Article
Infectious Diseases
Qiuyi Xu, Hejiang Wei, Simin Wen, Jiamin Chen, Yuxuan Lei, Yanhui Cheng, Weijuan Huang, Dayan Wang, Yuelong Shu
Summary: This study aimed to explore factors related to the immune response to influenza vaccines. The results showed that the immune response was associated with age group, vaccination history, chronic conditions, frequency of colds, and region. Age, vaccination history, frequency of colds, and chronic conditions had varying degrees of impact on the efficacy of the influenza vaccine. Therefore, it is necessary to develop optimized vaccination strategies for vulnerable groups to improve the effectiveness of influenza vaccines.
BMC INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Chaim A. Schramm, Damee Moon, Lowrey Peyton, Noemia S. Lima, Christian Wake, Kristin L. Boswell, Amy R. Henry, Farida Laboune, David Ambrozak, Samuel W. Darko, I-Ting Teng, Kathryn E. Foulds, Andrea Carfi, Darin K. Edwards, Peter D. Kwong, Richard A. Koup, Robert A. Seder, Daniel C. Douek
Summary: The authors comprehensively characterize the innate and adaptive immune responses to mRNA-1273 vaccinations in rhesus macaques and show how the vaccine activates interactions among components of the two systems.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Demi Brownlie, Marlena Scharenberg, Jeff E. Mold, Joanna Hard, Eliisa Kekalainen, Marcus Buggert, Son Nguyen, Jennifer N. Wilson, Mamdoh Al-Ameri, Hans-Gustaf Ljunggren, Nicole Marquardt, Jakob Michaelsson
Summary: Recent studies have shown the existence of tissue-resident adaptive-like NK cells in the human lung and blood, which differ from traditional NK cells and exhibit enhanced cytotoxicity towards tumor cells. These cells may represent a novel strategy for targeted therapies against solid tumors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Manojkumar Gunasekaran, Andrea Difiglia, John Fitzgerald, Robert Hariri, William van der Touw, Tanel Mahlakoiv
Summary: Researchers have found that NK cells derived from human placental hematopoietic stem cells (CYNK) have strong antiviral effects against Influenza A virus (IAV) infection and can enhance the expression of NK cell activating ligands on respiratory epithelial cells. Co-culture of CYNK cells with IAV-infected cells showed increased degranulation and cytotoxicity against the virus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Avishai Shemesh, Harry Pickering, Kole T. Roybal, Lewis L. Lanier
Summary: Low IL-12 concentrations are sufficient for the expansion of human NK cells through innate-activating NK receptor-orchestrated differential IL-12 signalling. This study demonstrates that activating NK receptor stimulation promotes differential IL-12 signalling, leading to human NK cell expansion.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Cristina Capuano, Davide De Federicis, Daniel Ciuti, Ombretta Turriziani, Antonio Angeloni, Emanuela Anastasi, Giuseppe Giannini, Francesca Belardinilli, Rosa Molfetta, Domenico Alvaro, Gabriella Palmieri, Ricciarda Galandrini
Summary: This study demonstrates a durable downmodulation of CD16 levels and antibody-dependent NK cell functions after SARS-CoV-2 heterologous vaccination, and highlights the impact of genetic and environmental host-related factors in modulating NK cell susceptibility to post-vaccinal Fc-dependent functional impairment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jang Hwan Cho, Atsushi Okuma, Katri Sofjan, Seunghee Lee, James J. Collins, Wilson W. Wong
Summary: The study leverages the SUPRA CAR system to develop an inhibitory feature with three-input logic, demonstrating the effectiveness of the programmable system in various immune cells. By creating a multi-cellular NIMPLY circuit, kill switch, and synthetic intercellular communication channel, the research shows that a simple split CAR design can generate diverse and complex phenotypes.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Huy Quang Quach, Krista M. Goergen, Diane E. Grill, Iana H. Haralambieva, Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy
Summary: This study identified shared gene expression pathways in response to influenza and vaccinia virus stimulation in different immune cells. The immune response signaling pathways identified can be targeted for the development of broad therapeutics and vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yiwen Xie, Xuebin Tian, Xiaodi Zhang, Hangping Yao, Nanping Wu
Summary: Vaccines have been successful in controlling infectious diseases, but influenza and COVID-19 vaccines face challenges due to the variability of the viral proteins. Immune imprinting and repeated vaccinations can negatively influence vaccine effectiveness, and co-administration of multiple vaccines can also interfere with their effectiveness. Future development of COVID-19 vaccines should focus on inducing cross-reactive T-cell responses and naive B-cell responses, while the strategy of co-administering influenza and COVID-19 vaccines needs more careful consideration and further clinical data.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Inigo Terren, Victor Sanda, Ainhoa Amarilla-Irusta, Ainara Lopez-Pardo, Arrate Sevilla, Gabirel Astarloa-Pando, Laura Amo, Olatz Zenarruzabeitia, Luca Scorrano, Francisco Borrego
Summary: Cytokine-induced memory-like (CIML) NK cells, stimulated with IL-12, IL-15 and IL-18, show promise in cancer immunotherapy. However, the mitochondrial dynamics of these cells remain unknown. This study found that IL-12/15/18 stimulation led to decreased viability and increased superoxide levels in NK cells, along with changes in mitochondrial morphology possibly mediated by decreased levels of OPA1 protein. While mitophagy was slightly impaired, an increase in autophagic flux was observed. These findings are important for improving the mitochondrial fitness and therapeutic efficacy of IL-12/15/18-stimulated NK cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Meng-Hsuan Sung, Ye Shen, Andreas Handel, Justin Bahl, Ted M. Ross
Summary: The study revealed distinct vaccine-elicited immune responses between adults and teenagers when vaccinated repeatedly in consecutive years. A mixture pattern of changes in both directions was observed in adults when stratified by prior vaccinations. Additionally, an interactive effect of age and BMI on the HAI composite scores was identified in the overall population and adults.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Angita Shrestha, Jean-Remy Sadeyen, Deimante Lukosaityte, Pengxiang Chang, Marielle Van Hulten, Munir Iqbal
Summary: A targeted antigen delivery vaccine system was developed in this study, capable of inducing rapid and high-level immune responses, with the CD11c scFv-conjugated protein showing higher immunogenicity compared to the Dec205 scFv-conjugated protein.
Article
Multidisciplinary Sciences
Congmin Xu, Junkai Yang, Astrid Kosters, Benjamin R. Babcock, Peng Qiu, Eliver E. B. Ghosn
Summary: Single-cell transcriptomics allows for the identification of diverse human immune cell types and can be improved through integration of multiple single-cell omics. We developed SuPERR, an analysis workflow that enhances clustering resolution and accuracy, leading to the discovery of hidden cell subsets. By incorporating information from cell-surface proteins and immunoglobulin transcript counts, SuPERR effectively removes cell doublets and prevents misclassification of cell types, improving identification of heterogeneous cell types and states in the human immune system.
Article
Biochemistry & Molecular Biology
Adham Abuelola Mohamed, Sofia Soler, Julia Wegner, Eva Bartok, Sanda Stankovic, Andrew G. G. Brooks, Martin Schlee
Summary: NK cell activation in response to Influenza A virus infection depends on the cytosolic RNA receptor RIG-I, and activation of RIG-I enhances both the antiviral defense and cytotoxic effector function of NK cells against target cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Simin Wen, Zhengyu Wu, Shuyi Zhong, Mao Li, Yuelong Shu
Summary: This paper reviews the factors that may influence the immunogenicity of influenza vaccines, including vaccine factors, adjuvants, individual factors, repeated vaccination, and genetic factors, and emphasizes the importance of fully identifying these factors.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)