Article
Infectious Diseases
Milo Gatti, Simona Barnini, Fabio Guarracino, Eva Maria Parisio, Michele Spinicci, Bruno Viaggi, Sara D'Arienzo, Silvia Forni, Angelo Galano, Fabrizio Gemmi
Summary: Infections associated with orthopaedic implants are a major health concern, and the treatment requires consideration of antimicrobial therapy and drug selection. Novel long-acting lipoglycopeptides, particularly dalbavancin, may represent the best antibiotic choice, and the implementation of a multidisciplinary taskforce and close cooperation between microbiologists and clinicians are essential for providing optimal care.
Article
Microbiology
Sylvia Ighem Chi, Sandra Ramirez-Arcos
Summary: Biofilm formation and slow growth of Staphylococcus aureus in platelet concentrates lead to missed detection and an increased risk of sepsis. Comparative RNAseq analyses and CRISPR mutagenesis of SE genes reveal that SEs play a role in biofilm development by providing a scaffold, mediating aggregation, and ensuring survival. The study uncovers new roles for SEs and explains the failed detection of S. aureus in platelet concentrates by automated culture systems.
Article
Engineering, Biomedical
Tiantong Sun, Jie Huang, Wang Zhang, Xuanqi Zheng, Hong Wang, Jing Liu, Huijie Leng, Wanqiong Yuan, Chunli Song
Summary: Sim-HA coatings effectively prevent Staphylococcus aureus infection and enhance the biocompatibility of titanium alloy, as well as promoting osteogenesis and osteointegration.
BIOACTIVE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Bahman Mirzaei, Ryhaneh Babaei, Sina Valinejad
Summary: The number and frequency of multidrug-resistant strains causing nosocomial infections, particularly Methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, have increased, partly due to device-related infections. Antibiotic-resistance in bacterial genes and immune escape increase the sustainability of biofilms, which are suggested as a target to prevent or treat staphylococcal infections. Developing vaccines with common staphylococcal antigens and multivalent vaccines could further enhance efficacy.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Microbiology
Shakilur Rahman, Amit Kumar Das
Summary: Staphylococcus aureus is a highly infectious pathogen that forms biofilms, reducing susceptibility to antibiotics and immune defenses. A study has identified a novel function of staphylococcal superantigen-like protein 10 (SSL10) in enhancing biofilm formation, through amyloid aggregation.
Article
Anatomy & Morphology
Salim Manoharadas, Mohammad Altaf, Abdulwahed Fahad Alrefaei, Shaik Althaf Hussain, Rajesh Mamkulathil Devasia, Ahmed Yacine M. Badjah Hadj, Mohammed Saeed Ali Abuhasil
Summary: The study showed that three clinically relevant bacterial strains can form mono biofilms on glass surfaces, with E. coli inhibiting S. aureus biofilm formation. Specific bacteriophages can effectively disrupt preformed biofilm structures, but have limited impact on mixed cultures.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Article
Polymer Science
Tzu-Yu Peng, Dan-Jae Lin, Yuichi Mine, Chi-Yang Tasi, Po-Jung Li, Yin-Hwa Shih, Kuo-Chou Chiu, Tong-Hong Wang, Shih-Min Hsia, Tzong-Ming Shieh
Summary: PEEK material showed less conducive to biofilm formation, making it suitable for dental implants or abutments, while PDT had good therapeutic effects on peri-implant mucositis.
Article
Biochemistry & Molecular Biology
Andreas Wiessner, Torsten Wassmann, Johanna Maria Wiessner, Andrea Schubert, Bernhard Wiechens, Tristan Hampe, Ralf Buergers
Summary: The formation of biofilms on dental implant surfaces can lead to implant failure. This study investigated biofilm formation on conventional (titanium and zirconia) and innovative (PEEK) implant abutment materials. The results showed that zirconia had the lowest biofilm formation, followed by titanium, PEEK, and PEEK-BioHPP. The choice of abutment material can help reduce the risk of peri-implantitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Soo Kyum Bihn, Keunbada Son, Young-Tak Son, Ram Hari Dahal, Shukho Kim, Jungmin Kim, Jun Ho Hwang, Sung-Min Kwon, Jong Hoon Lee, Hyun Deok Kim, Jae-Mok Lee, Myoung-Uk Jin, Kyu-Bok Lee
Summary: This study evaluated the effect of laser treatment on the surface of zirconia implants on biofilm formation. The results showed that the use of a nanosecond laser effectively inhibited the growth of Porphyromonas gingivalis.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Orthopedics
Zoe L. Harrison, Leslie R. Pace, Madison N. Brown, Karen E. Beenken, Mark S. Smeltzer, Joel D. Bumgardner, Warren O. Haggard, J. Amber Jennings
Summary: Antibiotic-loaded chitosan pastes with added mannitol show promise in treating complex musculoskeletal defects. The blend of chitosan and mannitol can decrease bacterial growth, reduce colony-forming unit counts, and potentially prevent biofilm formation on biomaterials and tissue.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Microbiology
Yuan Yue, Ke Chen, Changfeng Sun, Sarfraz Ahmed, Suvash Chandra Ojha
Summary: The antimicrobial peptidase lysostaphin (APLss) was found to inhibit staphylococcal adherence, biofilm formation, and toxin production, suggesting its potential as an anti-staphylococcal agent. Further investigation is warranted to explore its mechanism of action and its effectiveness in vivo.
Article
Biochemistry & Molecular Biology
Junfeng Ma, Xiang Cheng, Zhonghe Xu, Yikan Zhang, Jaione Valle, Shilong Fan, Xiaobing Zuo, Inigo Lasa, Xianyang Fang
Summary: This study reveals how Staphylococcal Bap proteins sense environmental signals to build amyloid scaffold biofilm matrices, and demonstrates the regulatory effect of different Ca2+ concentrations.
Article
Microbiology
Cristina Tello-Diaz, Marta Palau, Estela Munoz, Xavier Gomis, Joan Gavalda, Nuria Fernandez-Hidalgo, Sergi Bellmunt-Montoya
Summary: The aim of this study was to quantify in vitro biofilm formation by methicillin-susceptible Staphylococcus aureus (MSSA) on the surfaces of different types of commonly used vascular grafts. The Dacron silver-triclosan and Omniflow II vascular grafts showed the greatest resistance to in vitro methicillin-susceptible Staphylococcus aureus biofilm formation compared to other vascular grafts.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Mi-Sun Kang, Geun-Yeong Park
Summary: Oral probiotics, specifically W. cibaria CMU and CMS1, were found to inhibit the formation of multi-species biofilms on titanium implant surfaces. This suggests that these probiotics could be a promising approach for preventing peri-implant mucositis.
Article
Dentistry, Oral Surgery & Medicine
Erica Tambone, Emiliana Bonomi, Paolo Ghensi, Devid Maniglio, Chiara Ceresa, Francesca Agostinacchio, Patrizio Caciagli, Giandomenico Nollo, Federico Piccoli, Iole Caola, Letizia Fracchia, Francesco Tessarolo
Summary: The study demonstrates that R89 biosurfactant is effective in reducing the formation of Staphylococcus biofilms on titanium surfaces. The anti-biofilm properties of R89 can be achieved on various commercially available implant surfaces.
Article
Engineering, Biomedical
Hideyuki Sakoda, Shingo Niimi
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2016)
Article
Engineering, Biomedical
Yuki Morishita, Yusuke Nomura, Chie Fukui, Ayano Fujisawa, Kayo Watanabe, Hideo Fujimaki, Hidefumi Kumada, Kaoru Inoue, Tomomi Morikawa, Miwa Takahashi, Tsuyoshi Kawakami, Hideyuki Sakoda, Tomokazu Mukai, Toshiyasu Yuba, Ken-ichi Inamura, Akito Tanoue, Ken-ichi Miyazaki, Ung-il Chung, Kumiko Ogawa, Midori Yoshida, Yuji Haishima
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Engineering, Biomedical
Hideyuki Sakoda, Yuta Osaka, Keita Uetsuki, Yoshihiro Okamoto, Yuji Haishima
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2019)
Article
Microbiology
Itaru Yoda, Hironobu Koseki, Masato Tomita, Takayuki Shida, Hidehiko Horiuchi, Hideyuki Sakoda, Makoto Osaki
Article
Nanoscience & Nanotechnology
Takayuki Shida, Hironobu Koseki, Itaru Yoda, Hidehiko Horiuchi, Hideyuki Sakoda, Makoto Osaki
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2013)
Article
Biophysics
Dong Zhao, Hideyuki Sakoda, W. Gregory Sawyer, Scott A. Banks, Benjamin J. Fregly
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2008)
Article
Orthopedics
Satoshi Teramura, Hideyuki Sakoda, Tomohiro Terao, Miguel M. Endo, Kunihiko Fuiiwara, Naohide Tomita
JOURNAL OF ORTHOPAEDIC RESEARCH
(2008)
Article
Engineering, Biomedical
Hideyuki Sakoda, Yoshihiro Okamoto, Yuji Haishima
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Review
Pharmacology & Pharmacy
Hideyuki Sakoda, Masami Aizawa, Asako Ueda, Hitomi Toida, Miyuki Uematsu, Ryusuke Nakaoka, Atsuko Miyajima, Yuji Haishima
Summary: This study conducted a comprehensive analysis and verification tests on various combinations of polymeric materials and pharmaceutical ingredients, finding that failures of some medical devices are primarily caused by environmental stress cracking rather than insufficient chemical resistance of the materials.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2021)
Article
Engineering, Biomedical
Hideyuki Sakoda, Miyuki Uematsu, Yoshihiro Okamoto, Yuji Haishima
Summary: This study found that PEEK materials exhibit inferior delamination resistance compared to UHMWPE under low conformity contact conditions, highlighting the risk of delamination in clinical use. Careful consideration of material selection and component design is necessary when using PEEK materials as implant components under low conformity contact conditions.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2021)
Article
Engineering, Biomedical
Hideyuki Sakoda, Nobuhiko Sugano, Yoshihiro Okamoto, Yuji Haishima
BIO-MEDICAL MATERIALS AND ENGINEERING
(2020)
Article
Engineering, Biomedical
GI Howling, H Sakoda, A Antonarulrajah, H Marrs, TD Stewart, S Appleyard, B Rand, J Fisher, E Ingham
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2003)
Article
Orthopedics
Y Seto, N Tomita, Y Harada, H Sakoda, Y Takakura
JOURNAL OF ORTHOPAEDIC SCIENCE
(2006)
Article
Engineering, Biomedical
GI Howling, E Ingham, H Sakoda, TD Stewart, J Fisher, A Antonarulrajah, S Appleyard, B Rand
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2004)