Article
Biochemistry & Molecular Biology
Lei Xu, Fengling Shao, Tengling Luo, Qijun Li, Dongmei Tan, Yi Tan
Summary: This study evaluated the role of CHD5 in tumor immunity using multiple databases. The results showed differential expression of CHD5 in tumor tissues and its association with prognosis in glioma patients. Experimental findings further confirmed the impact of CHD5 on glioma cell proliferation and migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Qiangan Jing, Chen Yuan, Chaoting Zhou, Weidong Jin, Aiwei Wang, Yanfang Wu, Wenzhong Shang, Guibing Zhang, Xia Ke, Jing Du, Yanchun Li, Fangchun Shao
Summary: CLEC1B, encoding the CLEC-2 protein, is involved in platelet activation, angiogenesis, and immune and inflammatory responses. This study found that CLEC1B is downregulated in hepatocellular carcinoma (HCC) and has a good clinical prognostic value. CLEC1B expression is closely associated with immune cell infiltration and correlates with a variety of immunomodulators in the HCC tumor microenvironment. Furthermore, CLEC1B and its related genes or interacting proteins are implicated in multiple immune-related processes and signaling pathways. Overexpression of CLEC1B significantly influences the treatment effects of sorafenib on HCC cells.
CANCER CELL INTERNATIONAL
(2023)
Article
Biology
Ning Wang, Yuanyuan Li, Xue Zhou, Xue Wang, Guoyue Yang
Summary: This study found that ARHGEF6 was significantly downregulated in lung adenocarcinoma tissues and had high diagnostic value. Low expression of ARHGEF6 was associated with more somatic mutations, worse tumor stage, and poor clinical prognosis. Experimental validation showed that low expression of ARHGEF6 inhibited cell proliferation and colony formation. Additionally, ARHGEF6 expression was positively correlated with immune cell infiltration and immune checkpoints. Overall, ARHGEF6 could be a potential prognostic and immunological biomarker in lung adenocarcinoma.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jesus D. Melendez-Flores, Alexandra Carolina Cavazos-Benitez, Ingrid Estrada-Bellmann
Summary: Parkinson's disease is a neurodegenerative condition associated with various metabolic factors, such as proteinuria. Microalbuminuria may serve as a potential marker for evaluating PD severity, reflecting common pathological mechanisms including oxidative stress, insulin resistance, and endothelial dysfunction. Further evidence from white matter lesions suggests that microalbuminuria could provide insight into PD status and further research is needed to confirm this hypothesis.
MEDICAL HYPOTHESES
(2021)
Article
Clinical Neurology
Zhenwei Yu, Genliang Liu, Yuanchu Zheng, Guoshi Huang, Tao Feng
Summary: Through studying the levels of α-synuclein in the blood of patients with essential tremor (ET) and Parkinson's disease (PD), it was found that the levels of α-synuclein were significantly increased in both ET and PD patients compared to healthy controls. Additionally, the levels of aggregated α-synuclein were significantly decreased in ET patients compared to PD patients and healthy controls. These findings provide new insights into the potential use of α-synuclein as a biomarker for ET patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Genetics & Heredity
Huifang Xu, Linfang Zhang, Xiujuan Xia, Wei Shao
Summary: This study identified five mRNA biomarkers associated with survival in glioblastoma patients and successfully verified their prognostic value. These findings provide new prospective prognostic biomarkers for glioblastoma.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Bo Chen, Yongjun Wang, Qing Wang, Dingqi Li, Xiaotan Huang, Xiaojin Kuang, Shuzhong Wang, Zhaotun Hu
Summary: Crohn's disease is characterized by chronic inflammation of the gastrointestinal tract. This study used untargeted metabolomics analysis to identify potential biomarkers for CD diagnosis. Lipid metabolism was found to be significantly associated with CD pathogenesis, and specific metabolites such as ceramide, phosphatidylethanolamine, and taurochenodeoxycholic acid showed high predictive accuracy for CD patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Yuanchu Zheng, Zhenwei Yu, Jiajia Zhao, Huihui Cai, Zhan Wang, Xuemei Wang, Tao Feng
Summary: This study demonstrated for the first time increased expressions of alpha-Syn, pS129, and oligomeric alpha-Syn in oral mucosa cells from PD patients, which serve as useful and non-invasive PD diagnostic biomarkers.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Zhi-ting Chen, Chu-zhui Pan, Xing-lin Ruan, Li-ping Lei, Sheng-mei Lin, Yin-zhou Wang, Zhen-Hua Zhao
Summary: This study found that the levels of ferritin and TfR in plasma neural-derived exosomes of patients with PD were significantly higher, suggesting that they may serve as potential biomarkers for PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Mohamed Samir A. Zaki, Muhammad Alaa Eldeen, Waleed K. K. Abdulsahib, Ayed A. A. Shati, Youssef A. A. Alqahtani, Saleh M. M. Al-Qahtani, Hassan M. M. Otifi, Ashwag Asiri, Hesham M. M. Hassan, Hebatallah Emam Mohammed Ahmed, Samy A. A. Dawood, Amr Negm, Refaat A. A. Eid
Summary: Emerging research has found that the protein CEP55 may function as an oncogene in various human malignancies. However, there has been no comprehensive analysis conducted to investigate the role and behavior of CEP55 as an oncogene in different types of cancer. This study aims to provide a detailed analysis of CEP55, including its expression in different cancers, correlation with cancer stage, impact on patient survival, genetic alterations, methylation status, influence on immune cell infiltration, response to chemotherapeutic agents, and underlying molecular mechanisms. The findings suggest that CEP55 is upregulated in cancer tissues compared to normal controls and this upregulation is associated with poor prognosis in multiple forms of cancer. It also affects immune cell infiltration, chemokine levels, and response to anticancer drugs. Therefore, CEP55 could serve as a potential predictive marker and therapeutic target for cancer treatment.
Article
Immunology
Pingxin Zhang, Hang Gao, Chunwei Ye, Ruping Yan, Lu Yu, Chengxing Xia, Delin Yang
Summary: KIF2C is significantly up-regulated in prostate cancer and is associated with unfavorable prognosis, clinicopathological features, immune cell infiltration, cell cycle, and immune response. It is also linked to the tumor microenvironment, infiltrating cells, and immune checkpoint genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Tiegang Li, Weiqi Wang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Zheng Yan, Rixin Zhang, Min Yang
Summary: This study identified blood biomarkers for hypertensive left ventricular hypertrophy (LVH) using bioinformatics tools and experimental verification. LAPTM5 was found to be a potential diagnostic marker for LVH in patients with hypertension (HT).
Article
Nutrition & Dietetics
Shihona Ogino, Noriyoshi Ogino, Kotomi Tomizuka, Masamitsu Eitoku, Yosuke Okada, Yoshiya Tanaka, Narufumi Suganuma, Keiki Ogino
Summary: This study explored the mRNA levels of superoxide dismutase 2 in blood as a potential biomarker for exercise in healthy individuals. Results suggest that this could be a useful biomarker for monitoring exercise habits, particularly in non-smokers.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2021)
Article
Immunology
Junhong Shi, Meiyu Bao, Weifeng Wang, Xuan Wu, Yueying Li, Changdong Zhao, Weiwei Liu
Summary: PLOD3 is highly expressed in colorectal cancer and associated with advanced stage CRC and poor survival. High PLOD3 expression is correlated with low levels of immune cells such as B cells, CD4(+) T cells, M1 macrophages, and CD8(+) T cells. Patients with high PLOD3 expression may be resistant to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Donghai Zhou, Xue Yu, Kai Yu, Yating Ren, Kepeng Yang, Xinchang Wang, Qiao Wang
Summary: An integrated analysis of sequencing data identified SAMD9L as a promising biomarker for primary Sjogren's syndrome (pSS), with potential diagnostic and clinical significance. SAMD9L expression correlated with disease severity and showed high diagnostic performance for pSS.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jose A. Santiago, Virginie Bottero, Judith A. Potashkin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Judith A. Potashkin, Virginie Bottero, Jose A. Santiago, James P. Quinn
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Clinical Neurology
Thomas B. Stoker, Marta Camacho, Sophie Winder-Rhodes, Ganqiang Liu, Clemens R. Scherzer, Thomas Foltynie, Jonathan Evans, David P. Breen, Roger Barker, Caroline H. Williams-Gray
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2020)
Letter
Clinical Neurology
Thomas B. Stoker, Marta Camacho, Sophie Winder-Rhodes, Ganqiang Liu, Clemens R. Scherzer, Thomas Foltynie, Roger A. Barker, Caroline H. Williams-Gray
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2020)
Editorial Material
Clinical Neurology
Clemens R. Scherzer, Trond Riise, Joseph J. Locascio
Article
Neurosciences
Rachit Bakshi, Eric A. Macklin, Albert Y. Hung, Michael T. Hayes, Bradley T. Hyman, Anne-Marie Wills, Stephen N. Gomperts, John H. Growdon, Alberto Ascherio, Clemens R. Scherzer, Michael A. Schwarzschild
JOURNAL OF PARKINSONS DISEASE
(2020)
Review
Geriatrics & Gerontology
Jose A. Santiago, Judith A. Potashkin
Summary: Alzheimer's disease (AD) is often accompanied by a variety of other chronic diseases, including diabetes and cardiovascular disease, which may increase the risk of AD. Research suggests that disruption in several shared biological pathways could be the underlying mechanism for the association between AD and these comorbidities. Inflammation is considered a common dysregulated pathway shared by most comorbidities associated with AD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jose A. Santiago, James P. Quinn, Judith A. Potashkin
Summary: This study identified switch genes associated with drastic transcriptomic changes in ALS patients' blood, revealing potential sex-specific roles in the disease mechanism, with males showing metabolic pathway enrichment and females related to infectious diseases and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Virginie Bottero, Fahed Alrafati, Jose A. Santiago, Judith A. Potashkin
Summary: Frontotemporal lobar degeneration (FTLD) or frontotemporal dementia (FTD) is characterized by a progressive decline in executive function, affecting approximately 50-60,000 Americans. There are familial and sporadic forms of FTD, with GRN progranulin and C9orf72 mutations being common causes. Dysregulated genes in FTD are mainly found in the frontal cortex and Brodmann's area 8, with different signaling pathways associated with familial and sporadic forms. Therapeutic agents such as valproic acid may be beneficial in treating patients with FTD.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jose A. Santiago, James P. Quinn, Judith A. Potashkin
Summary: Physical activity has been found to have beneficial effects on brain health by offsetting cognitive decline and dementia. This study used bioinformatic methods to analyze the molecular mechanisms of physical activity in the brain. The results show that physical activity influences transcriptional changes in the brain through different pathways, providing neuroprotection in various neurodegenerative diseases by modulating protein processing, metabolic control, and synaptic signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Virginie Bottero, Jose A. Santiago, James P. Quinn, Judith A. Potashkin
Summary: This study directly investigates the root cause of ALS by examining the changes in gene expression in degenerated motor neurons of ALS patients. It identifies 610 switch genes enriched in several pathways and identifies ELK1 and GATA2 as key regulators. Potential therapeutics for ALS are also suggested. Furthermore, the study highlights metals and organic compounds as possible mediators of neurodegeneration.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Jose A. Santiago, James P. Quinn, Judith A. Potashkin
Summary: Sex-specific differences may contribute to the development of Alzheimer's disease, but the molecular mechanisms behind these differences are not well characterized. This study analyzed transcriptional changes in the brain of AD patients and identified sex-specific signatures and pathways that may be involved in AD progression.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jose A. Santiago, James P. Quinn, Judith A. Potashkin
Summary: Loneliness and social isolation have negative effects on mental health, and can lead to cognitive impairment and neurodegenerative diseases. Through bioinformatics analysis, we identified molecular mechanisms and genes associated with loneliness, which are also linked to neuropsychiatric and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Jose A. Santiago, Judith A. Potashkin
Summary: Neurodegenerative diseases have increased significantly in the past decade. Physical activity has emerged as the most accessible lifestyle modification to combat cognitive decline and neurodegeneration. This review discusses the potential of lifestyle modifications, including physical activity, diet, cognitive training, and sleep hygiene, to treat and prevent neurodegenerative diseases based on epidemiological, clinical, and molecular studies.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Jose A. Santiago, Mridula Karthikeyan, Madison Lackey, Diana Villavicencio, Judith A. Potashkin
Summary: Diabetes is associated with an increased risk and progression of Alzheimer's and Parkinson's diseases, but may confer neuroprotection against amyotrophic lateral sclerosis. Perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects could underlie the molecular mechanisms of diabetes on the brain.
TRENDS IN MOLECULAR MEDICINE
(2023)
