Article
Immunology
Jingjing Qi, Jiaqing Liu, Xiangge Zhao, Huina Huang, Yawei Tang, Xia Li
Summary: Our study found that IL-27 can promote B cell dysfunction in rheumatoid arthritis by activating the mTOR signaling pathway. The study aimed to explore the effects of IL-27 on B cell metabolism and clarify the mechanisms by which IL-27 enhances glycolysis to induce B cell hyperactivation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Jie Zhu, Ling Han, Ruilai Liu, Zhenghua Zhang, Qiong Huang, Xu Fang, Ke Yang, Guiqin Huang, Zhizhong Zheng, Nikhil Yawalkar, Hui Deng, Kexiang Yan
Summary: By analyzing the proteome profile of PBMCs from patients with PsA, PsO, and healthy controls, this study identified 14 potential biomarkers for PsA diagnosis. Additionally, the expression of SIRT2 was significantly higher in PsA patients compared to PsO and healthy controls, and was negatively correlated with the phosphorylation of p38MAPK.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Klara Prajzlerova, Olga Krystufkova, Petra Hanova, Veronika Horvathova, Monika Gregova, Karel Pavelka, Jiri Vencovsky, Ladislav Senolt, Maria Filkova
Summary: The study identified dysregulated miR-451 in the peripheral blood of individuals at risk of developing RA, which may play a role in regulating the expression of CXCL16 and influencing the pathogenesis of RA. Further investigation is needed to validate this hypothesis.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Constantina A. Bounia, Stamatis-Nick C. Liossis
Summary: Treatment with rituximab (RTX) significantly reduces circulating Th17 cell percentages in patients with RA, while Tregs remain stable. Reduction of Th17 cells is particularly evident in responders to RTX treatment, ACPA+ and RF (-) patients with RA.
CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Benita Buragaite-Staponkiene, Adomas Rovas, Alina Puriene, Kristina Snipaitiene, Egle Punceviciene, Arunas Rimkevicius, Irena Butrimiene, Sonata Jarmalaite
Summary: This study aimed to identify specific miRNAs associated with periodontitis (PD) in gingival tissues and evaluate their levels in saliva and blood plasma among participants with and without rheumatoid arthritis (RA). Genome-wide miRNA expression analysis revealed 177 deregulated miRNAs in 16 gingival tissue samples. Validation in 80 samples confirmed higher expression of miR-140-3p and -145-5p and lower expression of miR-125a-3p in PD-affected tissues. Further analysis in a larger sample showed increased salivary levels of miR-145-5p associated with PD severity and higher plasma levels of miR-140-3p in PD participants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Multidisciplinary Sciences
Maha Fahad Alenazy, Fatemeh Saheb Sharif-Askari, Mohammed A. Omair, Mohammad S. El-Wetidy, Maha A. Omair, Hussam Mitwalli, Saleh Al-Muhsen, Abeer Al-Masri, Qutayba Hamid, Rabih Halwani
Summary: An updated version of this paper is available via a link at the top of the original paper.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Shigeru Iwata, Mingzeng Zhang, Maiko Hajime, Naoaki Ohkubo, Koshiro Sonomoto, Keiichi Torimoto, Yukihiro Kitanaga, Gulzhan Trimova, Yasuyuki Todoroki, Hiroko Miyata, Masanobu Ueno, Atsushi Nagayasu, Ryuichiro Kanda, Kazuhisa Nakano, Shingo Nakayamada, Kei Sakata, Yoshiya Tanaka
Summary: This study investigated the role of mTOR in B cells in rheumatoid arthritis, showing that mTOR activation in CXCR3(+) memory B cells is associated with disease activity and mediated through IL-6 production and RANKL expression. Additionally, treatment with TNF inhibitors had an impact on the association between CXCL10 and mTOR activated CXCR3(+) memory B cells.
Review
Medicine, General & Internal
Stamatis-Nick C. Liossis, Constantina A. Bounia
Summary: Autoimmune rheumatic diseases can affect vital organs, with lung involvement being severe and difficult to treat. Rituximab is an off-label treatment for CTD-ILD, but studies have shown that it can effectively improve pulmonary function and reduce ILD symptoms.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Daniel Maunder, Philip M. Brown, Ben Barron-Millar, Dennis W. Lendrem, Najib Naamane, Jamie Macdonald, Xiao N. Wang, John D. Isaacs, Amy E. Anderson, Ann W. Morgan, Rachel E. Crossland, Sarah L. Mackie, Arthur G. Pratt
Summary: This study evaluated the potential of serum EV miRs as diagnostic and therapeutic biomarkers in early RA and found a novel potential mechanism by which MTX may exert its therapeutic effect in early RA.
Review
Immunology
Lingxia Xu, Cen Chang, Ping Jiang, Kai Wei, Runrun Zhang, Yehua Jin, Jianan Zhao, Linshuai Xu, Yiming Shi, Shicheng Guo, Dongyi He
Summary: Rheumatoid arthritis is an autoimmune disease characterized by metabolic alterations. Metabolomics technology can provide insights into the metabolic profiles of patients with rheumatoid arthritis, helping to understand the pathogenesis and treatment response of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Borja Hernandez-Breijo, Chamaida Plasencia-Rodriguez, Victoria Navarro-Compan, Carlota Garcia-Hoz, Israel Nieto-Ganan, Cristina Sobrino, Javier Bachiller-Corral, Mariana Diaz-Almiron, Ana Martinez-Feito, Teresa Jurado, Paloma Lapuente-Suanzes, Gema Bonilla, Cristina Pijoan-Moratalla, Garbine Roy, Monica Vazquez-Diaz, Alejandro Balsa, Luisa M. Villar, Dora Pascual-Salcedo, Eulalia Rodriguez-Martin
Summary: The study focused on analyzing the changes in PBMC of RA patients treated with TNFi, finding that a reduction in naive B-cell percentage was associated with achieving REM in patients who received concomitant therapy with MTX. No association was found for patients who did not receive concomitant MTX.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Gremese Elisa, Barbara Tolusso, Luca Petricca, Clara Di Mario, Maria Rita Gigante, Gianfranco Ferraccioli, Stefano Alivernini
Summary: This study suggests that baseline IL-6 serum levels and peripheral blood-derived CD4(pos) subpopulations may be potential novel prognostic biomarkers of CTLA4-Ig response in rheumatoid arthritis (RA) patients.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Immunology
Alison D. Petro, Joseph Dougherty, Bryant R. England, Harlan Sayles, Michael J. Duryee, Carlos D. Hunter, Joel M. Kremer, Dimitrios A. Pappas, William H. Robinson, Jeffrey R. Curtis, Geoffrey M. Thiele, Ted R. Mikuls
Summary: In rheumatoid arthritis patients, the number of positive autoantibodies is dose-dependently associated with treatment response to biologics, with anti-CCP antibody positivity having the strongest impact.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Ilka Liebold, Andreas Gruetzkau, Anika Goeckeritz, Velia Gerl, Randall Lindquist, Eugen Feist, Michael Zaenker, Thomas Haeupl, Denis Poddubnyy, Jan Zernicke, Biljana Smiljanovic, Tobias Alexander, Gerd R. Burmester, Steffen Gay, Bruno Stuhlmueller
Summary: The study investigated global DNA methylation in peripheral blood mononuclear cells of RA patients and found that it was associated with disease activity and treatment response. The degree of global methylation may be a promising biomarker for monitoring therapy and predicting outcomes in inflammatory diseases.
Article
Medicine, General & Internal
Andrea Cuervo, Raquel Celis, Antonio Julia, Alicia Usategui, Regina Fare, Julio Ramirez, Ana Belen Azuaga, Andres Lorenzo, Raimon Sanmarti, Jose L. Pablos, Juan D. Canete
Summary: The study found that the cellular composition of synovium in undifferentiated arthritis (UA) patients differs from rheumatoid arthritis (RA) and psoriatic arthritis (PsA), with higher cellular infiltrate density in the UA group. Initial expression of the interferon inducible gene MxA may serve as a biomarker for progression to RA, while higher mast cell and fibroblastic density may be associated with PsA progression.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
D. Oleksyn, J. Zhao, A. Vosoughi, J. C. Zhao, R. Misra, A. P. Pentland, D. Ryan, J. Anolik, C. Ritchlin, J. Looney, A. P. Anandarajah, G. Schwartz, L. M. Calvi, M. Georger, C. Mohan, I. Sanz, L. Chen
IMMUNOLOGY LETTERS
(2017)
Article
Immunology
Anna K. Bird, Martin Chang, Jennifer Barnard, Bruce I. Goldman, Nida Meednu, Javier Rangel-Moreno, Jennifer H. Anolik
JOURNAL OF IMMUNOLOGY
(2017)
Article
Rheumatology
Lin Gao, Anna K. Bird, Nida Meednu, Kristin Dauenhauer, Jane Liesveld, Jennifer Anolik, R. John Looney
ARTHRITIS & RHEUMATOLOGY
(2017)
Article
Immunology
Scott A. Jenks, Kevin S. Cashman, Esther Zumaquero, Urko M. Marigorta, Aakash V. Patel, Xiaoqian Wang, Deepak Tomar, Matthew C. Woodruff, Zoe Simon, Regina Bugrovsky, Emily L. Blalock, Christopher D. Scharer, Christopher M. Tipton, Chungwen Wei, S. Sam Lim, Michelle Petri, Timothy B. Niewold, Jennifer H. Anolik, Greg Gibson, F. Eun-Hyung Lee, Jeremy M. Boss, Frances E. Lund, Ignacio Sanz
Article
Multidisciplinary Sciences
Wen Sun, Nida Meednu, Alexander Rosenberg, Javier Rangel-Moreno, Victor Wang, Jason Glanzman, Teresa Owen, Xichao Zhou, Hengwei Zhang, Brendan F. Boyce, Jennifer H. Anolik, Lianping Xing
NATURE COMMUNICATIONS
(2018)
Article
Rheumatology
Lin Gao, Maria Slack, Andrew McDavid, Jennifer Anolik, R. John Looney
CURRENT RHEUMATOLOGY REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Lin Gao, Mary OConnell, Maria Allen, Jane Liesveld, Andrew McDavid, Jennifer H. Anolik, Richard J. Looney
Article
Immunology
Yannick Dieudonne, Vincent Gies, Aurelien Guffroy, Celine Keime, Anna K. Bird, Jane Liesveld, Jennifer L. Barnas, Vincent Poindron, Nawal Douiri, Pauline Soulas-Sprauel, Thierry Martin, Eric Meffre, Jennifer H. Anolik, Anne-Sophie Korganow
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Immunology
Fan Zhang, Kevin Wei, Kamil Slowikowski, Chamith Y. Fonseka, Deepak A. Rao, Stephen Kelly, Susan M. Goodman, Darren Tabechian, Laura B. Hughes, Karen Salomon-Escoto, Gerald F. M. Watts, A. Helena Jonsson, Javier Rangel-Moreno, Nida Meednu, Cristina Rozo, William Apruzzese, Thomas M. Eisenhaure, David J. Lieb, David L. Boyle, Arthur M. Mandelin, Brendan F. Boyce, Edward DiCarlo, Ellen M. Gravallese, Peter K. Gregersen, Larry Moreland, Gary S. Firestein, Nir Hacohen, Chad Nusbaum, James A. Lederer, Harris Perlman, Costantino Pitzalis, Andrew Filer, V. Michael Holers, Vivian P. Bykerk, Laura T. Donlin, Jennifer H. Anolik, Michael B. Brenner, Soumya Raychaudhuri, Jennifer Albrecht, S. Louis Bridges, Christopher D. Buckley, Jane H. Buckner, James Dolan, Joel M. Guthridge, Maria Gutierrez-Arcelus, Lionel B. Ivashkiv, Eddie A. James, Judith A. James, Josh Keegan, Yvonne C. Lee, Mandy J. McGeachy, Michael A. McNamara, Joseph R. Mears, Fumitaka Mizoguchi, Jennifer P. Nguyen, Akiko Noma, Dana E. Orange, Mina Rohani-Pichavant, Christopher Ritchlin, William H. Robinson, Anupamaa Seshadri, Danielle Sutherby, Jennifer Seifert, Jason D. Turner, Paul J. Utz
Article
Immunology
Evan Der, Hemant Suryawanshi, Pavel Morozov, Manjunath Kustagi, Beatrice Goilav, Saritha Ranabathou, Peter Izmirly, Robert Clancy, H. Michael Belmont, Mordecai Koenigsberg, Michele Mokrzycki, Helen Rominieki, Jay A. Graham, Juan P. Rocca, Nicole Bornkamp, Nicole Jordan, Emma Schulte, Ming Wu, James Pullman, Kamil Slowikowski, Soumya Raychaudhuri, Joel Guthridge, Judith James, Jill Buyon, Thomas Tuschl, Chaim Putterman, Jennifer Anolik, William Apruzzese, Arnon Arazi, Celine Berthier, Michael Brenner, Sean Connery, Melissa Cunningham, Maria Dall'Era, Anne Davidson, Andrea Fava, Chamith Fonseka, Richard Furie, Dan Goldman, Rohit Gupta, Joel Guthridge, Nir Hacohen, David Hildeman, Paul Hoover, Raymond Hsu, Ruba Kado, Kenneth Kalunian, Diane Kamen, Mattias Kretzler, Holden Maecker, Elena Massarotti, William McCune, Maureen McMahon, Meyeon Park, Fernanda Payan-Schober, William Pendergraft, Michelle Petri, Mina Pichavant, Deepak Rao, Paul Utz, Dia Waguespack, David Wofsy, Fan Zhang
Correction
Rheumatology
Lin Gao, Maria Slack, Jennifer L. Barnas, Andrew McDavid, Jennifer Anolik, R. John Looney
CURRENT RHEUMATOLOGY REPORTS
(2019)
Article
Immunology
Arnon Arazi, Deepak A. Rao, Celine C. Berthier, Anne Davidson, Yanyan Liu, Paul J. Hoover, Adam Chicoine, Thomas M. Eisenhaure, A. Helena Jonsson, Shuqiang Li, David J. Lieb, Fan Zhang, Kamil Slowikowski, Edward P. Browne, Akiko Noma, Danielle Sutherby, Scott Steelman, Dawn E. Smilek, Patti Tosta, William Apruzzese, Elena Massarotti, Maria Dall'Era, Meyeon Park, Diane L. Kamen, Richard A. Furie, Fernanda Payan-Schober, William F. Pendergraft, Elizabeth A. McInnis, Jill P. Buyon, Michelle A. Petri, Chaim Putterman, Kenneth C. Kalunian, E. Steve Woodle, James A. Lederer, David A. Hildeman, Chad Nusbaum, Soumya Raychaudhuri, Matthias Kretzler, Jennifer H. Anolik, Michael B. Brenner, David Wofsy, Nir Hacohen, Betty Diamond, Dia Waguespack, Sean M. Connery, Maureen A. McMahon, William J. McCune, Ruba B. Kado, Raymond Hsu, Melissa A. Cunningham, Paul J. Utz, Mina Pichavant, Holden T. Maecker, Rohit Gupta, Judith A. James, Joel M. Guthridge, Chamith Fonseka, Evan der, Robert Clancy, Thomas Tuschl, Hemant Suryawanshi, Andrea Fava, Daniel H. Goldman
Correction
Immunology
Arnon Arazi, Deepak A. Rao, Celine C. Berthier, Anne Davidson, Yanyan Liu, Paul J. Hoover, Adam Chicoine, Thomas M. Eisenhaure, A. Helena Jonsson, Shuqiang Li, David J. Lieb, Fan Zhang, Kamil Slowikowski, Edward P. Browne, Akiko Noma, Danielle Sutherby, Scott Steelman, Dawn E. Smilek, Patti Tosta, William Apruzzese, Elena Massarotti, Maria Dall'Era, Meyeon Park, Diane L. Kamen, Richard A. Furie, Fernanda Payan-Schober, William F. Pendergraft, Elizabeth A. McInnis, Jill P. Buyon, Michelle A. Petri, Chaim Putterman, Kenneth C. Kalunian, E. Steve Woodle, James A. Lederer, David A. Hildeman, Chad Nusbaum, Soumya Raychaudhuri, Matthias Kretzler, Jennifer H. Anolik, Michael B. Brenner, David Wofsy, Nir Hacohen, Betty Diamond
Article
Rheumatology
Laura T. Donlin, Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J. Lieb, Joshua Keegan, Kaylin Muskat, Joshua Hillman, Cristina Rozo, Edd Ricker, Thomas M. Eisenhaure, Shuqiang Li, Edward P. Browne, Adam Chicoine, Danielle Sutherby, Akiko Noma, Chad Nusbaum, Stephen Kelly, Alessandra B. Pernis, Lionel B. Ivashkiv, Susan M. Goodman, William H. Robinson, Paul J. Utz, James A. Lederer, Ellen M. Gravallese, Brendan F. Boyce, Nir Hacohen, Costantino Pitzalis, Peter K. Gregersen, Gary S. Firestein, Soumya Raychaudhuri, Larry W. Moreland, V. Michael Holers, Vivian P. Bykerk, Andrew Filer, David L. Boyle, Michael B. Brenner, Jennifer H. Anolik
ARTHRITIS RESEARCH & THERAPY
(2018)
Article
Medicine, Research & Experimental
Vincent Gies, Jean-Nicolas Schickel, Sophie Jung, Aurelie Joublin, Salome Glauzy, Anne-Marie Knapp, Anne Soley, Vincent Poindron, Aurelien Guffroy, Jin-Young Choi, Jacques-Eric Gottenberg, Jennifer H. Anolik, Thierry Martin, Pauline Soulas-Sprauel, Eric Meffre, Anne-Sophie Korganow