Article
Pediatrics
An-Ni Lin, Wei-Che Lin, Kai-Lun Cheng, Sheng-Dean Luo, Pi-Ling Chiang, Wei-Chih Chen, Yueh-Sheng Chen, Cheng-Kang Wang, Na-Ning Kan, Yan-Ye Su
Summary: The study demonstrates that radiofrequency ablation is a safe and effective treatment for benign thyroid nodules in pediatric patients, with significant reduction in nodule volume, improvement in symptoms, and certain safety profiles.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Daniela Esposito, Oskar Ragnarsson, Gudmundur Johannsson, Daniel S. Olsson
Summary: The risk of malignancies is slightly increased in acromegaly patients, especially for colorectal and anal cancer, and renal and ureteral cancer. Meanwhile, the incidence of benign tumors has more than doubled in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Nonhlanhla Chambara, Xina Lo, Tom Chi Man Chow, Carol Man Sze Lai, Shirley Yuk Wah Liu, Michael Ying
Summary: This study assessed the diagnostic value of the combination of EU TIRADS and SWE in thyroid nodules. The results showed that the combination was effective in discriminating nodules larger than 1cm, but not ideal for cytologically-equivocal nodules.
Review
Endocrinology & Metabolism
Ralph P. Tufano, Pia Pace-Asciak, Jonathon O. Russell, Carlos Suarez, Gregory W. Randolph, Fernando Lopez, Ashok R. Shaha, Antti Makitie, Juan P. Rodrigo, Luiz Paulo Kowalski, Mark Zafereo, Peter Angelos, Alfio Ferlito
Summary: Thermal and chemical ablation are minimally invasive procedures targeting symptomatic nodules, with Radiofrequency ablation (RFA) being one of the most widely used techniques. Surgery remains the standard of care for most thyroid cancer, while Active Surveillance (AS) can be an option for low risk disease. Minimally invasive techniques, such as RFA, are emerging as alternative options for high risk surgery patients or those seeking more active treatment approaches than AS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Lei Hu, Xiao Liu, Chong Pei, Li Xie, Nianan He
Summary: In this study, the diagnostic accuracy of perinodular stiffness, four risk stratification systems, and their combinations in differentiating malignant from benign thyroid nodules was evaluated. The combination of C-TIRADS and Eshell/E showed the highest diagnostic accuracy for all thyroid nodules and nodules with sizes <= 10 mm compared to other combinations.
ENDOCRINE CONNECTIONS
(2021)
Article
Medicine, General & Internal
Min Ji Hong, Hye Shin Ahn, Su Min Ha, Hyun Jeong Park, Jiyun Oh
Summary: This study investigated the usefulness of adding superb microvascular imaging (SMI) to B-mode ultrasound for distinguishing between benign and malignant thyroid nodules. The study found that SMI pixel count can effectively differentiate malignant thyroid nodules from benign ones.
Article
Computer Science, Artificial Intelligence
Lu Tang, Chuangeng Tian, Hang Yang, Zhiming Cui, Yu Hui, Kai Xu, Dinggang Shen
Summary: Recently, accurate diagnosis of thyroid nodules has become crucial, but still faces challenges. Learning-based computer-aided diagnosis systems have gained attention, but there is a lack of research on a deep learning-based system that better aligns with radiologists' decision-making. This study proposes a dual-stream attention neural network, TS-DSANN, that focuses on texture and shape for improved classification performance.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Automation & Control Systems
Wenkai Yang, Yunyun Dong, Qianqian Du, Yan Qiang, Kun Wu, Juanjuan Zhao, Xiaotang Yang, Muhammad Bilal Zia
Summary: The study proposes a multi-task cascade deep learning model that integrates radiologists' domain knowledge and uses multimodal ultrasound images for automatic thyroid nodule diagnosis. Experimental results show that the model can achieve similar classification performance to fully supervised learning with only about 35% of labeled dataset, saving time and effort compared to traditional methods.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Haliimah A. Nattabi, Norhafidzah M. Sharif, Noorazrul Yahya, Rozilawati Ahmad, Mazlyfarina Mohamad, Faizah M. Zaki, Ahmad N. Yusoff
Summary: This study is a systematic review on the clinical value of 2D-SWE in the differential diagnosis of benign and malignant thyroid nodules. The results showed that the diagnostic performance of quantitative 2D-SWE for malignancy risk stratification of thyroid nodules is suboptimal, with mediocre sensitivity and specificity, contrary to earlier reports of excellence.
ACADEMIC RADIOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Shi-Xuan Zhao, Yang Chen, Kai-Fu Yang, Yan Luo, Bu-Yun Ma, Yong-Jie Li
Summary: This study proposes a new local and global feature disentangled network (LoGo-Net) for classifying benign and malignant thyroid nodules. Experimental results show that the method achieves a high accuracy and has the potential for clinical application.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Oncology
Pei-Shan Zhu, Yu-Rui Zhang, Jia-Yu Ren, Qiao-Li Li, Ming Chen, Tian Sang, Wen-Xiao Li, Jun Li, Xin-Wu Cui
Summary: The study aimed to evaluate the accuracy of deep learning using the convolutional neural network VGGNet model in distinguishing benign and malignant thyroid nodules based on ultrasound images. The analysis showed that this model had good diagnostic efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Susmita Dutta, Soham Tarafdar, Pradip Mukhopadhyay, Nitai P. Bhattacharyya, Sujoy Ghosh
Summary: Measurement of cell-free DNA levels in plasma could be a useful tool for differentiating malignant from benign thyroid nodules, with a high sensitivity and specificity. The established cutoff value of cfDNA showed strong agreement with histopathological classification, indicating its potential clinical utility in the diagnosis of thyroid nodules.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Patrick J. Navin, Scott M. Thompson, Anil N. Kurup, Robert A. Lee, Matthew R. Callstrom, M. Regina Castro, Marius N. Stan, Brian T. Welch, John J. Schmitz
Summary: Thyroid nodule treatment has evolved significantly in recent years, aiming to individualize treatment based on the cause of the nodule and patient performance status. Radiofrequency ablation (RFA) has emerged as a viable therapeutic option, particularly for symptomatic benign nodules and autonomously functioning nodules. RFA is well tolerated and safe, with minimal major complications, making it an effective treatment choice for appropriate patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Giuliano Mariani, Massimo Tonacchera, Mariano Grosso, Emilio Fiore, Pierpaolo Falcetta, Lucia Montanelli, Brunella Bagattini, Paolo Vitti, H. William Strauss
Summary: This article discusses the clinical management and treatment options for nodular goiter, hypothyroidism, and subacute thyroiditis, which are common benign thyroid disorders. Diagnosing and treating these conditions often involves a combination of lab tests, imaging studies, and fine-needle aspiration biopsies to determine the best course of action for each patient.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Han Xu, Ximing Wang, Chaoqun Guan, Ru Tan, Qing Yang, Qi Zhang, Aie Liu, Qingwei Liu
Summary: The objective of this research is to explore the value of whole-thyroid CT-based radiomics in predicting benign and malignant thyroid nodules. A highly efficient CT radiomic model was constructed to differentiate between the two types of nodules based on the analysis of imaging and clinical data.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Enric Sanchez, Mohsen Kerkeni, Marta Hernandez, Ricard Gavalda, Ferran Rius, Ariadna Sauret, Gerard Torres, Marcelino Bermudez-Lopez, Elvira Fernandez, Eva Castro-Boque, Francisco Purroy, Didac Mauricio, Cristina Farras-Salles, Miquel Buti, Pere Godoy, Reinald Pamplona, Albert Lecube
Summary: This study found that although there is an increase in subcutaneous AGE accumulation in subjects with prediabetes, it is not significantly correlated with HbA1c levels. Furthermore, there is no independent association between skin autofluorescence (SAF) levels and prediabetes, and no suitable cutoff point for SAF to identify patients with prediabetes.
Article
Medicine, Research & Experimental
Dermot O'Toole, Pamela L. Kunz, Susan M. Webb, Grace Goldstein, Sheila Khawaja, Mark McDonnell, Sandra Boiziau, Delphine Gueguen, Aude Houchard, Antonio Ribeiro-Oliveira, Ally Prebtani
Summary: In patients with neuroendocrine tumors or acromegaly treated with long-acting somatostatin analogs, LAN demonstrated reduced injection-site pain and technical problems compared to OCT.
ADVANCES IN THERAPY
(2023)
Article
Endocrinology & Metabolism
Alicia Santos, Chiara Nalin, GianMario Bortolotti, Elisabet Dominguez-Clave, Gianola Daniela, Liana Cortesi, Marina Pagani, Maria A. M. Momblan, Ignasi Gich, Susan M. Webb, Roberto Trevisan, Eugenia Resmini
Summary: This study demonstrates the value of a mindfulness program in patients with acromegaly, showing improvements in sleep, reduction in pain, and increased self-compassion.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Alessandra Giannella, Esmeralda Castelblanco, Carlo Federico Zambon, Daniela Basso, Marta Hernandez, Emilio Ortega, Nuria Alonso, Didac Mauricio, Angelo Avogaro, Giulio Ceolotto, Saula Vigili de Kreutzenberg
Summary: This study analyzed the miRNA expression profile in patients with type 1 diabetes who had either carotid calcified or fibrous plaque. The results showed that miR-503-5p, let-7d-5p, miR-106b-3p, and miR-93-5p were significantly upregulated in patients with calcified plaque, while miR-10a-5p was downregulated. These findings provide new insights into the pathophysiology of plaque formation.
Article
Nutrition & Dietetics
Enric Sanchez, Marta Sanchez, Carolina Lopez-Cano, Marcelino Bermudez-Lopez, Jose Manuel Valdivielso, Cristina Farras-Salles, Reinald Pamplona, Gerard Torres, Didac Mauricio, Eva Castro, Elvira Fernandez, Albert Lecube
Summary: This study assessed the impact of obesity on the accumulation of advanced glycation end-products (AGEs) and found that AGE levels were associated with abdominal adiposity but not total body fat. Furthermore, elevated AGE levels were related to cardiovascular risk factors.
Article
Nutrition & Dietetics
Nuria Alcubierre, Minerva Granado-Casas, Patricia Bogdanov, Cristina Hernandez, Hugo Ramos, Esmeralda Castelblanco, Jordi Real, Esther Rubinat-Arnaldo, Alicia Traveset, Marta Hernandez, Carmen Jurjo, Jesus Vioque, Eva Maria Navarrete-Munoz, Rafael Simo, Didac Mauricio
Summary: The study evaluated the potential benefits of caffeine intake in preventing the development of diabetic retinopathy (DR) in patients with type 2 diabetes (T2D). The cross-sectional study showed a protective effect of moderate and high caffeine intake on DR. However, the experimental model did not demonstrate any improvement in reactive gliosis or retinal vascular permeability with caffeine administration.
Editorial Material
Medicine, General & Internal
Joana Rossell, Marina Idalia Rojo-Lopez, Josep Julve, Didac Mauricio
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lucia Sanjurjo, Esmeralda Castelblanco, Josep Julve, Nuria Villalmanzo, Erica Tellez, Anna Ramirez-Morros, Nuria Alonso, Didac Mauricio, Maria-Rosa Sarrias
Summary: The study aimed to investigate the contribution of oxLDL to the inflammatory response of macrophages under diabetic conditions. The results showed that oxLDL promoted intracellular lipid accumulation in macrophages under high glucose (HG) conditions and enhanced the production of pro-inflammatory cytokines. Moreover, HG and oxLDL upregulated the expression of the cell surface receptor TLR4 and increased the release of sCD14, which further exacerbated the inflammation.
Article
Biochemistry & Molecular Biology
Ricardo Rodriguez-Calvo, Minerva Granado-Casas, Alejandra Perez-Montes de Oca, Maria Teresa Julian, Mar Domingo, Pau Codina, Evelyn Santiago-Vacas, German Cediel, Josep Julve, Joana Rossell, Lluis Masana, Didac Mauricio, Josep Lupon, Antoni Bayes-Genis, Nuria Alonso
Summary: This study aimed to explore the prognostic value of cardiac-specific fatty acid binding proteins (FABP3) and adipose-tissue-specific fatty acid binding proteins (FABP4) in chronic heart failure (CHF) patients, with and without type 2 diabetes mellitus (T2D). It was found that the concentrations of FABP3 and FABP4 were associated with all-cause and cardiovascular mortality, particularly in patients with T2D. The study suggests that serum FABP3 and FABP4 concentrations can serve as independent predictors for the occurrence of all-cause and cardiovascular mortality in ambulatory CHF subjects with T2D.
Article
Endocrinology & Metabolism
Angels Mollo, Bogdan Vlacho, Monica Gratacos, Manel Mata-Cases, Esther Rubinat, Anna Berenguera Osso, Francesc Xavier Cos, Josep Franch-Nadal, Kamlesh Khunti, Didac Mauricio
Summary: The INTEGRA study aimed to evaluate the effectiveness of a specially designed multicomponent health care intervention in improving glycaemic control in poorly controlled type 2 diabetes patients. The intervention group showed a significant reduction in HbA1c values compared to the usual care group at 12 months, and more patients in the intervention group achieved target blood glucose levels.
DIABETES OBESITY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Julia Nino-Narvion, Marina Idalia Rojo-Lopez, Patricia Martinez-Santos, Joana Rossell, Antonio J. Ruiz-Alcaraz, Nuria Alonso, Bruno Ramos-Molina, Didac Mauricio, Josep Julve
Summary: NAD+ is crucial for cellular metabolism and plays a critical role in maintaining the integrity of the gut barrier. Its deficiency is associated with gut inflammation, leakage, and dysbiosis. NAD+-increasing therapies may protect against intestinal inflammation, potentially by modulating the composition of the intestinal microbiota. However, the mechanisms underlying these effects are not well understood.
Article
Nutrition & Dietetics
Jeimy Katherine Torres-Mendez, Julia Nino-Narvion, Patricia Martinez-Santos, Elena Maria Goretti Diarte-Anazco, Karen Alejandra Mendez-Lara, Tania Vazquez del Olmo, Noemi Rotllan, Maria Teresa Julian, Nuria Alonso, Didac Mauricio, Mercedes Camacho, Juan Pablo Munoz, Joana Rossell, Josep Julve
Summary: This study investigated the effects of nicotinamide (NAM) supplementation on brain inflammation and microglial activation in a mouse model of type 1 diabetes. The results showed that NAM supplementation prevented brain inflammation in diabetic mice through NAD+-dependent deacetylation mechanisms.
Article
Endocrinology & Metabolism
Cristina Lamas, Rosa Camara, Carmen Fajardo, Pablo Remon-Ruiz, Betina Biagetti, Fernando Guerrero-Perez, Marta Araujo-Castro, Mireia Mora, Felicia Hanzu, Pedro Iglesias, Rogelio Garcia-Centeno, Alfonso Soto
Summary: In this retrospective study, temozolomide was found to be an effective medical treatment for aggressive pituitary neuroendocrine tumors and pituitary carcinomas, but may sometimes lead to tumor progression. Co-administration with radiotherapy may increase progression-free survival.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Correction
Endocrinology & Metabolism
L. Martel-Duguech, A. Alonso-Jimenez, H. Bascunana, J. Diaz-Manera, J. Llauger, C. Nunez-Peralta, B. Biagetti, P. Montesinos, S. M. Webb, E. Valassi
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)