Disruption of Axonal Transport Perturbs Bone Morphogenetic Protein (BMP) - Signaling and Contributes to Synaptic Abnormalities in Two Neurodegenerative Diseases

Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo

(2013) Shermali Gunawardena et al.   HUMAN MOLECULAR GENETICS

Cellular and molecular mechanisms underlying presynapse formation

(2013) Poh Hui Chia et al.   JOURNAL OF CELL BIOLOGY

Microtubule-based transport - basic mechanisms, traffic rules and role in neurological pathogenesis

(2013) M. A. M. Franker et al.   JOURNAL OF CELL SCIENCE

Kinesin-1 Regulates Synaptic Strength by Mediating the Delivery, Removal, and Redistribution of AMPA Receptors

(2013) Frédéric J. Hoerndli et al.   NEURON

Spartin Regulates Synaptic Growth and Neuronal Survival by Inhibiting BMP-Mediated Microtubule Stabilization

(2013) Minyeop Nahm et al.   NEURON

Nanoparticles in the Brain: A Potential Therapeutic System Targeted to an Early Defect Observed in Many Neurodegenerative Diseases

(2013) Shermali Gunawardena   PHARMACEUTICAL RESEARCH

Epsin 1 Promotes Synaptic Growth by Enhancing BMP Signal Levels in Motoneuron Nuclei

(2013) Phillip A. Vanlandingham et al.   PLoS One

Relay of retrograde synaptogenic signals through axonal transport of BMP receptors

(2012) R. B. Smith et al.   JOURNAL OF CELL SCIENCE

Hereditary spastic paraplegia-causing mutations in atlastin-1 interfere with BMPRII trafficking

(2012) Jiali Zhao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

(2012) Manuel Torres et al.   Molecular Neurodegeneration

The p150Glued CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini

(2012) Thomas E. Lloyd et al.   NEURON

Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model

(2012) Petra Füger et al.   PLoS Genetics

Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer’s disease: implications for axoplasmic transport

(2011) Marina Morel et al.   ACTA NEUROPATHOLOGICA

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

(2011) Raquel Sanchez-Varo et al.   ACTA NEUROPATHOLOGICA

Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy

(2011) SooYeon Lee et al.   Autophagy

A presynaptic endosomal trafficking pathway controls synaptic growth signaling

(2011) Avital A. Rodal et al.   JOURNAL OF CELL BIOLOGY

The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases

(2010) Vafa Bayat et al.   CURRENT OPINION IN NEUROBIOLOGY

Identification of downstream targets of the Bone Morphogenetic Protein pathway in the Drosophila nervous system

(2010) Nam Chul Kim et al.   DEVELOPMENTAL DYNAMICS

Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis

(2010) L. Crews et al.   JOURNAL OF NEUROSCIENCE

Ménage à Trio during BMP-Mediated Retrograde Signaling at the NMJ

(2010) Yuly Fuentes-Medel et al.   NEURON

Retrograde BMP Signaling Controls Synaptic Growth at the NMJ by Regulating Trio Expression in Motor Neurons

(2010) Robin W. Ball et al.   NEURON

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormal Motor Cortex Excitability in Preclinical and Very Early Huntington's Disease

(2009) Sven Schippling et al.   BIOLOGICAL PSYCHIATRY

The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling

(2009) Hilda T.H. Tsang et al.   HUMAN MOLECULAR GENETICS

Nemo kinase interacts with Mad to coordinate synaptic growth at theDrosophilaneuromuscular junction

(2009) Carlos Merino et al.   JOURNAL OF CELL BIOLOGY

Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease

(2009) M. Orth et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Molecular Motors and Synaptic Assembly

(2009) Qian Cai et al.   NEUROSCIENTIST

Action in the axon: generation and transport of signaling endosomes

(2008) Katharina E Cosker et al.   CURRENT OPINION IN NEUROBIOLOGY

Amyloid precursor protein-induced axonopathies are independent of amyloid-β peptides

(2008) Gorazd B. Stokin et al.   HUMAN MOLECULAR GENETICS

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Nervous Wreck Interacts with Thickveins and the Endocytic Machinery to Attenuate Retrograde BMP Signaling during Synaptic Growth

(2008) Kate M. O'Connor-Giles et al.   NEURON

A Drosophila Model of ALS: Human ALS-Associated Mutation in VAP33A Suggests a Dominant Negative Mechanism

(2008) Anuradha Ratnaparkhi et al.   PLoS One

Modeling Spinal Muscular Atrophy in Drosophila

(2008) Howard Chia-Hao Chang et al.   PLoS One

Detection of Huntington's disease decades before diagnosis: the Predict-HD study

(2007) J S Paulsen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY