Article
Cell Biology
Zhicheng Yu, Jun Zhang, Qi Zhang, Sitian Wei, Rui Shi, Rong Zhao, Lanfen An, Richard Grose, Dilu Feng, Hongbo Wang
Summary: This study examines the heterogeneity and intratumoral crosstalk in human EC, and finds that malignant cells interact closely with immune cells and vascular CAFs, providing potential therapeutic targets.
CELL PROLIFERATION
(2022)
Article
Oncology
Luca Simula, Ylenia Antonucci, Giorgia Scarpelli, Valeria Cancila, Alessandra Colamatteo, Simona Manni, Biagio De Angelis, Concetta Quintarelli, Claudio Procaccini, Giuseppe Matarese, Claudio Tripodo, Silvia Campello
Summary: The PD-1 signaling pathway downregulates T-cell response by inhibiting Drp1 activity, leading to reduced motility and proliferation of tumor-infiltrating T cells. This highlights the potential of targeting Drp1 activity as a valuable strategy to enhance anticancer immune response in future immunotherapy approaches.
MOLECULAR ONCOLOGY
(2022)
Review
Immunology
Liguang Fang, Kunjing Liu, Cun Liu, Xiaomin Wang, Wenzhe Ma, Wenhua Xu, Jibiao Wu, Changgang Sun
Summary: This article summarizes the dynamic evolution of inflammation from acute to chronic in tumor development and its impact on T cells. Understanding the state of inflammation and T cells at different stages is crucial for clinical decision-making and improving the efficacy of tumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Mingyue Ma, Ying Yang, Zhouyi Chen, Xiaoyan Li, Zhicheng Yang, Ke Wang, Xusuo Li, Hao Fang, Yunfeng Cheng, Tiankui Qiao, Xin Zou, Zhiqiang Lu, Xiangdong Wang, Duojiao Wu
Summary: We conducted an integrated analysis of clinical measurements, immune cells, and plasma lipidomics in 2000 individuals of different age stages. Our study revealed the interaction between systemic lipid metabolism and circulating immune cells through in-depth analysis of immune cell phenotype and function in the peripheral lipids environment. The population makeup of immune cells and lipid metabolites changed dynamically with age. We also found that immune senescence is not isolated and is influenced by systemic metabolism, which has implications for immune-metabolic targeting.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Noam Levin, Biman C. Paria, Nolan R. Vale, Rami Yossef, Frank J. Lowery, Maria R. Parkhurst, Zhiya Yu, Maria Florentin, Gal Cafri, Jared J. Gartner, Mackenzie L. Shindorf, Lien T. Ngo, Satyajit Ray, Sanghyun P. Kim, Amy R. Copeland, Paul F. Robbins, Steven A. Rosenberg
Summary: This study identified T-cell receptors that recognize mutated RAS antigens with high specificity and avidity, potentially serving as promising reagents for adoptive cell therapies targeting RAS mutations in cancer patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Naama Margolis, Hanna Moalem, Tomer Meirson, Gilli Galore-Haskel, Ettai Markovits, Erez N. Baruch, Bella Vizel, Avner Yeffet, Julia Kanterman-Rifman, Assaf Debby, Michal J. Besser, Jacob Schachter, Gal Markel
Summary: The interaction between melanoma cells and T cells can enhance the chemotaxis of new T cells. ADAR1-p150 expression is correlated with immune infiltration and can be induced by immunotherapy. ADAR1 regulates T cell migration through the secretion of chemokines.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Tobias Burkard, Caroline Dreis, Martina Herrero San Juan, Meik Huhn, Andreas Weigert, Josef M. Pfeilschifter, Heinfried H. Radeke
Summary: The immune response to cancer can be disrupted by an immunosuppressive tumor microenvironment, including infiltrating regulatory T lymphocytes and metabolic stress. Molecules like IL-33 and S1P play a role in controlling T lymphocyte differentiation and migration. Nutrient deprivation can promote CD8(Low) T lymphocytes and limit cytotoxic effector functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohammed H. Abuwarwar, Alfie T. Baker, Jeffrey Harding, Natalie L. Payne, Andras Nagy, Konstantin Knoblich, Anne L. Fletcher
Summary: T cell immunotherapy is effective for blood-borne cancers and melanoma, but many epithelial tumors show poor response. Cancer-associated fibroblasts (CAFs) are emerging as key players in immunotherapy resistance. Immortalized CAF lines are valuable tools for studying mechanisms of CAF-mediated T cell suppression and developing novel cancer immunotherapy strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Karin Hoppe-Seyler, Anja L. Herrmann, Antonia Daeschle, Bianca J. Kuhn, Tobias D. Strobel, Claudia Lohrey, Julia Bulkescher, Jeroen Krijgsveld, Felix Hoppe-Seyler
Summary: The study reveals that Metformin can effectively suppress the expression of HPV oncogenes in HPV-positive cancer cells, leading to a reversible proliferative halt without inducing senescence completely.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Neurosciences
Isidora Paredes, Jose Ricardo Vieira, Bhavin Shah, Carla F. Ramunno, Julia Dyckow, Heike Adler, Melanie Richter, Geza Schermann, Evangelia Giannakouri, Lucas Schirmer, Hellmut G. Augustin, Carmen Ruiz de Almodovar
Summary: Bidirectional crosstalk between neural and vascular compartments plays a critical role in oligodendrocyte precursor cell specification, with neural progenitor cells expressing angiopoietin-1 and endothelial cells producing transforming growth factor beta 1 in response. This collaboration demonstrates the complex relationship between NPCs and the vasculature in regulating oligodendrogenesis.
NATURE NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Yutong Liu, Kwasi Adu-Berchie, Joshua M. Brockman, Matthew Pezone, David K. Y. Zhang, Jingyi Zhou, Jason W. Pyrdol, Hua Wang, Kai W. Wucherpfennig, David J. Mooney
Summary: This study uses nanotechnology to improve adoptive T cell transfer (ACT) therapies by metabolically labeling T cells with unnatural sugar nanoparticles, allowing direct conjugation of antitumor cytokines onto the T cell surface. This approach effectively enhances the efficacy of ACT therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Bettina Weigelin, Peter Friedl
Summary: This article summarizes the concepts of sublethal damage and additive cytotoxicity by cytotoxic T cells (CTLs) on target cells and discusses their implications for improving immunotherapy and multitargeted anticancer therapies.
Review
Immunology
Guillermo O. Rangel Rivera, Hannah M. Knochelmann, Connor J. Dwyer, Aubrey S. Smith, Megan M. Wyatt, Amalia M. Rivera-Reyes, Jessica E. Thaxton, Chrystal M. Paulos
Summary: The review discusses how targeting metabolic pathways can enhance the immune response of T cells to tumors, as tumors consume key metabolites in the host, depriving T cells of essential nutrients for growth and function. Furthermore, immunosuppressive molecules and checkpoint receptors further compromise the activity of T cells within tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Justin Taft, Michael Markson, Diana Legarda, Roosheel Patel, Mark Chan, Louise Malle, Ashley Richardson, Conor Gruber, Marta Martin-Fernandez, Grazia M. S. Mancini, Jan A. M. van Laar, Philomine van Pelt, Sofija Buta, Beatrijs H. A. Wokke, Ira K. D. Sabli, Vanessa Sancho-Shimizu, Pallavi Pimpale Chavan, Oskar Schnappauf, Raju Khubchandani, Muserref Kasap Cuceoglu, Seza Ozen, Daniel L. Kastner, Adrian T. Ting, Ivona Aksentijevich, Iris H. I. M. Hollink, Dusan Bogunovic
Summary: The loss of TBK1 leads to decreased IFN-I induction but affects autoinflammation and TNF-induced cell death, and treatment with anti-TNF can improve the clinical condition of patients.
Article
Immunology
Peizhe Lin, Yijing Yan, Ze Zhang, Qiutong Dong, Jia Yi, Qingbo Li, Ao Zhang, Xianbin Kong
Summary: Colorectal cancer (CRC) is highly prevalent and has a significant impact on human health globally. Current treatments are not effective in improving survival rate and quality of life, necessitating the development of new strategies. Adoptive cell therapy, specifically focusing on gamma delta T cells, has shown potential in triggering cytotoxicity, cytokine secretion, immune cell recruitment, and inhibiting CRC progress. However, there is a risk of inflammation and immune inhibition associated with gamma delta T cell therapy. This review highlights the dual function of gamma delta T cells and their relationship with intestinal flora, providing a conceptual framework for their application in CRC therapies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)