Article
Immunology
Lilan Li, Yu Li, Bingqiang He, Hui Li, Huiyuan Ji, Yingjie Wang, Zhenjie Zhu, Yuming Hu, Yue Zhou, Ting Yang, Chunshuai Sun, Ying Yuan, Yongjun Wang
Summary: Following SCI, two activation states of reactive astrocytes, A1 and A2 subtypes, emerge at lesion sites. A1 astrocytes are neurotoxic while A2 astrocytes have neuroprotective activity. HSF1 plays a key role in suppressing excessive increase of neurotoxic A1 astrocytes.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Neurosciences
Mohini Sengupta, Martha W. Bagnall
Summary: The spinal cord is the location of intrinsic networks for locomotion. Even when the brain is fully severed from the spinal cord, as long as some excitatory drive is provided, animals can still produce rhythmic, patterned movements. However, the underlying circuitry that produces these movements remains poorly understood due to the wide variety of neuron classes and their interconnectivity in the spinal cord. This review considers the classes of spinal neurons, their interconnectivity, and suggests several lines of analysis to improve our understanding of the spinal network.
ANNUAL REVIEW OF NEUROSCIENCE
(2023)
Article
Neurosciences
Ying Huang, Bo Jiao, Bo Zhu, Bingrui Xiong, Pei Lu, Ling Ai, Ning Yang, Yilin Zhao, Hui Xu
Summary: Exposure to chronic stress can exacerbate pain symptoms, leading to stress-induced hyperalgesia. The mechanisms underlying this hyperalgesia may involve modulation of the GCH1-BH4 system and constitutively expressed spinal iNOS. These findings suggest that the GCH1-BH4-iNOS signaling pathway may be a potential therapeutic target for pain relief in the spinal cord.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Ilyas M. Kabdesh, Yana O. Mukhamedshina, Svetlana S. Arkhipova, Davran K. Sabirov, Maxim S. Kuznecov, Alexandra B. Vyshtakalyuk, Albert A. Rizvanov, Victoria James, Yuri A. Chelyshev
Summary: This study investigated cellular and molecular gradients following spinal cord injury (SCI) using a rat contusion model. The expression of NG2, astrocyte markers, and axonal markers was analyzed at different distances from the injury site on 7 and 30 days post-injury (dpi). The results showed a gradient of NG2 expression, with the highest concentrations near the injury site. The expression of astrocyte markers increased close to the injury site but spread more distally by 30 dpi. Surprisingly, the expression of the perisynaptic marker GLT-1 increased in remote areas. The number of 5-HT+ axons decreased in the caudal direction, consistent with a decrease in beta 3-tubulin. These findings indicate significant cellular and molecular reactions in both the damaged area and adjacent and remote areas, which is important for assessing axonal growth.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Medicine, Research & Experimental
Ce Zhang, Jianning Kang, Xiaodi Zhang, Ying Zhang, Nana Huang, Bin Ning
Summary: Spinal cord injury leads to scar formation and irreversible loss of function due to complex inflammatory and pathological processes. Studies have shown promising therapeutic results by targeting the cellular and extracellular matrix components of spinal cord scars, such as chondroitin sulfate proteoglycans. Moreover, the application of new technologies has contributed to a better understanding of the cellular mechanisms involved in scar formation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Kensho Kanehisa, Keisuke Koga, Sho Maejima, Yuto Shiraishi, Konatsu Asai, Miho Shiratori-Hayashi, Mei-Fang Xiao, Hirotaka Sakamoto, Paul F. Worley, Makoto Tsuda
Summary: This study reveals that neuronal pentraxin 2 (NPTX2) upregulation in primary sensory neurons facilitates excitatory synaptic inputs onto gastrin-releasing peptide receptors (GRPR) expressing spinal neurons in chronic itch models.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Xue Bai, Min Gao, Yinxia Li, Haikun Chen, Xiaoyao Ma, Huhu Bai, Yanni Liu, Xiaodong Hu, Zhanwei Suo
Summary: This study found that RCAN1 is predominantly expressed in pain-related neurons in the spinal dorsal horn. Inflammation caused by CFA increased the expression of RCAN1.4 and its binding to CaN. Overexpression of RCAN1.4 led to mechanical allodynia and thermal hyperalgesia, accompanied by increased synaptic expression and phosphorylation of GluA1 subunit. Knockdown of RCAN1.4 attenuated pain hypersensitivity and decreased synaptic expression of GluA1.
NEUROSCIENCE LETTERS
(2022)
Review
Clinical Neurology
Mary Solou, Anastasios A. Politis, Ioannis Ydreos, Evangelos K. Papadopoulos, Stamatios Banos, Georgios Savvanis, Maria M. Gavra, Efstathios J. Boviatsis, Lampis C. Stavrinou
Summary: Treatment of spinal cord injury depends on the type and severity of the injury. Early decompression remains a reasonable option, but there is no specific evidence supporting the use of laminectomy alone.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Shuai Ren, Weihua Zhang, HongMiao Liu, Xin Wang, Xiangchen Guan, Mingzhe Zhang, Jian Zhang, Qiong Wu, Yan Xue, Dan Wang, Yong Liu, Jianyu Liu, Xiaoping Ren
Summary: The study focused on investigating the restoration of motor function following spinal cord injury through transplanting a vascularized pedicle of hemisected spinal cord to bridge the transected spinal cord. Results showed that electrical continuity was restored, leading to motor function recovery, supporting the potential effectiveness of similar operative techniques in treating SCI patients previously considered to have irreversible damage or paralysis.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Jadwiga N. Bilchak, Guillaume Caron, Marie-Pascale Cote
Summary: Exercise is the superior therapy for most SCI sequalae, influencing peripheral health and CNS disorders by activating relevant neural pathways. Recent research has focused on understanding the molecular underpinnings of exercise-induced effects, particularly the increase in neurotrophins, to enhance intervention strategies and improve quality of life for SCI-affected individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Adnan Hassan Tahir, Jia-Jia Li, Yong Tang
Summary: Visceral hypersensitivity (VH) is a significant characteristic feature of gastrointestinal disorders, and treatment efficacy is limited. Electro-acupuncture (EA) is a popular secondary therapy with fewer side effects for managing VH, but the underlying mechanisms still require further exploration.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Rubing Zhou, Junzhao Li, Ruideng Wang, Zhengyang Chen, Fang Zhou
Summary: This study found that moderate systemic therapeutic hypothermia for 4 hours does not have a protective effect on the disrupted blood-spinal cord barrier in early spinal cord injury.
FRONTIERS IN NEUROLOGY
(2022)
Letter
Medicine, General & Internal
Zhuang Zhang, Rubo Sui, Dongjian Xia
Summary: In this study, the role of rs531564 and its underlying signaling pathways were investigated. It was found that rs531564 can affect the expression of BIM through regulation of miR-124, which may serve as a biomarker for the length of recovery after spinal cord injury.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Hongtao Chen, Jiang Cao, Sheng Zhang, Tao Sui, Kaixiang Yang, Xiaojian Cao
Summary: This study aimed to determine the anatomical feasibility of transferring T9 or T11 ventral roots to L2 ventral roots and T10 or T12 ventral roots to L3 ventral roots in restoring lower limb function after spinal cord injury. The feasibility was confirmed through dissection of cadavers, showing that the procedure is anatomically feasible for restoring lower limb function.
Article
Immunology
Ya-Lin Lin, Mei-Yi Lu, Chi-Fen Chuang, Yali Kuo, Hong-En Lin, Fu-An Li, Jen-Ren Wang, Yi-Ping Hsueh, Fang Liao
Summary: The study found that TLR7 is not the absolute PRR for EV71 in the spinal cord, but plays a critical role in anti-viral humoral immunity. TLR7KO mice infected with EV71 showed delayed recovery from limb paralysis and significantly decreased levels of important antibodies for antiviral humoral immunity compared to WT mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Xiaofeng Xu, Zijing Liu, Hao Huang, Kang Zheng, Xuemei Hu, Zunyi Zhang, Mengsheng Qiu
Article
Neurosciences
Paul J. Kiser, Zijing Liu, Steven D. Wilt, George D. Mower
Article
Neurosciences
Zijing Liu, Hong Li, Xuemei Hu, Ling Yu, Hongbin Liu, Ruifa Han, Rita Colella, George D. Mower, Yiping Chen, Mengsheng Qiu
JOURNAL OF NEUROSCIENCE
(2008)
Article
Neurosciences
Claudia Lopes, Zijing Liu, Yi Xu, Qiufu Ma
JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Yu Sun, Dimphna H. Meijer, John A. Alberta, Shwetal Mehta, Michael F. Kane, An-Chi Tien, Hui Fu, Magdalena A. Petryniak, Gregory B. Potter, Zijing Liu, James F. Powers, I. Sophie Runquist, David H. Rowitch, Charles D. Stiles
Article
Developmental Biology
Zijing Liu, Xuemei Hu, Jun Cai, Ben Liu, Xiaozhong Peng, Michael Wegner, Mengsheng Qiu
DEVELOPMENTAL BIOLOGY
(2007)
Article
Neurosciences
J Cai, YC Qi, XM Hu, M Tan, ZJ Liu, JS Zhang, Q Li, M Sander, M Qiu
Article
Multidisciplinary Sciences
ZJ Liu, HY Yin, G Deng, YH Yuan, JZ Wang, YQ Geng, QM Chen
CHINESE SCIENCE BULLETIN
(2003)
Article
Neurosciences
H Fu, YC Qi, M Tan, J Cai, XM Hu, ZJ Liu, J Jensen, MS Qiu
JOURNAL OF COMPARATIVE NEUROLOGY
(2003)
Article
Biotechnology & Applied Microbiology
Jing Li, Zijing J. Liu, Yuchun C. Pan, Qi Liu, Xing Fu, Nigel G. F. Cooper, Yixue Li, Mengsheng Qiu, Tieliu Shi
Article
Anatomy & Morphology
Ben Liu, Zijing Liu, Tao Chen, Hong Li, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng, Mengsheng Qiu
DEVELOPMENTAL DYNAMICS
(2007)