Review
Pharmacology & Pharmacy
Camila Maurmann de Souza, Osmel Fleitas Martinez, Harry Morales Duque, Octavio Luiz Franco
Summary: Novel treatments are needed to combat resistant Gram-negative bacteria and predatory bacteria have emerged as a potential solution. However, the efficacy of predatory bacteria alone is limited, leading to the investigation of combination therapies with other agents. This article discusses recent advancements in the use of predatory bacteria for infections and proposes novel combination strategies with antivirulence compounds.
DRUG DISCOVERY TODAY
(2023)
Editorial Material
Microbiology
R. Elizabeth Sockett
Summary: Liz Sockett describes the lessons she learned from studying Bdellovibrio bacteriovorus, a single-celled predator that invades and kills Gram-negative bacteria from within.
NATURE MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
K. K. Sivakala, P. A. Jose, O. Matan, C. Zohar-Perez, A. Nussinovitch, E. Jurkevitch
Summary: This study demonstrates the potential of B. bacteriovorus to prey on and survive in the gut of the Mediterranean fruit fly, leading to a shift in the gut microbiome community structure.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Microbiology
Hyochan Jang, Wonsik Mun, Robert J. J. Mitchell, Seong Yeol Choi, Seok Hoon Jeong
Summary: As mankind explores the possibility of permanently inhabiting outer space and other planets, finding alternatives to antibiotics for controlling drug-resistant pathogens becomes crucial. This study examines the efficacy of Bdellovibrio bacteriovorus HD100 as an alternative to antibiotics. The results show that the activity of Bdellovibrio bacteriovorus HD100 is similar or even better in simulated microgravity conditions compared to flask and normal gravity cultures. The study also demonstrates that Bdellovibrio bacteriovorus HD100 is effective in killing carbapenem- and colistin-resistant pathogenic bacterial strains and can hydrolyze resistant genes in these clinical isolates. These findings suggest the potential applicability of Bdellovibrio bacteriovorus HD100 as an antibiotic against multidrug-resistant pathogens during spaceflight.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Ying Tang, Qian-Xiao Huang, Di-Wei Zheng, Yang Chen, Li Ma, Cui Huang, Xian-Zheng Zhang
Summary: By utilizing a material-assisted micro-organism (MAMO) strategy with ZnO nanorods engineered Bdellovibrio (ZnO@Bdello), the biofilm composed of Gram-negative bacteria can be effectively eradicated. This strategy demonstrates superior competence in alleviating inflammation and inhibiting bone resorption.
Article
Microbiology
Monique Waso-Reyneke, Sehaam Khan, Wesaal Khan
Summary: The interaction between Bdellovibrio bacteriovorus PF13 and mixed bacterial communities was studied. The results showed that PF13 preferentially preys on K. pneumoniae and the presence of Gram-positive bacteria does not affect its predation efficiency.
Article
Microbiology
Karolina Plaskowska, Lukasz Makowski, Agnieszka Strzalka, Jolanta Zakrzewska-Czerwinska
Summary: Most eukaryotic and bacterial cells divide by binary fission, while some bacteria can also divide by nonbinary fission. The predatory bacterium Bdellovibrio bacteriovorus exhibits bimodal fission, with the mode of division depending on the size of the prey bacterium. This finding provides insights into the proliferation and elimination strategies of antibiotic-resistant pathogens.
Review
Microbiology
Benjamin Havenga, Brandon Reyneke, Monique Waso-Reyneke, Thando Ndlovu, Sehaam Khan, Wesaal Khan
Summary: This article reviews the antibiotic resistance and virulence mechanisms of A. baumannii, and discusses the potential of biological control agents to target and combat this pathogen. Limitations and mitigation strategies are also outlined.
Article
Biotechnology & Applied Microbiology
Selcan Kahraman Vatansever, Yamac Tekintas, Fatma Feriha Cilli, Mine Hosgor-Limoncu
Summary: This study aimed to investigate the effect of the predator bacterium Bdellovibrio bacteriovorus HD100 on various clinical pathogens and their biofilms. It was found that this predator bacteria showed good antibacterial activity against most Gram-negative pathogens and some Gram-positive pathogens. The study also demonstrated the ability of Bdellovibrio bacteriovorus to control biofilm formation.
INDIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Catherine B. Volle, Megan E. Nunez, Eileen M. Spain, Bridget C. Hart, Michael B. Wengen, Sophia Lane, Alexa Criollo, Catherine A. . Mahoney, Megan A. . Ferguson
Summary: This study used atomic force microscopy to examine the force maps of predatory and non-predatory B. bacteriovorus cells. It was found that non-predatory cells have similar approach curves to other Gram-negative cells, while predatory cells have a unique approach curve. Predatory cells show minimal adhesion to surfaces, while non-predatory cells have multiple adhesion events, mainly due to the presence of Type IV pili. Exposure to cranberry juice containing type A proanthocyanidins reduces the adhesion of non-predatory cells.
Review
Microbiology
J. Kimberley Summers, Jan-Ulrich Kreft
Summary: With the increasing levels of antimicrobial resistance, there is an urgent need for novel means of treating resistant infections. Bacteriophages and predatory bacteria have been proposed as suitable candidates for this role. Mathematical models have been used to investigate the mechanisms of action of predators and predict the dynamics of predator-prey systems. These models have also provided insights into the qualitative and quantitative similarities or differences between bacterial predators and bacteriophages or protists. Additionally, models have helped study the effectiveness of predators in removing prey species and their potential effects on shaping ecosystems. Overall, mathematical models have played a crucial role in understanding and predicting the behavior of prokaryotic predators.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Christian Mariel Saenz-Santos, Omotayo Opemipo Oyedara, Yunia Veronica Garcia-Tejeda, Claudia A. Romero-Bastida, Esperanza Milagros Garcia-Oropesa, Eduardo Villalobo, Mario A. Rodriguez-Perez
Summary: The study evaluated the viability of Bdellovibrio bacteriovorus in biopolymeric films, with CA-S film showing less reduction in bacterial viability. This suggests that CA-S could be a better agent for immobilization and preservation of B. bacteriovorus for enhanced predatory activities against Escherichia coli.
Article
Multidisciplinary Sciences
Hannah Q. Hughes, Kyle A. Floyd, Sajjad Hossain, Sweta Anantharaman, David T. Kysela, Mikls Zoldi, Laszl Barna, Yuanchen Yu, Michael P. Kappler, Triana N. Dalia, Ram C. Podicheti, Douglas B. Rusch, Meng Zhuang, Cassandra L. Fraser, Yves Brun, Stephen C. Jacobson, James B. McKinlay, Fitnat H. Yildiz, Elizabeth M. Boon, Ankur B. Dalia
Summary: This research uncovers a regulatory pathway in Vibrio cholerae that allows rapid termination of biofilm formation, dependent on the phosphodiesterase CdpA and the signaling molecule nitric oxide. This sheds light on how bacterial species integrate environmental cues to regulate pilus dynamics and attachment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Fisheries
Xiaoli Chen, Huadong Yi, Shuang Liu, Yong Zhang, Yuqin Su, Xuange Liu, Sheng Bi, Han Lai, Zeyu Zeng, Guifeng Li
Summary: Addition of B. bacteriovorus to aquaculture water can significantly promote the pellet-feed feeding of mandarin fish, improve their survival rates and growth performance, as well as regulate intestinal flora and enhance innate immunity.
Article
Microbiology
Einav Aharon, Abhirup Mookherjee, Francisco Perez-Montano, Gustavo Mateus da Silva, Rajesh Sathyamoorthy, Saul Burdman, Edouard Jurkevitch
Summary: The study identified two loci associated with susceptibility to predatory bacterium Bdellovibrio bacteriovorus in a predation-resistant strain of Acidovorax citrulli, indicating a single gene mutation can impact prey resistance. This approach provides insights into the genetic basis of resistance against BALO predation.
RESEARCH IN MICROBIOLOGY
(2021)
Article
Microbiology
K. M. James, K. W. MacDonald, R. M. Chanyi, P. A. Cadieux, J. P. Burton
JOURNAL OF MEDICAL MICROBIOLOGY
(2016)
Article
Environmental Sciences
Ryan M. Chanyi, Susan F. Koval, Joanna S. Brooke
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2016)
Article
Nutrition & Dietetics
Ruth Harvie, Ryan M. Chanyi, Jeremy P. Burton, Michael Schultz
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2017)
Article
Medicine, General & Internal
Ryan M. Chanyi, Raidh Alzubaidi, Everett J. Y. Leung, Hannah B. Wilcox, Gerald B. Brock, Jeremy P. Burton
Article
Biochemistry & Molecular Biology
Ryan M. Chanyi, Caitlin Ward, Andrea Pechey, Susan F. Koval
CANADIAN JOURNAL OF MICROBIOLOGY
(2013)
Letter
Biochemistry & Molecular Biology
Ryan M. Chanyi
CANADIAN JOURNAL OF MICROBIOLOGY
(2018)
Article
Ecology
Z. Pasternak, M. Njagi, Y. Shani, R. Chanyi, O. Rotem, M. N. Lurie-Weinberger, S. Koval, S. Pietrokovski, U. Gophna, E. Jurkevitch
Article
Multidisciplinary Sciences
Brendan A. Daisley, Ryan M. Chanyi, Kamilah Abdur-Rashid, Kait F. Al, Shaeley Gibbons, John A. Chmiel, Hannah Wilcox, Gregor Reid, Amanda Anderson, Malcolm Dewar, Shiva M. Nair, Joseph Chin, Jeremy P. Burton
NATURE COMMUNICATIONS
(2020)
Article
Food Science & Technology
Hanh T. H. Nguyen, Mariza Gomes Reis, Yunchao Wa, Renna Alfante, Ryan M. M. Chanyi, Eric Altermann, Li Day
Summary: Texture and flavour, which are crucial attributes for sensory quality, are greatly influenced by starter cultures. Different phenotypic strains are required to create diverse texture and flavour in fermented milk to meet consumer preferences. This study investigated the use of five lactic acid bacteria strains in fermented milk production, looking at metabolite profiles, microstructure, and rheological properties. LH and ST showed stronger acidification but resulted in coarser protein networks compared to BL1 and CL3. LH had the highest viscosity and exopolysaccharide concentration, while ST had the highest concentration of diacetyl. CL3ST had minimal acidification capability but produced high levels of ethyl-derived compounds associated with sweet, fruity, and floral fragrances. LH and ST can be used as starter cultures for fermented milks with different viscosities, while BL1, CL3, and CL3ST are suitable as adjunct cultures for different acidic sharpness and flavour notes.
Article
Oncology
Saman Maleki Vareki, Ryan M. Chanyi, Kamilah Abdur-Rashid, Liam Brennan, Jeremy P. Burton
ECANCERMEDICALSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Damian McNeely, Ryan M. Chanyi, James S. Dooley, John E. Moore, Susan F. Koval
CANADIAN JOURNAL OF MICROBIOLOGY
(2017)
Review
Oncology
Yige Bao, Kait F. Al, Ryan M. Chanyi, Samantha Whiteside, Malcom Dewar, Hassan Razvi, Gregor Reid, Jeremy P. Burton
ANNALS OF TRANSLATIONAL MEDICINE
(2017)