Article
Biochemistry & Molecular Biology
Marina Yu Kopaeva, Irina B. Alchinova, Anton B. Cherepov, Marina S. Demorzhi, Mikhail Nesterenko, Irina Yu Zarayskaya, Mikhail Yu Karganov
Summary: In this study, the effects of human lactoferrin (hLf) on mice after acute gamma irradiation were investigated. The results showed that hLf had a positive pleiotropic effect, including increased animal survival and lifespan, compensation for radiation-induced body weight loss and changes in homeostasis parameters, and protection of the structural organization of the spleen. These findings suggest that hLf has potential as an early therapy after radiation exposure.
Article
Materials Science, Multidisciplinary
Yalcin Urfa, Vahit Corumlu, Ahmet Altindal
Summary: The study found that gamma ray irradiation can enhance the methanol sensing performance of zinc oxide nanoparticles based sensors, while the methanol adsorption kinetics is influenced by the irradiation dose.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Chemistry, Physical
Liangsen Liu, Lian Feng, Tianshuai Ma, Zhiwei Xu, Xiaoyuan Pei, Yi Liu, Haiting Shi, Youhong Tang, Liyan Liu, Hui Deng, Chunhong Wang
Summary: Carbon fiber-reinforced composites are highly resistant to ionizing radiation. This study investigated the effects of high gamma-ray absorbed dose on the mechanical properties, thermal stability, and microstructural changes of the composites. The results showed that low doses of radiation improved certain properties, but high doses led to a decrease in performance.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wei Liu, Mengting Li, Weiwei Li, Arturo A. Keller, Vera Slaveykova
Summary: This study investigates the metabolic perturbations in green alga C. reinhardtii exposed to different sizes and concentrations of nTiO(2). The results show that nTiO(2) exposure induces perturbations in amino acid, nucleotide, fatty acid metabolism, among others, but does not affect photosynthesis. The perturbations are size and concentration-dependent and also impact the overall nutrition of the microalgal cell.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Environmental Sciences
Alaa El-Din H. Sayed, Kento Nagata, Takuya Nakazawa, Hiroshi Mitani, Junya Kobayashi, Shoji Oda
Summary: The study showed that low dose-rate chronic irradiation of gamma rays can induce cytotoxic and genotoxic effects in the peripheral erythrocytes of medaka. Furthermore, p53-deficient medaka are more tolerant to the gamma-ray irradiation than the wild type.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Engineering, Environmental
Haoduo Zhao, Min Liu, Junjie Yang, Yuyang Chen, Mingliang Fang
Summary: This study investigates the time-dependent dysregulation of metabolites and perturbed biological functions in MCF-7 cells exposed to bisphenol A (BPA). The results show that BPA exposure leads to global dynamic metabolome adaptations, including amino acid, nucleoside, and sugar metabolism disorders. The dysregulated metabolites in different stages show significant temporal distinctions.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Fionn O. Fearghail, Patrice Behan, Niklas Engstrom, Nathalie Scheers
Summary: The developed LCMS metabolomic workflow allows for comparison of metabolic patterns from human intestinal cells exposed to different treatments, with the aim of identifying the most bioactive treatment. Changes in cellular metabolic patterns were found to be useful predictors of bioactivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Jayashree Sahana, Thomas J. Corydon, Markus Wehland, Marcus Krueger, Sascha Kopp, Daniela Melnik, Stefan Kahlert, Borna Relja, Manfred Infanger, Daniela Grimm
Summary: The study evaluated changes in focal adhesions in breast cancer cells exposed to simulated microgravity. The findings suggest that genes related to cytoskeleton, extracellular matrix, and focal adhesions are altered in response to microgravity. Fibronectin, vinculin, and E-cadherin play central roles in the formation of multicellular spheroids in breast cancer cells under such conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Pilar Lopez-Nieva, Iria Gonzalez-Vasconcellos, Laura Gonzalez-Sanchez, Maria A. Cobos-Fernandez, Sara Ruiz-Garcia, Raul Sanchez Perez, Angel Aroca, Jose Fernandez-Piqueras, Javier Santos
Summary: This study investigates the differential response of combined radiation treatments and single dose treatments. The findings highlight the different cell cycle responses and protein expression profiles, as well as the epigenetic regulation following combined radiation treatments. The results suggest that combined-dose radiation regimes could be more efficient at making cells respond to radiation.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Georgios Schoretsanitis, Celine Dubath, Claire Grosu, Marianna Piras, Nermine Laaboub, Setareh Ranjbar, Nicolas Ansermot, Severine Crettol, Frederik Vandenberghe, Franziska Gamma, Armin Gunten, Kerstin Jessica Plessen, Erich Seifritz, Philippe Conus, Chin B. Eap
Summary: This study assessed the effects of olanzapine on metabolic parameters, and found that high-dose olanzapine treatment may lead to early weight gain, while low-dose treatment is associated with increases in blood lipids and blood pressure. Treatment duration and co-prescription of other medications were also found to be related to weight gain.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Alina Efremenko, Pergentino Balbuena, Rebecca A. Clewell, Michael Black, Linda Pluta, Melvin E. Andersen, P. Robinan Gentry, Janice W. Yager, Harvey J. Clewell
Summary: Evidence shows that long-term exposure to arsenite results in significant changes in gene expression, including reversals in the direction of expression change in key regulatory genes. Cells treated with arsenic initially exhibit upregulation of oxidative stress responses and down-regulation of immune/inflammatory responses, followed by increased inflammatory and proliferative signaling, evidence of epithelial-to-mesenchymal transition, and alterations in DNA damage responses. The changing response of cells to arsenite over time appears to involve up-regulation of MDM2 by inflammatory signaling, leading to inhibition of P53 function.
Article
Neurosciences
Jenny Lange, Olivia Gillham, Michael Flower, Heather Ging, Simon Eaton, Sneha Kapadia, Andreas Neueder, Michael R. Duchen, Patrizia Ferretti, Sarah J. Tabrizi
Summary: Huntington's Disease is a neurodegenerative disease caused by a genetic mutation. Astrocyte dysfunction, specifically changes in gene expression and metabolic activity, plays a role in the pathogenesis of the disease. Additionally, all Huntington's Disease astrocytes exhibit increased DNA damage and a DNA damage response, suggesting a potential mechanism for their dysfunction.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Spectroscopy
Sylwia Terpilowska, Ewa Pieta, Maciej Roman, Czeslawa Paluszkiewicz, Wojciech M. Kwiatek
Summary: This study investigates the cellular response to various transition metals at the single-cell level using Raman and Fourier-transform infrared spectroscopic imaging. The results show that these transition metals can induce apoptosis and alter cellular metabolism at specific concentrations.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Oncology
Ravindra M. Samarth, Puneet Gandhi, Nabo Kumar Chaudhury
Summary: By studying the frequency of acrocentric chromosome associations (ACA) in human lymphocytes exposed to gamma radiation, we found that the frequency of ACA increased with radiation dose. We also observed a correlation between ACA frequency and dicentric chromosome (DC) frequency, indicating that ACA may serve as a potential cytogenetic biomarker for radiation biodosimetry.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Multidisciplinary Sciences
Aya Osman, Rebecca S. Hofford, Katherine R. Meckel, Yesha A. Dave, Sharon M. Zeldin, Ava L. Shipman, Kelsey E. Lucerne, Kyle J. Trageser, Tatsunori Oguchi, Drew D. Kiraly
Summary: Opioid Use Disorder (OUD) poses significant morbidity and mortality risks, but current pharmacotherapy options fall short for many patients. A study using a Bioactive Dietary Polyphenol Preparation (BDPP) found that it promotes resilience and adaptive neuroplasticity in neuropsychiatric disease models, showing potential as an intervention for OUD. The study examined the effects of BDPP treatment on behavioral and molecular responses to repeated morphine treatment in male mice, finding that polyphenols have dose-dependent effects on these responses, as well as the composition and function of the microbiome.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Mi Hye Kim, Haesu Lee, In Jin Ha, Woong Mo Yang
Summary: ZP administration in osteoporotic mice resulted in increased bone mineral density, restoration of serum bone biomarker levels, decreased osteoclast counts, and inhibition of osteoclast formation. These findings suggest that ZP may be a potential therapeutic agent for osteoporosis.
Article
Clinical Neurology
Kasra Amirdelfan, Hyun Bae, Tory McJunkin, Michael DePalma, Kee Kim, William J. Beckworth, Gary Ghiselli, James Scott Bainbridge, Randall Dryer, Timothy R. Deer, Roger D. Brown
Summary: The study evaluated the safety and efficacy of intradiscal injection of STRO-3+ adult allogeneic mesenchymal precursor cells (MPCs) combined with hyaluronic acid (HA) for chronic low back pain (CLBP) associated with degenerative disc disease (DDD). Results showed that MPC therapy was superior to controls in improving VAS and ODI and was well tolerated without clinical symptoms of immune reaction. The therapeutic effects were sustained up to 36 months.
Article
Clinical Neurology
Derek G. Ju, Linda E. Kanim, Hyun W. Bae
Summary: This study analyzed single-center data from four multicenter randomized controlled trials and found no difference in outcomes between therapeutic intradiscal agents (growth factor, fibrin sealant, or stem cells) and control saline groups. Patient reported pain and disability scores decreased significantly in all groups.
GLOBAL SPINE JOURNAL
(2022)
Correction
Biochemistry & Molecular Biology
Kwangho Song, Jae-Hyeon Oh, Min Young Lee, Seok-Geun Lee, In Jin Ha
Article
Cell & Tissue Engineering
Juliane D. Glaeser, Phillip Behrens, Tina Stefanovic, Khosrowdad Salehi, Angela Papalamprou, Wafa Tawackoli, Melodie F. Metzger, Samuel Eberlein, Trevor Nelson, Yasaman Arabi, Kevin Kim, Robert H. Baloh, Shiran Ben-David, Doron Cohn-Schwartz, Robert Ryu, Hyun W. Bae, Zulma Gazit, Dmitriy Sheyn
Summary: The study showed that coating allografts with iNCC-MPCs for mouse cranial defect repair resulted in a better integration compared to BM-MSCs, indicating the potential use of iNCC-MPCs as a cell source for cranial bone repair.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Young Yun Jung, In Jin Ha, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Summary: The study demonstrates that fangchinoline (FCN) can attenuate tumor growth and survival by modulating the STAT3 signaling pathway and inducing apoptosis in malignant cells. FCN abrogated protein expression levels of STAT3 and upstream signals, inhibited STAT3 DNA binding ability and translocation, increased SHP-1 levels, induced ROS production, and effectively suppressed tumor progression and STAT3 activation in a preclinical myeloma model.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Changhwan Yeo, Chae Ryeong Ahn, Jai-Eun Kim, Young Woo Kim, Jinbong Park, Kwang Seok Ahn, In Jin Ha, Yoon Jae Lee, Seung Ho Baek, In-Hyuk Ha
Summary: This study demonstrates the anti-inflammatory and articular regeneration effects of Chaenomeles Fructus (CF) on rat chondrocytes with osteoarthritis, suggesting it as a promising therapeutic option for the treatment of OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sanghee Han, Hail Kim, Min Young Lee, Junhee Lee, Kwang Seok Ahn, In Jin Ha, Seok-Geun Lee
Summary: A new herbal formula, PSY, composed of Patriniae Radix, Coix Seed, and Mori Cortex Radicis, shows potential therapeutic effects in human CRC cells by suppressing proliferation through the inhibition of the STAT3 signaling pathway. PSY ethanol extract contains 21 bioactive compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jaemoo Chun, Sang-Min Park, Minsung Lee, In Jin Ha, Mi-Kyung Jeong
Summary: By combining phytochemical, transcriptomic, and experimental analyses, the study identified the potential target of active compounds in Inula helenium and demonstrated that the sesquiterpene lactone-rich fraction of I. helenium (SFIH) enhances the antitumor effect of anti-PD-1 antibody in colorectal cancer. The combination therapy increased the proportion of cytotoxic T lymphocytes and M1-like macrophages, and activated immune-related pathways to a greater extent than monotherapy.
Article
Biochemistry & Molecular Biology
Jung Sun Kim, Sanghee Han, Hail Kim, So Youn Won, Hyun Woo Park, Hyunjin Choi, Minji Choi, Min Young Lee, In Jin Ha, Seok-Geun Lee
Summary: This study evaluated the anticancer activities of extracts from high glucosinolate content lines of Brassica rapa in human colorectal cancer cells and found that these extracts exhibited anti-proliferative and pro-apoptotic effects, as well as inhibited NF-kappa B and ERK pathways.
Article
Biochemistry & Molecular Biology
Young Yun Jung, In Jin Ha, Mina Lee, Kwang Seok Ahn
Summary: Yuja has antioxidant, anti-wrinkle, moisturizing, and whitening effects. It inhibits collagen degradation, induces moisturizing factors, and decreases melanin content. These findings contribute to the development of skin-improving cosmetics and pharmaceuticals.
Article
Biochemistry & Molecular Biology
Chae Ryeong Ahn, Hyo In Kim, Jai-Eun Kim, In Jin Ha, Kwang Seok Ahn, Jinbong Park, Young Woo Kim, Seung Ho Baek
Summary: Gastric cancer has a high incidence and mortality rate with poor prognosis. Hyperthermia therapy combined with Ponciri Fructus Immaturus (PF) showed synergistic effects in suppressing AGS gastric cancer cell proliferation, inducing cell cycle arrest, and inhibiting metastasis-related factors. The combination treatment also increased reactive oxygen species (ROS) levels and suppressed heat shock factor 1 and heat shock proteins (HSPs), suggesting a potential promising therapy for gastric cancer.
Article
Biology
Min Hee Yang, In Jin Ha, Seok-Geun Lee, Junhee Lee, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigated the effects of BSN on chronic myelogenous leukemia cells and found that it induces apoptosis, autophagy, and paraptosis. It was also discovered that BSN activates the MAPK signaling pathway.
Article
Biochemistry & Molecular Biology
Hyunjin Choi, Hail Kim, Sanghee Han, Hyun Woo Park, In Jin Ha, Jung Sun Kim, Seok-Geun Lee
Summary: This study assessed the capacity of HGSL DHLs to mitigate oxidative stress and inflammation in LPS-stimulated RAW264.7 cells. The results showed that HGSL DHLs exhibited better antioxidant and anti-inflammatory properties compared to the parental control pak choi, through enhanced antioxidant capacity and inhibition of pro-inflammatory cytokines.
Article
Integrative & Complementary Medicine
Ji Min Shin, Yang-Ju Son, In Jin Ha, Saruul Erdenebileg, Da Seul Jung, Dae-geun Song, Young Sik Kim, Sang Min Kim, Chu Won Nho
Summary: This study demonstrates the potential of Artemisia argyi, a medicinal herb, in alleviating inflammatory bowel disease (IBD). Both in vitro and in vivo experiments showed that the ethanol extract of A. argyi effectively reduced inflammation-related proteins and genes in colon and serum samples. Additionally, the extract enhanced immunomodulatory responses in lymphoid tissues and contained compounds with anti-inflammatory effects.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)