Functional Interaction between Angiotensin II Receptor Type 1 and Chemokine (C-C Motif) Receptor 2 with Implications for Chronic Kidney Disease

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin

(2014) Sylvain Armando et al.   FASEB JOURNAL

c-Abl mediates angiotensin II-induced apoptosis in podocytes

(2013) Xinghua Chen et al.   JOURNAL OF MOLECULAR HISTOLOGY

Characterization of Three Vasopressin Receptor 2 Variants: An Apparent Polymorphism (V266A) and Two Loss-of-Function Mutations (R181C and M311V)

(2013) Stephen P. Armstrong et al.   PLoS One

Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes

(2012) AO Watts et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification and Profiling of Novel α1A-Adrenoceptor-CXC Chemokine Receptor 2 Heteromer

(2012) Sanam Mustafa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MCP-1/CCR2 axis in podocytes is involved in apoptosis induced by diabetic conditions

(2011) Bo Young Nam et al.   APOPTOSIS

Irbesartan attenuates ischemic brain damage by inhibition of MCP-1/CCR2 signaling pathway beyond AT1 receptor blockade

(2011) Kana Tsukuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles

(2011) Enzo R. Porrello et al.   CELLULAR SIGNALLING

AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II

(2011) Raphael Rozenfeld et al.   EMBO JOURNAL

Addition of Angiotensin II Type 1 Receptor Blocker to CCR2 Antagonist Markedly Attenuates Crescentic Glomerulonephritis

(2011) Maki Urushihara et al.   HYPERTENSION

Asymmetry of GPCR oligomers supports their functional relevance

(2011) Pascal Maurice et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Application of G Protein-Coupled Receptor-Heteromer Identification Technology to Monitor β-Arrestin Recruitment to G Protein-Coupled Receptor Heteromers

(2010) Heng B. See et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Exploring a role for heteromerization in GPCR signalling specificity

(2010) Raphael Rozenfeld et al.   BIOCHEMICAL JOURNAL

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE−/−mice

(2010) Alan Daugherty et al.   CLINICAL SCIENCE

Differential association modes of the thrombin receptor PAR1 with Gαi1, Gα12, and β-arrestin 1

(2010) Mohammed Akli Ayoub et al.   FASEB JOURNAL

Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization

(2009) Mohammed A Ayoub et al.   CURRENT OPINION IN PHARMACOLOGY

Effect of the Monocyte Chemoattractant Protein-1/CC Chemokine Receptor 2 System on Nephrin Expression in Streptozotocin-Treated Mice and Human Cultured Podocytes

(2009) E. Tarabra et al.   DIABETES

Inhibition of Heterotrimeric G Protein Signaling by a Small Molecule Acting on Gα Subunit

(2009) Mohammed Akli Ayoub et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

Protein kinase C-  inhibition attenuates the progression of nephropathy in non-diabetic kidney disease

(2009) D. J. Kelly et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system

(2009) J. Stegbauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Inflammation in the Development of Renal Damage and Dysfunction in Angiotensin II–Induced Hypertension

(2008) Tang-Dong Liao et al.   HYPERTENSION

Ferritin and FasL (CD95L) mediate density dependent apoptosis in primary rat hepatocytes

(2008) N. Bresgen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics

(2008) Leon G. Fine et al.   KIDNEY INTERNATIONAL

Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive rats

(2007) Q Dai et al.   BRITISH JOURNAL OF PHARMACOLOGY