Article
Physiology
Wirongrong Wongkitikamjorn, Eiji Wada, Jun Hosomichi, Hideyuki Maeda, Sirichom Satrawaha, Haixin Hong, Ken-ichi Yoshida, Takashi Ono, Yukiko K. Hayashi
Summary: This study aimed to examine the effects of gestational intermittent hypoxia (IH) on the skeletal muscle of adolescent offspring rats. The findings showed that exposure to gestational IH reduced endurance running capacity in the offspring rats. The reduced running capacity was associated with altered energy metabolism, decreased expression of adiponectin receptors, and decreased capillary density in the skeletal muscles of the offspring rats.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Clinical Neurology
Wenjing Wang, Wenxiao Ding, Hanpeng Huang, Yina Zhu, Ning Ding, Ganzhu Feng, Xilong Zhang
Summary: The dysfunction of genioglossal mitophagy induced by chronic intermittent hypoxia (CIH) can be alleviated by supplementation of adiponectin (Ad) via increasing mitophagy.
SLEEP AND BREATHING
(2021)
Article
Medicine, Research & Experimental
Yue Liu, Yuan Yuan, Yi Yan, Ruyue Wang, Zhaohui Wang, Xiao Liu, Ying Zhang, Jianyu Hua, Yue Wang, Li Zhao
Summary: This research aims to investigate the impact of mitochondrial dysfunction on cerebral ischemia and explore the role of mitochondrial pyruvate carrier 1 (MPC1) in this process. The study demonstrates that MPC1 can exert a neuroprotective effect on cerebral ischemia by attenuating oxidative stress, mitochondrial dysfunction, calcium overload, and autophagy. The findings suggest that MPC1-related genes identified through RNA-seq may serve as a novel therapeutic target for cerebral ischemia.
Article
Clinical Neurology
Mohammad Badran, Shawn B. Bender, Abdelnaby Khalyfa, Jaume Padilla, Luis A. Martinez-Lemus, David Gozal
Summary: This study demonstrates that chronic intermittent hypoxia (IH) progressively impairs coronary vascular function and flow reserve, leading to endothelial dysfunction. However, a period of normoxic recovery can reverse these abnormalities.
Article
Biochemistry & Molecular Biology
Kutilda Soontarapornchai, Charles L. Cai, Taimur Ahmad, Jacob V. Aranda, Ivan Hand, Kay D. Beharry
Summary: The study found that caffeine can provide neuroprotection under normoxic conditions, reducing oxidative stress, increasing myelination, and increasing Golgi bodies. However, different oxygen environments may alter and modify the pharmacodynamic actions of caffeine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Haixin Hong, Jun Hosomichi, Hideyuki Maeda, Yuji Ishida, Risa Usumi-Fujita, Ken-ichi Yoshida, Takashi Ono
Summary: This study shows that chronic intermittent hypoxia (IH) can lead to activation of the sympathoadrenal system, resulting in sleep apnea-related symptoms and metabolic dysfunction. IH exposure causes hormonal imbalances and growth retardation of craniofacial bones. The activation of beta 2-adrenergic receptors and leptin signaling may be involved in IH-induced skeletal growth retardation, possibly mediated by changes in RANKL expression.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Food Science & Technology
Zhengcheng Huang, Shuai Wang, Yiyu Yang, Jianwei Lou, Zhaoxiong Liu, Zhidan Liu, Hui Yong, Shulin Shan, Fuyong Song
Summary: This study found that exposure to acrylamide (ACR) caused necroptosis of Purkinje cells, mitochondrial dysfunction, and inflammatory response. However, rapamycin alleviated mitochondrial dysfunction and inhibited the activation of necroptotic signaling pathway caused by ACR.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Peripheral Vascular Disease
Sara AlMarabeh, Eric F. Lucking, Ken D. O'Halloran, Mohammed H. Abdulla
Summary: In this study, the researchers investigated the role of the excitatory reno-renal reflex in chronic intermittent hypoxia (CIH)-induced hypertension in rats. The findings suggest that the excitatory reno-renal reflex does not contribute to CIH-induced sympathetic hyperactivity and hypertension, and there is evidence that this reflex is suppressed in CIH-exposed rats, possibly due to downregulation of bradykinin type 2 receptors (BK2R).
JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Feier Cheng, Zening Qiao, Guodong Liang, Jiaxin Li, Yaoyao Qiao, Shaojun Yun, Jinling Cao, Yanfen Cheng, Mingchang Chang, Cuiping Feng
Summary: This study explored the protective role of Sparassis latifolia polysaccharide (SLP) in safeguarding the intestinal barrier of lead-exposed mice. The results showed that SLP effectively alleviates intestinal lesions, reduces inflammation, and maintains the expression of key genes and proteins. Furthermore, SLP positively impacts the diversity and richness of the gut microbiota and increases the levels of short-chain fatty acids.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Neurosciences
Huiya Ying, Zilong Zhang, Wei Wang, Zijing Yang, Cancan You, Yuanai Li, Xiaohong Cai, Xiucui Li
Summary: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is characterized by chronic intermittent hypoxia (CIH) and cognitive dysfunction in children. In this study, the role of calcium-sensing receptor (CaSR) in CIH-induced memory dysfunction was investigated. CIH exposure led to cognitive dysfunction, hippocampal neuronal apoptosis, and synaptic plasticity deficit in mice. Inhibition of CaSR alleviated these effects in the hippocampus. Additionally, activation of CaSR accelerated CIH-induced apoptosis and synaptic plasticity deficit in PC12 cells.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ya Ru Yan, Liu Zhang, Ying Ni Lin, Xian Wen Sun, Yong Jie Ding, Ning Li, Hong Peng Li, Shi Qi Li, Jian Ping Zhou, Qing Yun Li
Summary: Chronic intermittent hypoxia-induced mitochondrial dysfunction mediates endothelial apoptosis through the TXNIP/NLRP3/IL-1β signaling pathway. Mitochondria-targeted antioxidant mito-TEMPO can improve mitochondrial function and alleviate CIH-induced endothelial apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yunfei Luo, Qiongfeng Chen, Junrong Zou, Jingjing Fan, Yuanjun Li, Zhijun Luo
Summary: This study explored the effects of hypoxia as a noninvasive and tolerable alternative treatment for obesity and nonalcoholic fatty liver disease (NAFLD). The results showed that hypoxia could alleviate bodyweight gain and insulin resistance induced by a high-fat diet, reverse enlargement of adipocytes and fatty liver, and protect liver function. Hypoxia also activated the energy sensing enzyme AMPK and increased serum levels of epinephrine, suggesting its potential therapeutic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joana L. Fernandes, Fatima O. Martins, Elena Olea, Jesus Prieto-Lloret, Patricia C. Braga, Joana F. Sacramento, Catarina O. Sequeira, Ana P. Negrinho, Sofia A. Pereira, Marco G. Alves, Asuncion Rocher, Silvia V. Conde
Summary: The association between obstructive sleep apnea (OSA) and metabolic disorders is well-established, but the underlying mechanisms remain unclear. This study investigated the role of liver dysfunction in the pathogenesis of OSA-related metabolic dysfunction. The results suggest that hepatic mitochondrial dysfunction and oxidative stress, leading to inflammation, may be significant factors contributing to the development of dysmetabolism associated with OSA.
Article
Cardiac & Cardiovascular Systems
Morin Lang, Valeria Paez, Giacomo Maj, Juan Silva-Urra, Cristian Labarca-Valenzuela, Sergio Caravita, Andrea Faini, Javier Cantuarias, Oscar Perez, Grzegorz Bilo, Gianfranco Parati
Summary: Limited information was available on BP behavior in workers exposed to chronic intermittent hypoxia (CIH) and less known on effects of CIH on 24-hour ambulatory BP in those affected by arterial hypertension at sea level (SL). This study aimed to assess clinic and 24-hour ambulatory BP at sea level and high altitude in workers exposed to CIH, comparing BP response to high altitude between normotensive and hypertensive workers. The results showed that exposure to CIH led to a significant increase in BP at high altitude, with hypertensive workers showing higher nocturnal DBP compared to normotensive workers, despite receiving treatment. 24-hour ambulatory BP monitoring was found to be a useful tool for evaluating BP in CIH workers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Abdelnaby Khalyfa, Wesley Warren, Jorge Andrade, Christopher A. Bottoms, Edward S. Rice, Rene Cortese, Leila Kheirandish-Gozal, David Gozal
Summary: The research evaluated the cellular heterogeneity in visceral white adipose tissues (vWAT) following intermittent hypoxia (IH) exposures mimicking obstructive sleep apnea using single nucleus RNA sequencing. The study revealed transcriptional changes, metabolic signaling pathways, and cellular subpopulation enrichment in vWAT under IH. Different adipocyte types were found to be differentially involved in key aspects of metabolic dysfunction, highlighting the importance of cellular heterogeneity in understanding and potentially targeting metabolic morbidity associated with OSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)