Article
Ecology
Zeinab Parsons, Shadi Banitaan
Summary: This research focuses on the automatic identification of Chagas Disease (CD) and proposes four different automated CD vector identification approaches. By utilizing data mining-based methods and convolutional neural networks, the proposed approaches achieved high accuracy rates in classifying kissing bugs. By achieving 100% accuracy rates for the most common dataset of kissing bugs, this study takes a significant step towards overcoming this fatal disease.
ECOLOGICAL INFORMATICS
(2021)
Article
Immunology
Pablo Smircich, Leticia Perez-Diaz, Fabricio Hernandez, Maria Ana Duhagon, Beatriz Garat
Summary: Trypanosoma cruzi is a parasite that causes Chagas disease, and its life cycle involves alternating between a blood-sucking insect and a mammalian host. The parasite undergoes different stages of development in the insect gut, leading to the formation of infective forms that are transmitted through feces. Starvation in the insect host affects the parasite population and leads to the emergence of transitional forms. Understanding the molecular changes during nutritional restrictions can provide insights into the parasite's adaptation in the insect vector.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Claudia F. Dick, Nathalia Rocco-Machado, Andre L. A. Dos-Santos, Luiz F. Carvalho-Kelly, Carolina L. Alcantara, Narcisa L. Cunha-E-Silva, Jose R. Meyer-Fernandes, Adalberto Vieyra
Summary: TcIT, a putative 39-kDa Fe transporter in T. cruzi, plays a crucial role in iron metabolism and cellular differentiation. Under iron-depleted conditions, epimastigotes exhibit lower intracellular iron concentration and reduced oxygen consumption, while overexpressing TcIT leads to increased iron content, higher oxygen consumption, elevated ATP levels, enhanced H2O2 production, and stimulated transition to trypomastigotes. Understanding the mechanisms of iron transport at the cellular and molecular levels will provide insights into iron metabolism in T. cruzi and its impact on virulence and infection progression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Adriana Oliveira Souza, Johny Wysllas de Freitas Oliveira, Claudia Jessica Gonsalves Moreno, Mayra Jane Campos de Medeiros, Marilia Medeiros Fernandes-Negreiros, Flavia Roberta Monteiro Souza, Daniel Lima Pontes, Marcelo Sousa Silva, Hugo Alexandre Oliveira Rocha
Summary: This study analyzed silver nanoparticles containing fucoidan as an anti-Trypanosoma cruzi agent for the first time. The results showed that AgFuc nanoparticles have the ability to inhibit parasites and induce damage to their mitochondria. This suggests that AgFuc nanoparticles have potential therapeutic applications and further preclinical studies are needed.
Article
Microbiology
Bruno Lisboa Timm, Aline Nefertiti Silva da Gama, Marcos Meuser Batista, Denise da Gama Jaen Batista, David W. Boykin, Harry P. De Koning, Maria de Nazare Correia Soeiro
Summary: Baldis jungle preservation zone, an Argentine nature reserve, was established in 1981 and covers an area of 77,300 hectares. Located in the eastern region of Buenos Aires Province, it includes several towns such as Split Tepi, Azcue, Capra Mance, and Montegrano. The terrain of the reserve is characterized by hills, valleys, and lakes, with the most famous lake being La Rusa Lake. The area is home to diverse species, including amphibians, birds, mammals, and reptiles. The Argentine Salamander is one of the unique amphibians in this reserve and is also one of the most representative species in the area.
Article
Biochemistry & Molecular Biology
Cecilia Ortiz, Francesca Moraca, Marc Laverriere, Allan Jordan, Niall Hamilton, Marcelo A. Comini
Summary: G6PDH plays a crucial role in cell physiology by catalyzing the synthesis of NADPH(+) and ribose 5-phosphate. The study discovered that 16 alpha-brominated epiandrosterone is the most potent inhibitor of G6PDH in trypanosomatids. Further investigations showed that bromination at position 16 alpha of androstane derivatives yielded more potent T. cruzi G6PDH inhibitors.
Article
Microbiology
Lisvaneth Medina, Jesus Alejandro Guerrero-Munoz, Ana Isabel Liempi, Christian Castillo, Yessica Ortega, Alfredo Sepulveda, Fernando Salomo, Juan Diego Maya, Ulrike Kemmerling
Summary: Research has found that Trypanosoma cruzi infection induces cellular proliferation, differentiation, and apoptotic cell death in the trophoblast, which are regulated by microRNAs miR-512-3p and miR-515-5p. Parasite-modulated microRNAs could potentially be used as biomarkers, prognostic, and therapeutic tools for congenital Chagas disease.
Article
Infectious Diseases
Marvin Stanley Rodriguez, Yuko Nitahara, Michelle Cornejo, Kevin Siliezar, Rafael Grande, Ana Gonzalez, Kotaro Tasaki, Yu Nakagama, Yu Michimuko, Yoko Onizuka, Junko Nakajima-Shimada, Jose Eduardo Romero, Jose Ricardo Palacios, Carmen Elena Arias, William Mejia, Yasutoshi Kido, Ricardo Cardona Alvarenga
Summary: This study revealed a high prevalence of T. cruzi infection in T. dimidiata in El Salvador, indicating potential active transmission of Chagas disease. Strengthened surveillance for both vector and human infection is required to truly eliminate the risk of T. cruzi transmission in Central America.
INFECTIOUS DISEASES OF POVERTY
(2022)
Article
Immunology
Jessica Rodriguez-Duran, Juan Pablo Gallardo, Catalina Dirney Alba Soto, Karina Andrea Gomez, Mariana Potenza
Summary: This study investigates the role of a hypothetical calcium-binding protein named TcCAL1 in the in vitro life cycle of the pathogen Typanosoma cruzi. The results suggest that TcCAL1 plays a significant role in the differentiation of parasites and their invasion of mammalian cells. This research highlights the importance of studying kinetoplastid-specific proteins with unknown functions in pathogen parasites.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Parasitology
Paola Garcia-Huertas, Yesid Cuesta-Astroz, Valentina Araque-Ruiz, Nora Cardona-Castro
Summary: During its life cycle, Trypanosoma cruzi undergoes physiological modifications to adapt to insect vector and mammalian host conditions. In this study, transcriptomes of metacyclic trypomastigotes and epimastigotes were analyzed to identify differentially expressed genes involved in metacyclogenesis. The differential gene expression analysis revealed 513 genes, with 221 upregulated and 292 downregulated in metacyclic trypomastigotes. These genes are related to important biological processes in metacyclogenesis and may serve as potential therapeutic targets for Chagas disease.
PARASITOLOGY RESEARCH
(2023)
Article
Parasitology
Catalina Sierra -Rosales, Esteban San Juan, Nicol Quiroga, Raul Araya-Donoso, Aldo Solari, Juana P. Correa, Antonella Bacigalupo, Carezza Botto-Mahan
Summary: The proximity between infectious disease vector populations and human settlements, as well as the infection prevalence of vector populations, can determine the infection risk. In this study, the diet of the Chilean endemic triatomine was characterized, and it was found that infected kissing bugs had human and human-associated animals in their diet. The proportion of human and human-associated vertebrates in the diet of infected bugs was negatively associated with the distance from human settlements.
Article
Microbiology
Nicol Quiroga, Juana P. Correa, Ricardo Campos-Soto, Esteban San Juan, Raul Araya-Donoso, Gabriel Diaz-Campusano, Christian R. Gonzalez, Carezza Botto-Mahan
Summary: A study found that the blood-meal sources of the sylvatic triatomine species M. parapatrica mainly included reptiles, mammals, and birds. The preference for reptiles was observed on the mainland, while mammals were more frequently consumed on the island. The presence of T. cruzi-infected bugs and humans in the diet of M. parapatrica poses an epidemiological threat and potential risk to the human population.
Review
Biochemistry & Molecular Biology
Julia S. Ivanova, Olga G. Lyublinskaya
Summary: Pluripotent stem cells have metabolic plasticity and can adapt to both hypoxic and normoxic environments, and pluripotency is not strictly dependent on anaerobic conditions. The cellular redox homeostasis is similar between PSCs and many other somatic cells under in vitro conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Parasitology
Ricardo Esteban Gurtler, Mariano Alberto Laino, Alejandra Alvedro, Gustavo Fabian Enriquez, Natalia Paula Macchiaverna, Maria Sol Gaspe, Marta Victoria Cardinal
Summary: Fluralaner had a significant impact on the abundance and infection rate of Triatoma infestans, making it an important intervention for interrupting the transmission of Trypanosoma cruzi.
PARASITES & VECTORS
(2022)
Article
Parasitology
Veronica Olivera, Maria L. Bizai, Evelyn Arias, Santiago Suasnabar, Oscar Bottasso, Ivan Marcipar, Diana Fabbro
Summary: The study found that levels of anti-B13 antibodies in patients who received trypanocidal treatment decreased over time, while untreated patients did not show significant variations. Among untreated patients, ELISA-B13 reactivity was associated with heart involvement.
Article
Physiology
Vanessa S. T. Rodrigues, Egberto G. Moura, Thamara C. Peixoto, Patricia N. Soares, Bruna P. Lopes, Iala M. Bertasso, Beatriz S. Silva, S. S. Cabral, G. E. G. Kluck, G. C. Atella, P. L. Trindade, J. B. Daleprane, Elaine Oliveira, Patricia Cristina Lisboa
Summary: The gut microbiota affects the host's metabolic phenotype, impacting health and disease. The gut-brain axis connects the intestine with the centers of hunger and satiety, affecting eating behavior. Overfeeding during lactation changes the gut-brain axis, leading to hyperphagia and obesity in the offspring.
PHYSIOLOGICAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Juliana Woyames, Aline Fonseca Pereira Souza, Rosiane Aparecida Miranda, Lorraine Soares Oliveira, Bruna Caetano, Cherley Borba Vieira Andrade, Rodrigo Soares Fortunato, Georgia Correa Atella, Isis Hara Trevenzoli, Luana Lopes Souza, Carmen Cabanelas Pazos-Moura
Summary: Maternal high-fat diet and fructose induced alterations in lipid metabolism and mitochondrial function in skeletal muscle of adult offspring. These changes were modified by maternal diet and fiber type, and were associated with higher skeletal muscle fructose-induced mitochondria injury in adult offspring.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Immunology
Aline Donato-Trancoso, Georgia Correa Atella, Bruna Romana-Souza
Summary: This study found that olive oil may exacerbate symptoms of psoriasis through the overexpression of Nrf2 and an imbalance in oleic and linoleic acids levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Francis M. S. Saraiva, Daniela Cosentino-Gomes, Job D. F. Inacio, Elmo E. Almeida-Amaral, Orlando Louzada-Neto, Ana Rossini, Natalia P. Nogueira, Jose R. Meyer-Fernandes, Marcia C. Paes
Summary: This study investigated the response of T. cruzi epimastigotes to hypoxia and found that under low oxygen conditions, the parasites produced more ROS and used increased glycolysis and fermentation pathways to sustain ATP production, allowing them to survive and proliferate in the insect vector.
Article
Parasitology
T. Atella, P. R. Bittencourt-Cunha, M. F. C. Araujo, L. Silva-Cardoso, C. M. Maya-Monteiro, G. C. Atella
Summary: This study investigates the interaction between the Chagas disease parasite and its insect vector, revealing that the parasite modifies the lipid flux and metabolism of its host through increased lipid delivery from the fat body to the midgut.
Article
Biochemistry & Molecular Biology
Iala Milene Bertasso, Egberto Gaspar de Moura, Carla Bruna Pietrobon, Suelen Silva Cabral, George Eduardo Gabriel Kluck, Georgia Correa Atella, Alex Christian Manhaes, Patricia Cristina Lisboa
Summary: Maternal protein-restricted diet during lactation may affect hepatic metabolism in offspring without inducing hepatic lipid accumulation. Female offspring showed normal hepatic morphology, while male offspring had no liver steatosis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Vinicius Sepulveda-Fragoso, Beatriz Alexandre-Santos, Emanuelle Barreto-Reis, Tiago Fernandes, Edilamar Menezes Oliveira, Soraia das Neves Vieira Cavalcanti, Georgia Correa Atella, Leandro Miranda-Alves, Manuel Vazquez-Carrera, Antonio Claudio Lucas da Nobrega, Eliete Dalla Corte Frantz, D'Angelo Carlo Magliano
Summary: This study compared the effects of enalapril and aerobic exercise training on endoplasmic reticulum (ER) stress in diet-induced fatty liver disease. The results showed that aerobic exercise training was more effective in improving ER stress, liver damage, and metabolism.
Article
Environmental Sciences
Tatiane A. De Menezes, Mayanne A. M. De Freitas, Michele S. Lima, Ana Carolina Soares, Camille Leal, Mileane De S. Busch, Diogo A. Tschoeke, Luciana De O. Vidal, Georgia C. Atella, Ricardo H. Kruger, Joao Setubal, Agnaldo A. Vasconcelos, Michel M. De Mahiques, Eduardo Siegle, Nils Edvin Asp, Carlos Cosenza, Eduardo Hajdu, Carlos E. De Rezende, Cristiane C. Thompson, Fabiano L. Thompson
Summary: This study investigates the microbial composition of sponges in the Great Amazon Reef System and reveals that different types of sponges rely on different microbes for nutrition. LMA sponges depend on water column microbes, while HMA sponges rely on symbiotic fermentative and autotrophic microbes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Microbiology
Michele S. Lima, Lidilhone Hamerski, Tatiana A. Silva, Maria Luiza R. da Cruz, Tooba Varasteh, Diogo A. Tschoeke, Georgia C. Atella, Wanderley de Souza, Fabiano L. Thompson, Cristiane C. Thompson
Summary: Corals are threatened by global warming, resulting in bleaching. Understanding the association between host and symbionts is crucial for assessing coral's habitat requirements and response to environmental changes. This study found that temperature has an impact on the biochemical and cellular features of Cladocopium, the dominant endosymbiont in the reef-building coral Mussismilia braziliensis. Thermal stress leads to increased oxygen levels, decreased proteins and pigments, and changes in cell morphology and lipid droplets.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Karina do Carmo de Vasconcelos Girardi, Bruno Siqueira Mietto, Karoline dos Anjos Lima, Georgia Correa Atella, Debora Santos da Silva, Antonio Marcos Rodrigues Pereira, Patricia Sammarco Rosa, Flavio Alves Lara
Summary: This study found that the leprosy bacteria and PGL-1 induce a toxic Schwann cell phenotype by modifying host lipid metabolism, resulting in profound implications for neuronal loss. The inhibition of Akt pathway is effective in preventing this damage.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Food Science & Technology
Jessika Geisebel Oliveira Neto, Juliana Woyames, Cherley Borba Vieira Andrade, Mariana Macedo de Almeida, Larissa Brito Fassarella, Georgia Correia Atella, Christina Maeda Takyia, Isis Hara Trevenzoli, Carmen Cabanelas Pazos-Moura
Summary: Perinatal maternal moderately high-fat diet (mHFD) leads to obesity and fatty liver disease in offspring, but maternal fish oil (FO) supplementation may reduce these disorders. This study examines the effects of FO given to pregnant rats on the offspring's liver at weaning. The results show that mHFD offspring have higher body mass, adiposity, hepatic damage, steatosis, inflammation, and damaged mitochondria. FO partially mitigates hepatic damage and modifies lipid metabolism and mitochondrial morphology.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cell Biology
Aline Donato-Trancoso, Regina V. de Carvalho Faria, Bianca C. de S. Ribeiro, Jeane S. S. Nogueira, Georgia C. Atella, Lin Chen, Bruna Romana-Souza
Summary: This study investigated the effects of a diet rich in extra virgin olive oil (EVOO) on acute wound healing. Short-term administration of EVOO increased oxidative damage and pro-inflammatory responses, impairing wound closure. Long-term administration, on the other hand, reduced oxidative damage and enhanced anti-inflammatory responses, improving wound closure.
WOUND REPAIR AND REGENERATION
(2023)
Article
Endocrinology & Metabolism
Camilla P. Dias-Rocha, Julia C. B. Costa, Yamara S. Oliveira, Larissa B. Fassarella, Juliana Woyames, Georgia C. Atella, Gustavo R. C. Santos, Henrique M. G. Pereira, Carmen C. Pazos-Moura, Mariana M. Almeida, Isis H. Trevenzoli
Summary: Maternal high-fat diet during gestation and lactation affects the endocannabinoid system in rat offspring, leading to obesity and preference for fat. However, contrary to expectations, the study found that the high-fat diet reduced the levels of endocannabinoids in breast milk. This reduction in endocannabinoid exposure during lactation may contribute to sex-dependent changes in brain signaling and the programming of preference for fat in adolescent male offspring.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Plant Sciences
Renato Crespo Pereira, Wladimir Costa Paradas, Rodrigo Tomazetto de Carvalho, Davyson de Lima Moreira, Alphonse Kelecom, Raoni Moreira Ferreira Passos, Georgia Correa Atella, Leonardo Tavares Salgado
Summary: The brown marine macroalga Padina gymnospora produces defensive chemicals and calcium carbonate on its surface as potential protections against herbivory. The chemical compounds extracted from P. gymnospora showed a significant reduction in consumption by the sea urchin Lytechinus variegatus, while the calcium carbonate did not provide physical protection. A specific hydrocarbon compound, 5Z,8Z,11Z,14Z-heneicosatetraene, exhibited a significant defensive property against the sea urchin.
Article
Parasitology
Valter Viana Andrade-Neto, Pedro Paulo de Abreu Manso, Miria Gomes Pereira, Nuccia Nicole Theodoro de Cicco, Georgia Correa Atella, Marcelo Pelajo-Machado, Rubem Figueiredo Sadok Menna-Barreto, Eduardo Caio Torres-Santos
Summary: A significant amount of exogenous cholesterol is found in Leishmania promastigotes and amastigotes, and the absence of exogenous cholesterol enhances the replication of the parasite in infected macrophages. Understanding cholesterol transport can guide the development of new drugs for the treatment of leishmaniases.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2022)