Article
Microbiology
P. Todd Benziger, Erik J. Kopping, Patrick A. McLaughlin, David G. Thanassi
Summary: This study investigates the host apoptotic responses to F. tularensis and identifies the signaling pathways that are modulated by the bacteria to delay apoptosis and promote virulence. The findings reveal the mechanisms by which intracellular pathogens subvert host responses and enhance our understanding of the pathogenesis of tularemia.
Article
Immunology
Samantha J. Krysa, Lee-Ann H. Allen
Summary: Infection with Francisella tularensis has been found to extend the lifespan of neutrophils through metabolic reprogramming. Infected neutrophils exhibit a unique metabolic signature, including increased glycolysis and glucose uptake.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Miruna Nemecz, Diana Simona Stefan, Ioana Karla Comarita, Alina Constantin, Gabriela Tanko, Cristian Guja, Adriana Georgescu
Summary: In this study, miR-218, miR-132, and miR-143 were identified as significantly up-regulated miRNAs in both circulating MVs and plasma from diabetic patients with dyslipidemia. These miRNAs showed significant correlations with important plasma markers representative of this pathology.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Immunology
Nasibeh Mohammadi, Helena Lindgren, Masahiro Yamamoto, Amandine Martin, Thomas Henry, Anders Sjostedt
Summary: The study found that the control of BMDM infection with F. tularensis LVS or F. novicida is GBP-dependent, whereas SCHU S4 was only controlled during co-infection. The results imply that SCHU S4 has an inherent ability to evade the GBP-dependent anti-bacterial mechanisms, despite similar expression of GBPs regardless of the infecting agent.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Lara R. Mittereder, Jonathan Swoboda, Roberto De Pascalis, Karen L. Elkins
Summary: IL-12p40 is important for the clearance of F. tularensis Live Vaccine Strain (LVS) and its role is independent of its functions as a part of the heterodimeric cytokines IL-12p70 or IL-23. The absence of IL-12p40 in infected mice leads to the development of a chronic and unresolved infection. The study also investigates potential mechanisms for IL-12p40 in F. tularensis clearance.
Article
Materials Science, Multidisciplinary
Li Ping Cao, Yao Wang, Yan Bai, Yong Jian Jiang, Chun Mei Li, Yuan Fang Li, Cheng Zhi Huang, Shu Jun Zhen
Summary: The combination of Cu-MOG with EDC was utilized for the detection of miR-155, showing promising applications in bioassays and opening up a new application field of MOGs in EDC development.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Microbiology
Zhuo Ma, Matthew Higgs, Maha Alqahtani, Chandra Shekhar Bakshi, Meenakshi Malik
Summary: This study reveals the important role of thioredoxin TrxA1 in the oxidative stress response of Francisella tularensis and its regulation of the master regulator oxyR. TrxA1 is also essential for the intracellular survival and growth of Francisella. These findings provide novel insights into the oxidative stress defense mechanisms of Francisella tularensis.
JOURNAL OF BACTERIOLOGY
(2022)
Article
Immunology
Jiayi Dong, Lindsey M. Warner, Ling-Li Lin, Mei-Chi Chen, Ryan M. O'Connell, Li-Fan Lu
Summary: miR-155 plays a crucial role in promoting tT reg cell differentiation by promoting mTEC maturation in the thymus. RANKL stimulation induces miR-155 expression to target molecules within the TGF beta signaling pathway, safeguarding thymic medulla integrity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Ariana N. Renrick, Menaka C. Thounaojam, Maria Teresa P. de Aquino, Evan Chaudhuri, Jui Pandhare, Chandravanu Dash, Anil Shanker
Summary: The study demonstrates that bortezomib can enhance the function of anti-tumor CD8(+) T cells by inducing the downregulation of negative regulatory proteins SOCS1 and SHIP1 through the miR-155 pathway, thus overcoming T cell exhaustion in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Hao Wang, Haiyan Zhang, Kai Fan, Danyang Zhang, Aihau Hu, Xiangzhou Zeng, Yan Li Liu, Guanghong Tan, Hua Wang
Summary: This study found that intra-articular injection of FGS can alleviate synovial inflammation and delay the development of OA in CIOA mice. Moreover, FGS inhibits macrophage M1 polarization in vitro and in vivo, reducing the secretion of IL-6 and TNF-alpha, thus delaying cartilage and ECM degradation. FGS achieves this by partially downregulating miR-155 levels.
Article
Multidisciplinary Sciences
Mateja Ozanic, Valentina Marecic, Masa Knezevic, Ina Kelava, Pavla Stojkova, Lena Lindgren, Jeanette E. Broms, Anders Sjostedt, Yousef Abu Kwaik, Marina Santic
Summary: Francisella tularensis is a highly pathogenic bacterium that causes tularemia. The bacterium encodes a type 4 pili (T4P) system, which is important for adherence to host cells, protein secretion, and virulence. The PilO protein plays an essential role in pilus assembly, adherence to human macrophages, effector protein secretion, and intracellular replication. A pilO mutant is attenuated for virulence in mice and shows impaired phagosomal escape and replication in lung, liver, and spleen.
Article
Biochemistry & Molecular Biology
Hui-Chun Yu, Hsien-Bin Huang, Hsien-Yu Huang Tseng, Ming-Chi Lu
Summary: The role of brain-derived neurotrophic factor (BDNF) and its signaling pathway in the production of proinflammatory cytokines in macrophages was investigated. BDNF suppressed the secretion of proinflammatory cytokines and the phosphorylation of JNK, while knockout of p75 neurotrophin receptor (p75NTR) suppressed the expression and secretion of proinflammatory cytokines. BDNF upregulated the expression of miR-3168.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alvaro Cerda, Adonai Aralim Amaral, Raquel de Oliveira, Tamiris Invencioni Moraes, Aecio Assuncao Braga, Magda Elizabeth Graciano-Saldarriaga, Cristina Moreno Fajardo, Thiago Dominguez Crespo Hirata, Vivian Bonezi, Antony Brayan Campos-Salazar, Egidio Lima Dorea, Marcia Martins Silveira Bernik, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata
Summary: This study identified 10 downregulated miRNAs in MetS patients, with miR-155 potentially interacting with CEBPB in the insulin receptor signaling pathway. Downregulation of miR-155 was associated with insulin resistance, poor glycemic control, and increased MetS-related cardiometabolic risk, potentially mediated by interaction with CEBPB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jiancong Lu, Junhong Lin, Yu Zhou, Kai Ye, Changquan Fang
Summary: In NSCLC, the majority of patients have lung adenocarcinoma (LA) with varying survival rates. PYCR1 gene and miR-328-3p are associated with cancer development, with miR-328-3p targeting PYCR1 to suppress LA cell malignancy by inhibiting cell proliferation and migration while promoting apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Naveen Challagundla, Reena Agrawal-Rajput
Summary: A novel approach of microRNA-induced trans-differentiation of macrophages to induced neuronal cells without exogenous use of transcription factors was reported. The reprogramming involved alteration of pluripotency genes and miRs, with functional and active neurons obtained, suggesting potential clinical applications.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Immunology
Matthew E. Long, William E. Eddy, Ke-Qin Gong, Lara L. Lovelace-Macon, Ryan S. McMahan, Jean Charron, W. Conrad Liles, Anne M. Manicone
JOURNAL OF IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Matthew E. Long, Ke-Qin Gong, Joseph S. Volk, William E. Eddy, Mary Y. Chang, Charles W. Frevert, William A. Altemeier, Michael Gale, W. Conrad Liles, Anne M. Manicone
Article
Allergy
Sina A. Gharib, Ryan S. McMahan, William E. Eddy, Matthew E. Long, William C. Parks, Moira L. Aitken, Anne M. Manicone
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Cell Biology
Sankar Baruah, Shubha Murthy, Kathy Keck, Isabel Galvan, Allan Prichard, Lee-Ann H. Allen, Mary Farrelly, Julia Klesney-Tait
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Review
Immunology
Lee-Ann H. Allen, Alison K. Criss
CURRENT OPINION IN IMMUNOLOGY
(2019)
Article
Neurosciences
Maria Claudia Oliveira-Fusaro, Nicholas S. Gregory, Sandra J. Kolker, Lynn Rasmussen, Lee-Ann H. Allen, Kathleen A. Sluka
MOLECULAR NEUROBIOLOGY
(2020)
Editorial Material
Biochemistry & Molecular Biology
Matthew E. Long, Anne M. Manicone
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Katherine B. Hisert, Timothy P. Birkland, Kelly Q. Schoenfelt, Matthew E. Long, Brenda Grogan, Suzanne Carter, W. Conrad Liles, Edward F. McKone, Lev Becker, Anne M. Manicone, Sina A. Gharib
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Veterinary Sciences
Jessica L. Felgenhauer, Jourdan E. Brune, Matthew E. Long, Anne M. Manicone, Mary Y. Chang, Thea L. Brabb, William A. Altemeier, Charles W. Frevert
COMPARATIVE MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Ke-Qin Gong, Carmen Mikacenic, Matthew E. Long, Charles W. Frevert, Timothy P. Birkland, Jean Charron, Sina A. Gharib, Anne M. Manicone
Summary: Inhibition of MAP2K2 can improve acute lung injury (ALI) and deficiency of MAP2K2 can accelerate the resolution of ALI. Genetic variants in MAP2K2 are associated with mortality from acute respiratory distress syndrome (ARDS). MAP2K2 plays an important role in promoting and sustaining proinflammatory pathway activation in ALI.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Immunology
Rama K. Mallampalli, Jessica Adair, Ajit Elhance, Daniela Farkas, Lexie Chafin, Matthew E. Long, Mithu De, Ana L. Mora, Mauricio Rojas, Victor Peters, Joseph S. Bednash, MuChun Tsai, James D. Londino
Summary: The study revealed the presence of the interferon lambda-IFNLR1 signaling axis in human lung macrophages and highlighted the critical role of IFN lambda signaling in combating influenza infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Matthew E. Long, Rama K. Mallampalli, Jeffrey C. Horowitz
Summary: Pneumonia and acute lung injury present challenges for healthcare professionals, and understanding their pathogenesis can help improve clinical interventions.
Letter
Respiratory System
Katherine B. Hisert, Timothy P. Birkland, Kelly Q. Schoenfelt, Matthew E. Long, Brenda Grogan, Suzanne Carter, W. Conrad Liles, Edward F. McKone, Lev Becker, Anne M. Manicone
Article
Medicine, Research & Experimental
Matthew E. Long, Ke-Qin Gong, William E. Eddy, Joseph S. Volk, Eric D. Morrell, Carmen Mikacenic, T. Eoin West, Shawn J. Skerrett, Jean Charron, W. Conrad Liles, Anne M. Manicone
Article
Cell Biology
Lauren C. Kinkead, Laura C. Whitmore, Jenna M. McCracken, Joshua R. Fletcher, Brandi B. Ketelsen, Justin W. Kaufman, Bradley D. Jones, David S. Weiss, Jason H. Barker, Lee-Ann H. Allen
CELLULAR MICROBIOLOGY
(2018)