Article
Biochemistry & Molecular Biology
Joon Seok Lee, Gyeong Hwa Kim, Jong Ho Lee, Jeong Yeop Ryu, Eun Jung Oh, Hyun Mi Kim, Suin Kwak, Keun Hur, Ho Yun Chung
Summary: In this study, miR-365a/b-3p was identified as a potential biomarker for hypertrophic scarring, suggesting its contribution to the formation of hypertrophic scars.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Larissa Costa de Almeida, Jorge Antonio Elias Godoy Carlos, Paula Rezende-Teixeira, Joao Agosrinho Machado-Neto, Leticia Veras Costa-Lotufo
Summary: This study investigated the potential of the multikinase inhibitor AD80 as a drug option for colorectal cancer therapy. Results showed that AD80 selectively reduces cell viability of CRC cells by targeting the upregulated PI3K/AKT/mTOR and MAPK signaling pathways, suggesting AD80 as a promising candidate for colorectal cancer treatment by inhibiting tumor growth via multiple mechanisms, including clonogenicity inhibition, G(2)/M arrest, DNA damage, apoptosis, and inhibition of S6RP phosphorylation.
Article
Chemistry, Medicinal
Chungen Li, Yue Zhou, Jing Xu, Xia Zhou, Zongkai Huang, Ting Zeng, Xiaowei Yang, Lei Tao, Kun Gou, Xi Zhong, Qiang Chen, Youfu Luo, Yinglan Zhao
Summary: In this study, thirty-seven novel teriflunomide derivatives were designed, synthesized, and evaluated. The optimal compound A37 exhibited potent hDHODH inhibitory activity and favorable antiproliferative activity, showing potential in the treatment of colorectal carcinoma.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chun Chen, Yifei Zhang, Yupeng Liu, Lei Hang, Jun Yang
Summary: The study revealed that SFRP1 is universally downregulated in oral squamous cell carcinoma (OSCC), low expression of which is significantly associated with advanced disease stage and poor prognosis. SFRP1 exerts a positive effect on tumor immune infiltration, with functional annotations indicating enrichment in calcium pathway and neuroactive ligand-receptor interaction.
Article
Chemistry, Medicinal
Xue-Mei Zheng, Yuan-Si Chen, Yu-Juan Ban, Yu-Jie Wang, Yong-Xi Dong, Li Lei, Bing Guo, Jian-Ta Wang, Lei Tang, Hong-Liang Li, Ji-Quan Zhang
Summary: In this study, a series of substituted benzoxazole derivatives were designed and synthesized. The compound 18a showed higher inhibitory activity against PI3Kα and better anti-cancer effects, as well as improved selectivity and pharmacokinetic properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Ji Hyung Hong, In Sook Woo
Summary: The use of immune checkpoint inhibitors (ICIs) in clinical practice for the treatment of metastatic colorectal cancer (mCRC) is currently limited to a small subset of patients. Combining ICIs with anti-angiogenic inhibitors has shown promising efficacy in early phase trials. Additionally, low-dose metronomic (LDM) chemotherapy has potential as a combination partner with ICIs for immunologically cold mCRC tumors.
Review
Oncology
Huimin Lei, Ading He, Yingying Jiang, Min Ruan, Nannan Han
Summary: Cells experience DNA damage daily and have evolved DNA damage response (DDR) pathways to repair DNA damage. Defects in DDR pathways are closely related to the occurrence, development, and treatment of head and neck squamous cell carcinoma (HNSCC). Therefore, targeting DNA repair pathways may be a promising treatment for HNSCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Gaopan Dong, Xiaohan Ye, Shumei Wang, Wenhua Li, Rong Cai, Lupei Du, Xiaodong Shi, Minyong Li
Summary: This study reports a novel TrxR inhibitor Au-24 and its inhibitory ability to hepatocellular carcinoma in vitro and in vivo. Au-24 suppresses the proliferation of HepG2 cells through regulating multiple signaling pathways and inducing oxidative stress. In vivo experiments demonstrate that Au-24 is more effective than the traditional drug AA1 in inhibiting tumor growth.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tianwei Niu, Peipei Wang, Cheng Li, Tong Dou, Huri Piao, Jia Li, Liangpeng Sun
Summary: Two series of 5-aryl-furan derivatives with a phenylalanine- or isoleucine-derived rhodanine moiety were identified as competitive PTP1B inhibitors. Compound 5g showed the best PTP1B inhibitory potency and CDC25B inhibitory potency, with the introduction of a sec-butyl group at the 2-position of the carboxyl group significantly improving the PTP1B inhibitory activity.
BIOORGANIC CHEMISTRY
(2021)
Article
Cell Biology
Yanhong Wang, Jiaqi Wang, Lingrong Yang, Liqing Qiu, Yuhui Hua, Shixiu Wu, Su Zeng, Lushan Yu, Xiaoli Zheng
Summary: The repression of PEPT1 in human colorectal cancer is due to DNA methylation mediated by DNMT1 and histone deacetylation mediated by HDAC1, which plays a vital role in the poor response of CRC to the common treatment ubenimex.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Savinee Chanvijit, Suttinee Phuagkhaopong, Panupong Mahalapbutr, Methus Klaewkla, Warinthorn Chavasiri, Piyanuch Wonganan
Summary: The study found that Mansonone G (MG) and its derivatives exhibited concentration-dependent cytotoxicity on CRC cell lines, with allyl ether mansonone G (MG7) being the most toxic. MG7 induced ROS generation and apoptosis, and modulated protein expression and signaling pathways related to cell survival and proliferation. Molecular docking analysis revealed the potential binding of MG7 to ATP-binding pockets of AKT and ERK1 proteins.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Eiji Kobayashi, Satoru Kondo, Hirotomo Dochi, Makiko Moriyama-Kita, Nobuyuki Hirai, Takeshi Komori, Takayoshi Ueno, Yosuke Nakanishi, Miyako Hatano, Kazuhira Endo, Hisashi Sugimoto, Naohiro Wakisaka, Tomokazu Yoshizaki
Summary: This article provides an overview of the molecular pathogenesis of nasopharyngeal carcinoma, focusing on the potential of farnesylation as a therapeutic target.
Article
Immunology
Chao Liu, Huiting Xiao, Luying Cui, Lin Fang, Shuling Han, Yuli Ruan, Wenyuan Zhao, Yanqiao Zhang
Summary: This study found that MSS-CRC patients with epigenetic-related gene mutations may benefit more from immune checkpoint inhibitor therapy, as these mutations are associated with increased tumor mutation burden, frameshift mutations, and favorable clinical outcomes. Epigenetic regulation impairment in MSS-CRC patients creates an immunologically active environment, making them more susceptible to ICIs treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yinnan Chen, Quanpeng Qiu, Junjun She, Jun Yu
Summary: Extrachromosomal circular DNA (ecDNA) is highly prevalent in various cancers, including colorectal cancer (CRC), and plays a critical role in regulating oncogene expression and resistance to therapy. Understanding the mechanisms and features of ecDNA in CRC provides insights into its pathogenesis and potential diagnostic and therapeutic implications. This review discusses the biogenesis, distinct features, and functional roles of ecDNA in CRC, including its involvement in oncogene overexpression, gene regulation, and topological interactions with active chromatin.
Article
Chemistry, Medicinal
Elin Julianti, Ikram Ammar Abrian, Marlia Singgih Wibowo, Muhammad Azhari, Nadya Tsurayya, Fauzia Izzati, Ario Betha Juanssilfero, Asep Bayu, Siti Irma Rahmawati, Masteria Yunovilsa Putra
Summary: This review presents recent updates on marine-derived fungi and actinobacteria as novel alternatives for cytotoxic agents against colorectal cancer. The study groups the compounds based on their chemical structures, with indole alkaloids and diketopiperazines found to be the most potent compounds.
