Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Heidi Espadas-Alvarez, Jacqueline Martinez-Rendon, Isabel Larre, Arturo Matamoros-Volante, Tatiana Romero-Garcia, Tamara Rosenbaum, Angelica Rueda, Refugio Garcia-Villegas
Summary: TRPV4 channel functions in the nucleus, inhibiting the transcriptional activity of beta-catenin through a direct interaction, and may regulate differentiation in various cellular contexts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Virology
Boris Ryabchenko, Vojtech Sroller, Lenka Hornikova, Alexey Lovtsov, Jitka Forstova, Sandra Huerfano
Summary: This review provides detailed descriptions of the diverse and complex interactions between small and medium size DNA viruses and promyelocytic leukemia nuclear bodies (PM NBs). The interactions between PM NB components and viruses can influence viral genome expression and/or replication, as well as IFN-mediated or apoptotic cell responses to viral infection. The review also discusses the interactions between PM NBs and Hepatitis B virus, papillomaviruses, polyomaviruses, and avian anellovirus. Despite numerous studies on the functions of PM NBs in the context of viral infection, there are still gaps in our understanding of the fine interactions between viruses and the highly dynamic PM NBs, which require further investigation.
Article
Biology
Myriam Scherer, Clarissa Read, Gregor Neusser, Christine Kranz, Anna K. Kuderna, Regina Mueller, Florian Full, Sonja Woerz, Anna Reichel, Eva-Maria Schilling, Paul Walther, Thomas Stamminger
Summary: PML nuclear bodies undergo rearrangement to form giant cages upon viral infection, trapping viral genomes and capsids, and providing a multilayered defense strategy against viral infections.
Article
Cell Biology
Yingying Tong, Zheng Zhang, Yurong Cheng, Jing Yang, Cong Fan, Xuyang Zhang, Jiandong Yang, Li Wang, Dong Guo, Dong Yan
Summary: NFATc3 is a transcriptional regulator that is constitutively activated in various cancer types, playing crucial roles in cancer development. In pancreatic ductal adenocarcinoma cells, excessive activation of NFATc3 is associated with advanced disease stages and shorter survival time. The deSUMOylation of NFATc3 by SENP3 under hypoxia serves as an essential modulator in PDAC tumor progression.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Abhishek Sinha, Vinson B. Fan, Aravinda-Bharathi Ramakrishnan, Nicole Engelhardt, Jennifer Kennell, Ken M. Cadigan
Summary: SOX9 promotes turnover of β-catenin independently of the destruction complex and proteasome in mammalian cell culture. This requires the activation of MAML2, which acts as a coactivator for SOX9 in antagonizing the Wnt/β-catenin pathway. This newly identified pathway provides a parallel mechanism for restricting Wnt/β-catenin signaling.
Editorial Material
Biochemistry & Molecular Biology
Charles A. Ettensohn
Summary: The establishment of early polarity in animal embryos is influenced by the dynamic redistribution of the Wnt signaling effector Dishevelled, a process regulated by the cell cycle and the Wnt receptor Frizzled 1.
Article
Cell Biology
Xueying Yang, Fei Shao, Dong Guo, Wei Wang, Juhong Wang, Rongxuan Zhu, Yibo Gao, Jie He, Zhimin Lu
Summary: FTO plays a critical role in cancer development by removing m(6)A modifications from genes. Downregulation of FTO expression in lung adenocarcinoma patients is associated with poor survival. Mechanistically, Wnt signaling induces EZH2 binding to beta-catenin, inhibiting FTO expression and promoting m(6)A modifications on specific genes like MYC to enhance tumor cell glycolysis and growth.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Chenge Zhang, Yinhua Jin, Marco Marchetti, Mitchell R. Lewis, Omar T. Hammouda, Bruce A. Edgar
Summary: This study reveals that the transcriptional repressor Cic and its targets, pnt and Ets21C, are downstream effectors of mitogenic EGFR signaling in Drosophila intestinal stem cells. These factors promote metabolic changes that increase ISC mass, mitochondrial growth, and activity. The study also shows that Pnt and Ets21C directly upregulate genes involved in DNA replication, cell cycle, oxidative phosphorylation, TCA cycle, and fatty acid beta-oxidation. The work highlights the role of EGFR signaling in coordinating cell growth and division through alterations in metabolism.
Article
Plant Sciences
Hongbo Li, Juan Wei, Yanglan Liao, Xiaoling Cheng, Shuhong Yang, Xiaohong Zhuang, Zhonghui Zhang, Wenjin Shen, Caiji Gao
Summary: This study reveals a previously unidentified function of plant-specific casein kinase I members in attenuating ABA signaling by regulating the phosphorylation and nuclear accumulation of FREE1.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Seishiro Hirano, Osamu Udagawa
Summary: Promyelocytic leukemia (PML) proteins play a role in the development of acute promyelocytic leukemia (APL) and can be affected by trivalent arsenic (As3+). The exposure to As3+ can lead to changes in PML-NBs, including solubility shift, SUMOylation, and late agglomeration. Understanding these changes is important for the regulation of intranuclear dynamics of PML-NBs.
Article
Oncology
Jiong Ning, Qi Sun, Zijie Su, Lifeng Tan, Yun Tang, Sapna Sayed, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Desheng Lu
Summary: CK1 delta/epsilon enhance beta-catenin-mediated transcription by regulating beta-catenin acetylation. CK1 delta/epsilon interact with Tip60 and facilitate its recruitment to the beta-catenin complex, leading to increased beta-catenin acetylation at K49. Furthermore, this study discovers that a complex consisting of CK1 delta/CK1 epsilon/beta-catenin/Tip60 is present in colon cancer cells, and this complex plays an important role in beta-catenin acetylation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shaojian Lin, Weiwei Zhang, Ziwen Shi, Langping Tan, Yue Zhu, Honghao Li, Xinzhi Peng
Summary: The study revealed the transcriptional regulation of LINC01278 by beta-catenin/LEF-1 transcription factor and its negative feedback regulation on beta-catenin signal in papillary thyroid carcinoma (PTC) cells. This negative regulation inhibits downstream target gene expression activated by the Wnt/beta-catenin pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Microbiology
Yifei Liao, Blanca Lupiani, Sanjay M. Reddy
Summary: The study reveals that MDV US3 disrupts PML and SP100 in a kinase dependent manner, and a proteasome dependent degradation pathway is involved in this disruption process. These findings provide the first evidence for the interplay between MDV proteins and PML-NBs.
Article
Multidisciplinary Sciences
Samuel J. Rodgers, Lisa M. Ooms, Viola M. J. Oorschot, Ralf B. Schittenhelm, Elizabeth Nguyen, Sabryn A. Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J. Eramo, Absorn Sriratana, Clare G. Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E. Abud, Georg Ramm, Antonella Papa, Andrew M. Ellisdon, Roger J. Daly, Catriona A. McLean, Christina A. Mitchell
Summary: INPP4B functions as a tumor suppressor in triple negative breast cancer by converting PI(3,4)P-2 to PI(3)P. However, in PIK3CA-mutant ER+ breast cancers, INPP4B enhances cell proliferation and tumor growth by promoting PI3K alpha-dependent late endosome formation and trafficking that activates Wnt/beta -catenin signaling.
NATURE COMMUNICATIONS
(2021)
Article
Pathology
Tao Zuo, Serena Wong, Natalia Buza, Pei Hui
Article
Pathology
Tao Zuo, Parker Wilson, Ali Fuat Cicek, Malini Harigopal
Review
Biochemistry & Molecular Biology
Huey-Jen L. Lin, Tao Zuo, Jennifer R. Chao, Zhengang Peng, Lisa K. Asamoto, Sonya S. Yamashita, Tim H. -M. Huang
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2009)
Article
Oncology
Lizhong Wang, Runhua Liu, Weiquan Li, Chong Chen, Hiroto Katoh, Guo-Yun Chen, Beth McNally, Lin Lin, Penghui Zhou, Tao Zuo, Kathleen A. Cooney, Yang Liu, Pan Zheng
Article
Oncology
Pei-Yin Hsu, Daniel E. Deatherage, Benjamin A. T. Rodriguez, Sandya Liyanarachchi, Yu-I Weng, Tao Zuo, Joseph Liu, Alfred S. L. Cheng, Tim H-M Huang
Article
Oncology
Tao Zuo, Ta-Ming Liu, Xun Lan, Yu-I Weng, Rulong Shen, Fei Gu, Yi-Wen Huang, Sandya Liyanarachchi, Daniel E. Deatherage, Pei-Yin Hsu, Cenny Taslim, Bhuvaneswari Ramaswamy, Charles L. Shapiro, Huey-Jen L. Lin, Alfred S. L. Cheng, Victor X. Jin, Tim H. -M. Huang
Article
Oncology
Benjamin A. T. Rodriguez, Yu-I Weng, Ta-Ming Liu, Tao Zuo, Pei-Yin Hsu, Ching-Hung Lin, Ann-Lii Cheng, Hengmi Cui, Pearlly S. Yan, Tim H-M. Huang
Article
Biochemical Research Methods
Ronald X. Xu, Jeff S. Xu, Tao Zuo, Rulong Shen, Tim H. Huang, Michael F. Tweedle
JOURNAL OF BIOMEDICAL OPTICS
(2011)
Article
Pharmacology & Pharmacy
Yu-I Weng, Pei-Yin Hsu, Sandya Liyanarachchi, Joseph Liu, Daniel E. Deatherage, Yi-Wen Huang, Tao Zuo, Benjamin Rodriguez, Ching-Hung Lin, Ann-Lii Cheng, Tim H. -M. Huang
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2010)
Article
Pathology
Tao Zuo, Angelique W. Levi, Qiongqiong Lin, Rita Abi-Raad, Adebowale J. Adeniran, Guoping Cai
Summary: This study showed that a positive hrHPV result, especially type 16 or 18, in women with AGC interpretation is associated with an increased risk of developing cervical CIN2-3 or higher lesions.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Cell Biology
Haihui Liao, Todd Sheridan, Ediz Cosar, Christopher Owens, Tao Zuo, Xiaofei Wang, Ali Akalin, Dina Kandil, Karen Dresser, Kevin Fogarty, Karl Bellve, Christina Baer, Andrew Fischer
Summary: Inexpensive deconvolution fluorescence microscopy improves the image quality of non-smeared fine needle aspiration tissue fragments, enabling more accurate diagnoses and preserving the material for further testing.
Article
Pathology
Michael Kritselis, Ilyas Yambayev, Andrey Prilutskiy, Artem Shevtsov, Charitha Vadlamudi, Hanqiao Zheng, Murad Elsadwai, Lina Ma, Emily Aniskovich, Yachana Kataria, Sara Higgins, Carmen Sarita-Reyes, Tao Zuo, Qing Zhao, Karen Quillen, Eric J. Burks
Summary: Comparison of lung tissue immunopathology in patients with severe COVID-19 and those with DAD before the COVID-19 pandemic revealed a distinctive pattern of pseudopalisaded histiocytic hyperplasia in COVID-19 associated DAD. This inflammatory pattern may represent the unique immunopathology associated with the dexamethasone responsive form of DAD in severe COVID-19.
Review
Oncology
Tong Sun, Tao Zuo, Pei Hui, Guoping Cai
Summary: This study evaluated the value of KRAS mutation testing in adding cytological diagnosis of biliary duct brushings. The results showed that KRAS mutations were more common in malignant biliary brushings and had a certain specificity and sensitivity.
CANCER CYTOPATHOLOGY
(2022)
Article
Pathology
Yuanxin Liang, Tao Zuo
HEAD & NECK PATHOLOGY
(2017)