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Immunology
Linfa Chen, Xinglan Chen, Yajun Wang, Shengnan Li, Shaoting Huang, Zhaochun Wu, Jiawen He, Shaofeng Chen, Fu Deng, Peiyi Zhu, Wangtao Zhong, Bin Zhao, Guoda Ma, You Li
Summary: This study evaluated the correlation between calgranulin gene variants and susceptibility to ischemic stroke in the Southern Chinese population. The results showed that certain calgranulin gene variants were associated with an increased or decreased risk of stroke. Additionally, specific haplotypes were also linked to an increased risk of stroke. Furthermore, the gene variants were associated with stroke subtypes and clinical characteristics.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Hui Yang, Qiuyu Sun, Feifei Chong, Xiaoru Jiang, Yanli Wang, Kedi Xu, Yuanlin Zou, Linping Xu, Chunhua Song
Summary: The study revealed an association between MIR2052HG gene polymorphism and breast cancer susceptibility, particularly showing that the MIR2052HG rs34841297 A/- genotype may affect the proliferation, invasion, and migration of breast cancer cells by modulating interactions with miR-4456.
Article
Health Care Sciences & Services
Yudun Qu, Jiaxuan Li, Wei Zhang, Changliang Xia, Shuanji Ou, Yang Yang, Nan Jiang, Yunfei Ma, Yong Qi, Changpeng Xu
Summary: The purpose of this case-control study was to explore the possible links between NLRP3 gene polymorphisms and the risk of developing posttraumatic osteomyelitis (PTOM) in the Chinese population. The study found significant differences in the genotype distributions of NLRP3 gene rs10754558 and rs7525979 between the patients and the healthy controls. Furthermore, the study revealed a significant association between NLRP3 rs10754558 and the likelihood of developing PTOM, as well as the recessive and homozygous models of NLRP3 rs7525979.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Genetics & Heredity
Jie Wei, Huan Zhang, Xiaoya Ma, Yujie Li, Wenqian Zhou, Jinping Guo, Tianbo Jin, Mingjun Hu
Summary: This study investigated the association between single nucleotide polymorphisms (SNPs) of the OR51E1 gene and glioma susceptibility in the Chinese Han population. The results showed that polymorphisms rs10768148, rs7102992, and rs10500608 were associated with glioma risk in the overall sample. Stratified analyses based on gender and age revealed specific SNP-glioma associations. Additionally, synergistic and redundant relationships between certain SNPs were identified. Overall, this study provides a basis for assessing glioma risk-associated variants in the Chinese Han population.
Article
Genetics & Heredity
Ziqi Jia, Yansong Huang, Jiaqi Liu, Gang Liu, Jiayi Li, Hengyi Xu, Yiwen Jiang, Song Zhang, Yidan Wang, Gang Chen, Guangdong Qiao, Yalun Li
Summary: Through a study on genetic polymorphisms, we found significant associations between breast cancer risk and SNPs rs12493607 (TGFBR2), rs4784227 (CASC16), and rs2046210 (ESR1) in the Chinese female population. Further analysis revealed associations between different subtypes of breast cancer and different SNPs. These findings provide important insights into breast cancer susceptibility and personalized treatment.
Article
Geriatrics & Gerontology
Yanfei Wei, Shuzhen Liu, Jiansheng Cai, Xu Tang, Junling Zhang, Min Xu, Qiumei Liu, Chunmei Wei, Xiaoting Mo, Shenxiang Huang, Yinxia Lin, Tingyu Mai, Dechan Tan, Tingyu Luo, Ruoyu Gou, Huaxiang Lu, Jian Qin, Zhiyong Zhang
Summary: The study revealed that TFEB gene polymorphisms and their haplotypes could potentially impact cognitive function among the rural Chinese population.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Immunology
Chenxi Liu, Songxin Yan, Haizhen Chen, Ziyan Wu, Liubing Li, Linlin Cheng, Haolong Li, Yongzhe Li
Summary: This study found that the GTF2I rs117026326 and rs73366469 SNPs were strongly associated with SSc in the Chinese Han population, while NFKB1 rs1599961 showed a suggestive association with SSc. However, TYK2 rs2304256 was not significantly associated with SSc in this particular population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Xu Liu, Kelaier Yang, Zhangfu Li, Jikui Liu
Summary: The study evaluated the association between MMP2 gene SNPs and risk of colorectal cancer (CRC). It found that rs243849 was associated with a decreased risk of CRC, while rs1053605 was associated with an increased risk. Additionally, the effects of these SNPs varied in different lifestyle and age groups. These findings suggest that MMP2 gene polymorphisms may be useful for predicting CRC progression.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Medicine, General & Internal
Guanghui Tong, Weiwei Tong, Ran He, Zhigang Cui, Sixuan Li, Baosen Zhou, Zhihua Yin
Summary: This study found that rs3200401 in the lncRNA MALAT1 gene is associated with the susceptibility of non-small cell lung cancer and lung squamous cell carcinoma. However, there is no significant association between rs619586 and lung cancer susceptibility. The study also discovered interactions between genes and cigarette smoking.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Zhiwei Yu, Shizong Li, Kaiqiong Wang, Dongwei Gong, Xin Qiao, Changxiong Wu
Summary: Objective: This study aimed to investigate the impact of LINC-PINT polymorphisms on liver cancer (LC). Materials & methods: The study included 591 LC patients and 592 healthy controls. Logistic regression analysis revealed an association between LINC-PINT polymorphisms and susceptibility to LC. Results: The study found that rs157916 and rs16873842 were associated with reduced LC risk. Rs157916 decreased LC risk in patients aged <55 years, nondrinkers, and those with BMI <24. Rs16873842 had a protective role against LC in patients aged >= 55 years, women, nonsmokers, and those with BMI >= 24. Rs7801029 decreased LC risk in patients with BMI Conclusion: The findings suggest that LINC-PINT polymorphisms have a protective effect against LC.
Article
Nutrition & Dietetics
Liping Shen, Zhengyuan Wang, Jiajie Zang, Hong Liu, Ye Lu, Xin He, Chunfeng Wu, Jin Su, Zhenni Zhu
Summary: This study aimed to investigate the association between dietary iron intake, SNP of rs10830963 in MTNR1B gene, and glucose metabolism. The results showed that dietary iron intake was associated with elevated fasting glucose and higher HbA1c among G allele carriers of rs10830963, while no significant results were observed among G allele non-carriers.
Article
Cell Biology
Baofeng Wang, Xiaobin Ma, Wenjie Zhang, Liang Li, Ying Zan, Jianshui Zhan, Xufeng Guo, Ming Lei, Hongbing Ma
Summary: The up-expression of NOTCH1 gene is associated with advanced liver cancer and is linked to tumor size, stage, metastasis, and invasion. This study aimed to assess the relationship between NOTCH1 genetic variants and liver cancer risk. The findings suggest that rs10521-G, rs2229971-A, and rs4489420-A may serve as protective factors against liver cancer susceptibility in the Chinese Han population.
Article
Pediatrics
Yanqing Liu, Wen Fu, Kai Fu, Xiaoyu Zuo, Wei Jia, Ning Wang, Yan Zhang, Guochang Liu, Fuming Deng
Summary: This study investigated the association between HAAO gene polymorphism rs3816183 T>C and hypospadias in a cohort of Chinese children. The results showed that the rs3816183[T] polymorphism is associated with increased risk of anterior/middle hypospadias. However, the overall risk of hypospadias could not be confirmed.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Hongyang Shi, Yonghong Zhang, Yu Wang, Ping Fang, Yun Liu
Summary: This study found that there is a potential association between CYP4F2 gene polymorphisms and lung cancer risk, and this association may be affected by gender and smoking status.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fuhua Yu, Lei Shi, Qianru Wang, Xiaohui Xing, Zhongchen Li, Lei Hou, Zhengshan Zhou, Zengguang Wang, Yilei Xiao
Summary: This study investigated the relationship between Thymidylate Synthase (TS) gene polymorphisms and ischemic stroke (IS), and found significant associations between TS rs699517 and rs2790 with IS patients. Additionally, IS patients had higher levels of low-density lipoprotein cholesterol and total homocysteine. The genotype distribution conformed to Hardy-Weinberg equilibrium, and GTEx database demonstrated the impact of rs699517 and rs2790 on TS expression in healthy individuals and a single tissue.
BIOCHEMICAL GENETICS
(2023)