Article
Biology
Suhayla Hamad Shareef, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Morteta H. Al-Medhtiy, Mahmood Ameen Abdulla
Summary: This study evaluated the hepatoprotective effects and mechanism of green tea extract in rats with liver fibrosis induced by TAA. Green tea showed potential in inhibiting liver cirrhosis progression, reducing cellular inflammation, and restoring antioxidant enzyme levels.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ahmed A. J. Jabbar, Zaenah Zuhair Alamri, Mahmood Ameen Abdulla, Ahmed S. AlRashdi, Soran Kayfi Najmaldin, Mustafa AbdulMonam Zainel
Summary: Sinapic acid (SA) has protective effects against thioacetamide (TAA) induced fibrosis in rats by reducing hepatocyte injuries, inhibiting fibrosis, promoting heat shock protein (HSP) up-regulation, down-regulating alpha-smooth muscle actin (a-SMA) expression, and improving liver index and antioxidant enzymes levels.
Article
Biochemistry & Molecular Biology
Bukola Christiana Adedayo, Oluwapelumi S. Jesubowale, Adeniyi Abiodun Adebayo, Ganiyu Oboh
Summary: The study revealed that the aqueous extract of Andrographis paniculata had a modulatory effect on scopolamine-induced cognitive impairment, potentially useful in the treatment of memory loss.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mohamed Yousif Ibrahim, Zaenah Zuhair Alamri, Ameena S. M. Juma, Sarah Ashour Hamood, Suhayla Hamad Shareef, Mahmood Ameen Abdulla, Soher Nagi Jayash
Summary: Biochanin A (BCA) has a protective effect on thioacetamide-induced liver cirrhosis by reducing hepatocyte propagation, cell injury, and improving antioxidant enzyme activity and liver function.
Article
Biology
Suhayla H. Shareef, Morteta H. Al-Medhtiy, Ahmed S. Al Rashdi, Peshawa Y. Aziz, Mahmood A. Abdulla
Summary: The study evaluated the effect of pinostrobin on liver cirrhosis induced by TAA in rats. Pinostrobin decreased liver index, hepatocyte propagation, and cell injury. It down-regulated PCNA and alpha-SMA proliferation and increased antioxidant enzyme activities. Pinostrobin also normalized serum biomarkers and modulated inflammatory cytokines. Acute toxicity tests showed no adverse effects. The hepatoprotective effect of pinostrobin was attributed to inhibiting cirrhosis progression, reducing inflammation, and improving liver function.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biology
Manisha Parthasarathy, Sabina Evan Prince
Summary: This study aimed to investigate the potential effect of aqueous leaf extract of Andrographis paniculata against methotrexate-induced hepatotoxicity. The results confirmed the beneficial effect of Andrographis paniculata extract on restoring hepatic enzyme markers, lipid profile, antioxidant level, anti-inflammatory marker (IL-10), anti-apoptosis (bcl-2), and suppressing inflammatory cytokines (TNF-α and IL-6), apoptosis marker (caspase 3), and cellular tissue damage caused by methotrexate. Overall, Andrographis paniculata reduces oxidative stress, inflammatory processes, and apoptosis, providing protection against methotrexate-induced hepatotoxicity.
Article
Biochemistry & Molecular Biology
Sudarma Bogahawaththa, Suranga P. Kodithuwakku, Kavindra K. Wijesundera, Eranga H. Siriweera, Lalith Jayasinghe, Waruna L. Dissanayaka, Jayanthe Rajapakse, Chandana B. Herath, Tadayuki Tsujita, Missaka P. B. Wijayagunawardane
Summary: In Sri Lanka, traditional medical practitioners often prescribe herbal preparations from Osbeckia octandra for liver disorders. Experimental results show that treatments with extracts from O. octandra have significant effects in ameliorating TAA-induced liver disease, including reducing liver weight, liver enzymes, inflammatory factors, and fibrosis-related genes.
Article
Multidisciplinary Sciences
Viji Paramasivam, Prema Paulpandian, Karthikeyan Venkatachalam, Shahid Hussain, Aleyna Kangal, Dunia A. Al Farraj, Mohamed S. Elshikh, Paulraj Balaji
Summary: This study aimed to synthesize gold nanoparticles using extracts from Andrographis paniculata leaves and evaluate their efficacy against MCF7 cells and selected human pathogens. The research concluded that gold nanoparticles derived from herbs have potential in cancer therapy and antimicrobial applications, but safe dosage and precise formulation are crucial.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Medicine, Research & Experimental
Bianca Sulzbacher da Silva, Angelica Macedo Borges Paulino, Maiara Taffarel, Ian Gabriel Borba, Luciana Ortega Telles, Victor Vitorino Lima, Danilo Henrique Aguiar, Marcos Correa Dias, Andre Ferreira Nascimento, Valeria Dornelles Gindri Sinhorin, Renata de Azevedo Melo Luvizotto, Gisele Facholi Bomfim
Summary: The study showed that a high sucrose diet in animals with thioacetamide-induced cirrhosis can reduce liver fibrosis and inflammatory infiltration, improve malnutrition, and alleviate oxidative stress.
Article
Multidisciplinary Sciences
Zeinab A. El-Gendy, Salma A. El-Marasy, Rania F. Ahmed, Seham A. El-Batran, Sahar S. Abd El-Rahman, A. Ramadan, S. A. H. Youssef
Summary: The study demonstrated the significant anti-fibrotic effect of Saccharomyces cervisciae cell wall extract against thioacetamide-induced liver fibrosis in rats by attenuating oxidative stress, inflammation, improving liver function, and reducing fibrotic biomarkers.
Article
Toxicology
Sasi Kumar Murugan, Bharathi Bethapudi, Amara Nageswara Rao, Joseph Joshua Allan, Deepak Mundkinajeddu, Prashanth D'Souza
Summary: This study evaluated the safety of AP-Bio (R), a standardized extract of Andrographis paniculata, in Sprague Dawley rats. The results showed that AP-Bio (R) did not cause any treatment-related toxicity or mortality in both acute and sub-chronic toxicity studies. The study concluded that AP-Bio (R) is safe for rats at higher pharmacological doses.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Plant Sciences
Ibrahim Sulaiman, Emmanuel Oshiogwe Okwuofu, Norhafizah Mohtarrudin, Jonathan Chee Woei Lim, Johnson Stanslas
Summary: The standardized Andrographis paniculata 50% ethanol extract (APEE50) showed anti-inflammatory effects in a mouse asthma model by down-regulating Th2 cytokine gene expression and oxidative stress levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Emmanuel U. Ejiofor, Sunday O. Oyedemi, Samuel O. Onoja, Ndukaku Y. Omeh
Summary: The hydroalcoholic leaf extract of Amaranthus hybridus showed antioxidant and hepatoprotective effects on TAA-induced hepatic damage in rats, attributed to its rich antioxidant compounds and nutritional components. The extract ameliorated tissue fibrosis and prevented progression to cirrhosis.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Kadmad Abdul Hameed Mohamed Azar, Devaraj Ezhilarasan, Karthik Shree Harini, Munusamy Karthick, Mani Uthirappan
Summary: This study investigated the protective effect of Coleus vettiveroides ethanolic root extract against thioacetamide-induced acute liver injury. The results showed that the extract could inhibit liver injury, reduce the activity of serum transaminases, and alleviate oxidative stress and inflammation caused by thioacetamide, providing protection against acute liver injury.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Multidisciplinary Sciences
Hadeer M. Abouelezz, George S. G. Shehatou, Abdelhadi M. Shebl, Hatem A. Salem
Summary: This study investigated the mechanism underlying the hepatoprotective effects of pomegranate fruit extract (PFE) against thioacetamide (THIO)-induced liver fibrosis in rats. The results showed that oral PFE treatment reduced liver/body weight ratio, improved liver function markers, increased antioxidant levels, and decreased fibrosis-related markers. Histopathological examination further confirmed these findings. These results suggest that PFE administration may slow down the progression of hepatic fibrogenesis by reducing oxidative stress and profibrotic factors.
Article
Biochemistry & Molecular Biology
Madeline Louise Reilly, Marijn F. Stokman, Virginie Magry, Cecile Jeanpierre, Marine Alves, Mohammadjavad Paydar, Jacqueline Hellinga, Marion Delous, Daniel Pouly, Marion Failler, Jelena Martinovic, Laurence Loeuillet, Brigitte Leroy, Julia Tantau, Joelle Roume, Cheryl Y. Gregory-Evans, Xianghong Shan, Isabel Filges, John S. Allingham, Benjamin H. Kwok, Sophie Saunier, Rachel H. Giles, Alexandre Benmerah
HUMAN MOLECULAR GENETICS
(2019)
Letter
Dentistry, Oral Surgery & Medicine
P. Hassandarvish, V. Tiong, A. B. Sazaly, N. A. Mohamed, H. Arumugam, A. Ananthanarayanan, M. Qasuri, M. Hadjiat
BRITISH DENTAL JOURNAL
(2020)
Article
Dentistry, Oral Surgery & Medicine
Pouya Hassandarvish, Vunjia Tiong, Nurul Azmawati Mohamed, Harsha Arumugam, Abhishek Ananthanarayanan, Murtaza Qasuri, Yacine Hadjiat, Sazaly Abubakar
BRITISH DENTAL JOURNAL
(2020)
Article
Virology
Rafidah Lani, Fatima Ezzahra Agharbaoui, Pouya Hassandarvish, Boon Teong Teoh, Sing Sin Sam, Keivan Zandi, Noorsaadah Abd Rahman, Sazaly AbuBakar
Summary: The study found that the flavonoid compounds, silymarin and fisetin, can interact strongly with the nsP2 and nsP3 proteins of CHIKV, thereby inhibiting viral replication. This supports previous experimental data on the anti-CHIKV activity of these compounds by highlighting interactions with key residues in the proteins.
Article
Microbiology
Keivan Zandi, Katie Musall, Adrian Oo, Dongdong Cao, Bo Liang, Pouya Hassandarvish, Shuiyun Lan, Ryan L. Slack, Karen A. Kirby, Leda Bassit, Franck Amblard, Baek Kim, Sazaly AbuBakar, Stefan G. Sarafianos, Raymond F. Schinazi
Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic with no effective antiviral treatment available. Studies have shown that baicalein and baicalin exhibit significant antiviral activity against SARS-CoV-2 and could potentially be developed as therapeutic agents for COVID-19.
Article
Nutrition & Dietetics
Chee-Sieng Khor, Ryohei Tsuji, Hai-Yen Lee, Siti-Sarah Nor'e, Norhidayu Sahimin, Adzzie-Shazleen Azman, Vunjia Tiong, Pouya Hasandarvish, Boon-Teong Teoh, Yih-Harng Soh, Jian-Hai Chai, Takeshi Kokubo, Osamu Kanauchi, Naoki Yamamoto, Sazaly AbuBakar
Summary: The study demonstrated that oral intake of Lactococcus lactis strain plasma (LC-Plasma) significantly reduces the cumulative days with dengue fever-like symptoms, including fever, muscle pain, joint pain, and pain behind the eyes. Furthermore, the severity score of symptoms was significantly reduced in the LC-Plasma group according to subgroup analysis.
Article
Multidisciplinary Sciences
Zhao Xuan Low, Brian Ming OuYong, Pouya Hassandarvish, Chit Laa Poh, Babu Ramanathan
Summary: Silymarin and baicalein showed the potential to inhibit the dengue virus, with baicalein demonstrating better antiviral effects compared to silymarin. Both flavonoids could serve as promising antiviral agents for further development against dengue infection.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Vunjia Tiong, Pouya Hassandarvish, Sazaly Abu Bakar, Nurul Azmawati Mohamed, Wan Shahida Wan Sulaiman, Nizam Baharom, Farishah Nur Abdul Samad, Ilina Isahak
Summary: COVID-19 is challenging to contain due to high transmission rates and asymptomatic carriers. Some mouthwash formulations with cetylperidinium chloride, chlorhexidine, and hexetidine showed significant virucidal activity against SARS-CoV-2 within 30 seconds, indicating potential for reducing viral load and transmission risk.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Kim-Ling Chin, Nurhafiza Zainal, Sing-Sin Sam, Pouya Hassandarvish, Rafidah Lani, Sazaly AbuBakar
Summary: The study investigates the potential role of HMGB1 protein in Zika virus (ZIKV) infection. It is found that ZIKV infection induces translocation of HMGB1 from the nucleus to the cytoplasm, and treatment with dexamethasone reduces the release of HMGB1 and the replication of ZIKV. These findings highlight the potential of targeting HMGB1 localization as a strategy to control ZIKV infection.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Rebecca Shu Ling Tan, Pouya Hassandarvish, Chin Fei Chee, Lai Wah Chan, Tin Wui Wong
Summary: This review discusses the progress in the design and application of chitosan and its derivatives for their antiviral effects, as well as the potential of processing them into nanomedicine for higher antiviral efficacy. The aims of targeting SARS-CoV-2 and evolving virus strains with chitosan designs are also explored to meet pandemic preparedness at the early stages of outbreak.
CARBOHYDRATE POLYMERS
(2022)
Review
Immunology
Rafidah Lani, Nurul Aqidah Senin, Sazaly AbuBakar, Pouya Hassandarvish
Summary: This article discusses the implications of COVID-19 vaccination and SARS-CoV-2 infection, taking into consideration the HLA types commonly present in the Chinese, Indian, and Malay populations in Peninsular Malaysia. It explores the potential for improving vaccines through the examination of SARS-CoV-2 mutations, T cell epitopes, risk factors, and current vaccine platforms. The inclusion of non-spike SARS-CoV-2 proteins in future vaccines is highlighted as a relevant consideration.
Article
Multidisciplinary Sciences
Zheng Hua Amelia-Yap, Van Lun Low, Atiporn Saeung, Fong Lee Ng, Chee Dhang Chen, Pouya Hassandarvish, Geok Yuan Annie Tan, Sazaly AbuBakar, Adzzie Shazleen Azman
Summary: A potentially new actinobacterium, Streptomyces sp. KSF103, was isolated from forest soil. The ethyl acetate (EA) extract of this bacterium showed significant insecticidal effects against several mosquito species, including Aedes aegypti, Aedes albopictus, Anopheles cracens, and Culex quinquefasciatus. The results suggest the potential use of Streptomyces sp. KSF103 as an environmentally-friendly approach in mosquito control.
SCIENTIFIC REPORTS
(2023)
Review
Virology
Umarqayum AbuBakar, Lina Amrani, Farah Ayuni Kamarulzaman, Saiful Anuar Karsani, Pouya Hassandarvish, Jasmine Elanie Khairat
Summary: An influenza pandemic occurs when a new influenza A virus is able to infect and transmit efficiently to a new host species. The emergence of pandemics is influenced by both viral and host factors. The interaction between the virus and the host determines the virus tropism, including binding, replication, assembly, and transmission between individuals. Avian influenza virus (AIV), which mainly infects wild birds asymptomatically, can cross into new species and occasionally achieve human-to-human transmission. This review focuses on the determinants of AIV for initiating a human pandemic and discusses the mechanisms of AIV mutation for establishing tropism and stable human adaptation. Understanding AIV tropism is crucial for preventing human transmission and improving vaccine and therapeutic agent design.
Correction
Virology
Rafidah Lani, Fatima Ezzahra Agharbaoui, Pouya Hassandarvish, Boon Teong Teoh, Sing Sin Sam, Keivan Zandi, Noorsaadah Abd Rahman, Sazaly AbuBakar
Article
Microbiology
Nur-Faralyza Mohd Baharudin, Nur Adila Malek, Nurfatihah Zulkifli, Rafidah Lani, Christina Injan Mawang, Pouya Hassandarvish, Jasmine Elanie Khairat, Adzzie Shazleen Azman
Summary: This study evaluated the anticancer potential of methanolic extract of Streptomyces sp. strain KSF 83 against breast and colon cancer cell lines, showing promising anticancer activity with low toxicity towards normal cell lines.
MALAYSIAN JOURNAL OF MICROBIOLOGY
(2021)