, Fei Liu, Xumei Liu, Wenyan Dong, Wenqian Cai, Huimin Chen, Minhua Xiao, Hongfeng Luo, Xihong Liu, Jinzhu Duan
Summary: This study systematically evaluated the cardiovascular characteristics of obese children in Guangzhou, China and found higher levels of cardiovascular disease biomarkers, as well as increased diastolic blood pressure and heart rate in obese children compared to normal weight children. The study also revealed a higher prevalence of cardiac dysfunction in obese children and a stronger correlation between anthropometric parameters of obesity and cardiac dysfunction compared to blood lipid profiles.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Susumu Z. Sudo, Tadeu L. Montagnoli, Bruna de S. Rocha, Aimee D. Santos, Mauro P. L. de Sa, Gisele Zapata-Sudo
Summary: Cardiovascular autonomic neuropathy (CAN) is a severe complication of advanced diabetes, which can have various clinical manifestations. Current treatment options for CAN are limited, but potential targets for therapy include inflammatory and endothelial dysfunction as well as oxidative stress.
Review
Biochemistry & Molecular Biology
Colm J. McElwain, Fergus P. McCarthy, Cathal M. McCarthy
Summary: Gestational diabetes mellitus is a pregnancy complication that can lead to maternal hyperglycemia and immune dysregulation, impacting fetal health and increasing the risk of developing diabetes. Understanding the origins and evolution of these pathways is crucial for improving therapeutic interventions and outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Xin Yuan, Ruimin Chen, Ying Zhang, Xiangquan Lin, Xiaohong Yang, Kenneth L. McCormick
Summary: The study found that the gut microbiome in obese children with insulin resistance was significantly different from those without resistance, and the abundance of certain metabolism-related bacteria was correlated with the serum concentrations of adropin and ANGPTL4.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Geography
Andrea Terlizzi, Giovanni Esposito
Summary: This article examines the role of New Public Management ideas in the reform of the health systems in Italy and Denmark. Through document analysis and interviews, it highlights the changes in institutional and territorial dimensions and the varying relationship between size and authority in relation to NPM ideas.
TERRITORY POLITICS GOVERNANCE
(2023)
Article
Biochemistry & Molecular Biology
Fabiola Marino, Nadia Salerno, Mariangela Scalise, Luca Salerno, Annalaura Torella, Claudia Molinaro, Antonio Chiefalo, Andrea Filardo, Chiara Siracusa, Giuseppe Panuccio, Carlo Ferravante, Giorgio Giurato, Francesca Rizzo, Michele Torella, Maria Donniacuo, Antonella De Angelis, Giuseppe Viglietto, Konrad Urbanek, Alessandro Weisz, Daniele Torella, Eleonora Cianflone
Summary: Diabetic cardiomyopathy (DCM) is a major cause of cardiovascular complications in diabetes mellitus (DM). Two different types of diabetes, type 1 and type 2, exhibit different effects on cardiac structure, function and gene expression. Animal models induced by different glucose regulators have been used to compare and study these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Francesca Dongiglio, Emanuele Monda, Giuseppe Palmiero, Federica Verrillo, Marta Rubino, Gaetano Diana, Annapaola Cirillo, Adelaide Fusco, Erica Vetrano, Michele Lioncino, Martina Caiazza, Giuseppe Cerciello, Laura Capodicasa, Flavia Chiosi, Vincenzo Simonelli, Maria Luisa De Rimini, Francesco Natale, Alessandro Di Santo, Elisabetta Moscarella, Paolo Calabro, Giuseppe Limongelli
Summary: Gastrointestinal involvement is common in systemic amyloidosis patients, leading to debilitating symptoms, nutrient deficiencies, and indicating disease severity. However, diagnosing gastrointestinal involvement in patients with isolated symptoms is challenging. The nutritional status in systemic amyloidosis is crucial and considered a significant prognostic factor, but defining it remains difficult due to the lack of standardized thresholds in specific populations. This review aims to provide insight into the fundamental steps of nutritional assessment using clinical and instrumental tools for improved prognostic stratification and patient management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Carmen A. M. Spaccarotella, Sabato Sorrentino, Annalisa Mongiardo, Vincenzo Riverso, Cinzia Mancuso, Salvatore Giordano, Giovanni Esposito, Ciro Indolfi
Summary: This study aimed to assess the acute adaptation of nitinol-based self-expandable valves in the aortic root after deployment. The results showed that the valve diameter significantly increased after implantation, and predilation and postdilation had an impact on valve expansion.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Carmen Spaccarotella, Salvatore Giordano, Davide Barbisan, Giovanni Esposito, Gianfranco Sinagra, Ciro Indolfi
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Roberto Diletti, Wijnand K. den Dekker, Johan Bennett, Carl E. Schotborgh, Rene van der Schaaf, Manel Sabate, Raul Moreno, Koen Ameloot, Rutger van Bommel, Daniele Forlani, Bert van Reet, Giovanni Esposito, Maurits T. Dirksen, Willem P. T. Ruifrok, Bert R. C. Everaert, Carlos Van Mieghem, Jacob J. Elscot, Paul Cummins, Mattie Lenzen, Salvatore Brugaletta, Eric Boersma, Nicolas M. Van Mieghem
Summary: Immediate complete revascularisation is non-inferior to staged complete revascularisation in patients with acute coronary syndrome and multivessel disease, and it is associated with a reduction in myocardial infarction and unplanned ischaemia-driven revascularisation.
Review
Medicine, General & Internal
Emanuele Monda, Marta Rubino, Giuseppe Palmiero, Federica Verrillo, Michele Lioncino, Gaetano Diana, Annapaola Cirillo, Adelaide Fusco, Francesca Dongiglio, Martina Caiazza, Ippolita Altobelli, Alfredo Mauriello, Natale Guarnaccia, Alessandra Scatteia, Arturo Cesaro, Giuseppe Pacileo, Berardo Sarubbi, Giulia Frisso, Barbara Bauce, Antonello D'Andrea, Santo Dellegrottaglie, Maria Giovanna Russo, Paolo Calabro, Giuseppe Limongelli
Summary: Arrhythmogenic cardiomyopathy (ACM) is a broad term for myocardial diseases characterized by progressive fibrotic or fibrofatty replacement, which leads to ventricular tachyarrhythmias and ventricular dysfunction. Arrhythmogenic left ventricular cardiomyopathy (ALVC) is a specific subtype that exclusively affects the left ventricle. Diagnosis of ALVC requires a combination of family history, clinical, electrocardiographic, and imaging features, with genetic testing for confirmation. Multimodality imaging techniques, such as echocardiography, cardiac magnetic resonance, and cardiac nuclear imaging, are essential for diagnosis, differential diagnosis, risk stratification, and management of ALVC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Sara Bombace, Maria Chiara Meucci, Federico Fortuni, Federica Ilardi, Rachele Manzo, Grazia Canciello, Giovanni Esposito, Paul A. A. Grayburn, Maria Angela Losi, Anna Sannino
Summary: Aortic stenosis (AS) commonly coexists with other valvular diseases or is combined with aortic regurgitation (AR), resulting in unique pathophysiological conditions. The combination of affected valves varies widely, leading to a lack of standardized diagnostic or therapeutic approaches. Echocardiography, although crucial, may be challenging due to the hemodynamic interactions between combined valvular defects. Hence, a multimodality imaging approach, such as computed tomography or cardiac magnetic resonance, is often crucial in diagnosing and understanding valvular pathology.
Article
Cardiac & Cardiovascular Systems
Valentina Trimarco, Maria Virginia Manzi, Raffaele Izzo, Pasquale Mone, Maria Lembo, Daniela Pacella, Giovanni Esposito, Angela Falco, Carmine Morisco, Paola Gallo, Gaetano Santulli, Bruno Trimarco
Summary: This study investigates the impact of a therapeutic concordance approach on adverse drug reactions (ADRs) in patients with therapy-resistant hypertension (TRH). The results show that the therapeutic concordance approach significantly reduces the occurrence of ADRs in TRH patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Fabiola Boccuto, Salvatore De Rosa, Daniele Torella, Pierangelo Veltri, Pietro Hiram Guzzi
Summary: Chronic heart failure (CHF) is a prevalent and multifactorial condition with a significant burden on healthcare systems and public budgets worldwide. Artificial intelligence (AI) shows promise in assisting clinical decision-making by analyzing raw image data and electrocardiogram recordings. This article provides an overview of the current gaps and needs in CHF research and clinical management and introduces AI-powered tools that may address these gaps and needs.
APPLIED SCIENCES-BASEL
(2023)
Article
Instruments & Instrumentation
Antonella Barone, Anna Maria Zimbo, Nicola d'Avanzo, Anna Maria Tolomeo, Stefano Ruga, Antonio Cardamone, Christian Celia, Mariangela Scalise, Daniele Torella, Massimo La Deda, Enrico Iaccino, Donatella Paolino
Summary: Nanomedicine and extracellular vesicles are powerful tools for enhancing anticancer therapies. This study aims to create a hybrid nanosystem by combining M1 macrophage-derived extracellular vesicles (EVs-M1) with thermoresponsive liposomes, in order to develop a drug delivery system that can utilize the tumor-targeting capability of immune cells and the thermoresponsiveness of synthetic nanovesicles.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jorge Sanz-Sanchez, Hector M. Garcia-Garcia, Mattia Branca, Enrico Frigoli, Sergio Leonardi, Andrea Gagnor, Paolo Calabro, Stefano Garducci, Paolo Rubartelli, Carlo Briguori, Giuseppe Ando, Alessandra Repetto, Ugo Limbruno, Roberto Garbo, Paolo Sganzerla, Filippo Russo, Alessandro Lupi, Bernardo Cortese, Arturo Ausiello, Salvatore Ierna, Giovanni Esposito, Andrea Santarelli, Gennaro Sardella, Fernando Varbella, Simone Tresoldi, Nicoletta de Cesare, Stefano Rigattieri, Antonio Zingarelli, Paolo Tosi, Arnoud van 't Hof, Giacomo Boccuzzi, Elmir Omerovic, Manel Sabate, Dik Heg, Pascal Vranckx, Marco Valgimigli
Summary: The role of coronary calcification in patients presenting with acute coronary syndromes (ACS) and different revascularization strategies has been investigated. This study evaluates the role of coronary calcification, detected by coronary angiography, in the overall spectrum of patients with acute ACS. The results suggest that patients with severe coronary calcification have worse clinical outcomes regardless of the management strategy.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Review
Cardiac & Cardiovascular Systems
Felice Gragnano, Antonio Capolongo, Fabrizia Terracciano, Giuseppe Gargiulo, Arturo Cesaro, Elisabetta Moscarella, Vincenzo De Sio, Giuseppe Patti, Italo Porto, Giovanni Esposito, Paolo Calabro
Summary: Dual antiplatelet therapy (DAPT) is an essential treatment for patients with acute coronary syndrome (ACS) and/or undergoing percutaneous coronary intervention (PCI). Recently, novel approaches based on escalating or de-escalating P2Y12 antagonists have been proposed to individualize the treatment of patients with coronary artery disease and improve their prognosis, taking into account clinical features, genetic factors, and platelet function.
GIORNALE ITALIANO DI CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Miriam Compagnone, Pierluigi Demola, Federica Serino, Giulia Masiero, Livio Giuliani, Serena Rossi, Alberto Polimeni, Tiziana Attisano, Marco Contarini, Battistina Castiglioni, Federico De Marco, Massimo Fineschi, Alberto Menozzi, Carmine Musto, Francesco Saia, Giuseppe Tarantini, Giovanni Esposito
Summary: This study aims to evaluate the practice of right heart catheterization (RHC) among the interventional cardiology community. The survey results show that most centers perform few RHC procedures per year and lack a dedicated cardiologist. The most common indication for RHC is the evaluation of pulmonary hypertension, followed by the diagnostics of valvular diseases and advanced heart failure/heart transplantation.
GIORNALE ITALIANO DI CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Pasquale Guarini, Francesco Saia, Milena Sidiropulos, Angelo Silverio, Santo Dellegrottaglie, Alessandra Scatteia, Francesco De Stefano, Carlo Tedeschi, Laura A. Dalla Vecchia, Alberto M. Cappelletti, Damiano Regazzoli, Alberto Benassi, Francesco Donatelli, Raffaella America, Gabriella Nosso, Piera Capranzano, Angelo Oliva, Raffaele Piccolo, Luca Testa, Tiziana Attisano, Battistina Castiglioni, Marco Contarini, Federico De Marco, Massimo Fineschi, Alberto Menozzi, Carmine Musto, Giulio Stefanini, Giuseppe Tarantini, Francesco Caiazza, Giovanni Esposito
Summary: This article discusses the proposed long-term management of post-ACS or post-PCI patients based on their individual residual risk of cardiovascular adverse events. It presents five patient risk classes and corresponding follow-up strategies, as well as guidance for selecting appropriate imaging techniques for assessment and detection.
GIORNALE ITALIANO DI CARDIOLOGIA
(2023)