Article
Infectious Diseases
Manawr AL-Quraini, Meher Rizvi, Zaaima AL-Jabri, Hiba Sami, Muna AL-Muzahmi, Zakariya AL-Muharrmi, Neelam Taneja, Ibrahim AL-Busaidi, Rajeev Soman
Summary: Fosfomycin has proven to be a useful antimicrobial for managing extremely drug resistant and pan drug resistant Klebsiella pneumoniae. Combining fosfomycin with meropenem or amikacin shows excellent synergy, while fosfomycin in combination with tigecycline exhibits antagonism. Despite the presence of resistance markers and porin proteins, synergy is still observed.
Article
Infectious Diseases
Jacinda C. Abdul-Mutakabbir, Juwon Yim, Logan Nguyen, Philip T. Maassen, Kyle Stamper, Zain Shiekh, Razieh Kebriaei, Ryan K. Shields, Mariana Castanheira, Keith S. Kaye, Michael J. Rybak
Summary: The study explored the potential utility of antibiotic combinations for carbapenem-resistant Acinetobacter baumannii isolates, identifying synergistic and bactericidal effects in certain combination therapies. Results suggest that certain antibiotic combinations can restore efficacy against resistant strains, offering new treatment options for difficult-to-treat infections caused by Acinetobacter baumannii.
Article
Microbiology
Yawei Zhang, Xiaojuan Wang, Shifu Wang, Shijun Sun, Henan Li, Hongbin Chen, Qi Wang, Hui Wang
Summary: This study revealed the association between colistin resistance and tigecycline pressure in CR-hvKP through clinical cases and in vitro experiments. It was found that developing colistin resistance under tigecycline or colistin pressure may result in a slight virulence cost for CR-hvKP, although the mutants still displayed higher virulence compared to the parent strain.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Jae-Min Park, Kyung-Sook Yang, You-Seung Chung, Ki-Byung Lee, Jeong-Yeon Kim, Sun-Bean Kim, Jang-Wook Sohn, Young-Kyung Yoon
Summary: This study compared the clinical outcomes and safety of meropenem-colistin versus meropenem-tigecycline in treating adult patients with carbapenem-resistant Acinetobacter baumannii (CRAB) pneumonia. The results suggest that meropenem-tigecycline combination therapy may be a valuable treatment option, while episodes of nephrotoxicity were significantly more common in the meropenem-colistin group.
Article
Infectious Diseases
Parnrada Nulsopapon, Worapong Nasomsong, Manat Pongchaidecha, Dhitiwat Changpradub, Piraporn Juntanawiwat, Wichai Santimaleeworagun
Summary: The study on antibiotic sensitivity and pharmacokinetic/pharmacodynamic data of CRKP and CoRKP suggests that increasing antibiotic treatment doses and combination therapy may be effective strategies against these bacteria.
Article
Microbiology
Jiawei Chen, Yu Zeng, Rong Zhang, Jiachang Cai
Summary: Three clonally related carbapenem-resistant Klebsiella pneumoniae (CRKP) strains harbored the same set of antimicrobial resistance genes. Among them, one strain with a type 1 Tet(A) variant carrying a G300E mutation on a plasmid exhibited significantly elevated tigecycline resistance.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Ghazal Bayatinejad, Mohammadreza Salehi, Reza Beigverdi, Shahnaz Halimi, Mohammad Emaneini, Fereshteh Jabalameli
Summary: The study evaluated the in vitro activity of several antibiotic combinations against planktonic and biofilm MDR-KPs isolated from patients with VAP. The results showed that combinations of amoxicillin/clavulanate with colistin, meropenem, or amikacin in the planktonic mode and colistin with amoxicillin/clavulanate, meropenem, or amikacin in the biofilm mode could effectively inhibit CRKP isolates, and thus could be further explored for the treatment of CRKPs.
Article
Public, Environmental & Occupational Health
Mohammad H. Gharaibeh, Dania A. Alyafawi, Ziad A. Elnasser, Shawkat Q. Lafi, Haneen M. Obeidat
Summary: This study investigated the antimicrobial resistance profile of clinical isolates of Klebsiella pneumoniae in Jordan and found the presence of the MCR-1 gene for the first time. It also identified KPC and IMP encoded carbapenemases as the most prevalent in Jordanian patients.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Immunology
Sarumathi Dhandapani, Sujatha Sistla, Anitha Gunalan, Meerabai Manoharan, Madhan Sugumar, Apurba Sankar Sastry
Summary: The study conducted in-vitro synergy testing using the checkerboard method on colistin-meropenem combination to determine whether the antibiotics had synergistic or antagonistic effects. The results showed that a significant reduction in MIC of colistin was observed when combined with meropenem, supporting the use of combination therapy for infections caused by multi-drug-resistant Klebsiella pneumoniae and Escherichia coli.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Microbiology
Baoyue Zhang, Bing Yu, Wei Zhou, Yue Wang, Ziyong Sun, Xiaojun Wu, Shiyun Chen, Ming Ni, Yangbo Hu
Summary: This study identified a clinical CRKP strain capable of transitioning to a colistin-resistant phenotype by inserting the ISKpn72 element, which could also confer colistin resistance to sensitive K. pneumoniae strains. Furthermore, it was found that the ISKpn72-containing plasmid could be transferred through conjugation, indicating potential challenges for colistin-resistance detection and CRKP treatment.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Sanjay Singh, Ashutosh Pathak, Mohibur Rahman, Avinash Singh, Soumyabrata Nag, Chinmoy Sahu, Kashi Nath Prasad
Summary: The study identified that colistin resistance in Klebsiella pneumoniae is mainly mediated by mcr-1. The co-existence of colistin, carbapenem, and other drug-resistant genes along with efflux pumps suggests significant genomic plasticity in K. pneumoniae, potentially leading to the emergence of super-spreaders of drug resistance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yishuai Lin, Ying Zhang, Shixing Liu, Dandan Ye, Liqiong Chen, Na Huang, Weiliang Zeng, Wenli Liao, Yizhou Zhan, Tieli Zhou, Jianming Cao
Summary: Colistin, considered as a last resort treatment for Gram-negative bacteria infections, is becoming ineffective against colistin-resistant strains of Escherichia coli and Klebsiella Pneumoniae. The combination of quercetin with colistin efficiently eradicates colistin-resistant bacteria by downregulating resistance genes and enhancing bacterial cell membrane damage. This colistin/quercetin combination shows promise as an alternative pathway against colistin-resistant infections.
FRONTIERS IN CHEMISTRY
(2021)
Article
Immunology
Xi Jin, Qiong Chen, Fang Shen, Yan Jiang, Xueqing Wu, Xiaoting Hua, Ying Fu, Yunsong Yu
Summary: This study reported a case of hv-CRKP-associated infection and revealed the in-host evolution of resistance to tigecycline and polymyxin during clinical therapy. The results suggest that the hypervirulent ST11-KL64 clone poses a potential threat to anti-infection treatment with rapid and diverse evolution of resistance.
EMERGING MICROBES & INFECTIONS
(2021)
Review
Medicine, General & Internal
Chienhsiu Huang, Ihung Chen, Tiju Tang
Summary: This meta-analysis compared the efficacy and safety of colistin monotherapy and colistin plus meropenem combination therapy in patients with drug-resistant Acinetobacter baumannii infection. The results showed that colistin monotherapy had similar clinical outcomes and safety profile compared to the combination therapy, with the exception of microbiological response, where the combination therapy was superior.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Ying Li, Yu Fu, Yichuan Qiu, Qian Liu, Ming Yin, Luhua Zhang
Summary: This study investigates the genetic elements involved in tigecycline resistance in Enterobacterales. The findings show that all E. coli strains carry the tet(X4) gene, while two K. pneumoniae strains carry the tmexCD1-toprJ1 gene. Overexpression of efflux genes in K. pneumoniae is likely caused by gene mutations. These findings contribute to our understanding of tigecycline resistance genetics.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Christina Bahrs, Sebastian Weis, Miriam Kesselmeier, Juliane Ankert, Stefan Hagel, Stephanie Beier, Jens Maschmann, Andreas Stallmach, Andrea Steiner, Michael Bauer, Wilhelm Behringer, Michael Baier, Cora Richert, Florian Zepf, Martin Walter, Andre Scherag, Michael Kiehntopf, Bettina Loeffler, Mathias W. Pletz
Summary: This study aims to assess the SARS-CoV-2 seroprevalence and infection status in staff members of Jena University Hospital in Germany. The results show that non-patient-related exposure to SARS-CoV-2 posed the highest infection risk for hospital staff members, with contact with household members and colleagues significantly increasing the risk of infection.
Letter
Infectious Diseases
Mathias W. W. Pletz, Andrea Steiner, Miriam Kesselmeier, Bettina Loeffler, Jens Maschmann, Andreas Stallmach, Sabine Trommer
Article
Chemistry, Physical
Haodong Shen, Petra Roesch, Lara Thieme, Mathias W. Pletz, Juergen Popp
Summary: It was found that different metabolic states of bacteria contribute to the formation of biofilms, and there are differences in their chemical composition. Micro-Raman spectroscopy was used to compare and investigate five species of bacteria in exponential phase, stationary phase, and biofilm. Spectral differences revealed variations in chemical composition among different metabolic states. Additionally, different species and strains of bacteria exhibited distinct behaviors based on spectral differences and principal component analysis. Furthermore, a combination of principal component analysis and support vector machines was applied to distinguish bacterial species within the same metabolic states. This study provides valuable data for comparing bacteria in different metabolic states using micro-Raman spectroscopy and chemometrics models.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Medicine, General & Internal
Georg W. Wurschi, Daniel Guellmar, Nikolaus Gassler, Joachim Clement, Miriam Kesselmeier, Julia J. Mueller-Wurschi, Utz Settmacher, Henning Mothes, Herry Helfritzsch, Yves Liebe, Tobias Franiel, Matthias A. Maeurer, Thomas Ernst, Nils H. Nicolay, Andrea Wittig
Summary: This study aims to evaluate early treatment response and establish a noninvasive response prediction model for personalized treatment adaptations based on response.
Article
Health Care Sciences & Services
Kathleen Streich, Christiane S. Hartog, Carolin Fleischmann-Struzek, Norman Rose, Anna Bichmann, Miriam Kesselmeier, Fridtjof Schiefenhoevel, Malte Schmieding, Sebastian Born
Summary: This study analyzed the psychometric properties of the German version of the Reintegration to Normal Living Index (RNLI) in sepsis survivors. The results showed good reliability, structural and concurrent validity of the RNLI in German sepsis survivors. The authors suggest using the RNLI in addition to generic health-related quality of life measures to assess reintegration to normal living after sepsis.
QUALITY OF LIFE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Stephan Kastner, Anne-Kathrin Dietel, Florian Seier, Shaunak Ghosh, Daniel Weiss, Oliwia Makarewicz, Andrea Csaki, Wolfgang Fritzsche
Summary: The need for rapid, simple, and accurate bioassays for nucleic acid detection has increased in recent years. This study utilized localized surface plasmon resonance (LSPR) spectroscopy to detect the antimicrobial resistance gene, sulfhydryl variable beta-lactamase (blaSHV), which confers resistance against a broad spectrum of beta-lactam antibiotics. The system was able to detect a 23 nucleotide DNA sequence at a limit of 25 nm, with signal intensity inversely correlated to sequence length. It was also capable of real-time monitoring and distinguishing single nucleotide polymorphism (SNP) variants of blaSHV.
Article
Infectious Diseases
David Attuy Vey da Silva, Ralf Dieckmann, Oliwia Makarewicz, Anita Hartung, Astrid Bethe, Mirjam Grobbel, Vitaly Belik, Mathias W. Pletz, Sascha Al Dahouk, Szilvia Neuhaus
Summary: Phenotypic susceptibility testing of ESBL and non-ESBL E. coli isolated from various sources showed differences in susceptibility to biocides and antimicrobials, with weakly positive correlations observed between biocide MICs/MBCs and antimicrobial MICs.
Article
Psychiatry
Johannes Reck, Romina Gawlytta, Miriam Kesselmeier, Maria Boettche, Helen Niemeyer, Christine Knaevelsrud, Jenny Rosendahl
Summary: This study aimed to investigate the differential effects of internet-based cognitive-behavioral writing therapy (iCBT) on post-traumatic stress disorder (PTSD) symptoms in patients and their spouses after intensive care. A reanalysis of a randomized controlled trial found a significant reduction in post-traumatic symptom severity after iCBT. The number of words written by participants in therapy modules had a significant impact on the efficacy of iCBT.
PSYCHIATRISCHE PRAXIS
(2023)
Letter
Respiratory System
Juliane Ankert, Stefan Hagel, Claudia Schwarz, Kaijie Pan, Liz Wang, Christof von Eiff, Bradford D. Gessner, Christian Theilacker, Mathias W. Pletz
Article
Infectious Diseases
Selma Tobudic, Christina Bahrs, Lisa Schneider, Emilia Paulussen, Lucie Bartonickova, Stefan Hagel, Peter Starzengruber, Heinz Burgmann, Mathias W. W. Pletz
Summary: This study aimed to compare treatment outcomes for bloodstream infections caused by a piperacillin/tazobactam-susceptible E. coli among three patient groups. The results showed that patients with BSI caused by AMP/SLB-resistant isolates treated with another monotherapy had an enhanced early treatment response compared to those treated with PIP/TAZ, indicating a potential association between initial use of PIP/TAZ and reduced treatment response.
Article
Infectious Diseases
Samira M. Hamed, Walid F. Elkhatib, Hanka Brangsch, Ahmed S. Gesraha, Shawky Moustafa, Dalia F. Khater, Mathias W. Pletz, Lisa D. Sprague, Heinrich Neubauer, Gamal Wareth
Summary: The genomic epidemiology and resistome structure of 46 A. baumannii clinical isolates were studied, revealing the extensive presence of resistance genes and their distribution among different global clones (GCs) in Egypt. This data is crucial for understanding A. baumannii infections and the dissemination of resistance genes.
Article
Gastroenterology & Hepatology
Johannes Stallhofer, Jan Guse, Miriam Kesselmeier, Philip Christian Grunert, Kathleen Lange, Robert Stalmann, Verena Eckardt, Andreas Stallmach
Summary: This study aimed to investigate the effects of immunomodulator comedication on anti-drug antibodies in patients with inflammatory bowel disease. The results of a real-world retrospective cohort study showed that immunomodulator comedication can successfully reverse the loss of therapeutic response to tumor necrosis factor inhibitors.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
