Article
Environmental Sciences
Tyler J. S. Smith, Ana Navas-Acien, Sarah Baker, Caryn Kok, Kate Kruczynski, Lindsay N. Avolio, Nora Pisanic, Pranay R. Randad, Rebecca C. Fry, Walter Goessler, Alexander van Geen, Jessie P. Buckley, Md Hafizur Rahman, Hasmot Ali, Rezwanul Haque, Saijuddin Shaikh, Towfida J. Siddiqua, Kerry Schulze, Keith P. West Jr, Alain B. Labrique, Christopher D. Heaney
Summary: This study investigated the association between anthropometric measures and arsenic methylation efficiency in pregnant women in rural northern Bangladesh, and found a positive correlation between body mass index (BMI) and arsenic methylation efficiency.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Karla Rangel-Moreno, Brenda Gamboa-Loira, Lizbeth Lopez-Carrillo, Mariano E. Cebrian
Summary: This study found that the metabolism of inorganic arsenic (iAs) in urine is associated with the prevalence of type 2 diabetes mellitus (T2DM), but not with the urinary arsenic levels. This suggests a link between iAs metabolism and T2DM, but further research is needed to explore the interplay among iAs metabolism, T2DM, and hypertension.
ENVIRONMENTAL RESEARCH
(2022)
Review
Medicine, General & Internal
Sajin Bae, Elena Kamynina, Heather M. Guetterman, Adetutu F. Farinola, Marie A. Caudill, Robert J. Berry, Patricia A. Cassano, Patrick J. Stover
Summary: The provision of folic acid supplements may benefit blood arsenic concentration, urinary arsenic methylation profiles, and plasma homocysteine concentration versus placebo with moderate-certainty evidence. Furthermore, there is low-certainty evidence that folic acid supplements plus other nutrients may benefit blood arsenic and plasma homocysteine concentrations versus nutrients alone. Given the limited number of studies, more research is needed to assess the effects of folic acid on arsenic-related health outcomes in diverse settings.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Environmental Sciences
Ahlam Abuawad, Jeff Goldsmith, Julie B. Herbstman, Faruque Parvez, Tariqul Islam, Nancy LoIacono, Joseph H. Graziano, Ana Navas-Acien, Mary Gamble
Summary: This study aimed to evaluate which urine dilution correction methods for urinary arsenic (uAs) most accurately predicted blood arsenic (bAs). The results showed that uAs adjusted for urinary creatinine (uCr) had stronger associations with bAs compared to specific gravity (SG), suggesting that considerations should be made regarding factors such as methylation or medical conditions when choosing urine dilution methods.
Article
Environmental Sciences
Yuko Takayama, Yuko Masuzaki, Futoshi Mizutani, Toyoto Iwata, Eri Maeda, Mikako Tsukada, Kyoko Nomura, Yasunori Ito, Yoichi Chisaki, Katsuyuki Murata
Summary: The study revealed significant associations between blood arsenic and urinary arsenic species, especially after adjustment for creatinine in urine samples. Plasma T-As concentration was suggested as the best indicator for low-level arsenic exposure in blood samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Jin Cheng, Yuanyuan Li, Qian He, Lanrong Luo, Yanting Zhang, Yanhui Gao, Hongqi Feng, Lijun Zhao, Wei Wei, Songbo Fu, Dianjun Sun
Summary: The study found that ADIPQO/rs266729 and FABP2/rs1799883 gene polymorphisms affect susceptibility to essential hypertension in individuals exposed to high levels of arsenic; there was a clear difference in the urinary arsenic metabolism pattern between hypertensive patients and controls.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Environmental Sciences
Abby F. Fleisch, Sudipta Kumer Mukherjee, Subrata K. Biswas, John F. Obrycki, Sheikh Muhammad Ekramullah, D. M. Arman, Joynul Islam, David C. Christiani, Maitreyi Mazumdar
Summary: While arsenic exposure during pregnancy has been associated with gestational diabetes mellitus, this study found no clear evidence of adverse effects on postpartum insulin resistance or beta cell function.
ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Haotian Wu, Vrinda Kalia, Megan M. Niedzwiecki, Marianthi-Anna Kioumourtzoglou, Brandon Pierce, Vesna Ilievski, Jeff Goldsmith, Dean P. Jones, Ana Navas-Acien, Douglas I. Walker, Mary Gamble
Summary: Chronic exposure to arsenic remains a global health concern, but the biological mechanisms underlying its adverse effects are not fully understood. This study used metabolomics to examine how arsenic affects metabolic pathways in humans. The results identified multiple metabolites and pathways associated with arsenic exposure.
Article
Pharmacology & Pharmacy
Teresa Garcia-Martinez, Maria Dolores Belles-Medall, Maria Garcia-Cremades, Raul Ferrando-Piqueres, Victor Mangas-Sanjuan, Matilde Merino-Sanjuan
Summary: This study aimed to develop a population pharmacokinetic/pharmacodynamic model of daptomycin and establish optimal dose recommendations in patients with normal and impaired renal function. The results indicate that bactericidal effects for Gram+ strains can be achieved with specific daily doses based on body weight and renal function. By evaluating the impact of different dosing regimens on treatment outcomes, the study provides insights for optimizing the use of daptomycin.
Article
Water Resources
Md Khalequzzaman Sarker, Selim Reza Tony, Abu Eabrahim Siddique, Nazmul Haque, Md Shofikul Islam, Faruk Hossain, Zohurul Islam, Shakhawoat Hossain, Md Ashraful Hoque, Zahangir Alam Saud, Daigo Sumi, Seiichiro Himeno, Khaled Hossain
Summary: This study reveals a potential association between arsenic exposure and an increased risk of metabolic syndrome (MeS), particularly affecting women. Women show a higher susceptibility to MeS components such as hyperglycemia, hypo-high-density lipoprotein-cholesterolemia, hyper-systolic blood pressure, and abdominal obesity in response to arsenic exposure compared to men.
EXPOSURE AND HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Aimo, Josep Lupon, Giosafat Spitaleri, Mar Domingo, Pau Codina, Evelyn Santiago-Vacas, German Cediel, Elizabet Zamora, Maribel Troya, Javier Santesmases, Gregorio A. Romero-Gonzalez, Julio Nunez, Nicola Martini, Michele Emdin, Antoni Bayes-Genis
Summary: This study analyzed the relationship between creatinine, estimated glomerular filtration rate (eGFR), and high temperatures in heart failure outpatients. The results showed that creatinine significantly increased during summer, while eGFR slightly decreased, and the magnitude of temperature elevation during summer has increased over time. This suggests that global warming has an impact on human health.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Linnea Malmgren, Fiona E. McGuigan, Anders Christensson, Kristina E. Akesson
Summary: It is common for elderly women to have eGFR(cysC)/eGFR(crea) ratio <0.6, which is associated with increased mortality risk.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Ram B. Jain
Summary: Analysis of data from the National Health and Nutrition Examination Survey for US adults aged 20 years and older between 2005 and 2016 showed variations in concentrations of arsenobetaine, monomethylarsonic acid, dimethylarsenic acid, and total arsenic in urine across different stages of renal function. Differences were observed in concentrations based on gender and racial/ethnic groups, with levels decreasing over the survey years.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Food Science & Technology
Sergej M. Ostojic
Summary: Based on 2017-2018 NHANES data, this study found no significant association between dietary creatine intake and kidney dysfunction in 2,955 U.S adults.
FOOD SCIENCE & NUTRITION
(2021)
Article
Nutrition & Dietetics
Sonoe Yoshida, Goki Suda, Masatsugu Ohara, Qingjie Fu, Zijian Yang, Shunichi Hosoda, Megumi Kimura, Kubo Akinori, Yoshimasa Tokuchi, Ren Yamada, Takashi Kitagataya, Kazuharu Suzuki, Naoki Kawagishi, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Osamu Maehara, Shunsuke Ohnishi, Naoya Sakamoto
Summary: The study found that up to 24.8% of Japanese patients with chronic liver disease had overestimated renal function, which was related to indicators of sarcopenia. Liver cirrhosis and psoas muscle mass index were significantly associated with overestimated renal function, and patients with overestimated renal function showed a more frequent loss of skeletal muscle mass.
Article
Immunology
Brandilyn A. Peters, Xiaonan Xue, Lila A. Sheira, Qibin Qi, Anjali Sharma, Nanette Santoro, Maria L. Alcaide, Igho Ofotokun, Adaora A. Adimora, Heather S. McKay, Phyllis C. Tien, Katherine G. Michel, Deborah Gustafson, Bulent Turan, Alan L. Landay, Robert C. Kaplan, Sheri D. Weiser
Summary: Menopause may lead to increased innate immune activation in women with HIV, but does not affect gut barrier or inflammation. Further research is needed to investigate the clinical significance of immune activation during the menopausal transition.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Brandilyn A. Peters, Jee-Young Moon, David B. Hanna, Olaf Kutsch, Margaret Fischl, Caitlin A. Moran, Adaora A. Adimora, Stephen Gange, Nadia R. Roan, Katherine G. Michel, Michael Augenbraun, Anjali Sharma, Alan Landay, Seema Desai, Robert C. Kaplan
Summary: Persistent CD4(+) T-cell activation and exhaustion may contribute to increased long-term mortality risk in women with HIV, independent of HIV disease progression.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Brandilyn A. Peters, David B. Hanna, Anjali Sharma, Kathryn Anastos, Donald R. Hoover, Qiuhu Shi, Caitlin A. Moran, Elizabeth A. Jackson, Maria L. Alcaide, Igho Ofotokun, Adaora A. Adimora, Sabina A. Haberlen, Mardge Cohen, Phyllis C. Tien, Katherine G. Michel, Steven R. Levine, Howard N. Hodis, Robert C. Kaplan, Michael T. Yin
Summary: In this cohort study, ever use of estrogen-based hormone therapy was associated with less progression of subclinical atherosclerosis over time in women with and without HIV. This suggests that hormone therapy may confer a similar cardiovascular benefit for both groups.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Obstetrics & Gynecology
Brandilyn A. Peters, Nanette Santoro, Robert C. Kaplan, Qibin Qi
Summary: The gut microbiome is influenced by sex hormones and undergoes changes during menopause, which may be associated with menopause-related disease risks.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Genetics & Heredity
Brandilyn A. Peters, Harvey Pass, Robert D. Burk, Xiaonan Xue, Chandra Goparaju, Christopher C. Sollecito, Evan Grassi, Leopoldo N. Segal, Jun-Chieh J. Tsay, Richard B. Hayes, Jiyoung Ahn
Summary: In this study, the lung microbiome and peripheral blood gene expression were investigated as potential biomarkers for predicting lung cancer recurrence after tumor resection. The results showed that certain microbial and gene profiles were associated with recurrence-free survival and disease-free survival, providing additional predictive value beyond standard demographic and clinical factors.
Article
Nutrition & Dietetics
Brandilyn A. Peters, Jiaqian Xing, Guo-Chong Chen, Mykhaylo Usyk, Zheng Wang, Amanda C. McClain, Bharat Thyagarajan, Martha L. Daviglus, Daniela Sotres-Alvarez, Frank B. Hu, Rob Knight, Robert D. Burk, Robert C. Kaplan, Qibin Qi
Summary: This study found that healthy dietary patterns are associated with the abundance of gut microbiome species in US Hispanics/Latinos, and are closely related to cardiometabolic health. Additionally, healthy dietary patterns are also associated with some favorable cardiometabolic traits.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Victoria Persky, Chibuzor Abasilim, Konstantina Tsintsifas, Tessa Day, Robert M. Sargis, Martha L. Daviglus, Jianwen Cai, Sally Freels, Terry Unterman, Noel Chavez, Robert Kaplan, Carmen R. Isasi, Amber Pirzada, Michelle L. Meyer, Gregory A. Talavera, Bharat Thyagarajan, Brandilyn A. Peters, Jessica M. Madrigal, Arielle Grieco, Mary E. Turyk
Summary: This study examined the associations between endogenous sex hormones and diabetes progression. It found an inverse association between testosterone levels in men and conversion from prediabetes to diabetes, and an inverse association between SHBG levels in women and various glycemic measures as well as prediabetes to diabetes conversion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Infectious Diseases
Brandilyn A. A. Peters, Robert D. D. Burk, Robert C. C. Kaplan, Qibin Qi
Summary: Recent studies have explored the link between the gut microbiome and microbial metabolites and cardiovascular disease in people living with HIV. However, there is insufficient and inconsistent evidence regarding specific microbial species and metabolites associated with cardiovascular outcomes in this population.
CURRENT HIV/AIDS REPORTS
(2023)
Article
Microbiology
Zheng Wang, Brandilyn A. Peters, MacKenzie Bryant, David B. Hanna, Tara Schwartz, Tao Wang, Christopher C. Sollecito, Mykhaylo Usyk, Evan Grassi, Fanua Wiek, Lauren St. Peter, Wendy S. Post, Alan L. Landay, Howard N. Hodis, Kathleen M. Weber, Audrey French, Elizabeth T. Golub, Jason Lazar, Deborah Gustafson, Anjali Sharma, Kathryn Anastos, Clary B. Clish, Robert D. Burk, Robert C. Kaplan, Rob Knight, Qibin Qi
Summary: The study found that alterations in gut microbiota are associated with HIV infection and cardiovascular disease. In this study, associations between gut microbial species and carotid artery plaque were examined in women with or at high risk of HIV. The findings suggest that certain bacterial species and a microbial metabolite called ImP are associated with carotid artery atherosclerosis, possibly through immune activation and inflammation.
Article
Gastroenterology & Hepatology
Brandilyn A. Peters, Qibin Qi, Mykhaylo Usyk, Martha L. Daviglus, Jianwen Cai, Nora Franceschini, James P. Lash, Marc D. Gellman, Bing Yu, Eric Boerwinkle, Rob Knight, Robert D. Burk, Robert C. Kaplan
Summary: This study found that there is an association between kidney function and the gut microbiome. The relationship between kidney damage and the gut microbiome depends on whether the individual has diabetes. The metabolites produced by the gut microbiome may contribute to the progression of chronic kidney disease.
Article
Endocrinology & Metabolism
Brandilyn A. Peters, David B. Hanna, Yi Wang, Kathleen M. Weber, Elizabeth Topper, Allison A. Appleton, Anjali Sharma, Howard N. Hodis, Nanette Santoro, Chantal Guillemette, Patrick Caron, Rob Knight, Robert D. Burk, Robert C. Kaplan, Qibin Qi
Summary: The study found that there is an interplay between sex hormones and the gut microbiome, which may impact cardiovascular risk. Serum sex hormones are associated with gut microbiome diversity and composition, and the gut microbiome may play a role in estrogen-related cardiovascular protection.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Caroline Y. Um, Brandilyn A. Peters, Hee Sun Choi, Paul Oberstein, Dia B. Beggs, Mykhaylo Usyk, Feng Wu, Richard B. Hayes, Susan M. Gapstur, Marjorie L. McCullough, Jiyoung Ahn
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Mykhaylo Usyk, Brandilyn A. Peters, Smruthi Karthikeyan, Daniel McDonald, Christopher C. Sollecito, Yoshiki Vazquez-Baeza, Justin P. Shaffer, Marc D. Gellman, Gregory A. Talavera, Martha L. Daviglus, Bharat Thyagarajan, Rob Knight, Qibin Qi, Robert Kaplan, Robert D. Burk
Summary: In a cohort study involving 1,772 participants, it was found that 16SV4 amplicon sequencing and shotgun metagenomics have similar taxonomic accuracy for bacteria at the genus level, even with shallow sequencing depths. However, there was not a significant agreement between shotgun and ITS1 amplicon results for fungal taxa. Additionally, pooling amplicon and shotgun data can generate larger microbiome datasets with excellent agreement, compared to pure shotgun metagenomic analysis.
CELL REPORTS METHODS
(2023)
Article
Immunology
Brandilyn A. Peters, Adam Whalen, Xiaonan Xue, Elizabeth F. Topper, Kathleen M. Weber, Phyllis C. Tien, Seble G. Kassaye, Howard Minkoff, Ervin Fox, Margaret A. Fischl, Lauren F. Collins, Michelle Floris-Moore, Howard N. Hodis, Qibin Qi, David B. Hanna, Anjali Sharma, Kathryn Anastos, Robert C. Kaplan
Summary: This study suggests that menopause may accelerate subclinical atherosclerosis as measured by CIMT in HIV patients.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
Kelsey R. Monson, Brandilyn A. Peters, Mykhaylo Usyk, Caroline Y. Um, Paul E. Oberstein, Marjorie L. McCullough, Mark P. Purdue, Neal D. Freedman, Richard B. Hayes, Jiyoung Ahn
Summary: This study demonstrates that diets high in carbohydrates and glycemic index (GI) may influence the composition of the oral microbiome, with high carbohydrate intake associated with certain carcinogenic bacteria and decreased abundance of protective bacteria, and high GI intake associated with increased abundance of certain inflammation-related bacteria.
CANCER RESEARCH COMMUNICATIONS
(2022)