Article
Endocrinology & Metabolism
Jinyun Wang, Dingwei Liu, Yong Xie
Summary: The study found that high levels of thyroid stimulating hormone are associated with H. pylori infection, especially among male, overweight, and elderly individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Hosu Kim, Jaehoon Jung, Young-Seok Cho, Joon Young Choi, Hyunju Park, You-Bin Lee, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim
Summary: This study examined the relationship between preoperative TSH levels and the prognosis of DTC by analyzing clinical records of patients at a medical center. Results showed a linear association between preoperative TSH levels and extra-thyroidal extension and lymph node metastasis, while primary tumor size and initial distant metastasis exhibited a bimodal pattern. The study provides insights into the complex relationship between preoperative TSH levels and DTC prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Krzysztof Kaliszewski, Dorota Diakowska, Marta Rzeszutko, Lukasz Nowak, Beata Wojtczak, Krzysztof Sutkowski, Maksymilian Ludwig, Bartlomiej Ludwig, Maria Greniuk, Urszula Tokarczyk, Jerzy Rudnicki
Summary: This study found that preoperative serum TSH levels are associated with cytological and histopathological diagnosis of thyroid nodules. Patients with AUS/FLUS diagnosis had significantly higher TSH concentrations than those with benign tumors. Serum TSH levels can serve as a prognostic factor for predicting the risk of malignancy in patients with thyroid nodules.
Article
Medical Laboratory Technology
Xin Zhou, Zaishuan Liu, Yining Ma, Chongwei Zhang, Yongkang Wu
Summary: The developed mathematical algorithm allows for harmonizing TSH measurements between different instruments, enabling comparability of TSH data across laboratories.
CLINICA CHIMICA ACTA
(2023)
Article
Oncology
Tae-Hwan Kim, Mi Yeon Lee, Sung Min Jin, Sang Hyuk Lee
Summary: The impact of serum thyroid hormone levels on thyroid cancer risk is still uncertain. This study found that low levels of TSH in men and high levels of TSH in women were associated with thyroid cancer. Additionally, high levels of free T4 and free T3 were also linked to thyroid cancer incidence.
ENDOCRINE-RELATED CANCER
(2022)
Review
Biochemistry & Molecular Biology
Eleonore Froehlich, Richard Wahl
Summary: Thyroid-stimulating hormone (TSH) and thyroid hormone levels are important parameters in blood analysis, but immunoassays used may produce inaccurate results due to interference from certain materials in the sample. Macro-TSH, a complex of TSH with immunoglobulin or albumin, can lead to falsely elevated TSH concentrations. While less well-known, PT-TSH plays a significant role in central regulation of thyroid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Molla Mesele Wassie, Lisa Gaye Smithers, Shao Jia Zhou
Summary: This study systematically reviewed the associations between newborn TSH and childhood neurodevelopment and growth. Findings showed a negative association between newborn TSH and cognitive development in iodine deficient populations, while a null association was found in iodine sufficient populations. Null association was observed between TSH and psychomotor development regardless of iodine status.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Chemistry, Analytical
Jingrong Liu, Chunxiao Yu, Luodan Han, Yiping Shen, Yao Fang, Yaokun Xia, Xu Yao, Fang Wu, Chunyan Li, Jinghua Chen, Xi Zhang, Jianming Lan
Summary: A wash-free biological aptasensor based on UCNPs and TAMRA was developed for high sensitive detection of TSH. The sensor achieved detection by changing the distance between UCNPs and TAMRA, and effectively eliminated background interference. With its high sensitivity and operational convenience, it is a promising method for clinical TSH determination.
Article
Geriatrics & Gerontology
Madeleen Bosma, Robert S. Du Puy, Bart E. P. B. Ballieux
Summary: By comparing fT4-based screening with TSH-based screening, our study suggests that screening for thyroid dysfunction in older individuals in primary care can be improved by using fT4 or adjusting the TSH cutoff value. This could potentially reduce costs and minimize unnecessary monitoring for patients.
Article
Biochemistry & Molecular Biology
Samaneh Nakhaee, Maryam Rezayee, Borhan Mansouri, Ali Hadianfar, Alireza Amirabadi Zadeh, Mahmoud Zardast, Malihe Parsa Sefat, Omid Mehrpour
Summary: This study found that lead poisoning affects thyroid function, reducing TSH levels and increasing T4 levels. The linear regression model results showed a significant difference between the two groups in terms of T3 and TSH levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Nutrition & Dietetics
Klara Gustin, Marie Vahter, Malin Barman, Bo Jacobsson, Helena Skroder, Helena Filipsson Nystrom, Anna Sandin, Ann-Sofie Sandberg, Agnes E. Wold, Maria Kippler
Summary: This study assessed the associations between thyroid hormones and the combined status of iodine, selenium, and zinc in pregnant women. The results showed a positive correlation between the joint status of these micronutrients and plasma TSH concentrations, with zinc and selenium having a greater influence on hormone concentrations compared to iodine. This study highlights the importance of considering multiple micronutrients in studies of thyroid hormone status.
JOURNAL OF NUTRITION
(2022)
Article
Medicine, General & Internal
Yuansong Zhu, Jian Shen, Yuzhou Xue, Zhenxian Xiang, Yi Jiang, Wei Zhou, Suxin Luo
Summary: In patients with acute ST segment elevation myocardial infarction, admission thyroid-stimulating hormone levels beyond the normal range (TSH >3.5 mIU/L) are associated with worse long-term outcomes, while high-normal TSH or reduced TSH do not impact long-term prognosis.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mirjana Babic Leko, Iva Juresko, Iva Rozic, Nikolina Pleic, Ivana Gunjaca, Tatijana Zemunik
Summary: Vitamin D is important for the normal functioning of organs, including the thyroid. Vitamin D deficiency is considered a risk factor for thyroid disorders, but the interaction between vitamin D and thyroid function is not fully understood. Studies comparing vitamin D status with thyroid function and the effect of vitamin D supplementation show inconsistent results, making it difficult to draw a definite conclusion. Additional studies with larger sample sizes are needed to fully understand the effect of vitamin D on thyroid function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Zhen Cao, Rui Liu, Mengwei Wu, Xiequn Xu, Ziwen Liu
Summary: Hypothyroidism is common after hemithyroidectomy, and almost half of the patients will need thyroid hormone replacement. Elevated preoperative serum TSH level and unilateral thyroid nodule were independent predictors of thyroid hormone replacement following hemithyroidectomy. The predictive nomogram could be a useful tool for clinical practice.
Article
Immunology
Ting Dong, Fen Zhao, Keyong Yuan, Xiaohan Zhu, Ningjian Wang, Fangzhen Xia, Yingli Lu, Zhengwei Huang
Summary: The study found that individuals with higher serum TSH levels had significantly higher diversity in their salivary microbiome. Fasting serum insulin, Homeostatic Model Assessment for Insulin Resistance, and hemoglobin A1 were elevated in the Abnormal Group, indicating the presence of insulin resistance in individuals with abnormal higher serum TSH levels.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Guilherme S. Lopes, Jaime L. Lopes, Suzette J. Bielinski, Sebastian M. Armasu, Ye Zhu, Dana C. Cavanaugh, Ann M. Moyer, Debra J. Jacobson, Liwei Wang, Ruoxiang Jiang, Jennifer L. St Sauver, Nicholas B. Larson
Summary: The study found associations between sex-specific genetic variations and opioid response, highlighting the importance of considering gender differences in opioid response studies.
PHARMACOGENOMICS JOURNAL
(2022)
Review
Genetics & Heredity
Allison L. Cirino, Stephanie L. Harris, Andrea M. Murad, Brittany Hansen, Jennifer Malinowski, Jaime L. Natoli, Melissa A. Kelly, Susan Christian
Summary: This systematic review and meta-analysis examines the uptake and utility of genetic counseling and genetic testing for patients with hypertrophic cardiomyopathy (HCM) and their at-risk family members, as well as the impact on patient-reported outcomes (PROs). The findings suggest that approximately half to three-quarters of patients with HCM and their relatives undergo genetic testing or cascade screening. The results of PROs varied after genetic testing, but genetic counseling was associated with high satisfaction and improved PROs.
JOURNAL OF GENETIC COUNSELING
(2022)
Article
Genetics & Heredity
Lacey Smith, Jennifer Malinowski, Sophia Ceulemans, Katlin Peck, Nephi Walton, Beth Rosen Sheidley, Natalie Lippa
Summary: This article provides evidence-based recommendations for genetic testing in epilepsy patients, emphasizing the importance of genetic testing and the role of qualified healthcare providers in selecting, ordering, and interpreting the tests.
JOURNAL OF GENETIC COUNSELING
(2023)
Article
Medicine, General & Internal
Sheila M. Manemann, Alanna M. Chamberlain, Suzette J. Bielinski, Ruoxiang Jiang, Susan A. Weston, Veronique L. Roger
Summary: The predictive ability of the Framingham Heart Study Dementia Risk Score (FDRS) was evaluated in heart failure and atrial fibrillation patients, and the addition of comorbidities and risk factors to improve risk prediction for AD/ADRD was explored. The FDRS variables performed well in predicting AD/ADRD in both populations, and the addition of comorbidities and risk factors slightly improved the performance.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Suzette J. Bielinski, Licy L. Yanes Cardozo, Paul Y. Takahashi, Nicholas B. Larson, Alexandra Castillo, Alana Podwika, Eleanna De Filippis, Valentina Hernandez, Gouri J. Mahajan, Crystal Gonzalez, Shubhangi, Paul A. Decker, Jill M. Killian, Janet E. Olson, Jennifer L. St Sauver, Pankaj Shah, Adrian Vella, Euijung Ryu, Hongfang Liu, Gailen D. Marshall, James R. Cerhan, Davinder Singh, Richard L. Summers
Summary: Demographic and clinical factors available in the electronic health record (EHR) can predict metformin failure. Baseline HbA1c is the strongest predictor, and the addition of other clinical factors improves the predictive model's performance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Computer Science, Information Systems
Pascal S. Brandt, Abel Kho, Yuan Luo, Jennifer A. Pacheco, Theresa L. Walunas, Hakon Hakonarson, George Hripcsak, Cong Liu, Ning Shang, Chunhua Weng, Nephi Walton, David S. Carrell, Paul K. Crane, Eric B. Larson, Christopher G. Chute, Iftikhar J. Kullo, Robert Carroll, Josh Denny, Andrea Ramirez, Wei-Qi Wei, Jyoti Pathak, Laura K. Wiley, Rachel Richesson, Justin B. Starren, Luke Rasmussen
Summary: This study analyzed a publicly available sample of rule-based phenotype definitions and found significant variability in logical constructs and used terminologies. Despite the range of conditions, all phenotype definitions consisted of logical criteria and tabular data. This study highlights the importance of standardizing the representation of phenotype definitions.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Correction
Multidisciplinary Sciences
Lili Liu, Atlas Khan, Elena Sanchez-Rodriguez, Francesca Zanoni, Yifu Li, Nicholas Steers, Olivia Balderes, Junying Zhang, Priya Krithivasan, Robert A. LeDesma, Clara Fischman, Scott J. Hebbring, John B. Harley, Halima Moncrieffe, Leah C. Kottyan, Bahram Namjou-Khales, Theresa L. Walunas, Rachel Knevel, Soumya Raychaudhuri, Elizabeth W. Karlson, Joshua C. Denny, Ian B. Stanaway, David Crosslin, Thomas Rauen, Juergen Floege, Frank Eitner, Zina Moldoveanu, Colin Reily, Barbora Knoppova, Stacy Hall, Justin T. Sheff, Bruce A. Julian, Robert J. Wyatt, Hitoshi Suzuki, Jingyuan Xie, Nan Chen, Xujie Zhou, Hong Zhang, Lennart Hammarstroem, Alexander Viktorin, Patrik K. E. Magnusson, Ning Shang, George Hripcsak, Chunhua Weng, Tatjana Rundek, Mitchell S. V. Elkind, Elizabeth C. Oelsner, R. Graham Barr, Iuliana Ionita-Laza, Jan Novak, Ali G. Gharavi, Krzysztof Kiryluk
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Konrad Teodor Sawicki, Drew R. Nannini, Suzette J. Bielinski, Nicholas B. Larson, Donald M. Lloyd-Jones, Bruce Psaty, Kent D. Taylor, Sanjiv J. Shah, Laura J. Rasmussen-Torvik, John T. Wilkins, Elizabeth M. McNally, Ravi B. Patel
Summary: Circulating protease inhibitors play a critical role in regulating inflammation and are related to the development of heart failure (HF). In this study, the researchers investigated the association between circulating secretory leukocyte protease inhibitor (SLPI) and incident HF in a multi-ethnic cohort. The results showed that higher baseline serum SLPI levels were independently associated with incident HF and HFpEF, but not HFrEF, over long-term follow-up. This suggests that serum SLPI may be a biomarker for inflammation and provides insights into the pathobiology of HFpEF.
SCIENTIFIC REPORTS
(2023)
Letter
Ophthalmology
Catherine A. McCarty, Hugh Taylor
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shaopeng Gu, Govarthanan Rajendiran, Kennedy Forest, Tam C. C. Tran, Joshua C. C. Denny, Eric A. A. Larson, Russell A. A. Wilke
Summary: This study used retrospective analysis of clinical data from the All of Us database to identify cases of drug-induced liver injury (DILI) related to the use of common antibiotics. The results showed that amoxicillin-clavulanate was the most common cause of DILI among the study participants. The findings highlight the efficiency of mining data from electronic health record-linked research cohorts to identify DILI cases associated with the use of common antibiotics.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Genetics & Heredity
Katelynn G. Sagaser, Jennifer Malinowski, Lauren Westerfield, Jennifer Proffitt, Melissa A. Hicks, Tomi L. Toler, Karin J. Blakemore, Blair K. Stevens, Lisa M. Oakes
Summary: Expanded carrier screening (ECS) aims to broadly screen healthy individuals to determine their reproductive chance for autosomal recessive (AR) and X-linked (XL) conditions with infantile or early-childhood onset, which may impact reproductive management. Compared to ethnicity-based screening, ECS panels consist of tens to hundreds of AR and XL conditions that may be individually rare in various ancestries but offer a comprehensive approach to inherited disease screening. As such, the term equitable carrier screening may be preferable.
JOURNAL OF GENETIC COUNSELING
(2023)
Article
Multidisciplinary Sciences
Laura D. Hughes, Ginger Tsueng, Jack DiGiovanna, Thomas D. Horvath, Luke V. Rasmussen, Tor C. Savidge, Thomas Stoeger, Serdar Turkarslan, Qinglong Wu, Chunlei Wu, Andrew I. Su, Lars Pache
Article
Multidisciplinary Sciences
Ginger Tsueng, Marco A. Alvarado Cano, Jose Bento, Candice Czech, Mengjia Kang, Lars Pache, Luke Rasmussen, Tor C. Savidge, Justin Starren, Qinglong Wu, Jiwen R. Xin, Michael Yeaman, Xinghua I. Zhou, Andrew Su, Chunlei Wu, Liliana Brown, Reed S. Shabman, Laura D. Hughes
Summary: Biomedical datasets are facing challenges in FAIRness due to their increasing size and storage in multiple repositories. A consortium of infectious disease researchers aimed to improve FAIRness and created a reusable metadata schema based on Schema.org to catalog datasets and computational tools. This approach enabled data discovery, increased dataset reusability, and accelerated research progress.
Article
Public, Environmental & Occupational Health
Rebecca L. Emery Tavernier, Marcia B. Mccoy, Catherine A. Mccarty, Susan M. Mason
Summary: This study examines the differences in prepregnancy weight status and gestational weight gain between rural and urban birthing people. The findings indicate that rural birthing people have a higher risk of prepregnancy overweight or obesity and excessive gestational weight gain compared to urban birthing people. These disparities between rural and urban individuals in terms of weight-related health outcomes widen over time.
WOMENS HEALTH ISSUES
(2023)
Article
Health Care Sciences & Services
David A. Mayer, Luke Rasmussen, Christopher D. Roark, Michael G. Kahn, Lisa M. Schilling, Laura K. Wiley
Summary: When conducting research using electronic health records, manually extracting data is a crucial but error-prone step. We have developed a tool called ReviewR to provide a unified environment for data review and chart abstraction data entry.