Article
Microbiology
Stephen C. Watts, Louise M. Judd, Rosemary Carzino, Sarath Ranganathan, Kathryn E. Holt
Summary: Respiratory infection during childhood is a key risk factor in early cystic fibrosis lung disease progression. Haemophilus influenzae and Haemophilus parainfluenzae are commonly isolated from the lungs of children with CF, with a high frequency of colonization and antimicrobial resistance. The genetic basis for AMR in these bacteria was identified, and Haemophilus parainfluenzae had a higher prevalence of acquired AMR genes than H. influenzae.
Review
Microbiology
Christina S. Thornton, Michael G. Surette
Summary: Cystic fibrosis is the most common and lethal genetic disease among the Caucasian population, leading to chronic airway inflammation and declining pulmonary function. Studies have shown a diverse community of anaerobic bacteria in CF patients' airways, potentially impacting disease progression through synergistic interaction with principal pathogens. Despite the understanding of this complex bacterial milieu, the specific roles of anaerobes in disease progression remain unclear.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Critical Care Medicine
Heather D. Green, Andrew M. Jones
Summary: Cystic fibrosis is a disease characterized by chronic airway infection and progressive decline in respiratory function. Recent changes in the landscape of airway infection in CF have resulted in an increased prevalence of atypical gram-negative bacterial infections. The clinical relevance and treatment strategies for many of these lower prevalence organisms are still not well understood.
Article
Infectious Diseases
Guillaume Millette, David Lalonde Seguin, Charles Isabelle, Suzanne Chamberland, Jean-Francois Lucier, Sebastien Rodrigue, Andre M. Cantin, Francois Malouin
Summary: Prototypic Staphylococcus aureus and their small-colony variants (SCVs) are predominant in cystic fibrosis (CF) patients. We characterized S. aureus isolates from adult CF patients over several years, finding that a majority of patients were positive for SCVs. Whole-genome sequencing revealed the presence of both prototypical and SCV-related clones in some patients, and SCVs showed characteristics that could contribute to resistance acquisition.
Review
Biochemistry & Molecular Biology
Alessandra Ghigo, Giulia Prono, Elisa Riccardi, Virginia De Rose
Summary: Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene, resulting in lung damage. Chronic airway inflammation plays a crucial role in the disease, and research on new anti-inflammatory drugs and treatments is crucial for improving the condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Juliette L. Simonin, Alexandre Luscher, Davide Losa, Mehdi Badaoui, Christian van Delden, Thilo Kohler, Marc Chanson
Summary: Defective hydration of airway surface mucosa is associated with recurrent lung infection in cystic fibrosis. The presence of a healthy airway surface liquid can prevent infection.
Review
Biology
Max Liu, Rahim Zaman, Victoria Sawczak, Ammasi Periasamy, Fei Sun, Khalequz Zaman
Summary: S-nitrosothiols (SNOs) are small molecules that play a critical role in cell signaling pathways in various diseases, such as cystic fibrosis, by regulating protein modifications and maturation, particularly of the CFTR protein. Researchers have found that SNO levels are lower in CF patients compared to non-CF patients, suggesting a potential therapeutic target for correcting CFTR mutations.
JOURNAL OF BIOSCIENCES
(2021)
Article
Microbiology
Tara Gallagher, Stefan Riedel, Joseph Kapcia, Lindsay J. Caverly, Lisa Carmody, Linda M. Kalikin, Junnan Lu, Joann Phan, Matthew Gargus, Miki Kagawa, Simon W. Leemans, Jason A. Rothman, Felix Grun, John J. LiPuma, Katrine L. Whiteson
Summary: Antibiotic therapy can significantly influence host microbial communities, but many studies lack details on antibiotic exposure. This research developed LC-MS methods to detect antibiotics in sputum samples from cystic fibrosis patients, revealing discrepancies between reported antibiotic use and actual detection, providing a means to incorporate antibiotic usage data into microbiome studies.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Immunology
John B. O'Connor, Madison Mottlowitz, Monica E. Kruk, Alan Mickelson, Brandie D. Wagner, Jonathan Kirk Harris, Christine H. Wendt, Theresa A. Laguna
Summary: This study characterizes the unique metabolic features of the cystic fibrosis (CF) airway and reveals complex correlations between metabolites, lower airway bacterial communities, and disease outcomes. The results highlight the potential of metabolomics in understanding CF airway infection and inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Conrad Izydorczyk, Barbara J. Waddell, Christina S. Thornton, John M. Conly, Harvey R. Rabin, Ranjani Somayaji, Michael G. Surette, Deirdre L. Church, Michael D. Parkins
Summary: This study investigated the natural history, transmission potential, and evolution of Stenotrophomonas maltophilia in a large Canadian cohort of 321 cystic fibrosis patients over a 37-year period. The findings revealed that S. maltophilia was recovered in 25.5% of the patients and shared pulsotypes were observed between different patients. Genomic analyses suggested common, indirect sources as the origins of S. maltophilia infections in the clinic population. These findings contribute to the understanding of S. maltophilia infection dynamics in cystic fibrosis patients.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Respiratory System
Qianting Lv, Leticia Gallardo-Estrella, Eleni-Rosalina Andrinopoulou, Yuxin Chen, Jean-Paul Charbonnier, Rikke Mulvad Sandvik, Daan Caudri, Kim Gjerum Nielsen, Marleen de Bruijne, Pierluigi Ciet, Harm Tiddens
Summary: An artificial intelligence algorithm was validated to assess dimensions of bronchus-artery pairs on chest CT scans from patients with CF. The automatic BA analysis could detect and monitor progression of bronchial wall thickening and bronchial widening in patients with CF.
Review
Microbiology
Christine Rumpf, Jonas Lange, Bianca Schwartbeck, Barbara C. Kahl
Summary: Staphylococcus aureus is a common pathogen in the airways of CF patients, which adapts and evolves in this specific environment through horizontal gene transfer and nucleotide variations. Methicillin-resistant S. aureus poses a greater risk for infected individuals with more severe lung disease.
Article
Microbiology
Antonin Praet, Laurent Bourguignon, Florence Vetele, Valentine Breant, Charlotte Genestet, Oana Dumitrescu, Anne Doleans-Jordheim, Philippe Reix, Sylvain Goutelle
Summary: This study developed nonparametric population pharmacokinetic (PK) models of tobramycin in children with CF for dosage design and model-guided therapeutic drug monitoring, with a recommended daily dose of 12.5 mg/kg optimizing efficacy and safety targets in most patients as validated through simulations.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Raphaelle Youf, Adeel Nasir, Mareike Mueller, Franck Thetiot, Tanguy Haute, Rosy Ghanem, Ulrich Jonas, Holger Schoenherr, Gilles Lemercier, Tristan Montier, Tony Le Gall
Summary: Antimicrobial photodynamic therapy (aPDT) is a treatment method that relies on various parameters. In this study, the application of Ruthenium(II) polypyridyl ([Ru(II)]) complexes in the airways of Cystic Fibrosis (CF) patients was investigated, and the influence of different parameters on their properties was studied. The results provide significant evidence for the clinical relevance of [Ru(II)]-based aPDT in CF lung airways.
Article
Microbiology
Margo Olbrecht, Fedoua Echahidi, Denis Pierard, Charlotte Peeters, Peter Vandamme, Ingrid Wybo, Thomas Demuyser
Summary: We conducted in vitro antimicrobial susceptibility testing of 267 Achromobacter isolates for 16 antibiotics from 2017 to 2022. The highest susceptibility was found for piperacillin-tazobactam (70%) and ceftazidime-avibactam (62%). Between 30% and 49% of strains were susceptible to tigecycline, ceftazidime, and meropenem. We applied species-specific Achromobacter xylosoxidans breakpoints for piperacillin-tazobactam, meropenem, and trimethoprim-sulfamethoxazole and EUCAST pharmacokinetic/pharmacodynamic (PK/PD) breakpoints for the others. A. xylosoxidans was the most frequently isolated species, followed by Achromobacter insuavis and Achromobacter ruhlandii.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eduardo J. Mortani Barbosa, Maarten Lanclus, Wim Vos, Cedric Van Holsbeke, William De Backer, Jan De Backer, James Lee
ACADEMIC RADIOLOGY
(2018)
Article
Clinical Neurology
Monique A. L. J. Slaats, Dieter Loterman, Cedric van Holsbeke, Wim Vos, Kim Van Hoorenbeeck, Jan de Backer, Wilfried de Backer, Marek Wojciechowski, An Boudewyns, Stijn Verhulst
JOURNAL OF CLINICAL SLEEP MEDICINE
(2018)
Article
Clinical Neurology
Richard J. Schwab, Stephen H. Wang, Johan Verbraecken, Olivier M. Vanderveken, Paul Van de Heyning, Wim G. Vos, Jan W. DeBacker, Brendan T. Keenan, Quan Ni, Wilfried DeBacker
Article
Radiology, Nuclear Medicine & Medical Imaging
Maarten Lanclus, Johan Clukers, Cedric Van Holsbeke, Wim Vos, Glenn Leemans, Birgit Holbrechts, Katherine Barboza, Wilfried De Backer, Jan De Backer
ACADEMIC RADIOLOGY
(2019)
Article
Anesthesiology
Tom Schepens, Xiao Lu, Cedric Van Holsbeke, Wim Vos, Jan De Backer, Paul M. Parizel, Wilfried De Backer, Qin Lu, Jean-Jacques Rouby, Philippe G. Jorens
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2020)
Article
Pediatrics
Glenn Leemans, Dennis Belmans, Cedric Van Holsbeke, Brian Becker, Dirk Vissers, Kris Ides, Stijn Verhulst, Kim Van Hoorenbeeck
PEDIATRIC PULMONOLOGY
(2020)
Article
Medicine, General & Internal
Julien Guiot, Akshayaa Vaidyanathan, Louis Deprez, Fadila Zerka, Denis Danthine, Anne-Noelle Frix, Marie Thys, Monique Henket, Gregory Canivet, Stephane Mathieu, Evanthia Eftaxia, Philippe Lambin, Nathan Tsoutzidis, Benjamin Miraglio, Sean Walsh, Michel Moutschen, Renaud Louis, Paul Meunier, Wim Vos, Ralph T. H. Leijenaar, Pierre Lovinfosse
Summary: In response to the COVID-19 pandemic, an automated AI framework to extract radiomics features from chest CT scans was developed to aid in diagnosis. The model demonstrated high accuracy and sensitivity in an independent test dataset. When benchmarked against confirmed COVID-19 cases, the AI framework was able to accurately differentiate COVID-19 from routine clinical conditions.
Article
Medicine, General & Internal
Perrine Canivet, Colin Desir, Marie Thys, Monique Henket, Anne-Noelle Frix, Benoit Ernst, Sean Walsh, Mariaelena Occhipinti, Wim Vos, Nathalie Maes, Jean Luc Canivet, Renaud Louis, Paul Meunier, Julien Guiot
Summary: During the COVID-19 pandemic, chest scans were used to diagnose and evaluate the extent of lesions, as well as to identify non-COVID-19-related chest pathologies. These pathologies were often missed by automated systems and required radiologists to identify them on chest CT scans. The detection of these non-COVID-19 lesions had a significant impact on the length of hospital stay and outcomes.
Article
Oncology
Francois Cousin, Thomas Louis, Sophie Dheur, Frank Aboubakar, Benoit Ghaye, Mariaelena Occhipinti, Wim Vos, Fabio Bottari, Astrid Paulus, Anne Sibille, Frederique Vaillant, Bernard Duysinx, Julien Guiot, Roland Hustinx
Summary: The aim of this retrospective multi-centric study was to determine the potential role of CT-based radiomics machine learning models in predicting treatment response and survival in patients with advanced NSCLC treated with immune checkpoint inhibitors. The results showed that the CT-based delta-radiomics signature could early identify patients who presented a clinical benefit at 6 months, with an AUC of 0.8 (95% CI: 0.65-0.95) on an external test dataset.
Article
Rheumatology
Johan Clukers, Maarten Lanclus, Dennis Belmans, Cedric Van Holsbeke, Wilfried De Backer, Dharshan Vummidi, Paul Cronin, Ben R. Lavon, Jan De Backer, Dinesh Khanna
Summary: This study evaluated the use of functional respiratory imaging quantitative computed tomography in staging systemic sclerosis-associated interstitial lung disease and its relationship with short-term changes in pulmonary function tests. The results showed that functional respiratory imaging can differentiate between moderate to severe disease and limited disease, as well as detect disease progression in systemic sclerosis.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2021)
Letter
Respiratory System
Thomas McLellan, Peter M. George, Paul Ford, Jan De Backer, Cedric Van Holsbeke, Benjamin Mignot, Nicholas J. Screaton, Alessandro Ruggiero, Muhunthan Thillai
Meeting Abstract
Pediatrics
G. Leemans, A. De Hondt, K. Ides, C. Van Holsbeke, D. Belmans, B. C. Becker, K. Van Hoorenbeeck
PEDIATRIC PULMONOLOGY
(2018)
Article
Respiratory System
Cedric Van Holsbeke, Jan De Backer, Wim Vos, Jonathan Marshall
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2018)