Article
Rheumatology
Lieve Van Hoovels, Bert Vander Cruyssen, Daniela Sieghart, Carolien Bonroy, Eszter Nagy, Rille Pullerits, Sasa Cucnik, Charlotte Dahle, Ingmar Heijnen, Luca Bernasconi, Farid Benkhadra, Laura Bogaert, Stefanie Van den Bremt, Ann Van Liedekerke, Geert Vanheule, Johan Robbrecht, Lucy Studholme, Claudine Wirth, Ruediger Mueller, Diego Kyburz, Christopher Sjowall, Alf Kastbom, Rok Jese, Boja Jovancevic, Emese Kiss, Peggy Jacques, Daniel Aletaha, Guenter Steiner, Patrick Verschueren, Xavier Bossuyt
Summary: This study aimed to refine the interpretation of RF and ACPA across commercial assays. By determining thresholds for antibody levels and assigning test result interval-specific LRs, clinical interpretation can be aligned for all RF and ACPA assays.
Article
Immunology
Marie F. Hemon, Nathalie C. Lambert, Fanny Arnoux, Jean Roudier, Isabelle Auger
Summary: The critical immunological event in rheumatoid arthritis is the production of antibodies to citrullinated proteins. A peptide array method was used to analyze the fine specificity of anti-citrullinated peptide antibodies and the results showed that different mouse strains have different IgG responses to citrullinated peptides.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Dylan T. Bergstedt, Wyatt J. Tarter, Ryan A. Peterson, Marie L. Feser, Mark C. Parish, Christopher C. Striebich, M. Kristen Demoruelle, LauraKay Moss, Elizabeth A. Bemis, Jill M. Norris, V. Michael Holers, Jess D. Edison, Geoffrey M. Thiele, Ted R. Mikuls, Kevin D. Deane
Summary: In rheumatoid arthritis (RA), ACPA and RF are predictive markers for future RA. This study found that changes in RF isotypes were associated with an increased risk for developing RA, and SE was associated with an increased risk of RA. These findings are important for counseling individuals at-risk for RA and designing clinical trials for RA prevention.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pathology
Nicole Hartwig Trier, Gunnar Houen
Summary: The serological biomarker anti-citrullinated protein antibodies (ACPAs) are important for the diagnosis of rheumatoid arthritis (RA) and can improve our understanding of the disease etiology. This review provides an overview of ACPAs and highlights their diagnostic and etiological significance in RA.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Rheumatology
Maria Sokolova, Fabian Hartmann, Daniela Sieghart, Holger Bang, Guenter Steiner, Arnd Kleyer, Georg Schett, Ulrike Steffen
Summary: The study aimed to investigate the events triggering disease outbreak in individuals at-risk for rheumatoid arthritis (RA at-risk) and the role of different isotypes of anticitrullinated protein antibody (ACPA) in this process. Serum levels of IgA1 and IgA2 ACPA were measured, and it was found that approximately two-thirds of at-risk individuals tested positive for IgA1 and IgA2 ACPA, with IgA1 ACPA being associated with the progression to RA. The decline in serum IgA1 ACPA levels before the onset of RA may indicate starting barrier leakiness prior to disease outbreak.
Review
Biochemistry & Molecular Biology
Chao-Yi Wu, Huang-Yu Yang, Shue-Fen Luo, Jenn-Haung Lai
Summary: RA is a chronic inflammatory disease involving synovial inflammation and articular destruction. RFs, ACPAs, and anti-CarP Abs have been identified as important autoantibodies in predicting and diagnosing RA, with potential implications for treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Summary: Limited data are available on test utilization and intraindividual changes in rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (anti-CCP) in Korean patients that visit local clinics and hospitals. This study retrospectively reviewed longitudinally measured RF and anti-CCP data in Korean patients and found qualitative changes in test results during follow-up in some patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Pit Hui Lew, Mohammad Tariqur Rahman, Syarida Hasnur Safii, Nor Adinar Baharuddin, Peter Mark Bartold, Sargunan Sockalingam, Noor Lide Abu Kassim, Rathna Devi Vaithilingam
Summary: The study found that serum ACPA levels were significantly higher in individuals with RAPd and RA compared to healthy individuals, but there was no significant correlation between ACPA levels and clinical periodontal and RA parameters within the respective groups. Further studies are needed to investigate the causal link between RA and Pd for such a trend.
Review
Pharmacology & Pharmacy
Xuan Tang, Zehao Liu, Zhihua Yang, Shengmei Xu, Maojie Wang, Xiumin Chen, Zehuai Wen, Runyue Huang
Summary: The use of Chinese medicine compound therapy in treating rheumatoid arthritis has been shown to effectively reduce serum levels of RF and anti-CCP, with potentially better clinical outcomes compared to Western medicine monotherapy. Active components in the Chinese medicine compound therapy may be responsible for its efficacy, warranting further investigation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yibo He, Changrong Ge, Alex Moreno-Giro, Bingze Xu, Christian M. Beusch, Katalin Sandor, Jie Su, Lei Cheng, Erik Lonnblom, Christina Lundqvist, Linda M. Slot, Dongmei Tong, Vilma Urbonaviciute, Bibo Liang, Taotao Li, Gonzalo Fernandez Lahore, Mike Aoun, Vivianne Malmstrom, Theo Rispens, Patrik Ernfors, Camilla I. Svensson, Hans Ulrich Scherer, Rene E. M. Toes, Inger Gjertsson, Olov Ekwall, Roman A. Zubarev, Rikard Holmdahl
Summary: Although anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), their in vivo functions remain unclear. In this study, monoclonal ACPAs derived from RA patients were expressed in mice and their functions were analyzed. One of the antibodies, clone E4, showed a protective effect against antibody-induced arthritis in mice, suggesting therapeutic potential for ACPAs in RA.
NATURE COMMUNICATIONS
(2023)
Review
Rheumatology
Anca Catrina, Akilan Krishnamurthy, Bence Rethi
Summary: ACPA may play a crucial role in the pathogenesis of RA, affecting the genetic and environmental risks in patients, leading to joint pain and bone loss. Research has shown that ACPAs can impact various cells, potentially triggering pathogenic pathways through multiple mechanisms.
Article
Rheumatology
E. Generali, M. De Santis, N. Isailovic, B. Palermo, G. M. Guidelli, A. Ceribelli, F. Alborghetti, G. Colloredo, L. Porrati, T. Matthias, A. Zucchi, C. Selmi
Summary: The study found that the positivity rates of RF and ACPA increased with age, and HBV and HCV infections were associated with RF positivity but not with ACPA positivity. Over 15 years, 10 RA cases occurred, with a lower risk of developing RA associated with RF compared to ACPA.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Immunology
Minjie Xu, Rong Du, Wenping Xing, Xueting Chen, Jian Wan, Shengqing Wang, Li Xiong, Kutty Selva Nandakumar, Rikard Holmdahl, Hui Geng
Summary: Citrullinated neoepitopes have been identified as key triggers for the synthesis of anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) patients. This study investigated the expression of citrullinated proteins and enzymes in human platelets and platelet-derived microparticles (PDP). The results revealed the presence of citrullinated autoantigens in platelets and PDPs, suggesting that they could be potential targets for ACPA in RA. These findings provide valuable insights into the role of platelets in triggering ACPA production in RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Pureun Won, Youngkyun Kim, Hyerin Jung, Yeri Alice Rim, Dong Hyun Sohn, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju
Summary: The study demonstrated that monoclonal antibody 12G1 can directly detect citrullinated proteins in rheumatoid arthritis (RA) target tissue and sera, indicating its potential in arthritis induction. 12G1 may be useful for diagnosing RA, including seronegative RA, and could help to understand the pathophysiological role of citrullination in RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Lisha Ma, Wensheng Wang, Lisha Li, Ying Chen, Binxuan Chen, Miaoli Shao, Yongjun Cheng, Renfang Zhou
Summary: This study evaluated a novel fully automated immunoturbidimetric assay for the detection of anti-CCP antibodies and compared it with the conventional ELISA method. The results showed that the four anti-CCP assays provided similar diagnostic information for rheumatoid arthritis (RA), with Qiangsheng's method being potentially more useful for large scale clinical screening due to its shorter testing time.
FRONTIERS IN IMMUNOLOGY
(2022)