Article
Biochemistry & Molecular Biology
Malgorzata Mirr, Anna Braszak-Cymerman, Aleksandra Ludziejewska, Matylda Kregielska-Narozna, Pawel Bogdanski, Wieslaw Bryl, Maciej Owecki
Summary: This study aimed to investigate the correlation between serum asprosin levels and insulin resistance indices, as well as the correlation between asprosin and obesity indices. The results showed that asprosin concentrations were significantly higher in obese patients, and there was a positive correlation between asprosin concentrations and body mass index, waist circumference, and all tested indices of insulin resistance. Therefore, asprosin can be considered a marker of obesity and insulin resistance.
Article
Nutrition & Dietetics
Allison M. Hodge, Md Nazmul Karim, James R. Hebert, Nitin Shivappa, Barbora de Courten
Summary: The study found that dietary inflammatory index and Alternative Healthy Eating Index-2010 were positively associated with diabetes incidence, while Mediterranean Diet Score was not. Mediation analysis indicated that body size played a moderate to large mediating role in the association between AHEI and DII and incident diabetes.
Article
Endocrinology & Metabolism
Kyuho Kim, Tae Jung Oh, Young Suk Park, Won Chang, Hyen Chung Cho, Jihye Lee, Yun Kyung Lee, Sung Hee Choi, Hak Chul Jang
Summary: This study found that obesity is independently associated with polyneuropathy in subjects without diabetes. However, in subjects with diabetes, although the association between obesity and polyneuropathy is not significant after adjusting for conventional risk factors, increased fibrotic gene expression in fat is associated with polyneuropathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Nella Polidori, Eleonora Agata Grasso, Francesco Chiarelli, Cosimo Giannini
Summary: The impaired plasmatic levels of BCAAs in obese children and adolescents are associated with obesity-related metabolic disorders, potentially through the activation of the mTORC1 complex causing insulin resistance, and the accumulation of toxic metabolites leading to mitochondrial dysfunction and damage to pancreatic cells. These compounds may help in the early identification of complications related to pediatric obesity, but further studies are needed.
Review
Nutrition & Dietetics
Valeria Calcaterra, Elvira Verduci, Matteo Vandoni, Virginia Rossi, Giulia Fiore, Giulia Massini, Clarissa Berardo, Alessandro Gatti, Paola Baldassarre, Alice Bianchi, Erika Cordaro, Caterina Cavallo, Cristina Cereda, Alessandra Bosetti, Gianvincenzo Zuccotti
Summary: Childhood obesity increases the risk of metabolic derangements such as insulin resistance. Adopting a healthy lifestyle, including physical exercise and balanced diet, has positive effects on managing insulin resistance and related metabolic disorders.
Article
Medicine, General & Internal
Jung Eun Yoo, Dahye Kim, Kyungdo Han, Sang Youl Rhee, Dong Wook Shin, Hyun Lee
Summary: The study found that there is an association between diabetes status and the development of tuberculosis. Individuals with diabetes have a higher risk of developing tuberculosis compared to those without diabetes, and the risk of tuberculosis increases with longer duration of diabetes.
Article
Nutrition & Dietetics
Rodolfo Deusdara, Amanda de Moura Souza, Moyses Szklo
Summary: The study finds that the level of obesity is strongly associated with insulin resistance in early adolescence, while waist circumference is more effective in identifying insulin resistance in late adolescence.
Article
Endocrinology & Metabolism
Xin Yuan, Ruimin Chen, Ying Zhang, Xiangquan Lin, Xiaohong Yang, Kenneth L. McCormick
Summary: The study found that the gut microbiome in obese children with insulin resistance was significantly different from those without resistance, and the abundance of certain metabolism-related bacteria was correlated with the serum concentrations of adropin and ANGPTL4.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Weinan Chen, Sailimai Man, Yang Hong, Gaohaer Kadeerhan, Liang Chen, Qingquan Xu, Liulin Xiong, Tao Xu, Bo Wang, Xiaobo Huang
Summary: This study investigated the association between metabolically healthy obesity (MHO) and kidney stones, and found that MHO individuals have a significantly higher risk of kidney stones. This suggests that obesity can contribute to kidney stones independently of metabolic abnormalities. Therefore, lifestyle interventions aimed at maintaining a healthy body composition may still benefit MHO individuals.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Yang Niu, Qingya Tang, Xuan Zhao, Xuelin Zhao, Xiaomeng Mao, Jinye Sheng, Wei Cai, Yi Feng
Summary: This study aimed to evaluate the role of serum uric acid (SUA) in mediating insulin resistance in obese children and adolescents. The results showed that SUA partially mediated the link between BMI, fasting insulin levels, and insulin resistance in this population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Haixia Lin, Kelly E. Mercer, Xiawei Ou, Kori Mansfield, Robert Buchmann, Elisabet Borsheim, Emir Tas
Summary: This study aimed to assess the relationship between serum miRNA profile in children with obesity, insulin resistance (IR), and non-alcoholic fatty liver disease (NAFLD). The results showed that several miRNAs were differentially expressed in children with IR and NAFLD, which may provide new targets for the diagnosis and treatment of pediatric NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lixia Shen, Dongyu Wang, Yihong Huang, Lisha Ye, Caixia Zhu, Shaofeng Zhang, Shiqin Cai, Zilian Wang, Haitian Chen
Summary: This study investigated the correlation between lipid profiles and insulin indices as well as the development of gestational diabetes mellitus (GDM) in pregnant women. The results showed that triglycerides (TG) were consistently correlated with insulin indices and glucose metabolism indices. Persistently high TG levels were independent risk factors for persistent insulin resistance (IR) and second-trimester IR alone. Lowering TG levels in early and middle pregnancy could help reduce the risk of developing IR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Wenqiang Li, Tong Liu, Liang Qian, Yiming Wang, Xiangming Ma, Liying Cao, Qingsong Zhang, Jun Qu
Summary: This study found that the association between abdominal obesity and colorectal cancer risk may be mediated by factors such as insulin resistance and inflammation. General and abdominal obesity were associated with an increased risk of colorectal cancer in males, while only abdominal obesity was associated with an increased risk in females. Additionally, the mediation effects of fasting triglyceride-glucose index and C-reactive protein were observed for the association between abdominal obesity and colorectal cancer risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Pilarski, Marta Pelczynska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulinska, Pawel Bogdanski
Summary: This study aimed to determine the association between vaspin concentration and metabolic disorders in obese individuals. The results showed that serum vaspin concentrations were significantly higher in the obese group compared to the control group. The findings suggest that vaspin may be a useful diagnostic parameter for obesity-related complications.
Review
Endocrinology & Metabolism
Fatemeh Kazeminasab, Fatemeh Sharafifard, Maryam Miraghajani, Nasim Behzadnejad, Sara K. Rosenkranz
Summary: Exercise training has positive effects on insulin resistance and body weight in children and adolescents with overweight or obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Hyun Kyung Namgung, Hye Won Woo, Jinho Shin, Min-Ho Shin, Sang Baek Koh, Hyeon Chang Kim, Yu-Mi Kim, Mi Kyung Kim
Summary: This study aimed to develop and validate hypertension risk prediction models. The models using the Framingham hypertension risk prediction factors showed good internal calibration, but their external calibration was not ideal.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Endocrinology & Metabolism
Sung Hye Kong, Joon-Hyop Lee, Jeong Mo Bae, Namki Hong, Hyeyoon Kim, So Young Park, Yong Jun Choi, Sihoon Lee, Yumie Rhee, Sang Wan Kim, Dohyun Han, Jung Hee Kim, Chan Soo Shin
Summary: This study aimed to identify protein signatures for the diagnosis of parathyroid carcinoma (PC) through quantitative proteomic analyses. It identified 5 proteins that can discriminate PC from parathyroid adenoma (PA) and found that the nuclear percentage of carbonic anhydrase 4 and laminin subunit beta-2 was significantly lower in PC tissue. The findings of this study can contribute to the accurate diagnosis of PC and the discovery of potential therapeutic targets.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Seung Won Burm, Hyeon Chang Kim, Chang Oh Kim, Yumie Rhee
Summary: Low countermovement jump power is associated with prevalent fracture, osteoporosis, and sarcopenia in older adults. However, whether jump power predicts incident fracture risk remains uninvestigated. This study found that low jump power is associated with a higher risk of fracture in older adults and can predict fracture risk independently of sarcopenia and osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Sang Wouk Cho, Sungjae Shin, Seunghyun Lee, Seol A. Jang, Seunghyun Roh, Young Han Lee, Yumie Rhee, Steven R. R. Cummings, Hwiyoung Kim, Kyoung Min Kim
Summary: By using deep learning methods on lateral spine radiography, osteoporosis and vertebral fractures can be better diagnosed, leading to improved referral of high-risk individuals to bone-density testing.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Ji-Sook Kong, Yu-Mi Kim, Hye-Won Woo, Min-Ho Shin, Sang-Baek Koh, Hyeon-Chang Kim, Jin-Ho Shin, Mi-Kyung Kim
Summary: This study examined the relationship between dietary intake of total flavonoids and their seven subclasses and the risk of hypertension. The results showed that there was a non-linear inverse association between total flavonoids and hypertension risk, particularly for anthocyanins and proanthocyanidins in overweight/obese men.
Article
Public, Environmental & Occupational Health
Eunji Kim, Ga Bin Lee, Dong Keon Yon, Hyeon Chang Kim
Summary: The prevalence of obesity among Korean adolescents has been increasing, with higher rates observed among boys and high school students. Socioeconomic disparities, particularly related to household income and parental educational attainment, are associated with obesity, with a greater impact on girls.
EPIDEMIOLOGY AND HEALTH
(2023)
Review
Peripheral Vascular Disease
Hack-Lyoung Kim, Eun Mi Lee, Shin Young Ahn, Kwang-il Kim, Hyeon Chang Kim, Ju Han Kim, Hae-Young Lee, Jang Hoon Lee, Jong-Moo Park, Eun Joo Cho, Sungha Park, Jinho Shin, Young-Kwon Kim
Summary: This review provides an update on the 2018 Korean Hypertension Society Guidelines for the management of hypertension. It highlights the importance of ambulatory and home blood pressure monitoring for diagnosis and treatment target determination. The updated guidelines recommend a target blood pressure below 130/80 mmHg for high-risk patients based on consensus and the SPRINT study. However, for conditions such as cerebral infarction and chronic kidney disease, as well as for elderly patients, the target blood pressure is generally set at <140/90 mmHg due to lack of evidence.
CLINICAL HYPERTENSION
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Jung Ho Kim, Graham Treece, Hyeon Chang Kim, Jun Yong Choi, Yumie Rhee
Summary: Middle-aged men living with human immunodeficiency virus (MLWH) have a significantly higher risk of hip fracture, almost a decade earlier than those without infection. Limited data on cortical and trabecular bone deficit in MLWH were observed. This study found that MLWH had lower hip bone density and deficits in certain bone parameters compared to age and body mass index-matched controls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jee-Seon Shim, Kyoung Hwa Ha, Dae Jung Kim, Hyeon Chang Kim
Summary: This study examined the relationship between ultraprocessed food (UPF) consumption and adiposity indicators among Korean adults. The results showed that UPF intake was positively associated with higher adiposity indicators, and this association was partially mediated by overall diet quality.
Article
Endocrinology & Metabolism
Namki Hong, Sungjae Shin, Seunghyun Lee, Yumie Rhee
Summary: This study found that romosozumab may be more effective in improving trabecular bone score compared to denosumab therapy in postmenopausal women who have previously received antiresorptive agents. Notably, romosozumab treatment resulted in similar improvement in trabecular bone score in patients previously treated with antiresorptive agents compared to drug-naive patients.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Seung-Rok Kim, Ey-In Lee, Yongnyun Kim, Sang Wouk Cho, Namki Hong, Yumie Rhee, Jin-Woo Park
Summary: This study presents a new jumping-power assessment tool in a preclinical rodent model to study sarcopenia. The device utilizes electrical stimulation and load cell to capture the jumping data of mice, and has various potential utilities.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Jee-Seon Shim, Kyoung Hwa Ha, Dae Jung Kim, Hyeon Chang Kim
Summary: This study investigated the association between consumption of ultra-processed foods (UPF) and obesity. The study found that UPF accounted for 17.9% of total energy intake and the prevalence of obesity and abdominal obesity was 35.4% and 30.2% respectively. Adults with higher UPF consumption had higher BMI, waist circumference, and greater odds of obesity and abdominal obesity. Dose-response associations between UPF consumption and obesity indicators were consistently found.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Endocrinology & Metabolism
Eun-Sun Jin, Jee-Seon Shim, Sung Eun Kim, Jae Hyun Bae, Shinae Kang, Jong Chul Won, Min-Jeong Shin, Heung Yong Jin, Jenny Moon, Hokyou Lee, Hyeon Chang Kim, In-Kyung Jeong, Korean Society Lipid Atherosclerosis
Summary: This study aimed to investigate the prevalence and status of dyslipidemia management among South Korean adults. The results showed that the prevalence of hypercholesterolemia and dyslipidemia has steadily increased, but the treatment rate remains low. Therefore, efforts are needed to strengthen cooperation between the national healthcare system, patients, and healthcare providers for dyslipidemia management.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Albert Youngwoo Jang, Hyeok-Hee Lee, Hokyou Lee, Hyeon Chang Kim, Wook-Jin Chung
Summary: Between 2002 or 2004 and 2018, the prevalence and incidence of pulmonary arterial hypertension (PAH) in Korea has increased significantly. The use of combination therapy has also increased. The 5-year survival rate of PAH in Korea is similar to western countries.
KOREAN CIRCULATION JOURNAL
(2023)
Article
Peripheral Vascular Disease
Sun Young Shim, Sun Jae Jung, Seung Up Kim, Hyeon Chang Kim
Summary: This study examined the association between cardiovascular health metrics and NAFLD in middle-aged Koreans. The findings showed that individuals with ideal cardiovascular health had a lower risk of NAFLD, while those with poor cardiovascular health had a higher risk.
CLINICAL HYPERTENSION
(2023)