Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory

Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease

(2015) Dan Xia et al.   NEURON

Jagged1 is necessary for postnatal and adult neurogenesis in the dentate gyrus

(2014) Alfonso Lavado et al.   DEVELOPMENTAL BIOLOGY

Regulation and Function of Adult Neurogenesis: From Genes to Cognition

(2014) James B. Aimone et al.   PHYSIOLOGICAL REVIEWS

Notch1 signaling modulates neuronal progenitor activity in the subventricular zone in response to aging and focal ischemia

(2013) Fen Sun et al.   AGING CELL

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Trans-Dominant Negative Effects of Pathogenic PSEN1 Mutations on  -Secretase Activity and A  Production

(2013) E. A. Heilig et al.   JOURNAL OF NEUROSCIENCE

Canonical Wnt Signaling is Necessary for Object Recognition Memory Consolidation

(2013) A. M. Fortress et al.   JOURNAL OF NEUROSCIENCE

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Presenilin-1 Regulates Neural Progenitor Cell Differentiation in the Adult Brain

(2011) A. Gadadhar et al.   JOURNAL OF NEUROSCIENCE

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation

(2011) James B. Aimone et al.   NEURON

A Presenilin-1 Mutation Identified in Familial Alzheimer Disease with Cotton Wool Plaques Causes a Nearly Complete Loss of γ-Secretase Activity

(2010) Elizabeth A. Heilig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch1 Is Required for Maintenance of the Reservoir of Adult Hippocampal Stem Cells

(2010) J. L. Ables et al.   JOURNAL OF NEUROSCIENCE

 -Secretase Gene Mutations in Familial Acne Inversa

(2010) B. Wang et al.   SCIENCE

Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo

(2010) Lodovica Borghese et al.   STEM CELLS

Adult neurogenesis: integrating theories and separating functions

(2010) James B. Aimone et al.   TRENDS IN COGNITIVE SCIENCES

Indirect Regulation of Presenilins in CREB-mediated Transcription

(2009) Hirotaka Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GABA-cAMP Response Element-Binding Protein Signaling Regulates Maturation and Survival of Newly Generated Neurons in the Adult Hippocampus

(2009) R. Jagasia et al.   JOURNAL OF NEUROSCIENCE

Noggin Expands Neural Stem Cells in the Adult Hippocampus

(2008) M. A. Bonaguidi et al.   JOURNAL OF NEUROSCIENCE

Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse

(2008) Qian Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The consolidation of object and context recognition memory involve different regions of the temporal lobe

(2008) I. Balderas et al.   LEARNING & MEMORY