Article
Cell Biology
Youkun Bi, Zhiguang Yang, Meng Jin, Kui Zhai, Jun Wang, Yang Mao, Yang Liu, Mingqin Ding, Huiwen Wang, Fengchao Wang, Hong Cai, Guangju Ji
Summary: This study demonstrates that the ERp44 gene plays a crucial role in the formation of endocardial cushions during heart development. It affects the development of the endocardial cushion by influencing VEGFA-mediated endocardial-mesenchymal transition.
CELL PROLIFERATION
(2022)
Article
Neurosciences
Guangmin Xu, Zigang Huang, Jiajing Sheng, Xiang Gao, Xin Wang, Jason Q. Garcia, Guanyun Wei, Dong Liu, Jie Gong
Summary: The study revealed the crucial role of fgfbp3 in axonal morphogenesis and regeneration of motor neurons in zebrafish, with loss of fgfbp3 leading to defects that can be partially rescued by fgfbp3 mRNA injection and overexpression. Transcriptome sequencing identified drd1b and neurod6a as potential rescuers for motor neuron malformation in fgfbp3 knockout embryos.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoming Zhao, Ti Shao, Yazhi Su, Jing Zhang, Xin Gou, Weimin Liu, Jianzhen Zhang
Summary: LmACP19 is a crucial gene in wing development and morphogenesis in Locusta migratoria, as it maintains the stability of epidermal cells and plays an essential role in the formation of normal wing structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Entomology
Xuekai Shi, Xiaojian Liu, Kristopher Silver, Kun Yan Zhu, Jianzhen Zhang
Summary: The study identified the important role of LmLgl in maintaining tissue structure and normal morphogenesis in Locusta migratoria. Silencing LmLgl resulted in increased body size but decreased bodyweight, as well as abnormal morphological structure in the midgut. This discovery may contribute to the development of dsRNA-based biological pesticides for insect pest management.
Article
Multidisciplinary Sciences
Paige V. Blinkiewicz, Makayla R. Long, Zachary A. Stoner, Elizabeth M. Ketchum, Sydney N. Sheltz-Kempf, Jeremy S. Duncan
Summary: This study demonstrates that Gata3 plays a crucial role in the development of sensory and neuronal cells in late proneurosensory stages. It is not only required for proper formation at the later proneurosensory stage, but also shows a time-sensitive and dose-dependent effect.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Cristina M. Cummings, Jeffrey D. Singer
Summary: Cul3 plays a crucial role in mammary gland development, as demonstrated by delays and defects observed in mice with Cul3 deletion in the mammary gland. While not essential for mammary gland function, Cul3 is required for normal development of the mammary gland.
CELL AND TISSUE RESEARCH
(2021)
Article
Cell Biology
Jianqiu Zou, Wenjuan Wang, Yi Lu, Juan Ayala, Kunzhe Dong, Hongyi Zhou, Jinxi Wang, Weiqin Chen, Neal L. Weintraub, Jiliang Zhou, Jie Li, Huabo Su
Summary: Cardiac maturation is regulated by neddylation, a post-translational modification process. Mosaic deletion of NAE1, a necessary enzyme for neddylation, in neonatal hearts leads to cardiomyopathy and heart failure. Neddylation is involved in transverse tubule formation, physiological hypertrophy, and fetal-to-adult isoform switching, promoting cardiac maturation through oxidative metabolism.
Article
Medicine, General & Internal
Julian Jakob, Odile Stalder, Tali Kali, Etienne Pruvot, Mark J. Pletcher, Jamal S. Rana, Stephen Sidney, Reto Auer
Summary: Recent current cannabis use is associated with lower resting heart rate, but this association appears to be transient as past cumulative exposure to cannabis was not related to heart rate.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shi Hao Lee, Yeannie H. Y. Yap, Chew Leng Lim, Amanda Rui En Woo, Valerie C. L. Lin
Summary: This study reveals the crucial role of the activation function AF1 of progesterone receptor (PGR) in mammary development. Gain of function mutant AF1_QQQ shows hyperactivity while loss of function mutant AF1_FFF exhibits hypoactivity on mammary development. AF1_FFF mutation significantly impairs mammary development in response to estrogen and progesterone and during pregnancy, but has no effect on mammary development in nulliparous mice. Furthermore, Rankl is identified as a major target gene of AF1.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Cell Biology
Pooja Popli, Ramakrishna Kommagani
Summary: Autophagy plays a crucial role in the normal growth and morphogenesis of various tissues, including the uterus. Our study reveals that BECN1-dependent autophagy is essential for stem cell-mediated endometrial programming and the establishment of pregnancy in mice. Inhibition of BECN1-mediated autophagy leads to severe endometrial defects and infertility, highlighting the critical role of autophagy in maintaining endometrial homeostasis and uterine differentiation.
Article
Cardiac & Cardiovascular Systems
Francesco Gentile, Vincenzo Castiglione, Raffaele De Caterinao
Summary: CAAs are a group of congenital conditions characterized by abnormal origin or course of the 3 main epicardial coronary arteries. While they have been identified as a common underlying condition in young athletes, their recognition among adults has increased with the widespread use of invasive and noninvasive coronary imaging. The clinical correlates and therapeutic choices for CAAs remain poorly understood, with studies suggesting that multimodality imaging may play a key role in management.
Article
Developmental Biology
Brent H. Wyatt, Nirav M. Amin, Kristen Bagley, Dustin Wcisel, Michael K. Dush, Jeffrey A. Yoder, Nanette M. Nascone-Yoder
Summary: This study reveals the role of single-minded 2 gene in regulating left-right symmetry in the development of frog embryo stomach, further illustrating the importance of laterality factors in morphogenesis.
Article
Biology
Eric Paulissen, Nicholas J. Palmisano, Joshua S. Waxman, Benjamin L. Martin
Summary: This study reveals the critical role of somite morphogenesis in organizing surrounding tissues to facilitate notochord positioning and angioblast migration, ultimately leading to the formation of a functional cardiovascular system in zebrafish embryos.
Review
Developmental Biology
Christopher J. Derrick, Emily S. Noel
Summary: This review discusses the spatiotemporal changes in ECM composition during cardiac development, highlighting the essential role of ECM in heart morphogenesis and potential for heart regeneration.
Article
Cell Biology
Yang Li, Shuting Yang, Ling Qin, Shuying Yang
Summary: Chondrogenesis is regulated by the transcriptional coactivator TAZ, whose expression increases during chondrogenic differentiation. TAZ deletion impairs skeletal development, joint maintenance, and fracture healing by affecting chondrocyte proliferation and differentiation, and interacting with Sox5.
Article
Materials Science, Multidisciplinary
Chenyu Yao, Libo Zhang, Yulu Chen, Cheng Guo, Liu Yang, Yang Lu, Kai Zhang, Lin Wang, Xiaoshuang Chen
Summary: Topological insulators (TIs) are being extensively studied in condensed matter physics due to their unique electronic properties. However, current research on the photocurrent generation in topological surface states (TSS) lacks sufficient evidence to differentiate from bulk states, which hampers their application in optoelectronics. In this study, the synthesis of GeBi4Te7 crystal through chemical vapor transport (CVT) with Ge intercalation is achieved, resulting in isolated Dirac points and high-mobility Dirac carriers, as well as larger Seebeck coefficients. A GeBi4Te7-based antenna-coupled photodetector is then developed, demonstrating sensitive terahertz response without bias. The GeBi4Te7-based photodetector exhibits a short response time and high photoresponsivity, with the potential for further improvement using the GeBi4Te7-graphene heterostructure.
PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Kaixuan Zhang, Zhen Hu, Libo Zhang, Yulu Chen, Dong Wang, Mengjie Jiang, Gianluca D'Olimpio, Li Han, Chenyu Yao, Zhiqingzi Chen, Huaizhong Xing, Chia-Nung Kuo, Chin Shan Lue, Ivana Vobornik, Shao-Wei Wang, Antonio Politano, Weida Hu, Lin Wang, Xiaoshuang Chen, Wei Lu
Summary: This study exploits low-energy type-II Dirac fermions in topological semimetals for ultrasensitive THz detection, and demonstrates a novel photodetector combining two Dirac materials, graphene and NiTeSe, with high responsivity, fast response time, and outstanding stability.
Article
Chemistry, Physical
Chunyu Li, Guiyu Jiang, Hongying Xia, Libo Zhang
Summary: In this study, Cu-Mn doped catalysts were synthesized using SiO2, gamma-Al2O3, and Beta molecular sieve as carriers for the catalytic degradation of propane. The modified H-Cu-Mn-Beta molecular sieve catalyst exhibited large pore size, smooth surface, good adsorption performance, and the highest catalytic degradation effect on propane. The optimized process conditions were determined through single factor tests: Cu: Mn = 2:1, pickling temperature of 50 degrees C, microwave calcination temperature of 500 degrees C, and a holding time of 40 min. The catalyst prepared under these conditions showed high catalytic activity, maintaining a degradation rate above 82.7% within 36 h at a temperature of 500 degrees C.
CATALYSIS COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Ya-Dong Li, Yan-Jia Luo, Ling Xie, Dalton S. Tart, Ryan N. Sheehy, Libo Zhang, Leon G. Coleman, Xian Chen, Juan Song
Summary: Patients with Alzheimer's disease (AD) show memory loss, depression, and anxiety, along with impaired adult hippocampal neurogenesis (AHN). This study demonstrates that optogenetic stimulation of the hypothalamic supramammillary nucleus (SuM) enhances AHN in AD mouse models, improving memory and emotion deficits. Activation of SuM-enhanced adult-born neurons (ABNs) triggers synaptic plasticity and microglia phagocytosis, providing insights into the signaling mechanisms involved.
Article
Physics, Multidisciplinary
Qing-Xin Dong, Bin-Bin Ruan, Yi-Fei Huang, Yi-Yan Wang, Li-Bo Zhang, Jian-Li Bai, Qiao-Yu Liu, Jing-Wen Cheng, Zhi-An Ren, Gen-Fu Chen
Summary: We conducted a comprehensive study on the layered-structure compound NaZn4As3 and found that it undergoes a structural transformation from rhombohedral to monoclinic phase with temperature. The electric resistivity shows a metal-to-insulator-like transition at around 100 K and then develops a plateau at low temperature, indicating the presence of protected topologically conducting surface states. First-principles calculations confirmed that NaZn4As3 is a topological insulator in both phases rather than a topological semimetal as previously proposed. The Hall resistivity indicates a dominance of hole carriers in the transport properties across the temperature range, and the thermopower exhibits a noticeable kink possibly related to the structure transition around 170 K. The large thermopower and moderate kappa suggest that NaZn4As3 and its derivatives can be a promising platform for optimizing and studying thermoelectric performance.
Article
Computer Science, Artificial Intelligence
Ruyi Ji, Jiaying Li, Libo Zhang
Summary: In this paper, a new Siamese Self-supervised Learning method is proposed to align different views of one image using attention mechanism and Siamese network. The center loss is introduced to ensure consistency between different views. Experimental results show that the proposed method performs on par with the state-of-the-art methods on three public benchmarks.
COMPUTER VISION AND IMAGE UNDERSTANDING
(2023)
Article
Immunology
Jing Ding, Changli Yue, Chengshuo Wang, Wei Liu, Libo Zhang, Bo Chen, Shen Shen, Yingshi Piao, Luo Zhang
Summary: This study aimed to establish the CRSAI 1.0, a convenient and accurate evaluation platform for chronic rhinosinusitis, based on four phenotypes of nasal polyps. Tissue sections were analyzed using the Unet++ algorithm with Efficientnet-B4 backbone to remove redundant tissues. Four types of inflammatory cells were detected and used to train the CRSAI 1.0. The results showed that CRSAI 1.0 can accurately identify various types of inflammatory cells in CRSwNP, enabling rapid diagnosis and personalized treatment.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Neurosciences
Xuejing Lu, Xin Hou, Libo Zhang, Hong Li, Yiheng Tu, Huqing Shi, Li Hu
Summary: Music shows great potential in pain relief due to its non-pharmacological nature, but the specific mechanisms behind music-induced analgesia (MIA) are not well understood. Positive emotional state induced by music is one of the key factors explaining MIA.
HUMAN BRAIN MAPPING
(2023)
Article
Engineering, Electrical & Electronic
Boying Wang, Ruyi Ji, Libo Zhang, Yanjun Wu
Summary: This paper proposes a multi-scale context-aware feature pyramid network that leverages cross-scale context aggregation block and adaptive context aggregation block to make full use of context information in the feature pyramid, improving the effectiveness of object detection.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Mengjie Jiang, Huaizhong Xing, Libo Zhang, Li Han, Kaixuan Zhang, Chenyu Yao, Dong Wang, Xiaodong Wang, Shiqi Lan, Xuyang Lv, Lin Wang
Summary: This paper demonstrates the direct detection of terahertz waveband using the bolometer effect and photo-thermoelectric effect. The 2H-NbSe2-based device with van der Waals heterostructure exhibits excellent sensitivity, self-powered photo-thermoelectric conversion, and low noise at room temperature, making it suitable for applications in various sectors. This versatile photodetector provides an opportunity for practical energy harvesting by detecting low-energy photons through hybrid integration of low-dimensional materials.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jian Wang, Changlong Liu, Libo Zhang, Jin Chen, Jian Chen, Feilong Yu, Zengyue Zhao, Weiwei Tang, Xin Li, Shi Zhang, Guanhai Li, Lin Wang, Ya Cheng, Xiaoshuang Chen
Summary: By using a ferroelectric-controlled van der Waals photodetector with vertically stacked 2D black phosphorus/indium selenide heterostructures, high-sensitivity photodetection can be achieved with fast response, self-driven operation, and three orders of magnitude detection improvement in the visible or near-infrared operation bands.
Article
Crystallography
Shijian Tian, Libo Zhang, Yuan Liang, Ruikuan Xie, Li Han, Shiqi Lan, Aijiang Lu, Yan Huang, Huaizhong Xing, Xiaoshuang Chen
Summary: The electronic and magnetic properties of Ga14N16-nGd2Cn monolayers were investigated through first principle calculation. The study considered the generalized gradient approximation (GGA) of density functional theory with the on-site Coulomb energy U (GGA + U). It was found that the magnetic moment of Ga14N16Gd2 monolayer is 14 mu B with an antiferromagnetic (AFM) phase. The substitutional impurity of C atoms effectively changed the magnetic state of Ga14N16-nGd2Cn monolayers to ferromagnetic phases (FM), with an increase in magnetic moment of 1 mu B/1C. The stable FM phase was attributed to the p-d coupling orbitals between C-2p and Gd-5d states. Moreover, a Curie temperature (T-C) close to room temperature (T-R, 300 K) was observed in Ga14N16Gd2C2 monolayer, with the highest value reaching 261.46 K. The strain effect had a significant positive impact on the TC of Ga14N16-nGd2Cn monolayer, surpassing TR, with the highest value at 525.50 K. This provides an opportunity to further explore the application of two-dimensional magnetic materials in spintronic devices.
Article
Physics, Multidisciplinary
Chenyu Yao, Mengjie Jiang, Dong Wang, Libo Zhang, Ning Zhang, Lin Wang, Xiaoshuang Chen
Summary: A self-mixing terahertz detector based on a hemispherical silicon lens and antenna-coupled InGaAs/AlGaAs high electron mobility transistor (HEMT) is developed, enabling wide spectrum detection and improved performance.
FRONTIERS IN PHYSICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Pinyu Liu, Qingxin Dong, Binbin Ruan, Libo Zhang, Jianli Bai, Jingwen Cheng, Qiaoyu Liu, Cundong Li, Yingrui Sun, Yu Huang, Gang Li, Zhian Ren, Genfu Chen
Summary: A new quasi-one-dimensional compound KNi5Bi5.6 has been synthesized and its crystal structure has been determined. The structure consists of double-walled anionic nanowires [Ni5Bi5.6] separated by potassium cations. KNi5Bi5.6 belongs to a new series of compounds with [Ni5Bi5.6]x (x = 1+, 0, 1-) nanowires, which can have cationic, neutral or anionic charge without significantly affecting the structure and composition. This provides a new platform for studying charge invertible quasi-one-dimensional transition metal systems. Resistivity measurement shows metallic conductivity and magnetic susceptibility exhibits modified Curie-Weiss behavior with weak magnetic anisotropy.
JOURNAL OF SOLID STATE CHEMISTRY
(2023)
Letter
Cardiac & Cardiovascular Systems
Jingdong Wu, Hong Zhao, Yanmeng Tao, Chunyan Yang, Yang Yang, Bin Zhou, Yang Zhao
