Article
Psychiatry
Taylor R. Thomas, Tanner Koomar, Lucas G. Casten, Ashton J. Tener, Ethan Bahl, Jacob J. Michaelson
Summary: The study reveals significant variability in genetic properties of autism traits, with different genetic factors and sex interactions having diverse impacts on autism. The RBS-R instrument demonstrates the strongest genetic signal in both autistic and general population samples, highlighting its potential importance in genetic research on autism.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Peter T. Euclide, Andrew Jasonowicz, Shawn P. Sitar, G. J. Fischer, Frederick W. Goetz
Summary: Genetic evidence suggests that the complex and polygenically regulated phenotypes of lake charr can be easily overlooked due to neutral population genetic structure and phenotypic plasticity. However, a common garden experiment reveals significant differences in lipid content, growth, weight, and length among different crosses of lake charr, indicating the important role of pedigree in their development. The study also identifies genetic associations between specific genotypes and phenotypes, highlighting the complexity and polygenic nature of ecotype diversity in lake charr.
Review
Endocrinology & Metabolism
Alina Lenghel, Alina Maria Gheorghita, Andrei Mircea Vacaru, Ana-Maria Vacaru
Summary: The unfolded protein response (UPR) is a conserved process that assists cells in coping with endoplasmic reticulum (ER) stress and improving secretory performance. In beta-cells, high demand for insulin production can lead to misfolded proteins, triggering a physiological upregulation of UPR. However, the transition from a homeostatic to a pathological UPR in diabetic disorders remains poorly understood, highlighting the need for further research in this emerging field for the development of more effective therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Dermatology
Sonal Muzumdar, Gloria Lin, Philip Kerr, Jane M. Grant-Kels
Summary: Melanoma incidence has increased since the 1970s, while melanoma-specific mortality has remained stable. Factors contributing to the rise in incidence include an aging population, ultraviolet exposure, increased skin biopsies, skin cancer screenings, and histopathologic criteria.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Engineering, Biomedical
Corin A. Seelemann, Thomas L. Willett
Summary: This study provides the first empirical evidence of bone collagen denaturation resulting from cortical bone fracture and extends our understanding of this mechanism towards the mechanical performance of cortical bone.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Substance Abuse
Tess L. Weber, Arielle Selya, Lauren S. Wakschlag, Lisa Dierker, Jennifer S. Rose, Don Hedeker, Robin J. Mermelstein
Summary: The study indicates that maternal smoking measures do not significantly impact offspring smoking, and heritable traits and initial smoking experiences also do not confound the effects of maternal smoking on offspring smoking. Further research is needed to explore the mechanisms linking prenatal tobacco exposure and maternal smoking to offspring smoking.
NICOTINE & TOBACCO RESEARCH
(2021)
Article
Biodiversity Conservation
Yi Wu, Li Cao, Yunguo Liu
Summary: China's population and carbon emissions will reach their peaks in 2030. This study examines the relationship between population and energy through the lens of metabolism, using panel data from China between 2003 and 2019. The findings indicate that the impact of population quality change on regional metabolism varies across different scales, with a generally positive response. These findings have important implications for global sustainable development.
ECOLOGICAL INDICATORS
(2023)
Review
Cell Biology
Evon Low, Ghazaleh Alimohammadiha, Lucy A. Smith, Lydia F. Costello, Stefan A. Przyborski, Thomas von Zglinicki, Satomi Miwa
Summary: Skin, as the largest organ of the body, is compromised with time due to intrinsic and extrinsic ageing processes, primarily at the cellular level through cellular senescence. While evidence suggests that cellular senescence is a relevant cause of intrinsic skin ageing, it is not yet completely conclusive.
AGEING RESEARCH REVIEWS
(2021)
Article
Immunology
Thiagarajan Venkataraman, Cristian Valencia, Massimo Mangino, William Morgenlander, Steven J. Clipman, Thomas Liechti, Ana Valencia, Paraskevi Christofidou, Tim Spector, Mario Roederer, Priya Duggal, H. Benjamin Larman
Summary: Human immune responses to viral infections are variable, and the genetic factors contributing to this variability are not well known. By using high-throughput epitope scanning technology, we analyzed the antibody reactivity profiles of twins and individuals with genotyped SNPs. We identified heritable features of the antibody response to viruses and genomic loci associated with antibody epitope selection and control of Epstein-Barr virus viral load.
Article
Environmental Sciences
Kaihua Wang
Summary: This study examines the asymmetrical impact of Beijing's and Shanghai's air quality on cross-industries stock returns using the quantile-on-quantile regression method. The findings show that there are heterogeneous responses and different links within the same city and industry. The study makes useful contributions by distinguishing the political and economic aspects of air pollution, considering the heterogeneity of industries, and using the QQ approach to capture quantile-varying relationships.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Parasitology
Alison Wunderlich, Willian Simioni, Erica Zica, Tadeu Siqueira
Summary: The study revealed that subadult hosts are more susceptible to parasite infection than juvenile and adult hosts, contrary to the initial prediction. This suggests that parasite host choice is age-dependent, with subadults representing the most favorable option for parasites in terms of balancing host quality and susceptibility.
PARASITOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Peng Zheng, Ashkan Afshin, Stan Biryukov, Catherine Bisignano, Michael Brauer, Dana Bryazka, Katrin Burkart, Kelly M. Cercy, Leslie Cornaby, Xiaochen Dai, M. Ashworth Dirac, Kara Estep, Kairsten A. Fay, Rachel Feldman, Alize J. Ferrari, Emmanuela Gakidou, Gabriela Fernanda Gil, Max Griswold, Simon Hay, Jiawei He, Caleb M. S. Irvine, Nicholas J. Kassebaum, Kate E. LeGrand, Haley Lescinsky, Stephen S. Lim, Justin Lo, Erin C. Mullany, Kanyin Liane Ong, Puja C. Rao, Christian Razo, Marissa B. Reitsma, Gregory A. Roth, Damian F. Santomauro, Reed J. D. Sorensen, Vinay Srinivasan, Jeffrey D. Stanaway, Stein Emil Vollset, Theo Vos, Nelson Wang, Catherine A. Welgan, Sarah S. Wozniak, Aleksandr Y. Aravkin, Christopher J. L. Murray
Summary: A new meta-analytic method is used to interpret the strength of evidence between different risk factors and health outcomes. This method corrects for bias between different study designs and accounts for between-study heterogeneity. It provides an objective and quantitative evaluation of risk evidence across different risk-outcome pairs, which helps in risk analysis conducted as part of global health studies.
Article
Plant Sciences
Xin Liu, Kathrin Rousk
Summary: The moss hydration rate is a key trait that explains variation in N-2 fixation and cyanobacterial colonization. Moss species with smaller leaves and higher leaf frequency have higher cyanobacterial abundance. High phenol concentration inhibits N-2 fixation but not colonization.
Article
Ecology
Kimberley D. Lemmen, Koen J. F. Verhoeven, Steven A. J. Declerck
Summary: The study found that even in the absence of initial genetic diversity and recombination, small populations can rapidly exhibit adaptive genetic changes, indicating that de novo genetic variation or alternative sources of phenotypic variation may help in the establishment and persistence of low-diversity populations.
FUNCTIONAL ECOLOGY
(2022)
Article
Multidisciplinary Sciences
Sumeet M. Jaswal, Andreas K. F. De Bleser, Todd C. Handy
Summary: Misokinesia, or the 'hatred of movements', is a psychological phenomenon characterized by a strong negative affective response to the sight of someone else's small and repetitive movements. Research shows that approximately one-third of the general population experience some degree of misokinesia sensitivity in daily life, and the intensity and range of sensitivities may increase with age.
SCIENTIFIC REPORTS
(2021)