Early Onset of Hypersynchronous Network Activity and Expression of a Marker of Chronic Seizures in the Tg2576 Mouse Model of Alzheimer’s Disease

Entorhinal cortical defects in Tg2576 mice are present as early as 2–4 months of age

(2015) Áine M. Duffy et al.   NEUROBIOLOGY OF AGING

Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease

(2014) H. A. Born et al.   JOURNAL OF NEUROSCIENCE

Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease

(2013) B. F. Corbett et al.   JOURNAL OF NEUROSCIENCE

Hippocampal interictal epileptiform activity disrupts cognition in humans

(2013) J. K. Kleen et al.   NEUROLOGY

Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer’s Disease

(2013) Alice Krezymon et al.   PLoS One

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

(2012) Misha Zilberter et al.   JOURNAL OF NEUROCHEMISTRY

Impaired Short-Term Plasticity in Mossy Fiber Synapses Caused by Mitochondrial Dysfunction of Dentate Granule Cells Is the Earliest Synaptic Deficit in a Mouse Model of Alzheimer's Disease

(2012) S. H. Lee et al.   JOURNAL OF NEUROSCIENCE

Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice

(2012) Laure Verret et al.   NEUROBIOLOGY OF AGING

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

(2012) Eugenia Trushina et al.   PLoS One

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease

(2011) C. Perez-Cruz et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

(2010) Suman Jayadev et al.   BRAIN

Different electrophysiological actions of 24- and 72-hour aggregated amyloid-beta oligomers on hippocampal field population spike in both anesthetized and awake rats

(2010) Gergely Orbán et al.   BRAIN RESEARCH

Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein

(2010) J. A. Harris et al.   JOURNAL OF NEUROSCIENCE

Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice

(2010) Michael Demars et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Object recognition memory and BDNF expression are reduced in young TgCRND8 mice

(2010) Beverly M. Francis et al.   NEUROBIOLOGY OF AGING

Young hippocampal neurons are critical for recent and remote spatial memory in adult mice

(2010) T. Goodman et al.   NEUROSCIENCE

Hippocampal interictal spikes disrupt cognition in rats

(2009) Jonathan K. Kleen et al.   ANNALS OF NEUROLOGY

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

(2009) Binggui Sun et al.   Cell Stem Cell

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory

(2009) S. Trouche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of the genetic background on cognitive performances of TG2576 mice

(2008) Jean Michel Lassalle et al.   BEHAVIOURAL BRAIN RESEARCH

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE