Article
Medicine, Research & Experimental
Patricia Ruiz-Limon, Natalia Mena-Vazquez, Isabel Moreno-Indias, Sara Manrique-Arija, Jose Manuel Lisbona-Montanez, Laura Cano-Garcia, Francisco J. Tinahones, Antonio Fernandez-Nebro
Summary: This study analyzed the gut microbiota of patients with rheumatoid arthritis (RA) according to disease activity. The results showed differences in gut microbiota between patients with moderate/high activity RA, patients with remission/low activity, and controls. The genus Collinsella, age, obesity, and physical function were found to be associated with cumulative inflammatory burden in RA.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Peripheral Vascular Disease
Takeko Kawabata, Takuro Kubozono, Satoko Ojima, Shin Kawasoe, Yuichi Akasaki, Anwar Ahmed Salim, Yoshiyuki Ikeda, Masaaki Miyata, Toshihiro Takenaka, Mitsuru Ohishi
Summary: This study investigated the relationship between blood pressure control status with or without antihypertensive drugs and arterial stiffness. The researchers found that even with antihypertensive drugs, poor blood pressure control is independently associated with increased arterial stiffness.
HYPERTENSION RESEARCH
(2022)
Review
Medicine, General & Internal
Ivan Giovannini, Alen Zabotti, Carmelo Ciccio, Matteo Salgarello, Lorenzo Cereser, Salvatore De Vita, Ilaria Tinazzi
Summary: The frequent involvement of the spine and sacroiliac joint in Psoriatic Arthritis (PsA) has led to its classification within the Spondyloarthritis group, although a clear distinction between PsA and Spondyloarthritis remains challenging. Axial involvement, ranging from 25 to 70% in PsA patients, must be taken into consideration alongside peripheral involvement for disease management. The lack of consensus in defining axial involvement in PsA has led to varying interpretations over the years, highlighting a need for improved clinical and radiological assessment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Holly R. Harris, Karen Moreno Nascimento Korkes, Tricia Li, Marina Kvaskoff, Eunyoung Cho, Luiz Fernando Carvalho, Abrar A. Qureshi, Mauricio Abrao, Stacey A. Missmer
Summary: A bidirectional association between endometriosis and psoriasis with PsA was found in this study. Psoriasis with concomitant PsA was associated with a higher risk of laparoscopically confirmed endometriosis, while the diagnosis of endometriosis was suggestive of subsequent risk of psoriasis with PsA.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Rheumatology
Kurt de Vlam, Serge Steinfeld, Adrien Nzeusseu Toukap, Filip van den Bosch, Rik Joos, Piet Geysens, Hermine Leroi, Rik Lories
Summary: The study revealed that a majority of psoriatic arthritis patients have both peripheral and axial involvement, with hip involvement also being common. Despite the availability of various treatment options, including biologics, a significant number of patients still experience active disease and high disease burden.
Article
Medicine, General & Internal
Gizem Ayan, Abdurrahman Sadic, Levent Kilic, Umut Kalyoncu
Summary: This study aimed to analyze the distribution of osteoproliferative lesions on the lumbar spine and their relations in patients with psoriatic arthritis under drug therapy. Osteophytes were the most frequently detected lesions, mostly found in the L2-L4 region. Syndesmophytes were present in one fourth of patients, and approximately 5% of patients had ambiguous lesions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yu-Tsung Chou, Hung-Yu Chen, Wei-Chen Shen, I-Hsuan Wu, Fei-Lin Su, Wen-Huang Lee, Hung-Lung Hsu, Jui-Ting Tai, Chung-Yi Li, Ting-Hsing Chao
Summary: High blood pressure indices are positively associated with arterial stiffness, and in normotensive individuals, systolic blood pressure and mean arterial pressure exhibit a more prominent relationship with arterial stiffness.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Rheumatology
Sayam Dubash, Oras A. Alabas, Xabier Michelena, Leticia Garcia-Montoya, Richard J. Wakefield, Philip S. Helliwell, Paul Emery, Dennis G. McGonagle, Ai Lyn Tan, Helena Marzo-Ortega
Summary: Dactylitis in DMARD-naive early psoriatic arthritis signifies a more severe disease phenotype independently associated with increased disease burden, presenting with greater tender and swollen joint counts, C reactive protein levels, and more prevalent ultrasound-detected synovitis and bone erosions.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Peripheral Vascular Disease
Xue Tian, Yingting Zuo, Shuohua Chen, Yijun Zhang, Xiaoli Zhang, Qin Xu, Shouling Wu, Anxin Wang
Summary: This study investigated the association between different blood pressure and arterial stiffness status with diabetes. The results showed that both hypertension and arterial stiffness were associated with diabetes. Additionally, arterial stiffness had a better predictive ability for diabetes than hypertension.
Article
Medicine, Research & Experimental
M. Ruiz-Ponce, L. Cuesta-Lopez, M. D. Lopez-Montilla, C. Perez-Sanchez, P. Ortiz-Buitrago, A. Barranco, M. D. Gahete, N. Herman-Sanchez, A. J. Lucendo, P. Navarro, Ch Lopez-Pedrera, A. Escudero-Contreras, E. Collantes-Estevez, C. Lopez-Medina, I. Arias-de la Rosa, N. Barbarroja
Summary: This study identifies the complex link between liver disease risk, comorbidities, and disease-specific features in Psoriatic Arthritis (PsA) patients. Methotrexate dose in PsA patients had no significant effect on liver parameters, confirmed by hepatocyte in vitro studies. Anti-PDE-4 and anti-JAK therapies show promise in reducing PsA serum-induced hepatocyte activation, potentially aiding liver complication management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Isaac T. Cheng, Huan Meng, Martin Li, Edmund K. Li, Priscilla C. Wong, Jack Lee, Bryan P. Yan, Alex P. W. Lee, Ho So, Lai-Shan Tam
Summary: This study found an association between serum calprotectin level and the presence of carotid plaque in patients with PsA. The levels of Ln-calprotectin and PsA disease duration were identified as predictors for CP presence. Further studies are needed to confirm the connection between this pathway and CV events in PsA.
FRONTIERS IN MEDICINE
(2022)
Article
Peripheral Vascular Disease
Philippe Gosse, Romain Boulestreau, Julien Doublet, Stephane Laurent, Antoine Cremer
Summary: Arterial stiffness is a key predictor of cardiovascular events and has two components: one related to the blood pressure at the time of measurement, and the other related to the long-term effects of cardiovascular risk factors, including blood pressure. This study aims to investigate the relationship between QKD(100-60), an index of arterial stiffness, and 24-hour blood pressure in different groups of patients. The results show that QKD(100-60) is independent of 24-hour blood pressure in normal and treated hypertensive patients, but weakly related to it in untreated hypertensive patients with long-term arterial damage caused by high blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Review
Medicine, General & Internal
Alfred Yu Ting Chia, Gladys Wei Xin Ang, Anita Sook Yee Chan, Webber Chan, Timothy Kit Yeong Chong, Ying Ying Leung
Summary: Psoriatic arthritis is a chronic inflammatory disease often associated with psoriasis and joint manifestations. While advancements have been made in understanding the disease and developing new treatments, the diverse comorbidities of PsA continue to present a clinical challenge in patient management.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Derya Kilic, Tolga Guler, Cihan Sevgican, Cihan Kabukcu, Ipek Buber, Mehmet Kilinc, Muhammet Arslan, Erkut Attar, Ismail D. Kilic
Summary: Women with endometriosis showed increased arterial stiffness measured by CAVI, along with higher levels of C-reactive protein. However, other cardiovascular indicators were similar between the endometriosis group and controls. Clinicians should be aware of the potential cardiovascular risks in patients with endometriosis.
KARDIOLOGIA POLSKA
(2021)
Review
Biochemistry & Molecular Biology
Andrea Picchianti-Diamanti, Francesca Romana Spinelli, Maria Manuela Rosado, Fabrizio Conti, Bruno Lagana
Summary: Phosphodiesterases (PDEs) are a diverse family of enzymes that regulate intracellular second messengers, with PDE4 being the most studied isoenzyme known for its role in down-regulating inflammatory responses. Inhibition of PDE4 can increase levels of cAMP, leading to decreased expression of inflammatory factors and increased regulatory cytokines, making it a potential therapeutic target for chronic inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Rheumatology
Dafna D. Gladman, Philip J. Mease, Paul Bird, Enrique R. Soriano, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Cinty Gong, Evan Leibowitz, Denis Poddubnyy, Lai-Shan Tam, Philip S. Helliwell, Arthur Kavanaugh, Atul A. Deodhar, Mikkel Ostergaard, Xenofon Baraliakos
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Philip J. Mease, Iain B. McInnes, Lai-Shan Tam, Raji Rajalingam, Steve Peterson, Fareen Hassan, Soumya D. Chakravarty, Christine Contre, Alison Armstrong, Wolf-Henning Boehncke, Christopher Ritchlin
Summary: The objective of this study was to update the network meta-analysis (NMA) comparing guselkumab with other targeted therapies for PsA. The results showed that guselkumab demonstrated better skin efficacy than most other PsA treatments and had comparable ACR responses to most agents.
Editorial Material
Rheumatology
Pei-En Kao, Yung-Heng Lee, Kevin Sheng-Kai Ma, Amy Ker, Ying-Ying Leung
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Immunology
Margaret Ma, Amelia Santosa, Warren Fong, Li-Ching Chew, Andrea H. L. Low, Annie Law, Yih Jia Poh, Siaw Ing Yeo, Ying Ying Leung, Victoria W. W. Ng, Joshua Z. E. Koh, Sen Hee Tay, Anselm Mak, Gim Gee Teng, Chuanhui Xu, Johnston G. X. Tang, Kok Ooi Kong, Stanley Angkodjojo, Wei-Rui Goh, Tyng Yu Chuah, Nur Emillia Roslan, Thaschawee Arkachaisri, Kai Liang Teh, Melonie Sriranganathan, Teck Choon Tan, Kee Fong Phang, Qai Ven Yap, Yiong Huak Chan, Peter P. M. Cheung, Manjari Lahiri
Summary: A national retrospective cohort study found a moderately high rate of flares of autoimmune inflammatory rheumatic diseases (AIIRD) after COVID-19 mRNA vaccination, but also improvement in several patients. Severe flares and hospitalization were rare. Thus, vaccination remains safe and highly recommended.
JOURNAL OF AUTOIMMUNITY
(2023)
Correction
Rheumatology
Ying-Ying Leung, Tatiana Korotaeva, Liliana Candia, Susanne Juhl Pedersen, Wilson Bautista Molano, Eric M. Ruderman, Radjesh Bisoendial, Rodolfo Perez-Alamino, Wendy Olsder, Burkhard Moller, Simeon Grazio, Tania Gudu, Girish M. Mody, Carlos Pineda, Helena Raffayova, Sherry Rohekar, Claudia Goldenstein-Schainberg, Sergio R. Gutierrez Urena, Julio Cesar Casasola Vargas, Bhowmik Meghnathi, Roopa Prasad, Pascal Richette, Jose Roberto S. Miranda, Nikolas Malliotis, Ulla Lind-Qvist, David Simon, Amara Ezeonyeji, Enrique R. Soriano, Oliver FitzGerald
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Nutrition & Dietetics
Yingzhao Jin, Ho So, Ester Cerin, Anthony Barnett, Sumaira Mubarik, Kamal Hezam, Xiaoqi Feng, Ziyue Wang, Junjie Huang, Chenwen Zhong, Khezar Hayat, Fang Wang, Ai-Min Wu, Suowen Xu, Zhiyong Zou, Lee-Ling Lim, Jiao Cai, Yimeng Song, Lai-shan Tam, Dongze Wu
Summary: The disease burden attributable to metabolic risk factors is rapidly increasing in China, especially in older people. This study estimated the pattern and trend of six metabolic risk factors in China from 1990 to 2019, and compared the disease burden among G20 countries. The results showed that population aging continuously accelerates the metabolic risk factor driven disease burden in China.
FRONTIERS IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Lin-Hong Shi, Steven H. H. Lam, Ho So, Crystal Y. Y. Chan, Tena K. K. Li, Cheuk-Chun Szeto, Lai-Shan Tam
Summary: This study found that patients with axial spondyloarthritis (axSpA) have a higher risk of cardiovascular disease, particularly hypertension. Through adjusting for traditional cardiovascular risk factors, the study determined that longer disease duration, delayed diagnosis, and higher ESR levels are independent predictors associated with the development of hypertension. These findings highlight the importance of routine hypertension screening in axSpA patients.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Engineering, Biomedical
Xuechen Zhang, Isaac Cheng, Shaojun Liu, Chenrui Li, Jing-Hao Xue, Lai-Shan Tam, Weichuan Yu
Summary: This paper presents an automatic erosion detection method based on HR-pQCT images, which includes constructing a closed cortical surface and analyzing curvature information to detect erosions. The results show that the proposed method achieves satisfactory and consistent performance compared to annotations provided by medical experts.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2023)
Article
Rheumatology
Marlene Sousa, Ennio Lubrano, Josef S. Smolen, Clemence Gorlier, Maarten de Wit, Laura C. Coates, Umut Kalyoncu, Adeline Ruyssen-Witrand, Ying-Ying Leung, Rossana Scrivo, Juan D. Canete, Penelope Palominos, Sandra Meisalu, Andra Balanescu, Uta Kiltz, Sibel Zehra Aydin, Inna Gaydukova, Emmanuelle Dernis, Bruno Fautrel, Ana-Maria Orbai, Laure Gossec
Summary: This study aimed to explore patient-defined flares in psoriatic arthritis (PsA) and compare them to an increase in disease activity in psoriatic arthritis (DAPSA). The validity of a patient-reported flare question was also analyzed. The results showed that patient-reported flares were associated with disease activity and symptoms, and there was moderate agreement between patient and physician definitions of worsening.
Editorial Material
Rheumatology
Ying-Ying Leung, Arthur Kavanaugh, Christopher T. Ritchlin
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Ho So, Tsz On Lam, Huan Meng, Steven Ho Man Lam, Lai-Shan Tam
Summary: The use of glucocorticoids (GC) increases the risk of cardiovascular events (CVE) in rheumatoid arthritis (RA) patients, but there is controversy regarding the threshold dose and duration of GC use that will increase the CVE rate. This study found that a daily prednisolone dose ≥5 mg significantly increased the risk of CVE, while a daily dose below 5 mg was not associated with CVE risk.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Xiujuan Hou, Yung-Heng Lee, Tangliang Qian, Connie Chen, Lai-Shan Tam
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ling Xiang, Sungwon Yoon, Andrea H. L. Low, Ying Ying Leung, Warren Fong, Tang Ching Lau, Dow Rhoon Koh, Julian Thumboo
Summary: This study explores the applicability of social cognitive theory (SCT) in improving symptom appraisal and help-seeking among patients with autoimmune rheumatic diseases (ARDs). Semi-structured interviews were conducted with 33 ARD patients and the transcripts were coded using SCT as the framework. The study found that behavioral capacity and self-efficacy were lacking in symptom interpretation, leading to delayed help-seeking. Possible approaches to address this include education to improve behavioral capacity and self-efficacy and enhance expectations, observational learning, reinforcements, and reciprocal determinism.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Warren Fong, Ting Hui Woon, Li-Ching Chew, Andrea Low, Annie Law, Yih Jia Poh, Siaw Ing Yeo, Ying Ying Leung, Margaret Ma, Amelia Santosa, Kok Ooi Kong, Chuanhui Xu, Gim Gee Teng, Anselm Mak, Sen Hee Tay, Tyng Yu Chuah, Nur Emillia Roslan, Stanley Angkodjojo, Kee Fong Phang, Melonie Sriranganathan, Teck Choon Tan, Peter Cheung, Manjari Lahiri
Summary: This study investigated the prevalence and factors associated with disease flares post COVID-19 mRNA vaccination in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and spondyloarthritis (SpA). The results showed that about one-fifth of patients experienced a disease flare after vaccination, but most flares were non-severe. Patients with active disease prior to vaccination, especially those with RA, should be closely monitored for disease flares.
ADVANCES IN RHEUMATOLOGY
(2023)
Article
Rheumatology
Ying Ying Leung, Lihi Eder, Ana-Maria Orbai, Laura C. Coates, Maarten de Wit, Josef S. Smolen, Uta Kiltz, Penelope Palominos, Juan D. Canete, Rossana Scrivo, Andra Balanescu, Emanuelle Dernis, Sandra Meisalu, Martin Soubrier, Umut Kalyoncu, Laure Gossec