Article
Agriculture, Dairy & Animal Science
Dandan Zhu, Tianyi Feng, Nan Mo, Rui Han, Wentao Lu, Zhaoxia Cui
Summary: This study reveals the role of the Fem-1c gene (EsFem-1c) in sex differentiation in Eriocheir sinensis. The results show that EsFem-1c affects sexual development in the intersex crab and is regulated by miRNAs. Specifically, tcf-miR-315-5p inhibits EsFem-1c translation, while tcf-miR-307 increases EsFem-1c expression by binding to the alternative splicing region in the 3' UTR sequence.
Article
Multidisciplinary Sciences
Xuan Xie, Shaogang Wang, Mingyi Li, Lei Diao, Xingyu Pan, Jijun Chen, Weiguo Zou, Xu Zhang, Wenfeng Feng, Lan Bao
Summary: The post-translational modification α-TubK40me3 plays a crucial role in neuronal polarization and migration by promoting microtubule formation. This modification is enriched in the mouse cerebral cortex during embryonic development, and its deficiency leads to defects in neuronal migration that can be rescued by overexpression of specific proteins. Additionally, α-TubK40me3 potently promotes tubulin nucleation and is involved in tubulin acetylation regulation, highlighting its importance in microtubule dynamics and neuronal development.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Daiki Karigane, Miho Haraguchi, Noriko Toyama-Sorimachi, Emi K. Nishimura, Keiyo Takubo
Summary: Thymic dendritic cells (DCs) play a pivotal role in immune tolerance by regulating negative selection of autoreactive T cells in the thymus. This study reveals that the transcription factor Mitf is involved in the regulation of DC homing to the thymus and maintenance of thymic DC population.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Miku Fukawa, Remina Shirai, Tomohiro Torii, Kenta Nakata, Shoya Fukatsu, Takanari Sato, Keiichi Homma, Yuki Miyamoto, Junji Yamauchi
Summary: The molecular mechanisms of neuronal process growth are complex and involve the regulation of extracellular and intracellular signals. This study discovered that HSPA5, a heat shock protein, is secreted from neuronal cells and inhibits the elongation of neuronal processes. The inhibition can be neutralized by antibodies, suggesting that HSPA5 acts as a negative regulator of neuronal differentiation. The study also implicates LRP1 as a potential receptor for HSPA5.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mizuki Uenaka, Akiko Uyeda, Tsutomu Nakahara, Rieko Muramatsu
Summary: The study found that LPA(2) is highly expressed in neural stem/progenitor cells during neocortical development. Activation of LPA(2) promotes neuronal differentiation and development through Erk1/2 signaling. Additionally, LPA(2) activation also enhances neurite elongation and branch formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Sara Bilekova, Balma Garcia-Colomer, Alberto Cebrian-Serrano, Silvia Schirge, Karsten Krey, Michael Sterr, Thomas Kurth, Stefanie M. Hauck, Heiko Lickert
Summary: Spermatogenesis is a crucial biological process that produces functional sperm for successful reproduction. The acrosome, a lysosome-related organelle in the sperm head, is essential for egg-sperm recognition and fusion. The role of the insulin inhibitory receptor (inceptor) in acrosome formation was investigated, and its absence resulted in acrosomal malformation and male infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Horticulture
Muhammad Mobeen Tahir, Shaohuan Li, Zhimin Liu, Li Fan, Ting Tang, Xiaoyun Zhang, Jiangping Mao, Ke Li, Abid Khan, Yun Shao, Dong Zhang, Juanjuan Ma
Summary: This study investigates the formation of adventitious roots (AR) in apples under drought stress. The results show that drought stress affects the levels of hormones and miRNAs, which in turn impact the development of ARs. The study also identifies several miRNAs and target genes that are related to stress response and cell development.
SCIENTIA HORTICULTURAE
(2022)
Article
Biochemistry & Molecular Biology
Gennady V. V. Vasiliev, Vladimir Y. Y. Ovchinnikov, Pavel D. D. Lisachev, Natalia P. P. Bondar, Larisa N. N. Grinkevich
Summary: Researchers performed sequencing and comparative bioinformatics analysis of microRNAs in the central nervous system (CNS) of the terrestrial mollusk Helix lucorum. They identified 95 different microRNAs, with the MIR-10 family being the most representative. The study showed the involvement of the MIR-10 family in long-term memory formation in Helix, and changes in the expression of 17 representatives of MIR-10 during different periods of memory consolidation. These findings have significant implications for further behavioral research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
De-Yao Wang, Cristina Melero, Ashwaq Albaraky, Paul Atherton, Karin A. Jansen, Andrea Dimitracopoulos, Federico Dajas-Bailador, Adam Reid, Kristian Franze, Christoph Ballestrem
Summary: Integrins and their associated proteins are essential for neuronal axon outgrowth, while vinculin plays a crucial role in integrin-mediated mechanosensing in neurons.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Ophthalmology
Hao Huang, Xielan Kuang, Yuxiu Zou, Jingshu Zeng, Han Du, Han Tang, Chongde Long, Yan Mao, Xinyue Yu, Chaojuan Wen, Jianhua Yan, Huangxuan Shen
Summary: The loss of MAP4K4 gene leads to neural developmental disorder and impairment of photoreceptor development. MAP4K4 promotes neuronal development and plays a vital role in vision formation.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Cell Biology
Jiansong Huang, Bowen Jiang, Guo-Wei Li, Dandan Zheng, Mingyi Li, Xuan Xie, Yuxiang Pan, Manyi Wei, Xiaoyan Liu, Xingyu Jiang, Xu Zhang, Li Yang, Lan Bao, Bin Wang
Summary: This study reveals the critical role of m6A-modified lincRNA in neuronal development, functioning through the regulation of RNA-binding protein degradation, which impacts axon elongation and migration of neurons.
Article
Neurosciences
Brikha R. Shrestha, Anita Burgos, Wesley B. Grueber
Summary: The study reveals the important role of the cell surface molecule Basigin in complex dendrite morphogenesis, with loss of the gene leading to defects in dendrite formation. Knock down of Basigin also affects dendrite elaboration of class IV neurons, suggesting a non-autonomous role in dendrite development.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell & Tissue Engineering
Jean-Marie Jacob, Selene E. Di Carlo, Igor Stzepourginski, Anthony Lepelletier, Papa Diogop Ndiaye, Hugo Varet, Rachel Legendre, Etienne Kornobis, Adam Benabid, Giulia Nigro, Lucie Peduto
Summary: The transcriptomic switch induced by PDGFR alpha in intestinal stromal cells is crucial for coordinating postnatal intestinal maturation and function.
Article
Biochemistry & Molecular Biology
Pei Chen, Yihui Wu, Jiejie Zhuang, Xuan Liu, Qian Luo, Qiyun Wang, Zihua Jiang, Anqi He, Shuilian Chen, Xi Chen, Jin Qiu, Yan Li, Ying Yang, Keming Yu, Jing Zhuang
Summary: Gata3, a zinc-finger transcription factor, plays a crucial role in neural development and in the retina. It maintains the precursor state of cells and its silencing promotes cell differentiation. Abnormal expression of Gata3 impairs neural activity and neurite outgrowth in retinal neurocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gubbi Govindaiah, Rong-Jian Liu, Yanyan Wang
Summary: This study found that D2L deficiency can cause abnormalities in cholinergic interneurons (ChIs). Specifically, quinpirole enhances the excitability of ChIs, loses influence on spike firing of medium spiny projection neurons (MSNs), and continues to have an inhibitory effect on spike firing of fast-spiking interneurons (FSIs). Additionally, reduced spontaneous GABA release and dendritic spine density in ChIs were observed in D2L knockout (KO) mice. These findings provide new molecular and cellular mechanisms for understanding Parkinson's disease and drug-induced dyskinesias.
Article
Virology
Lorena S. Ver, Laura Marcos-Villar, Sara Landeras-Bueno, Amelia Nieto, Juan Ortin
JOURNAL OF VIROLOGY
(2015)
Review
Virology
Juan Ortin, Jaime Martin-Benito
Article
Virology
Sara Landeras-Bueno, Juan Ortin
Article
Microbiology
Sara Landeras-Bueno, Yolanda Fernandez, Ana Falcon, Juan Carlos Oliveros, Juan Ortin
Article
Multidisciplinary Sciences
Ariel Rodriguez-Frandsen, Susana de Lucas, Alicia Perez-Gonzalez, Maite Perez-Cidoncha, Alejandro Roldan-Gomendio, Alejandra Pazo, Laura Marcos-Villar, Sara Landeras-Bueno, Juan Ortin, Amelia Nieto
SCIENTIFIC REPORTS
(2016)
News Item
Microbiology
Juan Valcarcel, Juan Ortin
NATURE MICROBIOLOGY
(2016)
Article
Microbiology
Isidoro Martinez, Juan C. Oliveros, Isabel Cuesta, Jorge de la Barrera, Vicente Ausina, Cristina Casals, Alba de Lorenzo, Ernesto Garcia, Belen Garcia-Fojeda, Junkal Garmendia, Mar Gonzalez-Nicolau, Alicia Lacoma, Margarita Menendez, David Moranta, Amelia Nieto, Juan Ortin, Alicia Perez-Gonzalez, Cristina Prat, Elisa Ramos-Sevillano, Veronica Regueiro, Ariel Rodriguez-Frandsen, Dolores Solis, Jose Yuste, Jose A. Bengoechea, Jose A. Melero
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Bernd Wicklein, M. Angeles Martin del Burgo, Maria Yuste, Ester Carregal-Romero, Andreu Llobera, Margarita Darder, Pilar Aranda, Juan Ortin, Gustavo del Real, Cesar Fernandez-Sanchez, Eduardo Ruiz-Hitzky
ADVANCED FUNCTIONAL MATERIALS
(2013)
Article
Biotechnology & Applied Microbiology
Blanca Garcia-Barreno, Teresa Delgado, Sonia Benito, Inmaculada Casas, Francisco Pozo, Maria Teresa Cuevas, Vicente Mas, Alfonsina Trento, Ariel Rodriguez-Frandsen, Ana Falcon, Juan Ortin, Amelia Nieto, Jose A. Melero
JOURNAL OF GENERAL VIROLOGY
(2014)
Article
Virology
Maite Perez-Cidoncha, Marian J. Killip, Juan C. Oliveros, Victor J. Asensio, Yolanda Fernandez, Jose A. Bengoechea, Richard E. Randall, Juan Ortin
JOURNAL OF VIROLOGY
(2014)
Article
Biochemistry & Molecular Biology
Susana de Lucas, Juan Carlos Oliveros, Monica Chagoyen, Juan Ortin
NUCLEIC ACIDS RESEARCH
(2014)
Article
Multidisciplinary Sciences
Ariel Rodriguez, Ana Falcon, Maria Teresa Cuevas, Francisco Pozo, Susana Guerra, Blanca Garcia-Barreno, Pamela Martinez-Orellana, Pilar Perez-Brena, Maria Montoya, Jose Antonio Melero, Manuel Pizarro, Juan Ortin, Inmaculada Casas, Amelia Nieto
Article
Multidisciplinary Sciences
Maite Perez-Cidoncha, Marian J. Killip, Victor J. Asensio, Yolanda Fernandez, Jose A. Bengoechea, Richard E. Randall, Juan Ortin
Article
Microbiology
Rocio Coloma, Rocio Arranz, Jose M. de la Rosa-Trevin, Carlos O. S. Sorzano, Sandie Munier, Diego Carlero, Nadia Naffakh, Juan Ortin, Jaime Martin-Benito
NATURE MICROBIOLOGY
(2020)