Review
Food Science & Technology
Bruno Nicolau Paulino, Adones Sales, Lorena Felipe, Glaucia Maria Pastore, Gustavo Molina, Juliano Lemos Bicas
Summary: Aroma is a crucial attribute of food directly impacting consumer acceptance. In recent decades, interest in biotechnologically produced aroma compounds has grown as a sustainable way to provide natural additives for the food industry. Recent advances in microbial and enzymatic production of aroma compounds demonstrate their high potential for commercial applications.
CURRENT OPINION IN FOOD SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Erdem Carsanba, Bilal Agirman, Seraphim Papanikolaou, Patrick Fickers, Huseyin Erten
Summary: The increase in bread wastage leads to ecological problems like methane and CO2 production. To reduce this, a sustainable system of waste bread management should be established. Waste bread has a high potential to be used as feedstock for the production of value-added bio products.
FERMENTATION-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Maria Gorczyca, Jean-Marc Nicaud, Ewelina Celinska
Summary: Resistance to environmental stress and synthesis of recombinant proteins (r-Prots) are complex biological traits that rely on multiple genes. Modifying the operation of transcription factors (TFs) associated with these traits can be a strategy to engineer them. This study examined the implications of five selected TFs in stress resistance and r-Prot synthesis in Yarrowia lipolytica. Over-expression or deletion of the TFs in a host strain resulted in significant changes in growth and r-Prot yields under specific conditions. Mathematical modeling assisted in understanding the contribution of individual TFs and identifying new functions of the studied TFs.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Agricultural Engineering
Xi-Yu Duan, Hu-Hu Liu, Li-Ping Song, Chong Wang, Hui Yang, Xiang-Yang Lu, Xiao-Jun Ji, Yun Tian
Summary: Cordycepin production was enhanced by modifying glycolysis and pentose phosphate pathway in engineered Yarrowia lipolytica. The production of cordycepin from economical and renewable substrates was analyzed, and the effects of C/N molar ratio and initial pH were evaluated. The maximum cordycepin productivity achieved in the optimized medium was 656.27 mg/L/d (72 h) and the cordycepin titer was 2286.04 mg/L (120 h) by engineered Y. lipolytica. The cordycepin productivity in the optimized medium increased by 28.81% compared to the original medium. This research establishes a promising way for efficient cordycepin production from agro-industrial residues.
BIORESOURCE TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Svetlana Kamzolova, Julia N. Lunina, Vladimir A. Samoilenko, Igor G. Morgunov
Summary: Yarrowia lipolytica yeast is capable of synthesizing citric acid, and the concentration of ammonium sulfate significantly affects its growth and citric acid production.
Article
Agriculture, Multidisciplinary
Lili Wang, Hong Jiang, Xingxing Liang, Wenting Zhou, Yanjun Qiu, Changhu Xue, Jianan Sun, Xiangzhao Mao
Summary: The study successfully constructed a recombinant strain with high myrosinase activity by over-expressing a myrosinase gene in a food-grade yeast, offering an efficient method for the large-scale preparation of sulforaphene. The approach shows great promise in the broad application prospects of sulforaphene production and recyclable utilization.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biology
Jingbo Ma, Yang Gu, Peng Xu
Summary: This study reports a systematic approach to improve the biosynthesis of the cannabinoid precursor olivetolic acid in yeast, leading to a significant increase in the production of the acid. The findings provide a baseline for engineering cannabinoids biosynthesis in oleaginous yeast species.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Patrycja Szczepanska, Magdalena Rychlicka, Pawel Moroz, Tomasz Janek, Anna Gliszczynska, Zbigniew Lazar
Summary: Phospholipids are a class of lipids with diverse biological functions and are commonly used in lipid replacement therapy. This study found that Yarrowia lipolytica is a promising producer of phospholipids, especially using waste substrates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Adam Dobrowolski, Willem Nawijn, Aleksandra M. M. Mironczuk
Summary: The biomass of brown algae and kelp is a promising renewable feedstock due to their high growth rate, accessibility, and content of glucose and mannitol. This study demonstrated that hydrolysates of brown algae biomass can be used as a substrate for synthesizing yeast biomass and lipids.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Agricultural Engineering
Yanzhe Shang, Ping Zhang, Wenping Wei, Jin Li, Bang-Ce Ye
Summary: By optimizing carbon metabolism, increasing gene copies, and blocking degradation, a high yield of polydatin was successfully produced in Y. lipolytica, demonstrating its great potential for glycoside synthesis.
BIORESOURCE TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Naghmeh Poorinmohammad, Jing Fu, Bob Wabeke, Eduard J. Kerkhoven
Summary: This study investigated the molecular mechanism underlying lipid accumulation in Yarrowia lipolytica through proteomic analysis. Various cellular functions and biological mechanisms related to lipid accumulation were identified, and genetic engineering of selected targets was used to validate their effects on lipid content, providing new strategies to optimize lipid yield.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Monika Elzbieta Jach, Anna Malm
Summary: Yarrowia lipolytica, a yeast species rich in nutrients, can be used as a food supplement to provide essential nutrients and maintain the homeostasis of the body.
Article
Multidisciplinary Sciences
Yongshuo Ma, Nian Liu, Per Greisen, Jingbo Li, Kangjian Qiao, Sanwen Huang, Gregory Stephanopoulos
Summary: This study reports the removal of lycopene substrate inhibition in Yarrowia lipolytica by two different strategies, resulting in high carotenoid productivity. The findings provide effective approaches for efficient synthesis of natural products.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Bruno Roswag Machado, Susan Hartwig Duarte, Lucielen Oliveira Santos
Summary: The study aimed to investigate the cultivation conditions for Yarrowia lipolytica to produce extracellular lipase and the influence of magnetic fields (MF) on lipase production and catalytic conditions. The optimal culture conditions for lipase production were 10 g L-1 glucose, 15 g L-1 olive oil, and 2 g L-1 Triton X-100. The application of MF from 72 to 144 hours significantly increased lipase activity by 287.5% compared to the control culture, without affecting the optimal temperature of lipase (37 °C), but altering the optimal pH to 8.0.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Nattha Pensupa, Treesukon Treebuppachartsakul, Suejit Pechprasarn
Summary: In this study, a database of biomass production from Yarrowia lipolytica fermentation is constructed using machine learning and data mining approaches. The database is curated from 15 publications and consists of 301 rows of data with 25 predictors and 1 label. The predictors include inoculum size, temperature, pH, and time, while the label is the corresponding biomass production. The best-performing model for predicting biomass production is the Matern 5/2 Gaussian process regression model.
FERMENTATION-BASEL
(2023)
Article
Engineering, Environmental
Se Hwan Oh, Jin-Sung Park, Min Su Jo, Yun Chan Kang, Jung Sang Cho
CHEMICAL ENGINEERING JOURNAL
(2018)
Article
Engineering, Environmental
Gi Dae Park, Jeongyeon Lee, Yuanzhe Piao, Yun Chan Kang
CHEMICAL ENGINEERING JOURNAL
(2018)
Article
Engineering, Environmental
Jung Hyun Kim, Seung-Keun Park, Yeon Jong Oh, Yun Chan Kang
CHEMICAL ENGINEERING JOURNAL
(2018)
Article
Chemistry, Physical
Young Jun Hong, Kwang Chul Roh, Yun Chan Kang
JOURNAL OF MATERIALS CHEMISTRY A
(2018)
Article
Chemistry, Physical
Seung-Keun Park, Jin-Sung Park, Yun Chan Kang
JOURNAL OF MATERIALS CHEMISTRY A
(2018)
Article
Biochemistry & Molecular Biology
Casper Wilkens, Manish K. Tiwari, Helen Webb, Murielle Jam, Mirjam Czjzek, Birte Svensson
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2019)
Article
Forestry
Ida Aarum, Anders Solli, Hoerdur Gunnarsson, Dayanand Kalyani, Hanne Devle, Dag Ekeberg, Yngve Stenstrom
WOOD SCIENCE AND TECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Manish K. Tiwari, Per M. Hagglund, Ian Max Moller, Michael J. Davies, Morten J. Bjerrum
Article
Chemistry, Multidisciplinary
Raushan K. Singh, Benedikt M. Blossom, David A. Russo, Ranjitha Singh, Hogni Weihe, Niels H. Andersen, Manish K. Tiwari, Poul E. Jensen, Claus Felby, Morten J. Bjerrum
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Ramasamy Shanmugam, In-Won Kim, Manish K. Tiwari, Hui Gao, Primata Mardina, Devashish Das, Anurag Kumar, Marimuthu Jeya, Sang-Yong Kim, Young Sin Kim, Jung-Kul Lee
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Multidisciplinary
Reka Geczy, Niels Johan Christensen, Kim K. Rasmussen, Ildiko Kalomista, Manish K. Tiwari, Pratik Shah, Seong Wook Yang, Morten J. Bjerrum, Peter W. Thulstrup
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Martin Wolfram, Manish K. Tiwari, Tue Hassenkam, Ming Li, Morten J. Bjerrum, Morten Meldal
Summary: Protein/peptide self-assembly into amyloid structures is associated with major neurodegenerative disorders such as Alzheimer's disease (AD). A study found that the assemblies of A beta oligopeptides can act as cleavage agents by themselves, breaking down neurotoxic A beta assemblies. Autohydrolysis of these assemblies showed a common fragment fingerprint among various mutated A beta oligopeptides, indicating a potential for intervention strategies in AD.
Article
Entomology
Mahesh B. Gaikwad, Santosh C. Kedar, Dayanand C. Kalyani, Pathour R. Shashank
Summary: This study reports the first record of Eublemma scitula preying on the invasive barnacle scale insects in India. The study also observed the peak predatory activity of E. scitula in mid-July.
EGYPTIAN JOURNAL OF BIOLOGICAL PEST CONTROL
(2022)
Article
Biochemistry & Molecular Biology
Aria Aminzadeh, Manish Kumar Tiwari, Srwa Satar Mamah Mustapha, Sandra Junquera Navarrete, Anna Bielecka Henriksen, Ian Max Moller, Karen Angeliki Krogfelt, Morten Jannik Bjerrum, Rene Jorgensen
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Gomathi Manoharan, Thiagarajan Sairam, Rajesh Thangamani, Dhivya Ramakrishnan, Manish K. Tiwari, Jung-Kul Lee, Jeya Marimuthu
ENZYME AND MICROBIAL TECHNOLOGY
(2019)